The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Anemia in Chronic Heart Failure: Prevalence, Etiology, Clinical Correlates, and Treatment Options
Abstract
A nemia occurs commonly in patients with chronic heart failure (CHF) and has been proposed as a novel therapeutic target in this patient population.The present review will summarize the current knowledge of the prevalence, causative factors, and pathophysiological correlates of anemia in CHF.Potential risks and benefits of therapy with erythropoietic agents for the treatment of anemia in CHF will also be discussed. Prevalence of Anemia in CHF][3][4][5][6][7][8][9][10][11][12][13][14][15] Variability in estimated prevalence is partly attributable to use of inconsistent definitions of anemia in individual reports.The World Health Organization definition of anemia (hemoglobin concentration Ͻ13.0 g/dL in men and Ͻ12.0 g/dL in women) takes into account known gender differences in distribution of hemoglobin values, 16 whereas the National Kidney Foundation defines anemia as hemoglobin Յ12 g/dL in men and postmenopausal women. 17These standard definitions of anemia are not based on wellestablished physiological or population norms.Published reports in CHF populations have used these and other study-specific definitions of anemia (including other arbitrary or statistically defined hemoglobin and hematocrit categories and administrative diagnostic codes from hospital records).Despite these inconsistencies in the definition of anemia cases, most studies indicate that the prevalence of anemia is increased in CHF populations with comorbid kidney disease, advanced age, and more severe symptoms (range, 30% to 61%) when compared with less symptomatic ambulatory populations (range, 4% to 23%).In patients with CHF and preserved ejection fraction, the few published reports indicate that anemia is also highly prevalent in this group.
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Cites
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Besarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544
Ezekowitz, J. A., McAlister, F. A., & Armstrong, P. W. (2003) · Circulation · doi:10.1161/01.cir.0000052622.51963.fc · Cited by 866
Plasma Cytokine Parameters and Mortality in Patients With Chronic Heart Failure
Rauchhaus, M., Doehner, W., Francis, D. P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H.-D., Coats, A. J. S., et al. (2000) · Circulation · doi:10.1161/01.cir.102.25.3060 · Cited by 810
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765
Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., & Borenstein, J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01854-5 · Cited by 712
Anemia predicts mortality in severe heart failure
Mozaffarian, D., Nye, R., & Levy, W. C. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00425-x · Cited by 294
Up-regulation of renal and vascular nitric oxide synthase in iron-deficiency anemia
Ni, Z., Morcos, S., & Vaziri, N. D. (1997) · Kidney International · doi:10.1038/ki.1997.319 · Cited by 72
Cited by
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083
Iron deficiency: an ominous sign in patients with systolic chronic heart failure
Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., Banasiak, W., Polonski, L., Filippatos, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq158 · Cited by 652
Exercise Intolerance in Patients With Heart Failure
Del Buono, M. G., Arena, R., Borlaug, B. A., Carbone, S., Canada, J. M., Kirkman, D. L., Garten, R., Rodriguez-Miguelez, P., Guazzi, M., Lavie, C. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.072 · Cited by 477
The non‐haematopoietic biological effects of erythropoietin
Arcasoy, M. O. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07014.x · Cited by 347
Metadata
- Authors
- Tang, Y.-D., & Katz, S. D.
- Venue
- Circulation
- Published
- 2006-05-23
- Volume
- 113
- Issue
- 20
- Pages
- 2454-2461
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2096750760
- Cited by
- 415
- References
- 11
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- closed
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