The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
Open accessAbstract
Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. Objective: We sought to determine the role of AMPK (AMP-activated protein kinase) in selective mitophagy during HF. Methods and Results: An isoform shift from AMPKα2 to AMPKα1 was observed in failing heart samples from HF patients and transverse aortic constriction–induced mice, accompanied by decreased mitophagy and mitochondrial function. The recombinant adeno-associated virus Serotype 9-mediated overexpression of AMPKα2 in mouse hearts prevented the development of transverse aortic constriction–induced chronic HF by increasing mitophagy and improving mitochondrial function. In contrast, AMPKα2 −/− mutant mice exhibited an exacerbation of the early progression of transverse aortic constriction–induced HF via decreases in cardiac mitophagy. In isolated adult mouse cardiomyocytes, AMPKα2 overexpression mechanistically rescued the impairment of mitophagy after phenylephrine stimulation for 24 hours. Genetic knockdown of AMPKα2, but not AMPKα1, by short interfering RNA suppressed the early phase (6 hours) of phenylephrine-induced compensatory increases in mitophagy. Furthermore, AMPKα2 specifically interacted with phosphorylated PINK1 (PTEN-induced putative kinase 1) at Ser495 after phenylephrine stimulation. Subsequently, phosphorylated PINK1 recruited the E3 ubiquitin ligase, Parkin, to depolarized mitochondria, and then enhanced the role of the PINK1–Parkin–SQSTM1 (sequestosome-1) pathway involved in cardiac mitophagy. This increase in cardiac mitophagy was accompanied by the elimination of damaged mitochondria, improvement in mitochondrial function, decrease in reactive oxygen species production, and apoptosis of cardiomyocytes. Finally, Ala mutation of PINK1 at Ser495 partially suppressed AMPKα2 overexpression-induced mitophagy and improvement of mitochondrial function in phenylephrine-stimulated cardiomyocytes, whereas Asp (phosphorylation mimic) mutation promoted mitophagy after phenylephrine stimulation. Conclusions: In failing hearts, the dominant AMPKα isoform switched from AMPKα2 to AMPKα1, which accelerated HF. The results show that phosphorylation of Ser495 in PINK1 by AMPKα2 was essential for efficient mitophagy to prevent the progression of HF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further, ser495 in PINK1 underwent phosphorylation by AMPKα2 upon the dissipation of the ΔΨm in cardiomyocytes [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“In contrast, AMPKα2−/− mice showed an exacerbated progression of TAC-induced HF through defected cardiac mitophagy [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“This phosphorylation proved critical for the efficient recruitment of PARKIN to mitochondria to initiate mitophagy during HF [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“In failing heart samples from patients or TAC mice, the isoform of AMPKα shifted from α2 to α1, which is associated with reduced mitophagy and dysfunctional mitochondria [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“Recently, studies in pressure overload-induced cardiac hypertrophy and HF models highlight the role of AMPKα2 in the regulation of PINK1–PARKIN-dependent mitophagy [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“The adenovirus overexpression of AMPKα2 in hearts blocked TAC-induced chronic HF via promoting mitophagy and mitochondrial function [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,799
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2422 · Cited by 1,738
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A., & Guan, K.-L. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,529
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323
Cited by
Sorted by citations
The mitophagy pathway and its implications in human diseases
Wang, S., Long, H., Hou, L., Feng, B., Ma, Z., Wu, Y., Zeng, Y., Cai, J., Zhang, D., & Zhao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01503-7 · Cited by 991
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Lü, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L. (2023) · Theranostics · doi:10.7150/thno.79876 · Cited by 738
Mitophagy in human health, ageing and disease
Picca, A., Faitg, J., Auwerx, J., Ferrucci, L., & D’Amico, D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00930-8 · Cited by 635
Metabolic Coordination of Physiological and Pathological Cardiac Remodeling
Gibb, A., & Hill, B. G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312017 · Cited by 393
AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286
Self-citationMitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment
Ajoolabady, A., Chiong, M., Lavandero, S., Klionsky, D. J., & Ren, J. T. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.06.007 · Cited by 263
Han, Y.-C., Tang, S.-Q., Liu, Y.-T., Li, A.-M., Zhan, M., Yang, M., Song, N., Zhang, W., Wu, X.-Q., Peng, C.-H., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04184-8 · Cited by 257
Ferroptosis and its emerging roles in cardiovascular diseases
Li, N., Jiang, W., Wang, W., Xiong, R., Wu, X., & Geng, Q. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105466 · Cited by 256
Doblado, L., Lueck, C., Rey, C., Samhan-Arias, A. K., Priéto, I., Stacchiotti, A., & Monsalve, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083903 · Cited by 238
Mitochondrial Structure and Function in Human Heart Failure
Hinton, A. O., Jr., Claypool, S. M., Neikirk, K., Senoo, N., Wanjalla, C. N., Kirabo, A., & Williams, C. R. (2024) · Circulation Research · doi:10.1161/circresaha.124.323800 · Cited by 239
Tahrir, F. G., Langford, D., Amini, S., Ahooyi, T. M., & Khalili, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27597 · Cited by 216
Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
Quan, Y., Xin, Y., Tian, G., Zhou, J., & Liu, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9423593 · Cited by 226
Iorio, R., Celenza, G., & Petricca, S. (2021) · Cells · doi:10.3390/cells11010030 · Cited by 222
Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037357 · Cited by 200
Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
Wu, N. N., Zhang, Y., & Ren, J. T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9825061 · Cited by 199
Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy
Chang, X., Liu, R., Li, R., Peng, Y., Zhu, P., & Zhou, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76223 · Cited by 196
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Packer, M. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00824-4 · Cited by 196
Emerging role of mitophagy in cardiovascular physiology and pathology
Morales, P. E., Arias-Durán, C., Ávalos-Guajardo, Y., Aedo, G., Verdejo, H., Parra, V., & Lavandero, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.09.006 · Cited by 179
Mitochondrial quality control in human health and disease
Liu, B., Xu, C.-Z., Liu, Y., Lu, Z., Fu, T.-L., Li, G., Deng, Y., Luo, G., Ding, S. Z., Li, N., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00536-5 · Cited by 211
Chen, L., Qin, Y. H., Liu, B., Gao, M. Q., Li, A., Li, X., & Gong, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.871357 · Cited by 186
Aragón‐Herrera, A., Feijóo‐Bandín, S., Otero-Santiago, M., Barral, L., Campos‐Toimil, M., Gil‐Longo, J., Pereira, T. D. M. C., García‐Caballero, T., Rodríguez‐Segade, S., Rodríguez, J., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113677 · Cited by 164
Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials
Nguyen, B. Y., Ruiz‐Velasco, A., Bùi, T. A., Collins, L., Wang, X., & Liu, W. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14431 · Cited by 156
Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases
Liu, Y., Huang, Y., Xu, C. B., An, P., Luo, Y., Jiao, L., Luo, J., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416053 · Cited by 151
Mitochondrial dysfunction and mitochondrial therapies in heart failure
Wu, C., Zhang, Z., Zhang, W., & Liu, X. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106038 · Cited by 148
Mitochondrial quality surveillance as a therapeutic target in myocardial infarction
Zhu, H., Toan, S., Mui, D., & Zhou, H. (2020) · Acta Physiologica · doi:10.1111/apha.13590 · Cited by 142
Autophagy and cardiac diseases: Therapeutic potential of natural products
Wu, X., Liu, Z., Yu, X., Xu, S., & Luo, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21733 · Cited by 137
Garbern, J. C., & Lee, R. T. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02252-6 · Cited by 146
Marino, A., Hausenloy, D. J., Andreadou, I., Horman, S., Bertrand, L., & Beauloye, C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.047 · Cited by 140
He, L., Zhou, Q., Huang, Z., Xu, J., Zhou, H., Lv, D., Lu, L., Huang, S., Tang, M., Zhong, J., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27527 · Cited by 137
Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy
Zhou, T., Chang, L., Luo, Y., Zhou, Y., & Zhang, J. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101120 · Cited by 131
Wang, D., Yin, Y., Wang, S., Zhao, T., Gong, F., Zhao, Y., Wang, B., Huang, Y., Cheng, Z., Zhu, G., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00542-2 · Cited by 131
Self-citationYu, W., Sun, S., Xu, H., Li, C., Ren, J. T., & Zhang, Y. (2020) · Theranostics · doi:10.7150/thno.46883 · Cited by 125
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice
An, D., Zeng, Q., Zhang, P., Ma, Z., Zhang, H., Liu, Z., Li, J., Ren, H., & Xu, D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102088 · Cited by 129
Mitophagy for cardioprotection
Titus, A. S., Sung, E., Zablocki, D., & Sadoshima, J. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-01009-x · Cited by 128
The role of autophagy in cardiovascular pathology
Gatica, D., Chiong, M., Lavandero, S., & Klionsky, D. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab158 · Cited by 123
Ahuja, P., Ng, C. F., Pang, B. P. S., Chan, W. S., Tse, M. C. L., Bi, X., Kwan, H.-L. R., Brobst, D., Herlea-Pana, O., Yang, X., et al. (2022) · Autophagy · doi:10.1080/15548627.2021.1985257 · Cited by 116
Li, S., Lin, Q., Shao, X., Zhu, X., Wu, J., Wu, B., Zhang, M., Zhou, W., Zhou, Y., Jin, H., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.005 · Cited by 112
Zhang, X., Liu, X., Hu, M., Zhao, G., Sun, D., Cheng, X., Xiang, H., Huang, Y., Tian, R., Shen, L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.014 · Cited by 114
Packer, M. (2020) · Circulation · doi:10.1161/circulationaha.119.045561 · Cited by 113
Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure
Abudureyimu, M., Yu, W., Cao, R. Y., Zhang, Y., Liu, H., & Zheng, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565751 · Cited by 109
Mitophagy and reactive oxygen species interplay in Parkinson’s disease
Xiao, B., Kuruvilla, J., & Tan, E. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00402-y · Cited by 117
Mitophagy in Cardiovascular Diseases
Morciano, G., Patergnani, S., Bonora, M., Pedriali, G., Tarocco, A., Bouhamida, E., Marchi, S., Ancora, G., Anania, G., Wieckowski, M. R., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030892 · Cited by 110
Zheng, J., Chen, L., Lu, T., Zhang, Y., Sui, X. Y., Li, Y., Huang, X., He, L., Cai, J., Zhou, C., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2424-1 · Cited by 105
Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing
Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y., & Ren, J. T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101129 · Cited by 103
Mitophagy in the pathogenesis and management of disease
Wang, Q., Sun, Y., Li, T. Y., & Auwerx, J. (2026) · Cell Research · doi:10.1038/s41422-025-01203-7 · Cited by 103
Wang, P., Wang, L., Lü, J., Hu, Y., Wang, Q., Li, Z., Cai, S., Liang, L., Guo, K., Xie, J., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.06.005 · Cited by 102
Self-citationMitochondrial Dysfunction in Cardiovascular Diseases: Potential Targets for Treatment
Yang, J., Guo, Q., Feng, X., Liu, Y., & Zhou, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.841523 · Cited by 105
The Role of Autophagy in Acute Myocardial Infarction
Wu, D. A., Zhang, K., & Hu, P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00551 · Cited by 100
Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease
Lin, J., Duan, J., Wang, Q., Xu, S., Zhou, S., & Yao, K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.917135 · Cited by 103
Yan, C., Tian, X., Li, J., Liu, D., Ye, D., Xie, Z., Han, Y., & Zou, M. (2020) · Diabetes · doi:10.2337/db20-0146 · Cited by 96
Self-citationCellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease
Camacho-Encina, M., Booth, L. K., Redgrave, R. E., Folaranmi, O., Spyridopoulos, I., & Richardson, G. D. (2024) · Cells · doi:10.3390/cells13040353 · Cited by 103
Packer, M. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1732 · Cited by 100
The mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94
Signaling cascades in the failing heart and emerging therapeutic strategies
He, X., Du, T., Long, T., Liao, X., Dong, Y., & Huang, Z. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00972-6 · Cited by 108
Zhou, H., Wang, X., Xu, T., Gan, D., Ma, Z., Zhang, H., Zhang, J., Zeng, Q., & Xu, D. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae238 · Cited by 100
Li, W., Yin, L., Sun, X., Wu, J., Dong, Z., Hu, K., Sun, A., & Ge, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02805-2 · Cited by 90
PINK1/Parkin-mediated mitophagy in cardiovascular disease: From pathogenesis to novel therapy
Wu, Y., Jiang, T., Hua, J., Xiong, Z., Dai, K., Chen, H., Li, L., Peng, J., Peng, X., Zheng, Z., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.05.025 · Cited by 91
Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy
Xu, M., Wan, C., Huang, S.-H., Wang, H., Fan, D., Wu, H., Wu, Q., Ma, Z., Deng, W., & Tang, Q. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1617-y · Cited by 90
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
Zhu, X., Shen, W., Yao, K., Wang, H., Лю, Б., Li, T., Song, L., Diao, D., Mao, G., Huang, P., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315529 · Cited by 88
Packer, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa064 · Cited by 86
PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis
Lee, S.-Y., An, H., Kim, J. M., Sung, M.-J., Kim, H. K., Kim, H. K., Oh, J., Jeong, H. Y., Lee, Y. H., Yang, T., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02656-4 · Cited by 84
Research progress on post-translational modification of proteins and cardiovascular diseases
Cheng, X., Wang, K., Zhao, Y., & Wang, K. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01560-5 · Cited by 86
Cardioprotective Role of Melatonin in Acute Myocardial Infarction
Fu, Z., Jiao, Y., Wang, J., Zhang, Y., Shen, M., Reiter, R. J., Xi, Q., & Chen, Y. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00366 · Cited by 79
Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing
Ravindran, R., & Gustafsson, Å. B. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01142-1 · Cited by 90
Sekar, P., Huang, D.-Y., Hsieh, S.-L. E., Chang, S., & Lin, W. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0293-3 · Cited by 82
Rahman, F. A., & Quadrilatero, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03807-9 · Cited by 77
The Role of Myocardial Mitochondrial Quality Control in Heart Failure
Qiu, Z., Yi, W., Song, Q., Du, B., Wang, H., Chu, Y., & Hu, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01404 · Cited by 74
Self-citationRole of Mitophagy in Cardiovascular Disease
Yang, Y., Li, T., Li, Z., Liu, N., Yan, Y., & Liu, B. (2020) · Aging and Disease · doi:10.14336/ad.2019.0518 · Cited by 74
Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management
Wang, J., Zou, J., Shi, Y., Zeng, N., Guo, D., Wang, H., Zhao, C., Luan, F., Zhang, X., & Sun, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155472 · Cited by 75
Hydroxytyrosol Promotes the Mitochondrial Function through Activating Mitophagy
Dong, Y., Yu, M., Wu, Y., Xia, T., Wang, L., Song, K., Zhang, C., Lu, K., & Rahimnejad, S. (2022) · Antioxidants · doi:10.3390/antiox11050893 · Cited by 70
Mitophagy Regulation Following Myocardial Infarction
Turkieh, A., Masri, Y. E., Pinet, F., & Dubois‐Deruy, E. (2022) · Cells · doi:10.3390/cells11020199 · Cited by 69
Packer, M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016270 · Cited by 66
Mitochondrial dysfunction in heart failure and its therapeutic implications
Liu, M., Lv, J., Pan, Z., Wang, D., Zhao, L., & Guo, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.945142 · Cited by 75
Self-citationDong, Y., Li, L., Espe, M., Lu, K., & Rahimnejad, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03310 · Cited by 66
Comprehensive autophagy evaluation in cardiac disease models
Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernández, Á. F., de Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz233 · Cited by 64
Wang, D., Yu, X. L., Gao, K., Li, F., Li, X., Pu, H., Zhang, P., Guo, S., & Wang, W. J. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103223 · Cited by 64
Self-citationBCL2L13: physiological and pathological meanings
Meng, F., Sun, N., Liu, D., Jia, J., Xiao, J., & Dai, H. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03702-9 · Cited by 63
Guan, Z., Chen, J., Wang, L., Hao, M., Dong, X., Luo, T., Jiang, J., Lin, Z., Li, X., Chen, P., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154494 · Cited by 63
Mitophagy in atherosclerosis: from mechanism to therapy
Zhang, Y., Weng, J., Huan, L., Sheng, S., & Xu, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1165507 · Cited by 67
Xu, L., Ye, Y., Gu, W., Xu, X., Chen, N., Zhang, L., Cai, W., Hu, J., Wang, T., Chao, H., et al. (2025) · Autophagy · doi:10.1080/15548627.2025.2471633 · Cited by 61
Lin, M., Xiong, W., Wang, S., Li, Y., Hou, C., Li, C., & Li, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.821663 · Cited by 60
Tang, Y., Feng, M., Su, Y., Ma, T., Zhang, H., Wu, H., Wang, X., Shi, S., Zhang, Y., Xu, Y., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064121 · Cited by 60
Yu, Z., Chen, R., Li, M., Yu, Y. Q., Liang, Y., Han, F., Qin, S., Chen, X., Su, Y., & Ge, J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.054 · Cited by 61
Cao, S., Xiao, H., Li, X., Zhu, J., Gao, J., Wang, L., & Hu, C. (2021) · Antioxidants · doi:10.3390/antiox10122010 · Cited by 58
Mitochondria as Therapeutic Targets in Heart Failure
Schwemmlein, J., Maack, C., & Bertero, E. (2022) · Current Heart Failure Reports · doi:10.1007/s11897-022-00539-0 · Cited by 59
Xu, Z., Pan, Z., Jin, Y. H., Gao, Z., Jiang, F., Fu, H., Chen, X., Zhang, X., Yan, H., Yang, X., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2259216 · Cited by 56
The effects of metformin in the treatment of osteoarthritis: Current perspectives
Song, Y., Wu, Z., & Zhao, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.952560 · Cited by 55
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Li, J., Zhang, D., Wiersma, M., & Brundel, B. J. J. M. (2018) · Cells · doi:10.3390/cells7120279 · Cited by 59
Li, Q., Dong, Z., Lian, W., Cui, J., Wang, J., Shen, H., Liu, W., Yang, J., Zhang, X., & Cui, H. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02433-6 · Cited by 54
LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy
Fan, J., Li, H., Xie, R., Zhang, X., Nie, X., Shi, X., Zhan, J., Yin, Z., Zhao, Y., Dai, B., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318437 · Cited by 52
Self-citationWang, X., Zhang, J., Xiu, C., Yang, J., Fang, J., & Lei, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7151946 · Cited by 51
Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids
Keshavarz-Bahaghighat, H., Darwesh, A. M., Sosnowski, D. K., & Seubert, J. M. (2020) · Cells · doi:10.3390/cells9071565 · Cited by 49
Fan, H., He, Z., Huang, H., Zhuang, H., Liu, H., Liu, X., Yang, S., He, P., Yang, H. M., & Feng, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00252 · Cited by 51
Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging
Ghosh, R., Vinod, V., Symons, J. D., & Boudina, S. (2020) · Cells · doi:10.3390/cells9040933 · Cited by 52
TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes
Lin, Y.-C., Lin, Y., Tsai, M.-L., Liao, W., & Hung, C. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00767-w · Cited by 49
Chen, C., Chen, Y. S., Liu, T., Song, D., Ma, D., & Cheng, O. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7511393 · Cited by 47
Self-citationMetabolic control of mitophagy
Zimmermann, A., Madeo, F., Diwan, A., Sadoshima, J., Sedej, S., Kroemer, G., & Abdellatif, M. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14138 · Cited by 49
Tan, Y., Zhang, Y., He, J., Wu, F., Wu, D., Shi, N., Liu, W., Li, Z., Liu, W., Zhou, H., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101567 · Cited by 47
Marek‐Iannucci, S., Thomas, A., Hou, J., Crupi, A. N., Sin, J., TAYLOR, D. J., Czer, L. S. C., Esmailian, F., Mentzer, R. M., Andres, A. M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46452-w · Cited by 46
Mitophagy in cardiovascular disease
Zhou, H., He, L., Xu, G., & Chen, L. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.033 · Cited by 48
Metadata
- Authors
- Wang, B., Nie, J., Wu, L., Hu, Y., Wen, Z., Dong, L., Zou, M.-H., Chen, C., & Wang, D. W.
- Affiliations
- Georgia State University (US)
- From the Division of Cardiology, Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College (B.W., J.N., L.W., Z.W.,C.C., D.W.W.), Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders (B.W., J.N., L.W., Z.W.,C.C., D.W.W.), and Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College (B.W., Y.H., L.D.), Huazhong University of Science and Technology, Wuhan, China; and Center for Molecular and Translational...
- Venue
- Circulation Research
- Published
- 2018-03-02
- Volume
- 122
- Issue
- 5
- Pages
- 712-729
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5834386
- OpenAlex
- W2778528862
- Cited by
- 334
- References
- 40
- Citations by year
- 2026: 37 · 2025: 45 · 2024: 45 · 2023: 43 · 2022: 50 · 2021: 39 · 2020: 43 · 2019: 19 · 2018: 13
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG047776)
- National Heart, Lung, and Blood Institute (R01HL079584, R01HL137371, R01HL132500, R01HL074399, R01HL080499, R01HL140954, R01HL110488, R01HL128014, R01HL089920)
- National Cancer Institute (R01CA213022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure, AMPKα2, mitophagy, Parkin, p62, mitochondrial dysfunction, transverse aortic constriction, cardiomyocyte apoptosis, reactive oxygen species, AAV9 gene therapy
- MeSH terms
- AMP-Activated Protein Kinase Kinases, PTEN-Induced Putative Kinase, Animals, Cells, Cultured, Heart Failure, Humans, Isoenzymes, Mitochondria, Heart, Phosphorylation, Protein Kinases, Myocytes, Cardiac, Mice, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
