Cited by 304Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAging and Gerontology Research

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Time and the Metrics of Aging

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Abstract

The study of aging relates to changes in physical and functional dimensions that occur over time in living organisms. Yet, a model that establishes the hierarchical relationship and interlaced time courses of molecular, phenotypic, and functional hierarchical domains of aging in humans has not been established. We propose that studying the mechanisms and consequences of aging through the lens of these hierarchical domains and their connections will provide clarity in semantics and enhance a translational perspective. The study of human aging would be most informative from a life course, longitudinal perspective, given that manifestations of aging are already detectable early in life at the molecular level, yet the phenotypic responses remain masked by compensatory/resiliency mechanisms. Understanding the nature of these mechanisms is paramount for developing interventions that reduce the burden of disease and disability in older persons.

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Crossref · 10.1161/circresaha.118.312816

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Metadata

Authors
Ferrucci, L., Levine, M. E., Kuo, P.-L., & Simonsick, E. M.
Affiliations
  • National Institute on Aging (US)
  • Yale University (US)
  • Johns Hopkins University (US)
Venue
Circulation Research
Published
2018-09-14
Volume
123
Issue
7
Pages
740-744
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2892085335
Cited by
303
References
20
Citations by year
2026: 55 · 2025: 61 · 2024: 48 · 2023: 37 · 2022: 35 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 1
FWCI
6.58
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (Z01AG000015, R00AG052604, P30AG021342)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords
aging, molecular aging, functional aging, life course, longitudinal aging study, compensatory mechanisms, resilience, aging interventions, older adults, disease burden
MeSH terms
Healthy Aging, Age Factors, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Health Status, Humans, Life Expectancy, Phenotype, Risk Factors, Time Factors, Signal Transduction

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