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Cited by 606Heart Failure Treatment and ManagementAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure

Kistorp, Caroline, Faber, Jens, Galatius, Søren, Gustafsson, Finn, Frystyk, Jan, Flyvbjerg, Allan, Hildebrandt, Per·2005·Circulation
DOI 10.1161/circulationaha.104.530972
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Abstract

Background— Recent studies have suggested that higher body mass index (BMI) is associated with improved prognosis in chronic heart failure (CHF). The adipocytokine adiponectin is inversely associated with BMI, and in healthy subjects, low adiponectin is a predictor of mortality. In a prospective study, we therefore evaluated the association between plasma adiponectin levels and mortality among patients with CHF. Methods and Results— In 195 CHF patients (age 69.3±10.2 years, BMI 27.3±5.2 kg/m 2 , left ventricular ejection fraction 30±8.9%, mean±SD), plasma adiponectin and N-terminal pro brain natriuretic peptide (NT-proBNP) were measured at baseline. Adiponectin was positively associated with NT-proBNP (β=0.47, P <0.001), and both biomarkers were negatively associated with BMI (β=−0.43, P <0.001 for adiponectin and β=−0.38, P <0.001 for NT-proBNP, respectively) During a median follow-up of 2.6 years, 46 (23.5%) of the patients died. After adjustment for clinical variables associated with CHF severity (age, systolic blood pressure, left ventricular ejection fraction <25%, duration of CHF, and creatinine clearance) and for NT-proBNP, the hazard ratio of mortality for values in the 2 upper tertiles relative to the lowest tertile of adiponectin was 3.23 ( P =0.032). BMI predicted mortality independently of clinical parameters of CHF severity (hazard ratio=0.63, P =0.012), but this association became insignificant after additional adjustment for NT-proBNP (hazard ratio=0.74, P =0.13). Conclusions— A high adiponectin level was a predictor of mortality, independent of risk markers of CHF severity, presumably because of its role as a marker for wasting. BMI was also associated with mortality, but a part of this relation may be mediated by adiponectin and NT-proBNP levels.

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  1. 10.1161/atvb.20.6.1595 · DOI
  2. 10.1210/jcem.86.8.7741 · DOI · Paper page

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Metadata

Authors
Kistorp, C., Faber, J., Galatius, S., Gustafsson, F., Frystyk, J., Flyvbjerg, A., & Hildebrandt, P.
Affiliations
Frederiksberg Hospital (DK)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-09-20
Volume
112
Issue
12
Pages
1756-1762
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.104.530972
OpenAlex
W2072526806
Cited by
605
References
39
Citations by year
2026: 4 · 2025: 8 · 2024: 8 · 2023: 22 · 2022: 21 · 2021: 13 · 2020: 20 · 2019: 17 · 2018: 12 · 2017: 25 · 2016: 32 · 2015: 18 · 2014: 23 · 2013: 48 · 2012: 48
FWCI
29.96
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adiponectin, chronic heart failure, body mass index, mortality, NT-proBNP, adipokines, prognostic factors, wasting, obesity paradox, left ventricular ejection fraction
MeSH terms
Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Heart Failure, Humans, Male, Middle Aged, Peptide Fragments, Regression Analysis, Biomarkers, Proportional Hazards Models, Survival Analysis, Natriuretic Peptide, Brain, Adiponectin

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