Cited by 2,081Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling

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Forrester, Steven J., Kikuchi, Daniel S., Hernandes, Marina S., Xu, Qian, Griendling, Kathy K.·2018·Circulation Research

DOI 10.1161/circresaha.117.311401PMC PMC5926825

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Abstract

Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulation, and diseases associated with metabolic dysfunction may be influenced by changes in redox balance. In this review, we summarize the current literature surrounding ROS and their role in metabolic and inflammatory regulation, focusing on ROS signal transduction and its relationship to disease progression. In particular, we examine ROS production in compartments such as the cytoplasm, mitochondria, peroxisome, and endoplasmic reticulum and discuss how ROS influence metabolic processes such as proteasome function, autophagy, and general inflammatory signaling. We also summarize and highlight the role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes mellitus, and stroke. In order to develop therapies that target oxidative signaling, it is vital to understand the balance ROS signaling plays in both physiology and pathophysiology, and how manipulation of this balance and the identity of the ROS may influence cellular and tissue homeostasis. An increased understanding of specific sources of ROS production and an appreciation for how ROS influence cellular metabolism may help guide us in the effort to treat cardiovascular diseases.

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Authors: Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K.
Affiliations: Emory University (US)
ORCID: Forrester, Steven J.
Kikuchi, Daniel S.
Hernandes, Marina S.
Xu, Qian
Griendling, Kathy K.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-03-16
Volume: 122
Issue: 6
Pages: 877-902
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.117.311401
PMC: PMC5926825
OpenAlex: W2791564057
Cited by: 2,081
References: 379
Citations by year: 2026: 232 · 2025: 300 · 2024: 317 · 2023: 324 · 2022: 316 · 2021: 281 · 2020: 195 · 2019: 97 · 2018: 15
FWCI: 14.44
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association (17SDG33410777)
National Heart, Lung, and Blood Institute (T32HL007745, P01HL095070)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: reactive oxygen species, redox signaling, metabolic regulation, inflammation, signal transduction, mitochondria, peroxisomes, endoplasmic reticulum, proteasome function, autophagy, atherosclerosis, diabetes mellitus, stroke, cardiovascular disease, oxidative stress
MeSH terms: Animals, Cardiovascular Diseases, Humans, Metabolic Diseases, Signal Transduction, Reactive Oxygen Species

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling

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