Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
Open accessAbstract
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and regenerative potentials. Preclinical studies and clinical trials have demonstrated promising therapeutic results although these have been somewhat limited. Aspects such as low in vivo MSC survival in inhospitable disease microenvironments, requirements for ex vivo cell overexpansion prior to infusions, intrinsic differences between MSC and different sources and donors, variability of culturing protocols, and potency assays to evaluate MSC products have been described as limitations in the field. In recent years, priming approaches to empower MSC have been investigated, thereby generating cellular products with improved potential for different clinical applications. Herein, we review the current priming approaches that aim to increase MSC therapeutic efficacy. Priming with cytokines and growth factors, hypoxia, pharmacological drugs, biomaterials, and different culture conditions, as well as other diverse molecules, are revised from current and future perspectives.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The immunoregulatory role of MSCs is stimulated in the presence of one or more cytokines, such as IFN-γ, IL-1α, IL-1β or TNF-α, all released by macrophages.
“The immunoregulatory role of MSCs was shown to be stimulated in the presence of one or more cytokines, such as IFN-γ, IL-1α, IL-1β or TNF-α, all released by macrophages [133], [134], [135].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [134]
The Background and cytokine-priming sections (page unavailable) report enhanced MSC immunomodulatory activity after exposure to IFN-γ, TNF-α, IL-1β, and, in one priming study, IL-1α. The copy does not say that macrophages release all four cytokines; its macrophage passages instead describe macrophages arising or changing in response to primed MSCs. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPriming is induced by cytokines, chemokines, growth factors, lipid-derived signalling molecules and physical cell-cell contact and adhesion.
“Priming is induced by cytokines, chemokines, growth factors, lipid-derived signalling molecules and physical cell–cell contact and adhesion [217].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [217]
Priming occurs at almost all levels of neutrophil function: adhesion, phagocytosis, cytokine secretion, leukotriene synthesis and degranulation.
“Priming occurs at almost all levels of neutrophil function: adhesion, phagocytosis, cytokine secretion, leukotriene synthesis and degranulation.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [217]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.052 · Cited by 3,791 · see citing works
Mesenchymal stem cells: immune evasive, not immune privileged
Ankrum, J. A., Ong, J. F., & Karp, J. M. (2014) · Nature Biotechnology · doi:10.1038/nbt.2816 · Cited by 1,537 · see citing works
Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238 · see citing works
Bianco, P., Cao, X., Frenette, P. S., Mao, J. J., Robey, P. G., Simmons, P. J., & Wang, C.-Y. (2013) · Nature Medicine · doi:10.1038/nm.3028 · Cited by 1,199 · see citing works
Amado, L. C., SALIARIS, A. P., Schuleri, K. H., John, M. S., Xie, J.-S., Cattaneo, S. M., Durand, D. J., Fitton, T. P., Kuang, J. Q., Stewart, G. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504388102 · Cited by 1,072 · see citing works
Indoleamine 2,3 dioxygenase and metabolic control of immune responses
Munn, D. H., & Mellor, A. L. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.10.001 · Cited by 1,037 · see citing works
Multipotent mesenchymal stromal cells and the innate immune system
Blanc, K. L., & Mougiakakos, D. (2012) · Nature reviews. Immunology · doi:10.1038/nri3209 · Cited by 1,019 · see citing works
Bartosh, T. J., Ylöstalo, J., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., Lee, R. H., Choi, H., & Prockop, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008117107 · Cited by 964 · see citing works
Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 758 · see citing works
François, M., Romieu, R., Li, M., & Galipeau, J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.189 · Cited by 694 · see citing works
How mesenchymal stem cells interact with tissue immune responses
Shi, Y., Su, J., Roberts, A. I., Shou, P., Rabson, A. B., & Ren, G. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.11.004 · Cited by 629 · see citing works
Galipeau, J., Krampera, M., Barrett, J., Dazzi, F., Deans, R., de Bruijn, J. D., Dominici, M., Fibbe, W. E., Gee, A. P., Gimble, J. M., et al. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.11.008 · Cited by 521 · see citing works
Nagaya, N., Fujii, T., Iwase, T., Ohgushi, H., Itoh, T., Uematsu, M., Yamagishi, M., Mori, H., Kangawa, K., & Kitamura, S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01071.2003 · Cited by 519 · see citing works
Fehrer, C., Brunauer, R., Laschober, G. T., Unterluggauer, H., Reitinger, S., Kloss, F. R., Gülly, C., Gassner, R. J., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498 · see citing works
Frith, J. E., Thomson, B. M., & Genever, P. G. (2009) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0432 · Cited by 478 · see citing works
Spheroid Culture of Mesenchymal Stem Cells
Cesarz, Z., & Tamama, K. (2016) · Stem Cells International · doi:10.1155/2016/9176357 · Cited by 475 · see citing works
Prasanna, S. J., Gopalakrishnan, D., Shankar, S. R., & Vasandan, A. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009016 · Cited by 468 · see citing works
Preconditioning influences mesenchymal stem cell properties in vitro and in vivo
Hu, C., & Li, L. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13492 · Cited by 444 · see citing works
Use of Mesenchymal Stem Cells for Therapy of Cardiac Disease
Karantalis, V., & Hare, J. M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303614 · Cited by 429 · see citing works
Kusuma, G. D., Carthew, J., Lim, R., & Frith, J. E. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0349 · Cited by 405 · see citing works
Rustad, K. C., Wong, V., Sorkin, M., Glotzbach, J. P., Major, M. R., Rajadas, J., Longaker, M. T., & Gurtner, G. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.041 · Cited by 401 · see citing works
Sart, S., Tsai, A., Li, Y., & Ma, T. (2013) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0537 · Cited by 382 · see citing works
González‐King, H., García, N. A., Ontoria‐Oviedo, I., Ciria, M., Montero, J., & Sepúlveda, P. (2017) · Stem Cells · doi:10.1002/stem.2618 · Cited by 353 · see citing works
Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges
Bagno, L., Hatzistergos, K. E., Balkan, W., & Hare, J. M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.009 · Cited by 342 · see citing works
Duijvestein, M., Wildenberg, M. E., Welling, M. M., Hennink, S. D., Molendijk, I., van Zuylen, V.-L., Bosse, T., Vos, A. C. W., de Jonge‐Muller, E. S. M., Roelofs, H., et al. (2011) · Stem Cells · doi:10.1002/stem.698 · Cited by 329 · see citing works
Chang, J., Liu, F., Lee, M., Wu, B. M., Ting, K., Zara, J., Soo, C., Hezaimi, K. A., Zou, W., Chen, X.-H., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1300532110 · Cited by 317 · see citing works
Tomé, M., López‐Romero, P., Albo, C., Sepúlveda, J. C., Fernández‐Gutiérrez, B., Dopazo, A., Bernad, A., & González, M. A. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.167 · Cited by 297 · see citing works
Estrada, J. C., Albo, C., Benguría, A., Dopazo, A., López-Romero, P., Carrera-Quintanar, L., Roche, E., Clemente, E. P., Enríquez, J. A., Bernad, A., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.172 · Cited by 297 · see citing works
Baldari, S., Rocco, G. D., Piccoli, M., Pozzobon, M., Muraca, M., & Toietta, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102087 · Cited by 281 · see citing works
Yu, J., Du, K. T., Fang, Q., Gu, Y., Mihardja, S. S., Sievers, R. E., Wu, J. C., & Lee, R. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.078 · Cited by 280 · see citing works
Huang, H., Kim, H. J., Chang, E.-J., Lee, Z. H., Hwang, S. J., Kim, H.-M., Lee, Y.-K., & Kim, H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.74 · Cited by 272 · see citing works
Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells
Najar, M., Raicevic, G., Fayyad‐Kazan, H., Bron, D., Toungouz, M., & Lagneaux, L. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2015.10.011 · Cited by 267 · see citing works
Chinnadurai, R., Copland, I. B., Patel, S. R., & Galipeau, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301828 · Cited by 266 · see citing works
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts
Fakhry, M. (2013) · World Journal of Stem Cells · doi:10.4252/wjsc.v5.i4.136 · Cited by 263 · see citing works
The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids
Petrenko, Y., Syková, E., & Kubinová, Š. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0558-6 · Cited by 246 · see citing works
Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells
Lavrentieva, A., Majore, I., Kasper, C., & Hass, R. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-18 · Cited by 241 · see citing works
Redondo‐Castro, E., Cunningham, C. J., Miller, J., Martuscelli, L., Sarah, A.-A., Rothwell, N. J., Kielty, C. M., Allan, S. M., & Pinteaux, E. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0531-4 · Cited by 239 · see citing works
Beegle, J. R., Lakatos, K., Kalomoiris, S., Stewart, H., Isseroff, R. R., Nolta, J. A., & Fierro, F. A. (2015) · Stem Cells · doi:10.1002/stem.1976 · Cited by 236 · see citing works
Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy
Haque, N., Rahman, M. T., Kasim, N. H. A., & Alabsi, A. M. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/632972 · Cited by 232 · see citing works
Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis
Lan, Y., Choo, K., Chen, C., Hung, T., Chen, Y.-B., Hsieh, C.-H., Kuo, H.-P., & Chong, K. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0081-6 · Cited by 232 · see citing works
Mesenchymal Stem Cells and Tissue Engineering
Marion, N. W., & Mao, J. J. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)20016-8 · Cited by 230 · see citing works
Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues
Nava, M. M., Raimondi, M. T., & Pietrabissa, R. (2012) · BioMed Research International · doi:10.1155/2012/797410 · Cited by 227 · see citing works
Salmon, J., Rat, A., Sellam, J., Michel, M., Eschard, J. P., Guillemin, F., Jolly, D., & Fautrel, B. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.03.012 · Cited by 226 · see citing works
Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis
Fan, H., Zhao, G., Liu, L., Liu, F., Gong, W., Liu, X., Yang, L., Wang, J., & Hou, Y. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.40 · Cited by 224 · see citing works
Mazhari, R., & Hare, J. M. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0770 · Cited by 210 · see citing works
Transplantation of Cord Blood Mesenchymal Stem Cells as Spheroids Enhances Vascularization
Bhang, S. H., Lee, S., Shin, J., Lee, T., & Kim, B. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0640 · Cited by 203 · see citing works
Cheng, N., Chen, S., Li, J., et al. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0007 · Cited by 201 · see citing works
Effects of high glucose on mesenchymal stem cell proliferation and differentiation
Li, Y., Schilling, T., Benisch, P., Zeck, S., Meißner-Weigl, J., Schneider, D., Limbert, C., Seufert, J., Kassem, M. S., Schütze, N., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.161 · Cited by 197 · see citing works
Mesenchymal Stromal Cells and Tissue‐Specific Progenitor Cells: Their Role in Tissue Homeostasis
Klimczak, A., & Kozłowska, U. (2015) · Stem Cells International · doi:10.1155/2016/4285215 · Cited by 196 · see citing works
Interleukin-17 enhances immunosuppression by mesenchymal stem cells
Han, X., Yang, Q., Lin, L., Xu, C., Zheng, C., Chen, X., Han, Y., Li, M., Cao, W., Cao, K., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.85 · Cited by 189 · see citing works
Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing
Chen, S., Shi, J., Zhang, M., et al. (2015) · Scientific Reports · doi:10.1038/srep18104 · Cited by 188 · see citing works
IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB
Carrero, R., Cerrada, I., Lledó, E., Dopazo, J., Garcia‐García, F., Rubio, M., Trigueros, C., Dorronsoro, A., Ruiz‐Saurí, A., Montero, J., et al. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9364-9 · Cited by 184 · see citing works
Leroux, L., Descamps, B., Tojais, N. F., Séguy, B., Oses, P., Moreau, C., Daret, D., Ivanović, Z., Boiron, J.-M., Lamazière, J. D., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.108 · Cited by 183 · see citing works
Role of Mechanical Factors in Fate Decisions of Stem Cells
Li, D., Zhou, J., Chowdhury, F., Cheng, J., Wang, N., & Wang, F. (2011) · Regenerative Medicine · doi:10.2217/rme.11.2 · Cited by 181 · see citing works
Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response
Saparov, A., Ogay, V. B., Nurgozhin, T. S., Jumabay, M., & Chen, W. C. W. (2016) · Stem Cells International · doi:10.1155/2016/3924858 · Cited by 170 · see citing works
Chinnadurai, R., Copland, I. B., Garcia, M. A., Petersen, C. T., Lewis, C. N., Waller, E. K., Kirk, A. D., & Galipeau, J. (2016) · Stem Cells · doi:10.1002/stem.2415 · Cited by 169 · see citing works
Zhang, Z., Teoh, S., Hui, J. H. P., Fisk, N. M., Choolani, M. A., & Chan, J. K. Y. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.025 · Cited by 156 · see citing works
Wang, Q., Yang, Q., Wang, Z., Tong, H., Ma, L., Zhang, Y., Shan, F., Meng, Y., & Yuan, Z. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1030549 · Cited by 154 · see citing works
Mesenchymal Stem Cells Inhibit Complement Activation by Secreting Factor H
Tu, Z., Li, Q., Bu, H., & Lin, F. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0418 · Cited by 149 · see citing works
Lee, J., Yoon, Y., & Lee, S. H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061320 · Cited by 145 · see citing works
Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization
Mizukami, A., & Swiech, K. (2018) · Stem Cells International · doi:10.1155/2018/4083921 · Cited by 142 · see citing works
Self-citationShuai, Y., Liao, L., Su, X., Yu, Y., Shao, B., Jing, H., Zhang, X., Deng, Z., & Jin, Y. (2016) · Theranostics · doi:10.7150/thno.15412 · Cited by 137 · see citing works
Shin, J. H., Shin, D. W., & Noh, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.008 · Cited by 133 · see citing works
Gorin, C., Rochefort, G. Y., Bascetin, R., Ying, H., Lesieur, J., Sadoine, J., Beckouche, N., Berndt, S., Novais, A., Lesage, M., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0166 · Cited by 132 · see citing works
Noone, C. M., Kihm, A. J., English, K., O’Dea, S., & Mahon, B. P. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0028 · Cited by 131 · see citing works
Najar, M., Raicevic, G., Fayyad‐Kazan, H., Bruyn, C. D., Bron, D., Toungouz, M., & Lagneaux, L. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9408-1 · Cited by 131 · see citing works
Wu, Y., Law, J. B. K., He, A. Y., Low, H. Y., Hui, J. H. P., Lim, C. T., Yang, Z., & Lee, E. H. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.04.002 · Cited by 128 · see citing works
Pourgholaminejad, A., Aghdami, N., Baharvand, H., & Moazzeni, S. M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.06.003 · Cited by 128 · see citing works
Sivanathan, K. N., Rojas‐Canales, D. M., Hope, C. M., Krishnan, R., Carroll, R. P., Gronthos, S., Grey, S. T., & Coates, P. T. H. (2015) · Stem Cells · doi:10.1002/stem.2075 · Cited by 127 · see citing works
Meng, Q., Man, Z., Dai, L., Huang, H., Zhang, X., Hu, X., Shao, Z., Zhu, J., Zhang, J., Fu, X., et al. (2015) · Scientific Reports · doi:10.1038/srep17802 · Cited by 118 · see citing works
Steinmetz, N. J., Aisenbrey, E. A., Westbrook, K. K., Qi, H. J., & Bryant, S. J. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.04.015 · Cited by 116 · see citing works
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., & Ekblond, A. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2015.0532 · Cited by 113 · see citing works
Bader, A. C., Klose, K., Bieback, K., Korinth, D., Schneider, M., Seifert, M., Choi, Y., Kurtz, A., Falk, V., & Stamm, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138477 · Cited by 111 · see citing works
Croes, M., Öner, F. C., Kruyt, M. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132781 · Cited by 110 · see citing works
Osteoarthritis in Young, Active, and Athletic Individuals
Amoako, A., & Pujalte, G. G. A. (2014) · Clinical Medicine Insights Arthritis and Musculoskeletal Disorders · doi:10.4137/cmamd.s14386 · Cited by 110 · see citing works
Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration
Zeitouni, S., Krause, U., Clough, B. H., Halderman, H., Falster, A. U., Blalock, D., Chaput, C. D., Sampson, H. W., & Gregory, C. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003396 · Cited by 109 · see citing works
Lin, T., Pajarinen, J., Nabeshima, A., Lu, L. Y., Nathan, K., Jämsen, E., Yao, Z., & Goodman, S. B. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0730-z · Cited by 109 · see citing works
Pourjafar, M., Saidijam, M., Mansouri, K., Ghasemibasir, H. R., Dermani, F. K., & Najafi, R. (2016) · Cell Proliferation · doi:10.1111/cpr.12315 · Cited by 105 · see citing works
Biomaterials and Mesenchymal Stem Cells for Regenerative Medicine
Zippel, N., Schulze, M., & Tobiasch, E. (2009) · Recent Patents on Biotechnology · doi:10.2174/187220810790069497 · Cited by 103 · see citing works
Toward Development of iMesenchymal Stem Cells for Immunomodulatory Therapy
de Witte, S. F. H., Franquesa, M., Baan, C. C., & Hoogduijn, M. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00648 · Cited by 103 · see citing works
Niemeyer, P., Krause, U., Fellenberg, J., Kasten, P., Seckinger, A., Ho, A. D., & Simank, H.-G. (2004) · Cells Tissues Organs · doi:10.1159/000079182 · Cited by 102 · see citing works
Liu, X., Wang, J., Ji, X., Yu, S. P., & Wei, L. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt499 · Cited by 102 · see citing works
Yang, H., Gu, Q., Huang, C., et al. (2012) · Pharmacognosy Magazine · doi:10.4103/0973-1296.99285 · Cited by 102 · see citing works
Insights into inflammatory priming of mesenchymal stromal cells: functional biological impacts
Najar, M., Krayem, M., Merimi, M., Burny, A., Meuleman, N., Bron, D., Raicevic, G., & Lagneaux, L. (2018) · Inflammation Research · doi:10.1007/s00011-018-1131-1 · Cited by 100 · see citing works
Introductory overview of purinergic signalling
Burnstock, G. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e298 · Cited by 98 · see citing works
Environmental physical cues determine the lineage specification of mesenchymal stem cells
Huang, C., Dai, J., & Zhang, X. A. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.02.011 · Cited by 96 · see citing works
Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells
Gao, W., Lin, M., Liang, A., Zhang, L., Chen, C., Liang, G., Xu, C., Peng, Y., Chen, C., Huang, D., et al. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12098 · Cited by 95 · see citing works
Ansari, S., Chen, C., Hasani‐Sadrabadi, M. M., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.07.017 · Cited by 95 · see citing works
Szabó, E. V., Fajka‐Boja, R., Kriston-Pál, É., Hornung, Á., Makra, I., Kudlik, G., Uher, F., Katona, R. L., Monostori, É., & Czibula, Á. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0581 · Cited by 92 · see citing works
Lee, S., Jung, Y. H., Oh, S. Y., Yun, S. P., & Han, H. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12179 · Cited by 87 · see citing works
Delivery of Mesenchymal Stem Cells in Chitosan/Collagen Microbeads for Orthopedic Tissue Repair
Wang, L., Rao, R. R., & Stegemann, J. P. (2013) · Cells Tissues Organs · doi:10.1159/000348359 · Cited by 85 · see citing works
Liu, J., Zhu, P., Song, P. K., et al. (2015) · Stem Cells International · doi:10.1155/2015/638153 · Cited by 83 · see citing works
Lee, S. C., Jeong, H. J., Lee, S. K., & Kim, S.-J. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0072-7 · Cited by 82 · see citing works
Mesenchymal stem cell-based tissue engineering strategies for repair of articular cartilage.
Ahmed, T. A., & Hincke, M. T. (2014) · PubMed · doi:10.14670/hh-29.669 · Cited by 80 · see citing works
Dubon, M. J., Yu, J., Choi, S., & Park, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25863 · Cited by 76 · see citing works
Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells
Gao, B., Gao, W., Wu, Z., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0892-3 · Cited by 76 · see citing works
Biomaterial–Mesenchymal Stem Cell Constructs for Immunomodulation in Composite Tissue Engineering
Hanson, S. E., D’Souza, R. N., & Hematti, P. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0359 · Cited by 75 · see citing works
Wu, Z., Qiu, X., Gao, B., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12483 · Cited by 74 · see citing works
Chen, X., Zhang, F., He, X., Xu, Y., Yang, Z., Chen, L., Zhou, S., Yang, Y., Zhou, Z., Sheng, W., et al. (2013) · Injury · doi:10.1016/j.injury.2012.09.024 · Cited by 73 · see citing works
A scaffold-free in vitro model for osteogenesis of human mesenchymal stem cells
Hildebrandt, C., Büth, H., & Thielecke, H. (2011) · Tissue and Cell · doi:10.1016/j.tice.2010.12.004 · Cited by 72 · see citing works
Bartosh, T. J., & Ylöstalo, J. (2014) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc02b06s28 · Cited by 71 · see citing works
Chen, W., Zhou, H., Weir, M. D., et al. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0172 · Cited by 71 · see citing works
Linares, G. R., Chiu, C., Scheuing, L., Leng, Y., Liao, H., Maric, D., & Chuang, D. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.003 · Cited by 69 · see citing works
Rey, S., Luo, W., Shimoda, L. A., & Semenza, G. L. (2011) · Blood · doi:10.1182/blood-2010-11-321190 · Cited by 68 · see citing works
Interleukin-17A increases leptin production in human bone marrow mesenchymal stem cells
Noh, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.010 · Cited by 68 · see citing works
Li, D., Liu, Q., Qi, L., Dai, X., Liu, H. L., & Wang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5416 · Cited by 67 · see citing works
Li, B., Li, C., Zhu, M., Zhang, Y., Du, J., Xu, Y., Liu, B., Gao, F., Liu, H., Cai, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485490 · Cited by 67 · see citing works
Wobma, H., Kanai, M., Ma, S. P., Shih, Y., Li, H. W., Duran‐Struuck, R., WINCHESTER, R. J., Goeta, S., Brown, L. M., & Vunjak‐Novakovic, G. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.01.001 · Cited by 66 · see citing works
Zhilai, Z., Biling, M., Sujun, Q., Chao, D., Benchao, S., Huang, S., Shun, Y., & Zhang, H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.025 · Cited by 65 · see citing works
Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells
Cong, X. X., Rao, X. S., Lin, J., Liu, X. C., Zhang, G. A., Gao, X. K., He, M. Y., Shen, W., Fan, W., Pioletti, D. P., et al. (2018) · Stem Cells · doi:10.1002/stem.2765 · Cited by 65 · see citing works
Interleukin-17A: A T-Cell-Derived Growth Factor for Murine and Human Mesenchymal Stem Cells
Huang, W., Russa, V. L., Alzoubi, A., & Schwarzenberger, P. O. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0156 · Cited by 63 · see citing works
Vigo, T., Procaccini, C., Ferrara, G. B., Baranzini, S. E., Oksenberg, J. R., Matarese, G., Diaspro, A., de Rosbo, N. K., & Uccelli, A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.004 · Cited by 62 · see citing works
Hypoxia Regulates the Therapeutic Potential of Mesenchymal Stem Cells Through Enhanced Autophagy
Liu, J., Hao, H., Huang, H., Tong, C., Ti, D., Dong, L., Chen, D., Zhao, Y., Liu, H., Han, W., et al. (2015) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734615573660 · Cited by 60 · see citing works
Chinnadurai, R., Rajan, D., Ng, S., McCullough, K., Arafat, D., Waller, E. K., Anderson, L. J., Gibson, G. C., & Galipeau, J. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017006205 · Cited by 60 · see citing works
Khan, M., Ali, F., Mohsin, S., Akhtar, S., Mehmood, A., Choudhery, M. S., Khan, S. N., & Riazuddin, S. A. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt207 · Cited by 57 · see citing works
Amati, E., Sella, S., Perbellini, O., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0465-2 · Cited by 57 · see citing works
Breyner, N. M., Hell, R. C. R., de Carvalho, L. R. P., et al. (2009) · Cells Tissues Organs · doi:10.1159/000231472 · Cited by 56 · see citing works
Kang, H.-S., Kim, K.-H., Lim, J., Kim, Y., Heo, J., Choi, J.-J., Jeong, J., Kim, Y., Kim, S. W., Oh, Y., et al. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0496 · Cited by 55 · see citing works
Costa, V., Raimondi, L., Conigliaro, A., Salamanna, F., Carina, V., Luca, A. D., Bellavia, D., Alessandro, R., Fini, M., & Giavaresi, G. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.09.007 · Cited by 55 · see citing works
D’Alimonte, I., Nargi, E., Lannutti, A., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.04.002 · Cited by 53 · see citing works
Tsai, T.-L., Manner, P. A., & Li, W. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.11.001 · Cited by 53 · see citing works
IL-17 Inhibits Chondrogenic Differentiation of Human Mesenchymal Stem Cells
Kondo, M., Yamaoka, K., Sonomoto, K., Fukuyo, S., Oshita, K., Okada, Y., & Tanaka, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079463 · Cited by 53 · see citing works
Rashed, L. A., Elattar, S., el Tablawy, N. M., Ashour, H., Mahmoud, L. M., & El-Esawy, Y. (2018) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0230 · Cited by 52 · see citing works
Strategies to retain properties of bone marrow–derived mesenchymal stem cellsex vivo
Zhou, Y., Tsai, T., & Li, W. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13451 · Cited by 51 · see citing works
Wang, B., Lin, Y., Hu, Y., Wei, S., Liu, S., Xu, Y., Zhang, H., Cai, S., Yu, X., Cai, Z., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0744-6 · Cited by 51 · see citing works
A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells
Levy, O., Mortensen, L. J., Boquet, G., Tong, Z., Perrault, C., Benhamou, B., Zhang, J., Stratton, T., Han, E., Safaee, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.057 · Cited by 50 · see citing works
Liu, X., Chen, H., Chen, H., Zhu, M., Hu, X., Wang, Y., Jiang, Z., Xu, Y., Xiang, M., & Wang, J. (2012) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1201004 · Cited by 49 · see citing works
Briggs, T., Treiser, M. D., Holmes, P. F., Kohn, J., Moghe, P. V., & Arinzeh, T. L. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32310 · Cited by 46 · see citing works
Hypoxia primed placental mesenchymal stem cells for wound healing
Mathew, S. A., Chandravanshi, B., & Bhonde, R. R. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.016 · Cited by 45 · see citing works
Restoration of angiogenic capacity of diabetes-insulted mesenchymal stem cells by oxytocin
Kim, Y. S., Kwon, J. S., Hong, M. H., Kang, W. S., Jeong, H.-Y., Kang, H., Jeong, M. H., & Ahn, Y. (2013) · BMC Cell Biology · doi:10.1186/1471-2121-14-38 · Cited by 44 · see citing works
Khan, I., Ali, A., Akhter, M. A., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.08.014 · Cited by 44 · see citing works
Fujisawa, K., Takami, T., Okada, S., Hara, K., Matsumoto, T., Yamamoto, N., Yamasaki, T., & Sakaida, I. (2018) · Stem Cells · doi:10.1002/stem.2826 · Cited by 43 · see citing works
Dong, L., Han, D. H., Fan, W., Zhang, R., Qiao, H., Fan, M., Su, T., Ma, S., Li, X., Chen, J., et al. (2016) · Scientific Reports · doi:10.1038/srep21914 · Cited by 43 · see citing works
Sivanathan, K. N., Rojas‐Canales, D. M., Grey, S. T., Gronthos, S., & Coates, P. T. H. (2017) · Stem Cells International · doi:10.1155/2017/1025820 · Cited by 41 · see citing works
Sun, X., Su, W., Ma, X., et al. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbx018 · Cited by 41 · see citing works
Mojsilović, S. B., Jauković, A., Santibanez, J. F., & Bugarski, D. S. (2015) · Mediators of Inflammation · doi:10.1155/2015/470458 · Cited by 37 · see citing works
Huang, Z., Nooeaid, P., Kohl, B., Roether, J. A., Schubert, D. W., Meier, C., Boccaccini, A. R., Godkin, O., Ertel, W., Arens, S., et al. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.01.082 · Cited by 37 · see citing works
Gonzalez, Y. I. R., Lynch, P. J., Thompson, E. E., Stultz, B. G., & Hursh, D. A. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.05.017 · Cited by 37 · see citing works
Yang, Z., Concannon, J. B., Ng, K. S., Seyb, K. I., Mortensen, L. J., Ranganath, S. H., Gu, F., Levy, O., Tong, Z., Martyn, K., et al. (2016) · Scientific Reports · doi:10.1038/srep30263 · Cited by 37 · see citing works
D’Alimonte, I., Mastrangelo, F., Giuliani, P., et al. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0190 · Cited by 36 · see citing works
Guan, Q., Ezzati, P., Spicer, V., Krokhin, O. V., Wall, D. A., & Wilkins, J. A. (2017) · Clinical Proteomics · doi:10.1186/s12014-017-9161-1 · Cited by 36 · see citing works
Lee, S., & Joe, Y. A. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.086 · Cited by 35 · see citing works
Lavrentieva, A. V., Hoffmann, A., & Lee‐Thedieck, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00316 · Cited by 35 · see citing works
IFN‐gamma priming of adipose‐derived stromal cells at “physiological” hypoxia
Andreeva, E. R., Udartseva, O. O., Zhidkova, O. V., Валентинович, Б. С., Ездакова, М. И., & Buravkova, L. B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26046 · Cited by 34 · see citing works
Dvořáková, J., Kučera, L., Kučera, J., Švík, K., Foglarová, M., Muthný, T., Pravda, M., Němcová, M., Velebný, V., & Kubala, L. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35033 · Cited by 33 · see citing works
LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells
Bravo, M. O., Sangiorgi, B., Schiavinato, J. L. D. S., Carvalho, J. L., Covas, D. T., Panepucci, R. A., Neves, F. D. A. R., Franco, O. L., Pereira, R. W., & Saldanha‐Araújo, F. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0448-3 · Cited by 33 · see citing works
Self-citationValproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells
Lim, J., Lee, S., Ju, H., Kim, Y., Heo, J., Lee, H. Y., Choi, K., Son, J., Oh, Y., Kim, I. G., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3053 · Cited by 33 · see citing works
Long-Term Outcome of Stem Cell Therapy for Acute Myocardial Infarction
Forrester, J. S., Makkar, R., & Marbán, E. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.023 · Cited by 32 · see citing works
Hou, J., Zhong, T., Guo, T., et al. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.01.015 · Cited by 32 · see citing works
IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation
Mojsilović, S., Krstić, J., Ilić, V. L., et al. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1284-5 · Cited by 30 · see citing works
‘Primed’ Mesenchymal Stem Cells: a Potential Novel Therapeutic for COVID19 Patients
Raza, S. S., Seth, P., & Khan, M. A. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09999-0 · Cited by 28 · see citing works
Betous, R., Renoud, M.-L., Hoede, C., González, I., Jones, N. B., Longy, M., Sensebé, L., Cazaux, C., & Hoffmann, J. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0401 · Cited by 27 · see citing works
Prospects of the Use of Cell Therapy to Induce Immune Tolerance
Wang, Z., Liu, X., Cao, F., Bellanti, J. A., Zhou, J., & Zheng, S. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00792 · Cited by 27 · see citing works
Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells
Sun, Y., Li, Q., Jia, Y., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430300 · Cited by 26 · see citing works
Burand, A. J., Gramlich, O. W., Brown, A. J., & Ankrum, J. A. (2016) · Stem Cells · doi:10.1002/stem.2528 · Cited by 25 · see citing works
Moreira, F., Mizukami, A., de Souza, L. E. B., Cabral, J. M. S., da Silva, C. L., Covas, D. T., & Swiech, K. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00307 · Cited by 24 · see citing works
Self-citationSangiorgi, B., de Freitas, H. T., Schiavinato, J. L. D. S., Leão, V., Haddad, R., Orellana, M. D., Faça, V. M., Ferreira, G. A., Covas, D. T., Zago, M. A., et al. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.04.004 · Cited by 23 · see citing works
Self-citationFayyad‐Kazan, H., Fayyad‐Kazan, M., Badran, B. M., Bron, D., Lagneaux, L., & Najar, M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1106-3 · Cited by 18 · see citing works
Deng, L., Wang, P., Li, Y., et al. (2015) · Stem Cells International · doi:10.1155/2015/484528 · Cited by 17 · see citing works
Activation of p70S6 Kinase-1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair
Takeda, K., Ning, F., Domenico, J. M., Okamoto, M., Ashino, S., Kim, S., Jeong, Y. Y., Shiraishi, Y., Terada, N., Sutherland, E. R., et al. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0200 · Cited by 17 · see citing works
Loganathan, A., Linley, J. E., Rajput, I., et al. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00472.2009 · Cited by 16 · see citing works
Fayyad‐Kazan, M., Najar, M., Fayyad‐Kazan, H., et al. (2017) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.903518 · Cited by 16 · see citing works
Tan, L., Zhao, B., Ge, F.-T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14875-y · Cited by 16 · see citing works
Xu, R., Chen, W., Zhang, Z., Qiu, Y., Wang, Y., Zhang, B., & Lü, W. (2018) · Gene · doi:10.1016/j.gene.2018.03.010 · Cited by 11 · see citing works
Galipeau, J. (2016) · Stem Cells · doi:10.1002/stem.2526 · Cited by 10 · see citing works
Dihydrotestosterone induces pro-angiogenic factors and assists homing of MSC into the cardiac tissue
Popa, M. A., Mihai, M. C., Constantin, A. L., Șuică, V. I., Ţucureanu, C., Costache, R. S., Antohe, F., Dubey, R. K., & Simionescu, M. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0185 · Cited by 9 · see citing works
Promising Scaffold-Free Approaches in Translational Dentistry
Tatullo, M., Marrelli, B., Palmieri, F., Amantea, M., Nuzzolese, M., Valletta, R., Zavan, B., & Vito, D. D. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17093001 · Cited by 9 · see citing works
Najar, M., Raicevic, G., Fayyad‐Kazan, H., et al. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9415-2 · Cited by 8 · see citing works
Hanken, H., Alpers, J., Böbel, M., et al. (2015) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Modulation of the Inflammatory Response and Bone Healing
Maruyama, M., Rhee, C., Utsunomiya, T., Zhang, N., Ueno, M., Yao, Z., & Goodman, S. B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00386 · Cited by 541 · see citing works
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 205 · see citing works
Park, B.-W., Jung, S.-H., Das, S., Lee, S. M., Park, J.-H., Kim, H., Hwang, J.-W., Lee, S., Kim, H.-J., Kim, H.-Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay6994 · Cited by 133 · see citing works
MSC-Exos: important active factor of bone regeneration
Ren, S., Lin, Y., Liu, W., Yang, L., & Zhao, M. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1136453 · Cited by 37 · see citing works
Brizio, M., Mancini, M., Lora, M., Joy, S., Zhu, S., Brilland, B., Reinhardt, D. P., Farge, D., Langlais, D., & Colmegna, I. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03916-9 · Cited by 13 · see citing works
- Authors
- Noronha, N. D. C., Mizukami, A., Caliári-Oliveira, C., Cominal, J. G., Rocha, J. L. M., Covas, D. T., Swiech, K., & Malmegrim, K. C. R.
- Affiliations
- Universidade de São Paulo (BR)
- SUPERA Park of Innovation and Technology of Ribeirão Preto (BR)
- Corresponding author
- Malmegrim, Kelen C. R.
- ORCID
- Venue
- Stem Cell Research & Therapy
- Published
- 2019-05-02
- Volume
- 10
- Issue
- 1
- Pages
- 131-131
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC6498654
- OpenAlex
- W2943031177
- Cited by
- 623
- References
- 170
- Citations by year
- 2026: 43 · 2025: 76 · 2024: 113 · 2023: 89 · 2022: 111 · 2021: 111 · 2020: 71 · 2019: 8
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-05-17)
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (No. 2013/08135-2)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, cell priming, cell therapy, immunomodulation, immunosuppression, cytokines and growth factors, hypoxia, biomaterials, culture conditions, donor variability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
