Cited by 127Cardiac electrophysiology and arrhythmiasCardiac Ischemia and ReperfusionCardiac pacing and defibrillation studies

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Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism

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Yang, Kai-Chien, Kyle, John W., Makielski, Jonathan C., Dudley, Samuel C.·2015·Circulation Research

DOI 10.1161/circresaha.116.304691PMC PMC4458707

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Abstract

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.

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Authors: Yang, K.-C., Kyle, J. W., Makielski, J. C., & Dudley, S. C.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Yang, Kai-Chien
Dudley, Samuel C.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-06-05
Volume: 116
Issue: 12
Pages: 1937-1955
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.116.304691
PMC: PMC4458707
OpenAlex: W2141265094
Cited by: 127
References: 276
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 15 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 3
FWCI: 7.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 BX000859)
National Heart, Lung, and Blood Institute (R01-HL-57414, R01HL122109, R01HL106592, R01HL104025, R01HL057414, R01HL071092, HL106592)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: sudden cardiac death, ventricular arrhythmias, myocardial metabolism, oxidative stress, redox imbalance, ion channel dysfunction, ion transporters, arrhythmogenic substrate, antiarrhythmic therapy, metabolic disorders
MeSH terms: Arrhythmias, Cardiac, Cardiovascular Agents, Heart Conduction System, Heart Diseases, Homeostasis, Humans, Ion Channels, Membrane Potentials, Metabolic Diseases, Mitochondria, Heart, Myocardium, Oxidation-Reduction, Potassium, Sodium, Ion Channel Gating, Death, Sudden, Cardiac, Reactive Oxygen Species, Gap Junctions, Oxidative Stress, Calcium Signaling

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Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism

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