The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure
Abstract
Background— Recent studies have suggested that higher body mass index (BMI) is associated with improved prognosis in chronic heart failure (CHF). The adipocytokine adiponectin is inversely associated with BMI, and in healthy subjects, low adiponectin is a predictor of mortality. In a prospective study, we therefore evaluated the association between plasma adiponectin levels and mortality among patients with CHF. Methods and Results— In 195 CHF patients (age 69.3±10.2 years, BMI 27.3±5.2 kg/m 2 , left ventricular ejection fraction 30±8.9%, mean±SD), plasma adiponectin and N-terminal pro brain natriuretic peptide (NT-proBNP) were measured at baseline. Adiponectin was positively associated with NT-proBNP (β=0.47, P <0.001), and both biomarkers were negatively associated with BMI (β=−0.43, P <0.001 for adiponectin and β=−0.38, P <0.001 for NT-proBNP, respectively) During a median follow-up of 2.6 years, 46 (23.5%) of the patients died. After adjustment for clinical variables associated with CHF severity (age, systolic blood pressure, left ventricular ejection fraction <25%, duration of CHF, and creatinine clearance) and for NT-proBNP, the hazard ratio of mortality for values in the 2 upper tertiles relative to the lowest tertile of adiponectin was 3.23 ( P =0.032). BMI predicted mortality independently of clinical parameters of CHF severity (hazard ratio=0.63, P =0.012), but this association became insignificant after additional adjustment for NT-proBNP (hazard ratio=0.74, P =0.13). Conclusions— A high adiponectin level was a predictor of mortality, independent of risk markers of CHF severity, presumably because of its role as a marker for wasting. BMI was also associated with mortality, but a part of this relation may be mediated by adiponectin and NT-proBNP levels.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In relation to the role of adiponectin in the obesity paradox, it was found that a high circulating adiponectin level was a predictor of mortality in patients with congestive heart failure (179).”
From Cardiac remodeling in obesity (2008) · cites this paper as [179]
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Prediction of Creatinine Clearance from Serum Creatinine
Cockcroft, D. W., & Gault, H. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000180580 · Cited by 15,291
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,782
Research works printed but not linked: 2
- 10.1161/atvb.20.6.1595 · DOI
- 10.1210/jcem.86.8.7741 · DOI · Paper page
Cited by
Sorted by citations
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
D, E. B. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800239 · Cited by 1,252
Physical Activity Is the Strongest Predictor of All-Cause Mortality in Patients With COPD
Waschki, B., Kirsten, A., Holz, O., Müller, K.-C., Meyer, T., Watz, H., & MAGNUSSEN, H. (2011) · CHEST Journal · doi:10.1378/chest.10-2521 · Cited by 977
Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar‐Zadeh, K., Kaysen, G. A., Mitch, W. E., Price, S. R., Wanner, C., Wang, A. Y.-M., et al. (2013) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2013.01.001 · Cited by 966
Body mass index and mortality in heart failure: a meta-analysis
Oreopoulos, A., Padwal, R., Kalantar-Zadeh, K., Fonarow, G. C., Norris, C. M., & McAlister, F. A. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.02.014 · Cited by 829
Metadata
- Authors
- Kistorp, C., Faber, J., Galatius, S., Gustafsson, F., Frystyk, J., Flyvbjerg, A., & Hildebrandt, P.
- Affiliations
- Frederiksberg Hospital (DK)
- Venue
- Circulation
- Published
- 2005-09-20
- Volume
- 112
- Issue
- 12
- Pages
- 1756-1762
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2072526806
- Cited by
- 605
- References
- 39
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 22 · 2022: 21 · 2021: 13 · 2020: 20 · 2019: 17 · 2018: 12 · 2017: 25 · 2016: 32 · 2015: 18 · 2014: 23 · 2013: 48 · 2012: 48
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, chronic heart failure, body mass index, mortality, NT-proBNP, adipokines, prognostic factors, wasting, obesity paradox, left ventricular ejection fraction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Heart Failure, Humans, Male, Middle Aged, Peptide Fragments, Regression Analysis, Biomarkers, Proportional Hazards Models, Survival Analysis, Natriuretic Peptide, Brain, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
