The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge: A Scientific Statement From the American Heart Association Council on Cardiovascular Disease in the Young: Endorsed by the American Academy of Pediatrics
Abstract
Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.
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“No clear association has been found in humans between moderate doses of caffeine ingestion during pregnancy and birth defects, including congenital heart disease (132).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [132]
Citations
Cites
Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.179918 · Cited by 3,277
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123
Maternal Pesticide Exposure from Multiple Sources and Selected Congenital Anomalies
Shaw, G. M., Wasserman, C. R., O’Malley, C. D., Nelson, V. E., & Jackson, R. J. (1999) · Epidemiology · doi:10.1097/00001648-199901000-00011 · Cited by 1,783
Clarren, S. K., & Smith, D. W. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805112981906 · Cited by 1,359
Major congenital malformations after first-trimester exposure to ACE inhibitors
Cooper, W. O., Hernandez-Diaz, S., Arbogast, P. G., Dudley, J. A., Dyer, S., Gideon, P. S., Hall, K., & Ray, W. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055202 · Cited by 1,192
CONGENITAL HEART DISEASE: PREVALENCE AT LIVEBIRTH
Ferencz, C., Rubin, J. D., McCarter, R., Brenner, J. I., Neill, C. A., Perry, L. W., Hepner, S. I., & Downing, J. W. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113979 · Cited by 1,025
Congenital Cataract Following German Measles in the Mother
Gregg, N. M. (1941) · Springer eBooks · doi:10.1007/978-94-011-6621-8_22 · Cited by 888
Genetic Basis for Congenital Heart Defects: Current Knowledge
Pierpont, M. E., Basson, C. T., Benson, D. W., Gelb, B. D., Giglia, T. M., Goldmuntz, E., McGee, G., Sable, C., Srivastava, D., & Webb, C. L. (2007) · Circulation · doi:10.1161/circulationaha.106.183056 · Cited by 850
Self-citation
Research works printed but not linked: 7
- Gregg NM. Further observations on congenital defects in infants following maternal rubella. Trans Ophthalmol Soc Aust. 1944; 4: 119–131.
- 10.1161/circ.56.1.301070 · DOI
- Bracken MB. Drug use in pregnancy and congenital heart disease in offspring. N Engl J Med. 1986; 314: 1120.
- 10.1001/jama.1981.03320040015021 · DOI
- Netter JC, Choulot JJ, Dagues-Bie M. Oligohydramnios and persistent pulmonary arterial hypertension after use of ketoprofen during pregnancy. Sem Hop Paris. 1990; 66: 1953–1954.Abstract.
- 10.1097/00001648-199909000-00008 · DOI
- 10.1161/circ.47.2.359 · DOI
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Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Metadata
- Authors
- Jenkins, K. J., Correa, A., Feinstein, J. A., Botto, L., Britt, A. E., Daniels, S. R., Elixson, M., Warnes, C. A., & Webb, C. L.
- Affiliations
- Boston Children's Hospital (US)
- ORCID
- Venue
- Circulation
- Published
- 2007-06-12
- Volume
- 115
- Issue
- 23
- Pages
- 2995-3014
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2617245041
- Cited by
- 818
- References
- 232
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 50 · 2023: 42 · 2022: 52 · 2021: 42 · 2020: 50 · 2019: 48 · 2018: 52 · 2017: 38 · 2016: 43 · 2015: 61 · 2014: 55 · 2013: 52 · 2012: 48
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- congenital heart disease, modifiable risk factors, fetal heart development, periconceptional folic acid supplementation, maternal rubella infection, phenylketonuria, pregestational diabetes, thalidomide, retinoids, prenatal drug exposure, environmental exposure, paternal exposure, pregnancy monitoring
- MeSH terms
- Female, Fetal Diseases, Heart Defects, Congenital, Humans, Pregnancy, Risk Factors, Cardiovascular Abnormalities, Maternal Exposure, Dietary Supplements
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