The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections
Open accessAbstract
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties of the wall. We have only limited understanding, however, of the mechanobiological processes that lead to these potentially lethal conditions. Homeostasis requires that intramural cells sense their local chemomechanical environment and establish, maintain, remodel, or repair the extracellular matrix to provide suitable compliance and yet sufficient strength. Proper sensing, in turn, necessitates both receptors that connect the extracellular matrix to intracellular actomyosin filaments and signaling molecules that transmit the related information to the nucleus. Thoracic aortic aneurysms and dissections are associated with poorly controlled hypertension and mutations in genes for extracellular matrix constituents, membrane receptors, contractile proteins, and associated signaling molecules. This grouping of factors suggests that these thoracic diseases result, in part, from dysfunctional mechanosensing and mechanoregulation of the extracellular matrix by the intramural cells, which leads to a compromised structural integrity of the wall. Thus, improved understanding of the mechanobiology of aortic cells could lead to new therapeutic strategies for thoracic aortic aneurysms and dissections.
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Citations
Cites
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527
Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 1×
“Stress shielding is consistent with the dynamic nature of mechanosensing, namely, turnover of focal adhesion and cytoskeletal proteins within minutes.(105,111) That is, although true load-bearing must be sustained, mechanosensing can be intermittent, particularly given that adjustments via matrix turnover occur over p…”
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Extracellular Matrix Degradation and Remodeling in Development and Disease
Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005058 · Cited by 2,265
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924
Dynamic molecular processes mediate cellular mechanotransduction
Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956
Self-citationIntegrins and Extracellular Matrix in Mechanotransduction
Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662
Self-citationCross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix
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Angiotensin II Activates Collagen I Gene Through a Mechanism Involving the MAP/ER Kinase Pathway
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Cited by
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ
Czerny, M., Grabenwöger, M., Berger, T., Aboyans, V., Della Corte, A., Chen, E. P., Desai, N. D., Dumfarth, J., Elefteriades, J. A., Etz, C. D., et al. (2024) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezad426 · Cited by 412
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Metadata
- Authors
- Humphrey, J. D., Schwartz, M. A., Tellides, G., & Milewicz, D. M.
- Venue
- Circulation Research
- Published
- 2015-04-10
- Volume
- 116
- Issue
- 8
- Pages
- 1448-1461
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2078956491
- Cited by
- 403
- References
- 11
- FWCI
- 14.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Humphrey, J. D., Schwartz, M. A., Tellides, G., & Milewicz, D. M. (2015). Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections. Circulation Research. https://doi.org/10.1161/circresaha.114.304936
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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