The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Role of Lymphocytes in Myocardial Injury, Healing, and Remodeling After Myocardial Infarction
Open accessAbstract
A large body of evidence produced during decades of research indicates that myocardial injury activates innate immunity. On the one hand, innate immunity both aggravates ischemic injury and impedes remodeling after myocardial infarction (MI). On the other hand, innate immunity activation contributes to myocardial healing, as exemplified by monocytes’ central role in the formation of a stable scar and protection against intraventricular thrombi after acute infarction. Although innate leukocytes can recognize a wide array of self-antigens via pattern recognition receptors, adaptive immunity activation requires highly specific cooperation between antigen-presenting cells and distinct antigen-specific receptors on lymphocytes. We have only recently begun to examine lymphocyte activation’s relationship to adaptive immunity and significance in the context of ischemic myocardial injury. There is some experimental evidence that CD4 + T-cells contribute to ischemia–reperfusion injury. Several studies have shown that CD4 + T-cells, especially CD4 + T-regulatory cells, improve wound healing after MI, whereas depleting B-cells is beneficial post MI. That T-cell activation after MI is induced by T-cell receptor signaling implicates autoantigens that have not yet been identified in this context. Also, the significance of lymphocytes in humans post MI remains unclear, primarily as a result of methodology. This review summarizes current experimental evidence of lymphocytes’ activation, functional role, and crosstalk with innate leukocytes in myocardial ischemia–reperfusion injury, wound healing, and remodeling after myocardial infarction.
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Cites
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Cited by
Inflammation and fibrosis in murine models of heart failure
Bacmeister, L., Schwarzl, M., Warnke, S., Stoffers, B., Blankenberg, S., Westermann, D., & Lindner, D. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0722-5 · Cited by 382
Myocardial aging as a T-cell–mediated phenomenon
Ramos, G. C., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621047114 · Cited by 168
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Yang, Y., Johnson, J., Troupes, C. D., Feldsott, E. A., Kraus, L., Megill, E., Bian, Z., Asangwe, N., Kino, T., Eaton, D. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102909 · Cited by 20
Metadata
- Authors
- Hofmann, U., & Frantz, S.
- Venue
- Circulation Research
- Published
- 2015-01-16
- Volume
- 116
- Issue
- 2
- Pages
- 354-367
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2043469918
- Cited by
- 296
- References
- 112
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hofmann, U., & Frantz, S. (2015). Role of Lymphocytes in Myocardial Injury, Healing, and Remodeling After Myocardial Infarction. Circulation Research. https://doi.org/10.1161/circresaha.116.304072
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