Prognostic Value of Coronary Vascular Endothelial Dysfunction
Abstract
Background — Whether patients at increased risk can be identified from a relatively low-risk population by coronary vascular function testing remains unknown. We investigated the relationship between coronary endothelial function and the occurrence of acute unpredictable cardiovascular events (cardiovascular death, myocardial infarction, stroke, and unstable angina) in patients with and without coronary atherosclerosis (CAD). Methods and Results — We measured the change in coronary vascular resistance (ΔCVR) and epicardial diameter with intracoronary acetylcholine (ACh, 15 μg/min) to test endothelium-dependent function and sodium nitroprusside (20 μg/min) and adenosine (2.2 mg/min) to test endothelium-independent vascular function in 308 patients undergoing cardiac catheterization (132 with and 176 without CAD). Patients underwent clinical follow-up for a mean of 46±3 months. Acute vascular events occurred in 35 patients. After multivariate analysis that included CAD and conventional risk factors for atherosclerosis, ΔCVR with ACh ( P =0.02) and epicardial constriction with ACh ( P =0.003), together with increasing age, CAD, and body mass index, were independent predictors of adverse events. Thus, patients in the tertile with the best microvascular responses with ACh and those with epicardial dilation with ACh had improved survival by Kaplan-Meier analyses in the total population, as did those in the subset without CAD. Similar improvement in survival was also observed when all adverse events, including revascularization, were considered. Endothelium-independent responses were not predictive of outcome. Conclusions — Epicardial and microvascular coronary endothelial dysfunction independently predict acute cardiovascular events in patients with and without CAD, providing both functional and prognostic information that complements angiographic and risk factor assessment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Endothelial dysfunction occurs early in the pathogenesis of atherosclerosis, and predicts future cardiovascular events.
“Endothelial dysfunction occurs early in the pathogenesis of atherosclerosis, and predicts future cardiovascular events.”
From The Vasculature in Prediabetes (2018) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467 · see citing works
Barr, A. J. (1979) · Medical Entomology and Zoology · Cited by 7,198 · see citing works
(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261 · see citing works
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622 · see citing works
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · BMJ · doi:10.1136/bmj.308.6921.81 · Cited by 4,198 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · Cited by 3,322 · see citing works
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,584 · see citing works
Galis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,537 · see citing works
Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction
Suwaidi, J. M. S. A., Hamasaki, S., Higano, S. T., Nishimura, R. A., Holmes, D. R., & Lerman, A. (2000) · Circulation · doi:10.1161/01.cir.101.9.948 · Cited by 2,044 · see citing works
Tuomilehto, J., Vidgrén, G., Toivanen, L., Tuomilehto-Wolf, E., Kohtamäki, K., Stengård, J., Zimmet, P., Mackay, I., Rowley, M., & Koskela, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92521-6 · Cited by 1,658 · see citing works
Rajagopalan, S., Meng, X. P., Ramasamy, S., Harrison, D. G., & Galis, Z. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119076 · Cited by 1,137 · see citing works
Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity.
Doucette, J. W., Corl, P. D., Payne, H. M., Flynn, A. E., Goto, M., Nassí, M., & Segal, J. (1992) · Circulation · doi:10.1161/01.cir.85.5.1899 · Cited by 1,017 · see citing works
Quyyumi, A. A., Dakak, N., Andrews, N. P., Husain, S., Arora, S., Gilligan, D. M., Panza, J. A., & Cannon, R. O. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117852 · Cited by 444 · see citing works
Self-citationEndothelial function in health and disease: new insights into the genesis of cardiovascular disease
Quyyumi, A. A. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00209-5 · Cited by 405 · see citing works
Self-citationMügge, A., Elwell, J. H., Peterson, T. E., & Harrison, D. G. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.2.c219 · Cited by 314 · see citing works
Newby, D. E., McLeod, A. L., Uren, N. G., Flint, L., Ludlam, C. A., Webb, D. J., Fox, K. A. A., & Boon, N. A. (2001) · Circulation · doi:10.1161/01.cir.103.15.1936 · Cited by 244 · see citing works
Rajavashisth, T. B., Liao, J. K., Galis, Z. S., Tripathi, S., Laufs, U., Tripathi, J., Chai, N., Xu, X., Jovinge, S. V., Shah, P. K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11924 · Cited by 210 · see citing works
Nitric Oxide Activity in the Atherosclerotic Human Coronary Circulation
Quyyumi, A. A., Dakak, N., Mulcahy, D., Andrews, N. P., Husain, S., Panza, J. A., & Cannon, R. O. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00472-x · Cited by 150 · see citing works
Self-citationEffect of Atherosclerosis on Endothelium-Dependent Inhibition of Platelet Activation in Humans
Diodati, J. G., Dakak, N., Gilligan, D. M., & Quyyumi, A. A. (1998) · Circulation · doi:10.1161/01.cir.98.1.17 · Cited by 94 · see citing works
Self-citationNewby, D. E., Wright, R. A., Dawson, P., Ludlam, C. A., Boon, N. A., Fox, K. A. A., & Webb, D. J. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00017-0 · Cited by 58 · see citing works
Jern, S., Wall, U., Bergbrant, A., Sjögren, L. S., & Jern, C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3376 · Cited by 47 · see citing works
Contribution of bradykinin receptor dysfunction to abnormal coronary vasomotion in humans
Prasad, A., Husain, S., Schenke, W. H., Mincemoyer, R., Epstein, N., & Quyyumi, A. A. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00892-5 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,818 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423 · see citing works
Self-citationFrom Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,686 · see citing works
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710 · see citing works
Role of Endothelial Dysfunction in Atherosclerosis
Davignon, J., & Ganz, P. (2004) · Circulation · doi:10.1161/01.cir.0000131515.03336.f8 · Cited by 2,513 · see citing works
2007 Guidelines for the management of arterial hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cifkova, R., Fagard, R., Germano, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm236 · Cited by 2,384 · see citing works
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087480.94275.97 · Cited by 2,270 · see citing works
Bonetti, P. O., Lerman, L. O., & Lerman, A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051384.43104.fc · Cited by 2,199 · see citing works
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Jia, Q.-W., Chen, Z.-H., Ding, X.-Q., Liu, J.-Y., Ge, P.-C., An, F.-H., Li, L.-H., Wang, L.-S., Ma, W.-Z., Yang, Z.-J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000478071 · Cited by 1,693 · see citing works
Kinaan, M., Ding, H., & Triggle, C. R. (2015) · Medical Principles and Practice · doi:10.1159/000381643 · Cited by 1,515 · see citing works
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326 · see citing works
The role of shear stress in the pathogenesis of atherosclerosis
Cunningham, K. S., & Gotlieb, A. I. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700215 · Cited by 1,155 · see citing works
The Assessment of Endothelial Function
Flammer, A. J., Anderson, T. J., Celermajer, D. S., Creager, M. A., Deanfield, J. E., Ganz, P., Hamburg, N. M., Lüscher, T. F., Shechter, M., Taddei, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.093245 · Cited by 1,157 · see citing works
Tjønna, A. E., Lee, S. J., Rognmo, Ø., Stølen, T. O., Bye, A., Haram, P. M., Loennechen, J. P., Al-Share, Q. Y., Skogvoll, E., Slørdahl, S. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772822 · Cited by 1,145 · see citing works
The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome
Zhang, J., Bottiglieri, T., & McCullough, P. A. (2016) · Cardiorenal Medicine · doi:10.1159/000452283 · Cited by 1,082 · see citing works
Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events
Schmidt‐Lucke, C., Rössig, L., Fichtlscherer, S., Vasa‐Nicotera, M., Britten, M. B., Kämper, U., Dimmeler, S., & Zeiher, A. M. (2005) · Circulation · doi:10.1161/circulationaha.104.504340 · Cited by 1,060 · see citing works
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Vasan, R. S. (2006) · Circulation · doi:10.1161/circulationaha.104.482570 · Cited by 1,212 · see citing works
Jespersen, L., Hvelplund, A., Abildstrom, S. Z., Pedersen, F., Galatius, S., Madsen, J. K., Jørgensen, E. O., Kelbæk, H., & Prescott, E. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr331 · Cited by 955 · see citing works
Endothelial dysfunction and vascular disease - a 30th anniversary update
Vanhoutte, P. M., Shimokawa, H., Feletou, M., & Tang, E. H. C. (2017) · Acta Physiologica · doi:10.1111/apha.12646 · Cited by 937 · see citing works
Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve
Murthy, V. L., Naya, M., Foster, C. R., Hainer, J. M., Gaber, M., Carli, G. D., Blankstein, R., Dorbala, S., Sitek, A., Pencina, M. J., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.050427 · Cited by 852 · see citing works
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851 · see citing works
Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study
Merz, C. N. B., Shaw, L. J., Reís, S. E., Bittner, V., Kelsey, S. F., Olson, M. B., Johnson, B. D., Pepine, C. J., Mankad, S. V., Sharaf, B. L., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.084 · Cited by 849 · see citing works
Self-citationNoninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events
Oliver, J. J., & Webb, D. J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000060460.52916.d6 · Cited by 820 · see citing works
Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome.
Hadi, H. A. R., Carr, C. S., & Suwaidi, J. M. S. A. (2005) · PubMed Central · Cited by 807 · see citing works
Pepine, C. J., Anderson, R. D., Sharaf, B. L., Reís, S. E., Smith, K., Handberg, E. M., Johnson, B. D., Sopko, G. S., & Merz, C. N. B. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.054 · Cited by 808 · see citing works
Endothelial dysfunction and vascular disease
Vanhoutte, P. M., Shimokawa, H., Tang, E. H. C., & Félétou, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01964.x · Cited by 808 · see citing works
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Nedeljkovic, Z. S., Menzoı́an, J. O., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00333-4 · Cited by 776 · see citing works
Vita, J. A., & Keaney, J. F. (2002) · Circulation · doi:10.1161/01.cir.0000028581.07992.56 · Cited by 743 · see citing works
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Oxidant Mechanisms in Renal Injury and Disease
Ratliff, B. B., Abdulmahdi, W., Pawar, R. D., & Wolin, M. S. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6665 · Cited by 699 · see citing works
Rubinshtein, R., Kuvin, J. T., Soffler, M. I., Lennon, R. J., Lavi, S., Nelson, R. E., Pumper, G. M., Lerman, L. O., & Lerman, A. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq010 · Cited by 683 · see citing works
Renin-angiotensin system and cardiovascular risk
Schmieder, R. E., Hilgers, K. F., Schlaich, M. P., & Schmidt, B. M. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60242-6 · Cited by 659 · see citing works
Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis
Mills, N. L., Törnqvist, H., Robinson, S. D., Gonzalez, M. A., Darnley, K., MacNee, W., Boon, N. A., Donaldson, K., Blomberg, A., Sandström, T., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.588962 · Cited by 648 · see citing works
Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus
Meigs, J. B. (2004) · JAMA · doi:10.1001/jama.291.16.1978 · Cited by 643 · see citing works
Endothelial function and dysfunction. Part I
Deanfield, J. E., Donald, A. E., Ferri, C., Giannattasio, C., Halcox, J., Halligan, S., Lerman, A., Mancia, G., Oliver, J. J., Pessina, A. C., et al. (2005) · Journal of Hypertension · doi:10.1097/00004872-200501000-00004 · Cited by 634 · see citing works
Self-citationPyke, K. E., & Tschakovsky, M. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089755 · Cited by 615 · see citing works
Adverse Cardiovascular Outcomes in Women With Nonobstructive Coronary Artery Disease
Gulati, M., Cooper‐DeHoff, R. M., McClure, C., Johnson, B. D., Shaw, L. J., Handberg, E. M., Zineh, I., Kelsey, S. F., Arnsdorf, M. F., Black, H. R., et al. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.50 · Cited by 585 · see citing works
Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications
Tabit, C. E., Chung, W. B., Hamburg, N. M., & Vita, J. A. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9134-4 · Cited by 584 · see citing works
Endothelial Function Testing as a Biomarker of Vascular Disease
Verma, S., Buchanan, M. R., & Anderson, T. J. (2003) · Circulation · doi:10.1161/01.cir.0000089191.72957.ed · Cited by 565 · see citing works
Francque, S., van der Graaff, D., & Kwanten, W. J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.005 · Cited by 557 · see citing works
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases
Cersósimo, E., & DeFronzo, R. A. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.634 · Cited by 525 · see citing works
E-Cigarettes: Use, Effects on Smoking, Risks, and Policy Implications
Glantz, S. A., & Bareham, D. (2018) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040617-013757 · Cited by 551 · see citing works
Angina With “Normal” Coronary Arteries
Bugiardini, R., & Merz, C. N. B. (2005) · JAMA · doi:10.1001/jama.293.4.477 · Cited by 516 · see citing works
Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501 · see citing works
Polyphenols and cardiovascular disease: effects on endothelial and platelet function
Vita, J. A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.292s · Cited by 495 · see citing works
Endothelial Dysfunction, Arterial Stiffness, and Heart Failure
Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., & Butler, J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.082 · Cited by 481 · see citing works
Self-citationWaßmann, S., Stumpf, M., Strehlow, K., Schmid, A., Schieffer, B., Böhm, M., & Nickenig, G. (2003) · Circulation Research · doi:10.1161/01.res.0000115557.25127.8d · Cited by 469 · see citing works
O’Neill, M. S., Veves, A., Zanobetti, A., Sarnat, J. A., Gold, D. R., Economides, P. A., Horton, E. S., & Schwartz, J. D. (2005) · Circulation · doi:10.1161/circulationaha.104.517110 · Cited by 464 · see citing works
Diabetes mellitus as a prothrombotic condition
Grant, P. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01824.x · Cited by 443 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Onuma, Y., & Serruys, P. W. J. C. (2011) · Circulation · doi:10.1161/circulationaha.110.971606 · Cited by 434 · see citing works
TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure
Kleinbongard, P., Heusch, G., & Schulz, R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.05.002 · Cited by 408 · see citing works
The health effects of dietary unsaturated fatty acids
Lunn, J., & Theobald, H. E. (2006) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2006.00571.x · Cited by 401 · see citing works
Alexander, M. Y., Osto, E., Schmidt‐Trucksäss, A., Shechter, M., Trifunović, D., Duncker, D. J., Aboyans, V., Bäck, M., Badimón, L., Cosentino, F., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa085 · Cited by 401 · see citing works
Persistent Endothelial Dysfunction in Humans after Diesel Exhaust Inhalation
Törnqvist, H., Mills, N. L., Gonzalez, M. A., Miller, M. R., Robinson, S. D., Megson, I. L., MacNee, W., Donaldson, K., Söderberg, S., Newby, D. E., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-872oc · Cited by 390 · see citing works
Appel, L. J., Frohlich, E. D., Hall, J. E., Pearson, T. A., Sacco, R. L., Seals, D. R., Sacks, F. M., Smith, S. C., Vafiadis, D. K., & Horn, L. V. (2011) · Circulation · doi:10.1161/cir.0b013e31820d0793 · Cited by 391 · see citing works
Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 384 · see citing works
Exercise and the Nitric Oxide Vasodilator System
Maiorana, A., Driscoll, G. O., Taylor, R. R., & GREEN, D. J. (2003) · Sports Medicine · doi:10.2165/00007256-200333140-00001 · Cited by 382 · see citing works
Microvascular Function Predicts Cardiovascular Events in Primary Prevention
Anderson, T. J., Charbonneau, F., Title, L. M., Buithieu, J., Rose, M. S., Conradson, H. E., Hildebrand, K., Fung, M., Verma, S., & Lonn, E. (2011) · Circulation · doi:10.1161/circulationaha.110.953653 · Cited by 381 · see citing works
Abnormal Coronary Vasomotion as a Prognostic Indicator of Cardiovascular Events in Women
von Mering, G. O., Arant, C. B., Wessel, T. R., McGorray, S. P., Merz, C. N. B., Sharaf, B. L., Smith, K., Olson, M. B., Johnson, B. D., Sopko, G. S., et al. (2004) · Circulation · doi:10.1161/01.cir.0000115525.92645.16 · Cited by 368 · see citing works
Different Effect of Antihypertensive Drugs on Conduit Artery Endothelial Function
Ghiadoni, L., Magagna, A., Versari, D., Kardasz, I., Huang, Y., Taddei, S., & Salvetti, A. (2003) · Hypertension · doi:10.1161/01.hyp.0000070956.57418.22 · Cited by 366 · see citing works
Association Between Electronic Cigarette Use and Myocardial Infarction
Alzahrani, T., Peña, I., Temesgen, N., & Glantz, S. A. (2018) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2018.05.004 · Cited by 372 · see citing works
Tjønna, A. E., Stølen, T. O., Bye, A., Volden, M., Slørdahl, S. A., Ødegård, R., Skogvoll, E., & Wisløff, U. (2009) · Clinical Science · doi:10.1042/cs20080249 · Cited by 362 · see citing works
Erdman, J. W., Balentine, D. A., Arab, L., Beecher, G. R., Dwyer, J. T., Folts, J. D., Harnly, J. M., Hollman, P. C. H., Keen, C. L., Mazza, G., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.718s · Cited by 361 · see citing works
Koga, H., Sugiyama, S., Kugiyama, K., Watanabe, K., Fukushima, H., Tanaka, T., Sakamoto, T., Yoshimura, M., Jinnouchi, H., & Ogawa, H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.047 · Cited by 362 · see citing works
Is Flow-Mediated Dilation Nitric Oxide Mediated?
GREEN, D. J., Dawson, E. A., Groenewoud, H., Jones, H., & Thijssen, D. H. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02044 · Cited by 362 · see citing works
Invasive Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease
Lee, B., Lim, H., Fearon, W. F., Yong, A. S. C., Yamada, R., Tanaka, S., Lee, D. P., Yeung, A. C., & Tremmel, J. A. (2015) · Circulation · doi:10.1161/circulationaha.114.012636 · Cited by 360 · see citing works
2007 ESH‐ESC Guidelines for the management of arterial hypertension
Mansia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Blood Pressure · doi:10.1080/08037050701461084 · Cited by 358 · see citing works
Endothelial Function Predicts Future Development of Coronary Artery Disease
Bugiardini, R., Manfrini, O., Pizzi, C., Fontana, F., & Morgagni, G. (2004) · Circulation · doi:10.1161/01.cir.0000128208.22378.e3 · Cited by 350 · see citing works
Endothelial dysfunction over the course of coronary artery disease
Gutiérrez, E., Flammer, A. J., Lerman, L. O., Elı́zaga, J., Lerman, A., & Fernández‐Avilés, F. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht351 · Cited by 334 · see citing works
Age-related Impairment of Vascular Structure and Functions
Xu, X., Wang, B. Z., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L., & Jin, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0430 · Cited by 351 · see citing works
Saam, T., Hatsukami, T. S., Takaya, N., Chu, B., Underhill, H. R., Kerwin, W. S., Cai, J., Ferguson, M. S., & Yuan, C. (2007) · Radiology · doi:10.1148/radiol.2441051769 · Cited by 332 · see citing works
Gutterman, D. D., Chabowski, D. S., Kadlec, A. O., Durand, M. J., Freed, J. K., Ait‐Aissa, K., & Beyer, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.305364 · Cited by 327 · see citing works
Chan, S., Mancini, G. B. J., Kuramoto, L., Schulzer, M., Frohlich, J. J., & Ignaszewski, A. P. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00927-6 · Cited by 326 · see citing works
Endothelial Function Predicts Progression of Carotid Intima-Media Thickness
Halcox, J., Donald, A. E., Ellins, E. A., Witte, D. R., Shipley, M. J., Brunner, E. J., Marmot, M. G., & Deanfield, J. E. (2009) · Circulation · doi:10.1161/circulationaha.108.765701 · Cited by 315 · see citing works
Self-citationLekakis, J. P., Abraham, P., Balbarini, A., Blann, A. D., Boulanger, C. M., Cockcroft, J., Cosentino, F., Deanfield, J. E., Gallino, A., Ikonomidis, I., et al. (2011) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/1741826711398179 · Cited by 313 · see citing works
Obesity, Insulin Resistance, and the Metabolic Syndrome
Lteif, A. A., Han, K., & Mather, K. J. (2005) · Circulation · doi:10.1161/circulationaha.104.520130 · Cited by 305 · see citing works
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 309 · see citing works
Regulation of Coronary Blood Flow
Goodwill, A. G., Dick, G. M., Kiel, A. M., & Tune, J. D. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160016 · Cited by 301 · see citing works
Padró, T., Manfrini, O., Bugiardini, R., Canty, J. M., Cenko, E., Luca, G. D., Duncker, D. J., Eringa, E. C., Koller, Á., Tousoulis, D., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa003 · Cited by 298 · see citing works
Coronary Endothelial Dysfunction Is Associated With an Increased Risk of Cerebrovascular Events
Targonski, P. V., Bonetti, P. O., Pumper, G. M., Higano, S. T., Holmes, D. R., & Lerman, A. (2003) · Circulation · doi:10.1161/01.cir.0000072765.93106.ee · Cited by 292 · see citing works
Assessment of atherosclerosis: the role of flow-mediated dilatation
Charakida, M., Masi, S., Lüscher, T. F., Kastelein, J. J. P., & Deanfield, J. E. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq340 · Cited by 288 · see citing works
Bisoendial, R. J., Hovingh, G. K., Levels, J. H. M., Lerch, P. G., Andresen, I., Hayden, M. R., Kastelein, J. J. P., & Stroes, E. S. G. (2003) · Circulation · doi:10.1161/01.cir.0000070934.69310.1a · Cited by 287 · see citing works
Surrogate Markers for Cardiovascular Disease
Cohn, J. N., Quyyumi, A. A., Hollenberg, N. K., & Jamerson, K. (2004) · Circulation · doi:10.1161/01.cir.0000133442.99186.39 · Cited by 284 · see citing works
Self-citationNADPH oxidase and endothelial cell function
Ray, R., & Shah, A. M. (2005) · Clinical Science · doi:10.1042/cs20050067 · Cited by 278 · see citing works
Hyde, E. R., Andrade, F., Vaksman, Z., Parthasarathy, K., Jiang, H., Parthasarathy, D. K., Torregrossa, A. C., Tribble, G., Kaplan, H. B., Petrosino, J. F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088645 · Cited by 275 · see citing works
Indoor Particles Affect Vascular Function in the Aged
Bräuner, E. V., Forchhammer, L., Möller, P., Barregård, L., Gunnarsen, L., Afshari, A., Wåhlin, P., Glasius, M., Dragsted, L. O., Basu, S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200704-632oc · Cited by 265 · see citing works
Obstructive Coronary Atherosclerosis and Ischemic Heart Disease: An Elusive Link!
Marzilli, M., Merz, C. N. B., Boden, W. E., Bonow, R. O., Capozza, P., Chilian, W. M., DeMaria, A. N., Guarini, G., Huqi, A., Morrone, D., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.082 · Cited by 265 · see citing works
Roman, M. J., Naqvi, T. Z., Gardin, J. M., Gerhard‐Herman, M. D., Jaff, M. R., & Mohler, E. R. (2006) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2006.04.020 · Cited by 260 · see citing works
Endothelial function, inflammation, and prognosis in cardiovascular disease
Gonzalez, M. A., & Selwyn, A. P. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.016 · Cited by 258 · see citing works
Endothelium‐dependent contractions and endothelial dysfunction in human hypertension
Versari, D., Daghini, E., Virdis, A., Ghiadoni, L., & Taddei, S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00240.x · Cited by 255 · see citing works
Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes
Fichtlscherer, S., Breuer, S., & Zeiher, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000143378.58099.8c · Cited by 251 · see citing works
Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment
Matsuzawa, Y., & Lerman, A. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000178 · Cited by 249 · see citing works
Testing Endothelial Vasomotor Function
Ganz, P., & Vita, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000089507.19675.f9 · Cited by 249 · see citing works
Abrams, J. (2005) · New England Journal of Medicine · doi:10.1056/nejmcp042317 · Cited by 246 · see citing works
Montorsi, P., Ravagnani, P. M., Galli, S., Salonia, A., Briganti, A., Werba, J. P., & Montorsi, F. (2006) · European Urology · doi:10.1016/j.eururo.2006.07.015 · Cited by 239 · see citing works
González‐Juanatey, C., Llorca, J., Testa, A., Revuelta, J., Garcı́a-Porrúa, C., & González-Gay, M. Á. (2003) · Medicine · doi:10.1097/01.md.0000101572.76273.60 · Cited by 238 · see citing works
- Authors
- Halcox, J. P. J., Schenke, W. H., Zalos, G., Mincemoyer, R., Prasad, A., Waclawiw, M. A., Nour, K. R. A., & Quyyumi, A. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- Circulation
- Published
- 2002-08-06
- Volume
- 106
- Issue
- 6
- Pages
- 653-658
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2019338486
- Cited by
- 1,385
- References
- 24
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 25 · 2023: 33 · 2022: 21 · 2021: 33 · 2020: 49 · 2019: 50 · 2018: 56 · 2017: 51 · 2016: 51 · 2015: 70 · 2014: 87 · 2013: 59 · 2012: 70
- FWCI
- 51.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- coronary endothelial dysfunction, coronary artery disease, acetylcholine provocation test, sodium nitroprusside, adenosine, coronary vascular resistance, cardiovascular events, prognosis, myocardial infarction, unstable angina, stroke, cardiovascular mortality, revascularization
- MeSH terms
- Angina, Unstable, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Endothelium, Vascular, Female, Follow-Up Studies, Humans, Male, Microcirculation, Middle Aged, Myocardial Infarction, Pericardium, Prognosis, Vascular Resistance, Vasodilator Agents, Disease-Free Survival, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
