The DOI matches its Crossref record; 276 of the 276 references it cites were found in a registry or an index.
Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism
Open accessAbstract
Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.
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“In general, ventricular tachycardia, evolving to ventricular fibrillation, often precedes sudden cardiac death [2].”
From Modeling of artifacts in the wrist photoplethysmogram: Application to the detection of life-threatening arrhythmias (2021) · cites this paper as [2]
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Metadata
- Authors
- Yang, K.-C., Kyle, J. W., Makielski, J. C., & Dudley, S. C.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Circulation Research
- Published
- 2015-06-05
- Volume
- 116
- Issue
- 12
- Pages
- 1937-1955
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4458707
- OpenAlex
- W2141265094
- Cited by
- 127
- References
- 276
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 15 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 3
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX000859)
- National Heart, Lung, and Blood Institute (R01-HL-57414, R01HL122109, R01HL106592, R01HL104025, R01HL057414, R01HL071092, HL106592)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- sudden cardiac death, ventricular arrhythmias, myocardial metabolism, oxidative stress, redox imbalance, ion channel dysfunction, ion transporters, arrhythmogenic substrate, antiarrhythmic therapy, metabolic disorders
- MeSH terms
- Arrhythmias, Cardiac, Cardiovascular Agents, Heart Conduction System, Heart Diseases, Homeostasis, Humans, Ion Channels, Membrane Potentials, Metabolic Diseases, Mitochondria, Heart, Myocardium, Oxidation-Reduction, Potassium, Sodium, Ion Channel Gating, Death, Sudden, Cardiac, Reactive Oxygen Species, Gap Junctions, Oxidative Stress, Calcium Signaling
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