The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation
Open accessAbstract
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which differentiate into myofibroblasts in response to injury or stress. Although myofibroblast formation is a physiological response to acute injury, such as myocardial infarction, myofibroblast persistence, as occurs in heart failure, contributes to maladaptive remodeling and progressive functional decline. Although traditional pathways of activation, such as TGFβ (transforming growth factor β) and AngII (angiotensin II), have been well characterized, less understood are the alterations in mitochondrial function and cellular metabolism that are necessary to initiate and sustain myofibroblast formation and function. In this review, we highlight recent reports detailing the mitochondrial and metabolic mechanisms that contribute to myofibroblast differentiation, persistence, and function with the hope of identifying novel therapeutic targets to treat, and potentially reverse, tissue organ fibrosis.
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Cites
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Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model
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Novel insights from a multiomics dissection of the Hayflick limit
Chan, M., Yuan, H., Soifer, I., Maile, T. M., Wang, R. Y., Ireland, A., O'Brien, J. J., Goudeau, J., Chan, L. J., Vijay, T., et al. (2022) · eLife · doi:10.7554/elife.70283 · Cited by 99
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Varzideh, F., Kansakar, U., Wilson, S., Jankauskas, S. S., & Santulli, G. (2024) · Cell Cycle · doi:10.1080/15384101.2025.2492423 · Cited by 10
Metadata
- Authors
- Gibb, A. A., Lazaropoulos, M. P., & Elrod, J. W.
- Venue
- Circulation Research
- Published
- 2020-07-17
- Volume
- 127
- Issue
- 3
- Pages
- 427-447
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W3043390187
- Cited by
- 434
- References
- 201
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gibb, A. A., Lazaropoulos, M. P., & Elrod, J. W. (2020). Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation. Circulation Research. https://doi.org/10.1161/circresaha.120.316958
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
