The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Transvenous Pacing Leads and Systemic Thromboemboli in Patients With Intracardiac Shunts: A Multicenter Study
Open accessAbstract
Background— The risk of systemic thromboemboli associated with transvenous leads in the presence of an intracardiac shunt is currently unknown. Methods and Results— To define this risk, we conducted a multicenter, retrospective cohort study of 202 patients with intracardiac shunts: Sixty-four had transvenous leads (group 1), 56 had epicardial leads (group 2), and 82 had right-to-left shunts but no pacemaker or implantable cardioverter defibrillator leads (group 3). Patient-years were accrued until the occurrence of systemic thromboemboli or study termination. Censoring occurred in the event of complete shunt closure, death, or loss to follow-up. Mean ages for groups 1, 2, and 3 were 33.9±18.0, 22.2±12.6, and 22.9±15.0 years, respectively. Respective oxygen saturations were 91.2±9.1%, 88.1±8.1%, and 79.7±6.7%. During respective median follow-ups of 7.3, 9.3, and 17.0 years, 24 patients had at least 1 systemic thromboembolus: 10 (15.6%), 5 (8.9%), and 9 (11.0%) in groups 1, 2, and 3, respectively. Univariate risk factors were older age (hazard ratio [HR], 1.05; P =0.0001), ongoing phlebotomy (HR, 3.1; P =0.0415), and an transvenous lead (HR, 2.4; P =0.0421). In multivariate, stepwise regression analyses, transvenous leads remained an independent predictor of systemic thromboemboli (HR, 2.6; P =0.0265). In patients with transvenous leads, independent risk factors were older age (HR, 1.05; P =0.0080), atrial fibrillation or flutter (HR, 6.7; P =0.0214), and ongoing phlebotomy (HR, 14.4; P =0.0349). Having had aspirin or warfarin prescribed was not protective. Epicardial leads were, however, associated with higher atrial ( P =0.0407) and ventricular ( P =0.0270) thresholds and shorter generator longevity (HR, 1.9; P =0.0176). Conclusions— Transvenous leads incur a >2-fold increased risk of systemic thromboemboli in patients with intracardiac shunts.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
Transient Ischemic Attack — Proposal for a New Definition
Albers, G. W., Caplan, L. R., Easton, J. D., Fayad, P. B., Mohr, J. P., Saver, J. L., & Sherman, D. G. (2002) · New England Journal of Medicine · doi:10.1056/nejmsb020987 · Cited by 840
Rashkind, W. J. (1966) · JAMA · doi:10.1001/jama.196.11.991 · Cited by 787
Rashkind, W. J. (1966) · JAMA · doi:10.1001/jama.1966.03100240125026 · Cited by 710
Atrial Arrhythmia after Surgical Closure of Atrial Septal Defects in Adults
Gatzoulis, M. A., Freeman, M. A., Siu, S. C., Webb, G. D., & Harris, L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903183401103 · Cited by 504
Self-citationValue of Programmed Ventricular Stimulation After Tetralogy of Fallot Repair: A Multicenter Study
Khairy, P., Landzberg, M. J., Gatzoulis, M. A., Lucron, H., Lambert, J., Marçon, F., Alexander, M. E., & Walsh, E. P. (2004) · Circulation · doi:10.1161/01.cir.0000126495.11040.bd · Cited by 436
Self-citationKhairy, P., O'Donnell, C. P., & Landzberg, M. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00010 · Cited by 388
Self-citationFortescue, E. B., Berul, C. I., Cecchin, F., Walsh, E. P., Triedman, J. K., & Alexander, M. E. (2004) · Heart Rhythm · doi:10.1016/j.hrthm.2004.02.020 · Cited by 275
Self-citationCerebrovascular events in adult patients with cyanotic congenital heart disease
Ammash, N., & Warnes, C. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00196-9 · Cited by 239
Iron deficiency: A cause of stroke in infants and children
Hartfield, D. S., Lowry, N. J., Keene, D. L., & Yager, J. Y. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(96)00290-1 · Cited by 201
Cited by
ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,066
Self-citation2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab364 · Cited by 2,019
Stout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000603 · Cited by 1,602
Self-citationACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.001 · Cited by 1,533
Self-citation
Metadata
- Authors
- Khairy, P., Landzberg, M. J., Gatzoulis, M. A., Mercier, L.-A., Fernandes, S. M., Côté, J.-M., Lavoie, J.-P., Fournier, A., Guerra, P. G., Frogoudaki, A., Walsh, E. P., & Dore, A.
- Venue
- Circulation
- Published
- 2006-05-23
- Volume
- 113
- Issue
- 20
- Pages
- 2391-2397
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2154666326
- Cited by
- 300
- References
- 26
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Transvenous Pacing Leads and Systemic Thromboemboli in Patients With Intracardiac Shunts: A Multicenter Study. https://app.cochat.ai/papers/10.1161/circulationaha.106.622076
- The paper
- Khairy, P., Landzberg, M. J., Gatzoulis, M. A., Mercier, L.-A., Fernandes, S. M., Côté, J.-M., Lavoie, J.-P., Fournier, A., Guerra, P. G., Frogoudaki, A., Walsh, E. P., & Dore, A. (2006). Transvenous Pacing Leads and Systemic Thromboemboli in Patients With Intracardiac Shunts: A Multicenter Study. Circulation. https://doi.org/10.1161/circulationaha.106.622076
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
