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Cited by 601

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells: The Role of Angiogenic Cytokines and Matrix Metalloproteinases

Yoon, Chang-Hwan, Hur, Jin, Park, Kyung-Woo, Kim, Ji-Hyun, Lee, Choon-Soo, Oh, Il-Young, Kim, Tae-Youn, Cho, Hyun-Jai, Kang, Hyun-Jae, Chae, In-Ho, Yang, Han-Kwang, Oh, Byung-Hee, Park, Young-Bae, Kim, Hyo-Soo·2005·Circulation
DOI 10.1161/circulationaha.104.503433
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Abstract

Background— Two types of cells are cultured from the human peripheral blood, early endothelial progenitor cells (EPCs) and outgrowth endothelial cells (OECs), as previously reported. Here, we further characterize these cells, especially with respect to their different origins and functions both in vitro and in vivo. We also investigated whether the combination of these different cell types shows synergism during neovascularization. Methods and Results— Early EPCs were heterogeneously made up of both CD14 + monocyte-derived cells, which secrete cytokines, and CD14 − -derived cells, which contain high levels of CD34 + KDR + cells. OECs were cultured almost exclusively from CD14 − cells, not CD14 + cells, and were distinct from mature endothelial cells in terms of proliferation potential, KDR + expression level, and telomerase activity. A portion of cells from CD14 − cells and early EPCs produced rapidly proliferating, capillary-forming cells in both the Matrigel plug and the ischemic hind limb similar to OECs. Early EPCs and OECs expressed receptors for vascular endothelial growth factor and interleukin-8, cytokines secreted by early EPCs. There was a differential increase in matrix metalloproteinases (MMPs): MMP-9 in early EPCs and MMP-2 in OECs. In vitro, the angiogenic capability of the 2 cell types was augmented by mutual interaction through cytokines and MMPs. Injection of a mixture of the 2 cells resulted in superior neovascularization in vivo to any single-cell-type transplantation. Conclusions— Distinct origins of the different types of EPCs exist that have different functions in neovascularization. Mixed transplantation of these cells results in synergistic neovascularization through cytokines and MMPs.

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Metadata

Authors
Yoon, C.-H., Hur, J., Park, K.-W., Kim, J.-H., Lee, C.-S., Oh, I.-Y., Kim, T.-Y., Cho, H.-J., Kang, H.-J., Chae, I.-H., Yang, H.-K., Oh, B.-H., Park, Y.-B., & Kim, H.-S.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-09-13
Volume
112
Issue
11
Pages
1618-1627
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.104.503433
OpenAlex
W2161041506
Cited by
601
References
27
FWCI
11.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells: The Role of Angiogenic Cytokines and Matrix Metalloproteinases. https://app.cochat.ai/papers/10.1161/circulationaha.104.503433
The paper
Yoon, C.-H., Hur, J., Park, K.-W., Kim, J.-H., Lee, C.-S., Oh, I.-Y., Kim, T.-Y., Cho, H.-J., Kang, H.-J., Chae, I.-H., Yang, H.-K., Oh, B.-H., Park, Y.-B., & Kim, H.-S. (2005). Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells: The Role of Angiogenic Cytokines and Matrix Metalloproteinases. Circulation. https://doi.org/10.1161/circulationaha.104.503433

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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