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Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms
Abstract
Endothelial dysfunction contributes to cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. Insulin resistance is a hallmark of metabolic disorders, including type 2 diabetes mellitus and obesity, which are also characterized by endothelial dysfunction. Metabolic actions of insulin to promote glucose disposal are augmented by vascular actions of insulin in endothelium to stimulate production of the vasodilator nitric oxide (NO). Indeed, NO-dependent increases in blood flow to skeletal muscle account for 25% to 40% of the increase in glucose uptake in response to insulin stimulation. Phosphatidylinositol 3-kinase-dependent insulin-signaling pathways in endothelium related to production of NO share striking similarities with metabolic pathways in skeletal muscle that promote glucose uptake. Other distinct nonmetabolic branches of insulin-signaling pathways regulate secretion of the vasoconstrictor endothelin-1 in endothelium. Metabolic insulin resistance is characterized by pathway-specific impairment in phosphatidylinositol 3-kinase-dependent signaling, which in endothelium may cause imbalance between production of NO and secretion of endothelin-1, leading to decreased blood flow, which worsens insulin resistance. Therapeutic interventions in animal models and human studies have demonstrated that improving endothelial function ameliorates insulin resistance, whereas improving insulin sensitivity ameliorates endothelial dysfunction. Taken together, cellular, physiological, clinical, and epidemiological studies strongly support a reciprocal relationship between endothelial dysfunction and insulin resistance that helps to link cardiovascular and metabolic diseases. In the present review, we discuss pathophysiological mechanisms, including inflammatory processes, that couple endothelial dysfunction with insulin resistance and emphasize important therapeutic implications.
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“Endothelial dysfunction is attributed to many causes, including oxidative stress, chronic inflammation, and endothelium activation, in diabetes, which exhibits excessive free fatty acid (FFA), insulin resistance, and/or hyperglycemia [216,217].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [217]
In the citing paper
“The insulin receptor shares a signaling pathway with the activation of endothelial NOS (eNOS) [19,48,49,50,51,52] to regulate the postprandial blood flow and efficient nutrient disposition to peripheral tissues”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [50]
In the citing paper
“insulin resistance is always associated with impaired NO availability, suggesting that a reciprocal relationship exists between insulin activation and endothelial function [50,53].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [50]
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439
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Research works printed but not linked: 15
- 10.1161/circ.101.13.1539 · DOI
- Formoso G Chen H Kim J Montagnani M Consoli A Quon MJ. DHEA mimics acute actions of insulin to stimulate production of both NO and ET-1 via distinct PI 3-kinase- and MAP-kinase-dependent pathways in vascular endothelium. Mol Endocrinol. In press.
- 10.1161/circ.100.8.820 · DOI
- 10.1161/hyp.34.4.586 · DOI
- Renkin EM. Control of microcirculation and blood-tissue exchange. In: Handbook of Physiology: The Cardiovascular System: Microcirculation. Bethesda Md: American Physiological Society; 1984: 627–687.
- 10.1161/circ.103.21.2531 · DOI
- 10.1161/circ.102.18.2165 · DOI
- 10.1161/circ.101.6.676 · DOI
- 10.1161/hyp.35.6.1270 · DOI
- 10.1161/circ.100.15.1646 · DOI
- 10.1161/circ.102.11.1296 · DOI
- 10.1161/hyp.26.2.290 · DOI
- Potenza MA, Marasciulo FL, Tarquinio M, Quon MJ, Montagnani M. Rosiglitazone improves hypertension in spontaneously hypertensive rats (SHR) by decreasing endothelial MAP kinase signaling and endothelin-1 (ET-1) secretion. Diabetes. 2005; 54 (suppl 1): A320. Abstract.
- 10.1161/atvb.21.12.1891 · DOI
- 10.1161/atvb.20.6.1595 · DOI
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Sorted by citations
Items 701–800 of 999
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Lim, S. K., Sakuma, I., Quon, M. J., & Koh, K. K. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5531 · Cited by 25
The Ins and Outs of Small GTPase Rac1 in the Vasculature
Marinković, G., Heemskerk, N., van Buul, J. D., & de Waard, V. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.223610 · Cited by 25
Johansson, G., Chisalita, S. I., & Arnqvist, H. J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.012 · Cited by 25
Insulin resistance in Type 2 diabetes and obesity: implications for endothelial function
Aziz, A., & Wheatcroft, S. B. (2011) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.11.20 · Cited by 25
Yang, W., Zhang, X., Wu, K., Liu, X., Jiao, Y., & Zhou, C. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.07.006 · Cited by 25
Diabetes, dysglycemia, and vascular surgery
Duwayri, Y. M., & Jordan, W. D. (2019) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2019.05.027 · Cited by 27
Dong, Z., Wu, M., Zhang, Y., Wang, Q., Liang, C., Yan, X., Zou, L., Chen, C., Han, X., Zhang, B., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00569-1 · Cited by 25
Nevelsteen, I., den Bergh, A. V., der Mieren, G. V., Vanderper, A., Mubagwa, K., Bult, H., & Herijgers, P. (2013) · Journal of Vascular Research · doi:10.1159/000355221 · Cited by 25
Insulin resistance induces a segmental difference in thoracic and abdominal aorta
Karpe, P. A., Gupta, J., Marthong, R. F., Ramarao, P., & Tikoo, K. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834d9efe · Cited by 25
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Nacci, C., Leo, V., Benedictis, L. D., Carratù, M. R., Bartolomeo, N., Altomare, M., Giordano, P., Faienza, M. F., & Montagnani, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4119 · Cited by 25
Oudot, A., Behr‐Roussel, D., Compagnie, S., Caisey, S., Coz, O. L., Gorny, D., Alexandre, L., & Giuliano, F. (2009) · Physiological Research · doi:10.33549/physiolres.931583 · Cited by 25
Chadderdon, S. M., Belcik, J. T., Bader, L., Peters, D., Kievit, P., Alkayed, N. J., Kaul, S., Grove, K. L., & Lindner, J. R. (2016) · Diabetes · doi:10.2337/db15-1574 · Cited by 25
Černý, D., Sartori, C. S., Rimoldi, S. F., Meister, T. A., Soria, R., Bouillet, E., Scherrer, U., & Rexhaj, E. (2017) · Endocrinology · doi:10.1210/en.2016-1475 · Cited by 25
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Taguchi, K., Hida, M., Hasegawa, M., Narimatsu, H., Matsumoto, T., & Kobayashi, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-08998-5 · Cited by 25
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Picard, F. A., Adjedj, J., & Varenne, O. (2017) · Annales de Cardiologie et d Angéiologie · doi:10.1016/j.ancard.2017.10.011 · Cited by 25
Workman, G. A., & Sage, E. H. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23015 · Cited by 25
Slow gait speed – an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus
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Steiner, G. A. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.067 · Cited by 24
Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance
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Watanabe, S., Matsumoto, T., Oda, M., Yamada, K., Takagi, J., Taguchi, K., & Kobayashi, T. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1759-4 · Cited by 24
Omentina: papel en la resistencia a la insulina, inflamación y protección cardiovascular
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Yamagata, K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100026 · Cited by 25
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Shi, Y., Hu, L., Li, M., Zhou, W., Wang, T., Zhu, L., Bao, H., Li, P., & Cheng, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.760361 · Cited by 24
Agouni, A., Tual‐Chalot, S., Chalopin, M., Duluc, L., Mody, N., Martínez, M. C., Andriantsitohaina, R., & Delibegović, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.10.008 · Cited by 24
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Olson, K. M., Augeri, A. L., Seip, R. L., Tsongalis, G. J., Thompson, P. D., & Pescatello, L. S. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.01.027 · Cited by 23
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Gilbert, S. E., Tew, G. A., Bourke, L., Winter, E., & Rosario, D. J. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.073353 · Cited by 23
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Vecoli, C., Andreassi, M. G., Liga, R., Colombo, M. G., Coceani, M., Carpeggiani, C., L’Abbate, A., & Neglia, D. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-92 · Cited by 22
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Ren, G., Bhatnagar, S., Hahn, D. J., & Kim, J. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2020 · Cited by 21
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KASE, N. G., Friedman, E. G., Brodman, M. L., Kang, C., Gallagher, E. J., & LeRoith, D. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.05.051 · Cited by 24
Straznicky, N. E., Grima, M. T., Lambert, E. A., Sari, C. I., Eikelis, N., Nestel, P. J., Phillips, S. E., Hering, D., Karapanagiotidis, S., Dixon, J. B., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3796 · Cited by 20
Karakasis, P., Patoulias, D., Rizzo, M., Fragakis, N., & Mantzoros, C. S. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16258 · Cited by 20
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Yang, H.-Y., Hu, L., Chen, H.-J., Chen, R.-Y., Hu, C.-K., & Shen, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912331 · Cited by 20
Vecoli, C., Novelli, M., Pippa, A., Giacopelli, D., Beffy, P., Masiello, P., L’Abbate, A., & Neglia, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104156 · Cited by 20
Elçioğlu, H. K., Kabasakal, L., Özkan, N., Çelikel, Ç., & Ayanoğlu‐Dülger, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.030 · Cited by 20
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Sjögren, P., Cederholm, T., Heimbürger, M., Stenvinkel, P., Vedin, I., Palmblad, J. E. W., & Hellénius, M.-L. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.182 · Cited by 20
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Markelic, M. B., Veličković, K., Golić, I., Otašević, V., Stančić, A., Janković, A., Vučetić, M., Buzadžić, B., Korać, B., & Korać, A. (2011) · European Journal of Histochemistry · doi:10.4081/ejh.2011.e34 · Cited by 20
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Treviño, S., Díaz, A., Sánchez‐Lara, E., Sarmiento-Ortega, V. E., Flores-Hernández, J. Á., Brambila, E., Meléndez, F. J., & Vergara, E. G. (2018) · Bioinorganic Chemistry and Applications · doi:10.1155/2018/2151079 · Cited by 20
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Roberto, S., Milia, R., Doneddu, A., Pinna, V., Palazzolo, G., Serra, S., Orrù, A., Kakhak, S. A. H., Ghiani, G. M., Mulliri, G., et al. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00794.2018 · Cited by 20
Ragno, V. M., Zello, G. A., Klein, C. D., & Montgomery, J. B. (2019) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2019.06.003 · Cited by 21
Metadata
- Authors
- Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J.
- Affiliations
- National Institutes of Health (US)
- Venue
- Circulation
- Published
- 2006-04-18
- Volume
- 113
- Issue
- 15
- Pages
- 1888-1904
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2126412451
- Cited by
- 1,652
- References
- 186
- Citations by year
- 2026: 68 · 2025: 80 · 2024: 61 · 2023: 55 · 2022: 67 · 2021: 71 · 2020: 67 · 2019: 64 · 2018: 76 · 2017: 70 · 2016: 76 · 2015: 99 · 2014: 96 · 2013: 119 · 2012: 108
- FWCI
- 61.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Center for Complementary and Alternative Medicine
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- insulin resistance, endothelial dysfunction, nitric oxide, endothelin-1, phosphatidylinositol 3-kinase signaling, glucose uptake, skeletal muscle blood flow, type 2 diabetes, obesity, cardiovascular disease, inflammation, bidirectional relationship
- MeSH terms
- Animals, Disease Models, Animal, Endothelium, Vascular, Glucose, Hemodynamics, Homeostasis, Humans, Insulin, Insulin Resistance, Signal Transduction, Metabolic Syndrome
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