The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Time and the Metrics of Aging
Open accessAbstract
The study of aging relates to changes in physical and functional dimensions that occur over time in living organisms. Yet, a model that establishes the hierarchical relationship and interlaced time courses of molecular, phenotypic, and functional hierarchical domains of aging in humans has not been established. We propose that studying the mechanisms and consequences of aging through the lens of these hierarchical domains and their connections will provide clarity in semantics and enhance a translational perspective. The study of human aging would be most informative from a life course, longitudinal perspective, given that manifestations of aging are already detectable early in life at the molecular level, yet the phenotypic responses remain masked by compensatory/resiliency mechanisms. Understanding the nature of these mechanisms is paramount for developing interventions that reduce the burden of disease and disability in older persons.
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“Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [2]
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“With aging, resilience mechanisms become less effective at repairing or removing damage and preventing its deleterious effects on health (2).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [2]
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An epigenetic biomarker of aging for lifespan and healthspan
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Self-citationDNA methylation-based biomarkers and the epigenetic clock theory of ageing
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“tophagy or mitophagy cause cardiovascular disorders, including cardiac myopathy and heart failure.(8) Evidence of”
BackgroundAging, inflammation and the environment
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Self-citationClonal Hematopoiesis and Evolution to Hematopoietic Malignancies
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Redox resilience in skeletal muscle aging: cellular adaptations and exercise-mediated homeostasis
Tamayo-Torres, E., Martinez‐Canton, M., Soto-Rodriguez, S., Gorgori-González, A., Carretero, J., Cervera-Miguel, J. I., Laosa, O., Rodriguez-Mañas, L., & Gómez‐Cabrera, M. C. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.10.023
Allen, G. S. (2026) · Research Square · doi:10.21203/rs.3.rs-9829732/v3
Metadata
- Authors
- Ferrucci, L., Levine, M. E., Kuo, P.-L., & Simonsick, E. M.
- Affiliations
- National Institute on Aging (US)
- Yale University (US)
- Johns Hopkins University (US)
- Venue
- Circulation Research
- Published
- 2018-09-14
- Volume
- 123
- Issue
- 7
- Pages
- 740-744
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC6205734
- OpenAlex
- W2892085335
- Cited by
- 303
- References
- 20
- Citations by year
- 2026: 55 · 2025: 61 · 2024: 48 · 2023: 37 · 2022: 35 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 1
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (Z01AG000015, R00AG052604, P30AG021342)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- aging, molecular aging, functional aging, life course, longitudinal aging study, compensatory mechanisms, resilience, aging interventions, older adults, disease burden
- MeSH terms
- Healthy Aging, Age Factors, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Health Status, Humans, Life Expectancy, Phenotype, Risk Factors, Time Factors, Signal Transduction
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