Left Ventricular Hypertrophy: Pathogenesis, Detection, and Prognosis

Lorell, Beverly H.; Carabello, Blase A.

doi:10.1161/01.cir.102.4.470

Cited by 1,232Cardiovascular Function and Risk FactorsCardiomyopathy and Myosin StudiesCardiac Fibrosis and Remodeling

Left Ventricular Hypertrophy: Pathogenesis, Detection, and Prognosis

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Lorell, Beverly H., Carabello, Blase A.·2000·Circulation

DOI 10.1161/01.cir.102.4.470

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The mechanical signal from increased LV systolic pressure initiates a cascade including re-expression of immature fetal genes, leading to coordinated cardiac growth in AS patients.
“The mechanical signal generated by increased LV systolic pressure initiates a cascade of biological events, including re-expression of immature fetal genes, which lead to coordinated cardiac growth in patients with AS114.”
From Calcific aortic stenosis (2016) · cites this paper as [114]
In “Pathogenesis of Load-Induced Hypertrophy” (page not provided), the review says a mechanical signal is generally believed to initiate a cascade leading to cardiac growth, and it describes fetal-gene re-expression in hypertrophy, including in aortic stenosis. The citing sentence presents that proposed mechanism as established and specifically attributes its initiation to increased LV systolic pressure in AS patients; the passage does not establish that specific causal sequence. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Myocyte growth in AS must be accompanied by coordinated increases in connective tissue architecture, capillary networks, and nerve networks to support the increased biomechanical load.
“To support the increased biomechanical load, the myocyte growth must be accompanied by coordinated increases in the surrounding architecture of connective tissue as well as the capillary and nerve networks114.”
From Calcific aortic stenosis (2016) · cites this paper as [114]

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Authors: Lorell, B. H., & Carabello, B. A.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Carabello, Blase A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-07-25
Volume: 102
Issue: 4
Pages: 470-479
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.102.4.470
OpenAlex: W1983692570
Cited by: 1,232
References: 115
Citations by year: 2026: 34 · 2025: 33 · 2024: 33 · 2023: 47 · 2022: 42 · 2021: 45 · 2020: 43 · 2019: 50 · 2018: 45 · 2017: 58 · 2016: 82 · 2015: 77 · 2014: 76 · 2013: 59 · 2012: 44
FWCI: 6.56
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: left ventricular hypertrophy
MeSH terms: Humans, Hypertrophy, Left Ventricular

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Left Ventricular Hypertrophy: Pathogenesis, Detection, and Prognosis

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