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Cited by 572Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactHealth, Environment, Cognitive Aging

Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06

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Melzer, David, Rice, Neil E., Lewis, Ceri, Henley, William E., Galloway, Tamara S.·2010·PLoS ONE
DOI 10.1371/journal.pone.0008673PMC PMC2800195
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Abstract

BACKGROUND: Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. Associations have previously been reported between urinary BPA concentrations and heart disease, diabetes and liver enzymes in adult participants of the National Health and Nutrition Examination Survey (NHANES) 2003/04. We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years. METHODOLOGY AND FINDINGS: A cross-sectional analysis of NHANES: subjects were n = 1455 (2003/04) and n = 1493 (2005/06) adults aged 18-74 years, representative of the general adult population of the United States. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, BMI, waist circumference, and urinary creatinine concentration. Main outcomes were reported diagnoses of heart attack, coronary heart disease, angina and diabetes and serum liver enzyme levels. Urinary BPA concentrations in 2005/06 (geometric mean 1.79 ng/ml, 95% CI: 1.64 to 1.96) were lower than in 2003/04 (2.49 ng/ml, CI: 2.20 to 2.83, difference p-value = 0.00002). Higher BPA concentrations were associated with coronary heart disease in 2005/06 (OR per z-score increase in BPA = 1.33, 95%CI: 1.01 to 1.75, p = 0.043) and in pooled data (OR = 1.42, CI: 1.17 to 1.72, p = 0.001). Associations with diabetes did not reach significance in 2005/06, but pooled estimates remained significant (OR = 1.24, CI: 1.10 to 1.40, p = 0.001). There was no overall association with gamma glutamyl transferase concentrations, but pooled associations with alkaline phosphatase and lactate dehydrogenase remained significant. CONCLUSIONS: Higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. Studies to clarify the mechanisms of these associations are urgently needed.

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  • BPA may cause homeostatic disruptions including cardiovascular effects and hypertension, and by extension other EDCs may do so.

    “This would suggest an avenue for homeostatic disruptions including cardiovascular effects and hypertension associated with BPA and, by extension, other EDCs (142, 143).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [143]

    The Discussion (page unavailable) reports an association between urinary BPA and heart disease and considers possible cardiovascular mechanisms, while cautioning that the cross-sectional findings do not establish causation. It links hypertension to lead, not BPA; its discussion of other contaminants does not establish that other endocrine-disrupting chemicals share BPA’s effects. (LLM, conf=0.88)

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Authors
Melzer, D., Rice, N. E., Lewis, C., Henley, W. E., & Galloway, T. S.
Affiliations
  • University of Exeter (GB)
  • University of Plymouth (GB)
Corresponding author
Melzer, David
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2010-01-13
Volume
5
Issue
1
Pages
e8673
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0008673
PMC
PMC2800195
OpenAlex
W2088514819
Cited by
572
References
3
Citations by year
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FWCI
35.51
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion)
  • Open Research Exeter (University of Exeter) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
bisphenol A, coronary artery disease, myocardial infarction, angina pectoris, diabetes mellitus, liver enzymes, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, endocrine disruptors, NHANES, biomonitoring, cardiovascular risk
MeSH terms
Bisphenol A Compounds, Benzhydryl Compounds, Cross-Sectional Studies, Heart Diseases, Humans, Nutrition Surveys, Phenols

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