The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
The Ins and Outs of Mitochondrial Calcium
Open accessAbstract
Calcium is thought to play an important role in regulating mitochondrial function. Evidence suggests that an increase in mitochondrial calcium can augment ATP production by altering the activity of calcium-sensitive mitochondrial matrix enzymes. In contrast, the entry of large amounts of mitochondrial calcium in the setting of ischemia-reperfusion injury is thought to be a critical event in triggering cellular necrosis. For many decades, the details of how calcium entered the mitochondria remained a biological mystery. In the past few years, significant progress has been made in identifying the molecular components of the mitochondrial calcium uniporter complex. Here, we review how calcium enters and leaves the mitochondria, the growing insight into the topology, stoichiometry and function of the uniporter complex, and the early lessons learned from some initial mouse models that genetically perturb mitochondrial calcium homeostasis.
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Cites
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Cited by
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Metadata
- Authors
- Finkel, T., Menazza, S., Holmström, K. M., Parks, R. J., Liu, J., Sun, J., Liu, J., Pan, X., & Murphy, E.
- Venue
- Circulation Research
- Published
- 2015-05-22
- Volume
- 116
- Issue
- 11
- Pages
- 1810-1819
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2119956853
- Cited by
- 286
- References
- 79
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Finkel, T., Menazza, S., Holmström, K. M., Parks, R. J., Liu, J., Sun, J., Liu, J., Pan, X., & Murphy, E. (2015). The Ins and Outs of Mitochondrial Calcium. Circulation Research. https://doi.org/10.1161/circresaha.116.305484
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