The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Use of Mesenchymal Stem Cells for Therapy of Cardiac Disease
Open accessAbstract
Despite substantial clinical advances over the past 65 years, cardiovascular disease remains the leading cause of death in America. The past 15 years has witnessed major basic and translational interest in the use of stem and precursor cells as a therapeutic agent for chronically injured organs. Among the cell types under investigation, adult mesenchymal stem cells are widely studied, and in early stage, clinical studies show promise for repair and regeneration of cardiac tissues. The ability of mesenchymal stem cells to differentiate into mesoderm- and nonmesoderm-derived tissues, their immunomodulatory effects, their availability, and their key role in maintaining and replenishing endogenous stem cell niches have rendered them one of the most heavily investigated and clinically tested type of stem cell. Accumulating data from preclinical and early phase clinical trials document their safety when delivered as either autologous or allogeneic forms in a range of cardiovascular diseases, but also importantly define parameters of clinical efficacy that justify further investigation in larger clinical trials. Here, we review the biology of mesenchymal stem cells, their interaction with endogenous molecular and cellular pathways, and their modulation of immune responses. Additionally, we discuss factors that enhance their proliferative and regenerative ability and factors that may hinder their effectiveness in the clinical setting.
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Citations
Cites
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BackgroundAdult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
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Cited by
Biological functions of mesenchymal stem cells and clinical implications
Naji, A., Eitoku, M., Favier, B., Deschaseaux, F., Rouas-Freiss, N., & Suganuma, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03125-1 · Cited by 624
Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Cardiomyocyte Regeneration: A Consensus Statement
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Self-citationMesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
Wu, X., Jiang, J., Gu, Z., Zhang, J., Chen, Y., & Liu, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01855-9 · Cited by 343
Metadata
- Authors
- Karantalis, V., & Hare, J. M.
- Venue
- Circulation Research
- Published
- 2015-04-10
- Volume
- 116
- Issue
- 8
- Pages
- 1413-1430
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2054238236
- Cited by
- 425
- References
- 169
- FWCI
- 30.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
