The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
Open accessAbstract
Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. Objective: We sought to determine the role of AMPK (AMP-activated protein kinase) in selective mitophagy during HF. Methods and Results: An isoform shift from AMPKα2 to AMPKα1 was observed in failing heart samples from HF patients and transverse aortic constriction–induced mice, accompanied by decreased mitophagy and mitochondrial function. The recombinant adeno-associated virus Serotype 9-mediated overexpression of AMPKα2 in mouse hearts prevented the development of transverse aortic constriction–induced chronic HF by increasing mitophagy and improving mitochondrial function. In contrast, AMPKα2 −/− mutant mice exhibited an exacerbation of the early progression of transverse aortic constriction–induced HF via decreases in cardiac mitophagy. In isolated adult mouse cardiomyocytes, AMPKα2 overexpression mechanistically rescued the impairment of mitophagy after phenylephrine stimulation for 24 hours. Genetic knockdown of AMPKα2, but not AMPKα1, by short interfering RNA suppressed the early phase (6 hours) of phenylephrine-induced compensatory increases in mitophagy. Furthermore, AMPKα2 specifically interacted with phosphorylated PINK1 (PTEN-induced putative kinase 1) at Ser495 after phenylephrine stimulation. Subsequently, phosphorylated PINK1 recruited the E3 ubiquitin ligase, Parkin, to depolarized mitochondria, and then enhanced the role of the PINK1–Parkin–SQSTM1 (sequestosome-1) pathway involved in cardiac mitophagy. This increase in cardiac mitophagy was accompanied by the elimination of damaged mitochondria, improvement in mitochondrial function, decrease in reactive oxygen species production, and apoptosis of cardiomyocytes. Finally, Ala mutation of PINK1 at Ser495 partially suppressed AMPKα2 overexpression-induced mitophagy and improvement of mitochondrial function in phenylephrine-stimulated cardiomyocytes, whereas Asp (phosphorylation mimic) mutation promoted mitophagy after phenylephrine stimulation. Conclusions: In failing hearts, the dominant AMPKα isoform switched from AMPKα2 to AMPKα1, which accelerated HF. The results show that phosphorylation of Ser495 in PINK1 by AMPKα2 was essential for efficient mitophagy to prevent the progression of HF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further, ser495 in PINK1 underwent phosphorylation by AMPKα2 upon the dissipation of the ΔΨm in cardiomyocytes [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“In contrast, AMPKα2−/− mice showed an exacerbated progression of TAC-induced HF through defected cardiac mitophagy [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“This phosphorylation proved critical for the efficient recruitment of PARKIN to mitochondria to initiate mitophagy during HF [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“In failing heart samples from patients or TAC mice, the isoform of AMPKα shifted from α2 to α1, which is associated with reduced mitophagy and dysfunctional mitochondria [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“Recently, studies in pressure overload-induced cardiac hypertrophy and HF models highlight the role of AMPKα2 in the regulation of PINK1–PARKIN-dependent mitophagy [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
In the citing paper
“The adenovirus overexpression of AMPKα2 in hearts blocked TAC-induced chronic HF via promoting mitophagy and mitochondrial function [117].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,799
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2422 · Cited by 1,738
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A., & Guan, K.-L. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,529
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323
Cited by
Sorted by citations
Items 201–300 of 333
AMPK, a hub for the microenvironmental regulation of bone homeostasis and diseases
Liu, J., Liu, J.-X., Li, R., Zhang, Z., Zhang, X., Xing, S., Sui, B., Jin, F., Ma, B., & Zheng, C. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31393 · Cited by 14
Guo, C., Chen, M., Zhao, J., Wu, R., Zhang, Y., Li, Q., Zhao, H., Dou, J., Song, S., & Wei, J. (2022) · Experimental Physiology · doi:10.1113/ep090374 · Cited by 12
Wang, T., Yuan, C., Liu, J., Deng, L., Li, W., He, J., Liu, H., Qu, L., Wu, J., & Zou, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020897 · Cited by 12
Apelin-13: A Protective Role in Vascular Diseases
Zeng, G.-G., Tang, S.-S., Jiang, W., Jiang, Y., Nie, G.-Y., & Tang, C.-K. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102088 · Cited by 12
Roles of Autophagy and Oxidative Stress in Cardiovascular Disease
Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025) · Antioxidants · doi:10.3390/antiox14101263 · Cited by 13
Sharma, A., Raut, S. S., Shukla, A. K., Singh, A. K., & Mishra, A. (2026) · Translational research · doi:10.1016/j.trsl.2026.03.004 · Cited by 14
FOXO3a Induces Myocardial Fibrosis by Upregulating Mitophagy
Lin, D., Luo, H., Dong, B., He, Z., Ma, L., Wang, Z., Wu, X., & Sui, Q. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902056 · Cited by 11
Lu, L., Shao, Y., Wang, N., Xiong, X., Zhai, M., Tang, J., Yang, L., Yang, J., & Yang, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04955-9 · Cited by 12
Zhang, H., Xu, T., Mei, X., Zhao, Q., Yang, Q., Zeng, X., Ma, Z., Zhou, H., Qingchun, Z., Xu, D., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70166 · Cited by 11
The multifaceted role of autophagy and mitophagy in cardiovascular health and disease
Nàger, M., Calvoli, M., Larsen, K. B., & Birgisdottir, Å. B. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2572511 · Cited by 11
Jackson, A. O., Rahman, G. A., Kai, Y., & Long, S. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-10085-6 · Cited by 12
Mitophagy: A Potential Target for Pressure Overload‐Induced Cardiac Remodelling
Shao, R., Li, J., Qu, T., Liao, Y., & Chen, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2849985 · Cited by 11
The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
Leites, E. P., & Morais, V. A. (2021) · Cells · doi:10.3390/cells10061395 · Cited by 12
Targeting PINK1 Using Natural Products for the Treatment of Human Diseases
Li, Y.-Q., Zhang, F., Yu, L., Mu, J.-K., Yang, Y., Yu, J., & Yang, X. (2021) · BioMed Research International · doi:10.1155/2021/4045819 · Cited by 11
Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylationPreprint
Waddell, A. D., Ojha, H., Agarwal, S., Clarke, C. J., Terriente-Félix, A., Zhou, H., Kakade, P. S., Knebel, A., Shaw, A. M., Gourlay, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.31.534916 · Cited by 11
Callaghan, N. I., Durland, L. J., Ireland, R. G., Santerre, J. P., Simmons, C. A., & Huyer, L. D. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00246-3 · Cited by 10
An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress
Sorge, M., Savoré, G., Gallo, A., Acquarone, D., Sbroggió, M., Velasco, S., Zamporlini, F., Femminò, S., Moiso, E., Morciano, G., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00132-z · Cited by 11
Jing, K., Gu, R., Chen, F., Wan, J., Sun, Y., Guo, P., Chen, F., Feng, J., Guo, J., & Liu, X. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107422 · Cited by 11
Mitochondrial metabolism and hypoxic signaling in differentiated human cardiomyocyte AC16 cell line
Alán, L., Opletalová, B., Hayat, H., Markovic, A., Hlaváčková, M., Vrbacký, M., Mráček, T., & Alánová, P. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00083.2025 · Cited by 13
The Role of AMPKα in the Mechanism of Development and Treatment of Heart Failure
Feng, Y., Zhu, Z., He, Y., & Li, X. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm36391 · Cited by 11
Gao, K., Li, Y., Su, Y., Lin, Z., Yang, X., Xu, M., Huang, Y., Chen, S., Xie, Y., & Li, Z. (2021) · PubMed Central · Cited by 10
Wang, Q., Su, H., & Liu, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3617086 · Cited by 10
Hang, P., Li, P., Liu, J., Li, F., Chen, T., Pan, Y., Zhang, M.-R., Yu, H.-Q., Ji, H.-Y., Du, Z., et al. (2022) · PubMed Central · doi:10.11909/j.issn.1671-5411.2022.11.002 · Cited by 10
Zheng, Y., Cai, J.-J., Yang, X., Shao, Z., Liu, J.-Q., Yang, X., Sun, R.-H., Hu, B., Mo, S., & Li, L. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113804 · Cited by 10
Nie, X., Xie, R., Fan, J., & Wang, D. W. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122290 · Cited by 10
Self-citationLu, Y., Zhang, C., Chen, J., Zou, Q., Li, B., Wei, H., Chang, M. P., Liao, X., & Hu, C. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221081546 · Cited by 10
Torres, A. S., Lee, J.-E., Caporali, A., Semple, R. K., Horrocks, M. H., & MacRae, V. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010973 · Cited by 9
Role of Autophagy in Myocardial Remodeling After Myocardial Infarction
Tian, R.-Z., Zhuang, D., Vong, C. T., He, X., Ouyang, Q., Liang, J.-H., Guo, Y.-P., Wang, Y., Zhao, S., Yuan, H., et al. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001646 · Cited by 9
Oxygen consumption rate to evaluate mitochondrial dysfunction and toxicity in cardiomyocytes
Ahn, D., Go, R., & Choi, K. (2023) · Toxicological Research · doi:10.1007/s43188-023-00183-3 · Cited by 9
Li, N., Li, X., Zhang, X., Zhang, L., Wu, H., Yu, Y., Jia, G., & Yu, S. (2024) · PeerJ · doi:10.7717/peerj.17837 · Cited by 8
Lü, J., Zhang, Y., Song, H., Wang, F., Wang, L., Xiong, L., & Shen, X. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400699 · Cited by 8
Wang, Y., Lin, S., Liu, J., Hu, S., Zeng, J., Wang, M., Li, X., He, Y., Ren, S., Lyu, Y., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.036 · Cited by 8
Su, Z., Li, H., Ye, Z., Zhu, Y., Feng, B. C., Tang, L., & Zheng, G. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116091 · Cited by 8
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure
Tang, J., Tam, E., Song, E., Xu, A., & Sweeney, G. (2024) · Autophagy Reports · doi:10.1080/27694127.2024.2320605 · Cited by 7
Nie, X., Fan, J., Wang, Y., Xie, R., Chen, C., Li, H., & Wang, D. W. (2024) · Frontiers of Medicine · doi:10.1007/s11684-023-1036-4 · Cited by 8
Self-citationWang, J., Yang, K., Liu, C., Wang, F., Liang, X., Wu, J., Hong, S., Yin, X., & Zhang, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113664 · Cited by 8
Chaanine, A. H., Higgins, L., Lauterboeck, L., Markowski, T. W., Yang, Q., & Delafontaine, P. (2022) · Cells · doi:10.3390/cells11091572 · Cited by 9
Yang, Z., Sun, L., & Wang, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1166324 · Cited by 8
Li, J., Li, H., Niu, N., Zhu, Y., Hou, S., & Zhao, W. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114472 · Cited by 7
Chen, H., Lin, Q., Zeng, Y., Chen, P., Guo, P., Feng, R., Guo, Z., Kang, J., Chen, Q., & Zhou, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119666 · Cited by 7
Wang, J., Pan, J., Luan, F., Shi, H., Xie, Y., Zhao, C., Zou, J., Shi, Y., Guo, D., Sun, J., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107898 · Cited by 7
Mitochondrial quality control in human ageing and longevity
Picca, A., & Ferrucci, L. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01563-3 · Cited by 10
Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies
He, Y., Liu, Y., Zheng, M., Zou, Y., Huang, M., Wang, L., Gao, G., Zhou, Z., & Jin, G. (2024) · Advanced Science · doi:10.1002/advs.202404109 · Cited by 8
Liu, J., Zhong, L., & Guo, R. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635836 · Cited by 7
RetractedKoike, S., Hsu, M.-F., Bettaieb, A., Chu, B., Matsumoto, N., Morisseau, C. H. P., Havel, P. J., Huising, M. O., Hammock, B. D., & Haj, F. G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.029 · Cited by 8
RAB7 protects against ischemic heart failure via promoting non-canonical TUFM mitophagy pathway
Sun, Y., Wang, W., Li, M., Guan, W., Gao, Z., Wang, L., Lou, G., Shen, A., Wu, J., Yu, X., et al. (2025) · Theranostics · doi:10.7150/thno.104124 · Cited by 6
Wilkinson, M., Rollin, T., Kuriakose, M., Haggerty-Goede, R. A. L., Miller, D. M., & Dunham‐Snary, K. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110370 · Cited by 6
Potential regulatory role of epigenetic modifications in aging-related heart failure
Lv, L., Chen, Q., Lü, J., Zhao, Q., Wang, H., Li, J., Yuan, K., & Dong, Z. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.131858 · Cited by 6
Wang, Z., Liu, X., Wu, Y., Chen, G., Wang, J., Qi, Y., Wu, R. Y., Wang, J., Meng, Q., & Yu, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178376 · Cited by 5
Activating protein kinases to treat diseases: Current understanding and future challenges
Jin, P., Liao, M., Liu, H., Huang, K., Fu, L., & Jin, X. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.12.004 · Cited by 6
Autophagy in striated muscle diseases
Bailin, P. L., Zhang, L., Zhang, L., & Han, R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1000067 · Cited by 5
Deng, Y., Chen, S., Zhang, M., Li, C., He, J., & Tan, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00833 · Cited by 5
Su, L., Feng, Z., Liu, S., Hu, P., Ding, H., Huang, R., Qi, S., Qian, Y., Wu, K., Tian, X., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167672 · Cited by 4
He, Y., Wu, D., Wu, Q., Huang, S., Zhan, Y., Deng, J., Chen, J. Y., Xie, L., & Zheng, J.-H. (2025) · Scientific Reports · doi:10.1038/s41598-025-17253-1 · Cited by 4
Choi, D. H., Lee, S. M., Park, B. N., Lee, M. H., Yang, D. E., Son, Y. K., Kim, S. E., & An, W. S. (2024) · Biomedicines · doi:10.3390/biomedicines12092107 · Cited by 4
Zhang, X., Song, Y., Mai, H., Feng, W., Sun, J., Zhao, Z., Zhou, S., Zhao, A. Z., Mu, Y., & Li, F. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117366 · Cited by 4
Advances in natural compounds modulating autophagy for the therapeutic intervention of heart failure
Tang, J., Zhou, C., Li, M., Tao, J., Deng, R., Ouyang, X., Zhang, G., & Liu, H. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05473-y · Cited by 5
Research Advances in Targeted Therapy for Heart Failure
Miao, L., & Liu, Y. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2410276 · Cited by 4
Chen, L., Fan, C., Zhang, X., Chen, S., Ye, L., & Zheng, X. (2023) · The Journal of Toxicological Sciences · doi:10.2131/jts.48.585 · Cited by 4
Jeon, S. J., & Chung, K. C. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107198 · Cited by 4
Amador‐Martínez, I., Aranda‐Rivera, A. K., Martínez-Castañeda, M. R., & Pedraza-Chaverrí, J. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102040 · Cited by 3
Liu, Q., Meng, F.-L., Du, J., Li, W., Zhou, S., & Li, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112170 · Cited by 4
Huang, X., & Wan, H. (2026) · Biomedicines · doi:10.3390/biomedicines14040765 · Cited by 3
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases
Li, M., Zhang, R., Li, X., & Huang, H. (2026) · Exploration · doi:10.1002/exp.20240414 · Cited by 3
AMPK Signalling in Heart Failure: From Metabolic Sensor to Context-Dependent Therapeutic Target
Arzouni, R., Aazar, R. F. M., Asakrieh, S., Cattan, S., & Jovanović, A. (2026) · Biomedicines · doi:10.3390/biomedicines14061362 · Cited by 4
Jiang, X., Liu, S., Yang, J., Lin, Y., Zhang, W., Tao, J., Zhong, H., Xu, J., & Zhang, M. (2024) · Shock · doi:10.1097/shk.0000000000002304 · Cited by 3
Pink1-dependent mitophagy in vascular smooth muscle cells: Implications for arterial constriction
Li, D., Nie, J., Shi, Z., Yu, S., Li, Y., Zheng, F., Bo, S., Wang, N., & Zhang, Y. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.306 · Cited by 3
Self-citationZhang, L., Feng, H., Fu, S., & Sun, D. (2024) · Current Medical Science · doi:10.1007/s11596-024-2834-x · Cited by 3
Hu, T., Jiang, Y., Yang, J., Hu, F.-J., Yuan, Y., Liu, J., & Wang, L. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12521 · Cited by 3
Chen, L.-D., Chen, K., Chen, K., Ai, L., Kang, M.-R., Yi, W.-M., & Li, J.-J. (2023) · Pharmacognosy Magazine · doi:10.1177/09731296231172540 · Cited by 2
Role of AMPK/ULK1 signaling in mitophagy
Iorio, R., & Petricca, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00011-9 · Cited by 2
Zhao, Z., Sun, Y., Jia, M., Jiang, M., & Ruan, X. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106633 · Cited by 2
Cao, B., Fang, L., Zhang, Y., Lin, C., Liu, P., Zhang, H., Fan, O. R., Xu, M., Qin, Z., & Wang, C. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.08.007 · Cited by 2
Feng, Y., Zhu, Z., Jing, X., Zhang, Y., He, Y., & Li, X. (2025) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2025.05.008 · Cited by 2
Chen, L., Zheng, L., Qin, Y. H., Liu, B., Zheng, Y., Tong, X., Dai, M., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.053 · Cited by 2
Natural products modulate mitochondria-associated membranes to prevent cardiovascular diseases
Zhang, Y. L., Ning, B., He, W., Wang, K., Chen, H., Zhang, Z., Zhang, Z., He, L., Lei, Y., Zhao, M., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157786 · Cited by 2
Mastering cardiomyocyte mitophagy: molecular governance, pathological derailment and therapeutics
Liu, P., Wu, H., Ren, H., Wang, J., & Yang, F. (2026) · PeerJ · doi:10.7717/peerj.20700 · Cited by 2
Regulation of mitochondrial biogenesis and energy metabolism in the heart
She, P., 莫非, Zhu, P., & Zhong, T. P. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004011 · Cited by 2
Chen, L., Yang, X. Y., Jiang, Y., Cheng, S.-Q., Wan, Z., Wu, J.-W., Chen, M., Li, Y., Luo, G., & Liu, M. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124413 · Cited by 2
Mitochondrial dyshomeostasis in cardiac aging and related diseases
Wang, J., YuJing, L. I., ZHANG, H., SiQi, C. H. E. N., Wang, Y., & Song, M. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2021-0366 · Cited by 2
Sepehri, G., Shirazpour, S., Rostamzadeh, F., Jafari, H., & Iranpour, M. (2025) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001715 · Cited by 2
Marek‐Iannucci, S., Thomas, A., & Gottlieb, R. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00346 · Cited by 2
Anzmann, A. F., Carney, O. S., Pado, A. M., Busa, V. F., Vaz, F. M., Kreimer, S. D., Cole, R. N., Le, A., Kirsch, B. J., Claypool, S. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.06.425502 · Cited by 2
Atabekov, T. A., Криволапов, С. Н., Хлынин, М. С., Корепанов, В. А., Rebrova, Т. Y., Фаритовна, М. Э., Afanasiev, S. A., Batalov, R. E., & Popov, S. V. (2024) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2024.10.006 · Cited by 1
Yan, F., & Bao, L. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10606-1 · Cited by 1
Wu, Y., Wang, S., Zhang, J., Wang, W., Zeng, Z., Fu, L., & Li, B. (2025) · Cardiology Research and Practice · doi:10.1155/crp/5677597 · Cited by 1
Yang, H., Zhang, L., & Qian, H. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103318 · Cited by 1
Liu, Z., He, Y., & Zhu, W. (2026) · Biochemistry and Cell Biology · doi:10.1139/bcb-2025-0075 · Cited by 1
The role of selective autophagy in cardiovascular diseases: mechanisms and therapeutic potential
Zeng, T., Zhang, Z., Qian, C., Li, X., & Li, S. (2026) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.46 · Cited by 1
Zhang, Z. F., Zhou, X., Wei, T., Meng, L., & Long, K. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1824349 · Cited by 1
Yang, X., Cheng, K., Chen, C., Zhang, Y., & Wang, D. W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177734 · Cited by 1
Self-citationMethylmalonate Overload Despite Glycemic Control Drives Diabetic Heart Damage
Wang, S., Yan, M., Zhang, Y., Tang, F., Wang, Y., Guo, J., Chen, Z., Liu, X., Li, Z., Lu, R., et al. (2026) · Circulation Research · doi:10.1161/circresaha.125.327192 · Cited by 1
AMP-activated protein kinase activation: therapeutic potential in human diseases
Xu, W., Zhang, Y., & Xiao, H. (2019) · 中国科学通报：英文版 · doi:10.1016/j.scib.2019.07.032 · Cited by 1
Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases
Carrizzo, A., Izzo, C., & Vecchione, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78965 · Cited by 1
Autophagy in the cardiovascular system
Peña‐Oyarzún, D., Garrido‐Moreno, V., Garrido‐Olivares, L., Corbalan, R. L., Criollo, A., & Lavandero, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00003-6 · Cited by 1
Mechanisms of Cardiomyocyte Death
Kartha, C. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-85536-9_13
Lashgari, A. A., Azarbayjani, M. A., Peeri, M., & Nasehi, M. (2022) · فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران · doi:10.52547/iau.32.3.281
Mitophagy Regulation by Kangxian Yixin Granule in a Mouse Model of Dilated Cardiomyopathy
Liu, S., Hei, X., Wu, H., & Wang, Z. (2023) · Chinese medicine and natural products · doi:10.1055/s-0043-1770075
Xiao, H., Xu, W., Zhao, M., Zhang, M., Chen, X., Song, Y., Liu, H., Dong, E., & Zhang, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-3351285/v1
Mitochondrial Autophagy in APAP-Induced Liver Injury
翟, 燕. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.143956
Metadata
- Authors
- Wang, B., Nie, J., Wu, L., Hu, Y., Wen, Z., Dong, L., Zou, M.-H., Chen, C., & Wang, D. W.
- Affiliations
- Georgia State University (US)
- From the Division of Cardiology, Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College (B.W., J.N., L.W., Z.W.,C.C., D.W.W.), Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders (B.W., J.N., L.W., Z.W.,C.C., D.W.W.), and Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College (B.W., Y.H., L.D.), Huazhong University of Science and Technology, Wuhan, China; and Center for Molecular and Translational...
- Venue
- Circulation Research
- Published
- 2018-03-02
- Volume
- 122
- Issue
- 5
- Pages
- 712-729
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5834386
- OpenAlex
- W2778528862
- Cited by
- 334
- References
- 40
- Citations by year
- 2026: 37 · 2025: 45 · 2024: 45 · 2023: 43 · 2022: 50 · 2021: 39 · 2020: 43 · 2019: 19 · 2018: 13
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG047776)
- National Heart, Lung, and Blood Institute (R01HL079584, R01HL137371, R01HL132500, R01HL074399, R01HL080499, R01HL140954, R01HL110488, R01HL128014, R01HL089920)
- National Cancer Institute (R01CA213022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure, AMPKα2, mitophagy, Parkin, p62, mitochondrial dysfunction, transverse aortic constriction, cardiomyocyte apoptosis, reactive oxygen species, AAV9 gene therapy
- MeSH terms
- AMP-Activated Protein Kinase Kinases, PTEN-Induced Putative Kinase, Animals, Cells, Cultured, Heart Failure, Humans, Isoenzymes, Mitochondria, Heart, Phosphorylation, Protein Kinases, Myocytes, Cardiac, Mice, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
