The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Open accessAbstract
Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets’ role in the vasculature has led to many advances in understanding not only how platelets interact with the vessel wall but also how they convey changes in the environment to other circulating cells. In addition to their well-described hemostatic function, platelets are active participants in the immune response to microbial organisms and foreign substances. Although incompletely understood, the immune role of platelets is a delicate balance between its pathogenic response and its regulation of thrombotic and hemostatic functions. Platelets mediate complex vascular homeostasis via specific receptors and granule release, RNA transfer, and mitochondrial secretion that subsequently regulates hemostasis and thrombosis, infection, and innate and adaptive immunity.
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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
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Thrombosis as an intravascular effector of innate immunity
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Platelets and the immune continuum
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Self-citationIntravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
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Platelet biology and functions: new concepts and clinical perspectives
van der Meijden, P. E. J., & Heemskerk, J. W. M. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0110-0 · Cited by 1,041
The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases
Gasparyan, A. Y., Ayvazyan, L., Mukanova, U., Yessirkepov, M., & Kitas, G. D. (2019) · Annals of Laboratory Medicine · doi:10.3343/alm.2019.39.4.345 · Cited by 607
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
McFadyen, J. D., Stevens, H., & Peter, K. (2020) · Circulation Research · doi:10.1161/circresaha.120.317447 · Cited by 592
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
Gusev, E., & Sarapultsev, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097910 · Cited by 312
Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
Mandel, J., Casari, M., Stepanyan, M., Martyanov, A., & Deppermann, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073868 · Cited by 253
Metadata
- Authors
- Koupenova, M., Clancy, L., Corkrey, H. A., & Freedman, J. E.
- Venue
- Circulation Research
- Published
- 2018-01-19
- Volume
- 122
- Issue
- 2
- Pages
- 337-351
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2784146546
- Cited by
- 980
- References
- 121
- FWCI
- 41.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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