The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis
Open accessAbstract
Background— Although the mechanisms are unknown, it has been suggested that transient exposure to traffic-derived air pollution may be a trigger for acute myocardial infarction. The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans. Methods and Results— In a double-blind, randomized, cross-over study, 30 healthy men were exposed to diluted diesel exhaust (300 μg/m 3 particulate concentration) or air for 1 hour during intermittent exercise. Bilateral forearm blood flow and inflammatory factors were measured before and during unilateral intrabrachial bradykinin (100 to 1000 pmol/min), acetylcholine (5 to 20 μg/min), sodium nitroprusside (2 to 8 μg/min), and verapamil (10 to 100 μg/min) infusions 2 and 6 hours after exposure. There were no differences in resting forearm blood flow or inflammatory markers after exposure to diesel exhaust or air. Although there was a dose-dependent increase in blood flow with each vasodilator ( P <0.0001 for all), this response was attenuated with bradykinin ( P <0.05), acetylcholine ( P <0.05), and sodium nitroprusside ( P <0.001) infusions 2 hours after exposure to diesel exhaust, which persisted at 6 hours. Bradykinin caused a dose-dependent increase in plasma tissue plasminogen activator ( P <0.0001) that was suppressed 6 hours after exposure to diesel ( P <0.001; area under the curve decreased by 34%). Conclusions— At levels encountered in an urban environment, inhalation of dilute diesel exhaust impairs 2 important and complementary aspects of vascular function in humans: the regulation of vascular tone and endogenous fibrinolysis. These important findings provide a potential mechanism that links air pollution to the pathogenesis of atherothrombosis and acute myocardial infarction.
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Cites
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592
Prognostic Value of Coronary Vascular Endothelial Dysfunction
Halcox, J. P. J., Schenke, W. H., Zalos, G., Mincemoyer, R., Prasad, A., Waclawiw, M. A., Nour, K. R. A., & Quyyumi, A. A. (2002) · Circulation · doi:10.1161/01.cir.0000025404.78001.d8 · Cited by 1,385
Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Air Pollution and Cardiovascular Disease
Rajagopalan, S., Al-Kindi, S. G., & Brook, R. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.07.099 · Cited by 1,299
Cardiovascular effects of air pollution.
Bourdrel, T., Bind, M.-A., Béjot, Y., Morel, O., & Argacha, J.-F. (2017) · Archives of Cardiovascular Diseases · doi:10.1016/j.acvd.2017.05.003 · Cited by 783
Deposition and biokinetics of inhaled nanoparticles
Geiser, M., & Kreyling, W. G. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-2 · Cited by 747
Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
Melzer, D., Rice, N. E., Lewis, C., Henley, W. E., & Galloway, T. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008673 · Cited by 572
Cassee, F. R., Héroux, M.-E., Gerlofs-Nijland, M. E., & Kelly, F. J. (2013) · Inhalation Toxicology · doi:10.3109/08958378.2013.850127 · Cited by 448
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Stone, V., Miller, M. R., Clift, M. J. D., Elder, A., Mills, N. L., Møller, P., Schins, R. P. F., Vogel, U., Kreyling, W. G., Alstrup Jensen, K., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp424 · Cited by 370
Self-citationPublic health and components of particulate matter: The changing assessment of black carbon
Grahame, T. J., Klemm, R., & Schlesinger, R. B. (2014) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2014.912692 · Cited by 294
“The effect was suggested as due to reduced availability of nitric oxide (NO) in the vasculature, postulated, in turn, as due to oxidative stress induced by DEE (Mills et al., 2005; Wauters et al., 2013).”
BackgroundResultInfluentialVita, J. A. (2011) · Circulation · doi:10.1161/circulationaha.111.078824 · Cited by 195
Mossman, B. T., Borm, P. J., Castranova, V., Costa, D. L., Donaldson, K., & Kleeberger, S. R. (2007) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-4-4 · Cited by 150
Self-citationCD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure
Robertson, S., Colombo, E. S., Lucas, S. N., Hall, P. R., Febbraio, M., Paffett, M. L., & Campen, M. J. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft107 · Cited by 82
Weldy, C. S., Liu, Y., Chang, Y.-C., Medvedev, I. O., Fox, J. R., Larson, T. V., Chien, W.-M., & Chin, M. T. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-59 · Cited by 63
Chronic snus use in healthy males alters endothelial function and increases arterial stiffness
Antoniewicz, L., Kabele, M., Nilsson, U., Pourazar, J., Rankin, G., Bosson, J. A., & Lundbäck, M. (2022) · PLOS ONE · doi:10.1371/journal.pone.0268746 · Cited by 12
Metadata
- Authors
- Mills, N. L., Törnqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., Boon, N. A., Donaldson, K., Blomberg, A., Sandstrom, T., & Newby, D. E.
- Venue
- Circulation
- Published
- 2005-12-20
- Volume
- 112
- Issue
- 25
- Pages
- 3930-3936
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2104761649
- Cited by
- 646
- References
- 3
- FWCI
- 22.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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