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Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study
Abstract
Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic risk. The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting. Methods and Results— Participants (n=3001) were drawn from the Framingham Heart Study (48% women; mean age, 50 years), were free of clinical cardiovascular disease, and underwent multidetector computed tomography assessment of SAT and VAT volumes between 2002 and 2005. Metabolic risk factors were examined in relation to increments of SAT and VAT after multivariable adjustment. Heritability was calculated using variance-components analysis. Among both women and men, SAT and VAT were significantly associated with blood pressure, fasting plasma glucose, triglycerides, and high-density lipoprotein cholesterol and with increased odds of hypertension, impaired fasting glucose, diabetes mellitus, and metabolic syndrome ( P range <0.01). In women, relations between VAT and risk factors were consistently stronger than in men. However, VAT was more strongly correlated with most metabolic risk factors than was SAT. For example, among women and men, both SAT and VAT were associated with increased odds of metabolic syndrome. In women, the odds ratio (OR) of metabolic syndrome per 1–standard deviation increase in VAT (OR, 4.7) was stronger than that for SAT (OR, 3.0; P for difference between SAT and VAT <0.0001); similar differences were noted for men (OR for VAT, 4.2; OR for SAT, 2.5). Furthermore, VAT but not SAT contributed significantly to risk factor variation after adjustment for body mass index and waist circumference ( P ≤0.01). Among overweight and obese individuals, the prevalence of hypertension, impaired fasting glucose, and metabolic syndrome increased linearly and significantly across increasing VAT quartiles. Heritability values for SAT and VAT were 57% and 36%, respectively. Conclusions— Although both SAT and VAT are correlated with metabolic risk factors, VAT remains more strongly associated with an adverse metabolic risk profile even after accounting for standard anthropometric indexes. Our findings are consistent with the hypothesized role of visceral fat as a unique, pathogenic fat depot. Measurement of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.
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“Body fat has better predictive validity on the development of the metabolic syndrome192 and cardiovascular disease risk193 than BMI.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [192]
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“Moreover, ectopic fat depots, such as epicardial and perivascular fat, might exert local pathogenic effects on heart and blood vessels.[7][8][9]”
From Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial (2025) · cites this paper as [7]
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“In addition to the association between triglyceride levels and BMI, the Framingham Heart Study 155 reported strong associations of triglyceride levels with both subcutaneous abdominal adipose tissue and visceral adipose tissue in men and women (mean age 50 years).”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [155]
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“Thus, although it is clear that excess adiposity is associated with elevated triglyceride levels, visceral adiposity is a greater contributor than subcutaneous adipose tissue.155,156”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [155]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedGrundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
Heart Disease and Stroke Statistics—2006 Update
Writing Group Members, Thom, T., Haase, N., Rosamond, W. D., Howard, V. J., Rumsfeld, J. S., Manolio, T. A., Zheng, Z., Flegal, K. M., O’Donnell, C. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.171600 · Cited by 3,453
Self-citationOverweight and obesity in the United States: prevalence and trends, 1960–1994
Flegal, K., Carroll, M., Kuczmarski, R., & Johnson, C. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800541 · Cited by 3,045
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
Almasy, L. A., & Blangero, J. (1998) · The American Journal of Human Genetics · doi:10.1086/301844 · Cited by 3,021
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
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Items 901–1,000 of 1,013
Proteomics and polycystic ovary syndrome
Insenser, M. R., & Escobar-Morreale, H. F. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.837665 · Cited by 35
Gharib, S. A., Khalyfa, A., Abdelkarim, A., Ramesh, V., Buazza, M., Kaushal, N., Bhushan, B., & Gozal, D. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0830-7 · Cited by 39
Lee, J., Yin, X., Hoffmann, U., Fox, C. S., & Benjamin, E. J. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.08.011 · Cited by 36
Self-citationPrecision of DXA‐Derived Visceral Fat Measurements in a Large Sample of Adults of Varying Body Size
Meredith-Jones, K. A., Haszard, J. J., Stanger, N., & Taylor, R. W. (2017) · Obesity · doi:10.1002/oby.22108 · Cited by 36
Obesity, ectopic fat and cardiac metabolism
Piché, M., & Poirier, P. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1500894 · Cited by 37
Role of autophagy in the regulation of adipose tissue biology
Romero, M., & Antonio Zorzano, A. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1624110 · Cited by 37
“An increase in the abundance of subcutaneous fat therefore promotes beneficial effects on glucose homeostasis and insulin sensitivity [11], whereas the accumulation of visceral adipose tissue (vWAT) favors the risk of T2D and other complications [12].”
BackgroundReijrink, M., de Boer, S. A., Spoor, D. S., Lefrandt, J. D., Heerspink, H. J. L., Boellaard, R., Greuter, M. J. W., Borra, R., Hillebrands, J., Slart, R. H. J. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.09.016 · Cited by 36
Abe, T., Song, J. S., Bell, Z. W., Wong, V. H. Y., Spitz, R. W., Yamada, Y., & Loenneke, J. P. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00942-1 · Cited by 36
“For example, epidemiological studies have repeatedly shown how large amounts of VAT are associated with multiple cardiovascular disease risk factors, which include but not limited to hypertension, dyslipidemia, and diabetes [2].”
BackgroundWaist Circumference Predicts Increased Complications in Rectal Cancer Surgery
Balentine, C. J., Robinson, C. N., Marshall, C. L., Wilks, J. A., Buitrago, W. F., Haderxhanaj, K., Sansgiry, S., Petersen, N. J., Bansal, V., Albo, D., et al. (2010) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-010-1343-3 · Cited by 36
Targeting abdominal obesity and the metabolic syndrome to manage cardiovascular disease risk
Després, J. (2009) · Heart · doi:10.1136/hrt.2008.151274 · Cited by 38
Obesity and Metabolic Abnormalities in Chronic Obstructive Pulmonary Disease
Wouters, E. F. �. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201705-371aw · Cited by 39
Banack, H. R., Bea, J. W., Chen, Z., Blew, R. M., Nicholas, S., Stefanick, M. L., Wild, R. A., Manson, J. E., & Odegaard, A. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01266-9 · Cited by 41
Relative Contributions of Afferent Vagal Fibers to Resistance to Diet-Induced Obesity
Stearns, A. T., Balakrishnan, A., Radmanesh, A., Ashley, S. W., Rhoads, D. B., & Tavakkolizadeh, A. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1968-4 · Cited by 35
Ma, J., Jiang, Z., Shen, H., Liu, Y., Chen, L., Long, K., Jin, L. G., Jiang, A., Zhu, L., Wang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080041 · Cited by 36
Meijnikman, A. S., Block, C. E. M. D., Verrijken, A., Mertens, I. L., Corthouts, B., & Gaal, L. F. V. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.05.004 · Cited by 35
Xiao, D. Y., Luo, S., O’Brian, K., Sanfilippo, K. M., Ganti, A., Riedell, P. A., Lynch, R. C., Liu, W., Kahl, B. S., Cashen, A. F., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw145 · Cited by 36
Bachlechner, U., Floegel, A., Steffen, A., Prehn, C. P., Adamski, J., Pischon, T., & Boeing, H. (2016) · Nutrition and Diabetes · doi:10.1038/nutd.2016.23 · Cited by 36
Forte, R., Pesce, C., VITO, G. D., & Boreham, C. A. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0783-1 · Cited by 35
“In particular, fat accumulation in the abdomen is a key factor associated with the development of such conditions even in normal weight individuals, particularly in women (1-4).”
Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Storz, C., Kraus, M. S., Schlett, C. L., Roemer, F. W., Wintermeyer, E., et al. (2018) · European Journal of Radiology · doi:10.1016/j.ejrad.2018.06.023 · Cited by 35
Simeone, P., Liani, R., Tripaldi, R., Castelnuovo, A. F. D., Guagnano, M. T., Tartaro, A., Bonadonna, R. C., Federico, V., Cipollone, F., Consoli, A., et al. (2018) · Nutrients · doi:10.3390/nu10121872 · Cited by 37
The triglyceride paradox in the mortality of coronary artery disease
Xia, T., Li, Y., Huang, F., Chai, H., Huang, B., Li, Q., Zhao, Z., Liao, Y., Zuo, Z., Peng, Y., et al. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0972-0 · Cited by 37
“The Framingham Heart Study revealed that TG levels are strongly associated with abdominal subcutaneous fat and visceral fat distribution [26].”
BackgroundRegional Adipose Compartments Confer Different Cardiometabolic Risk in Children and Adolescents:
Yan, Y., Liu, J., Zhao, X., Cheng, H., Huang, G., Mi, J., Mi, J., Yan, Y., Dong, H., Liu, J., et al. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.05.026 · Cited by 37
Shen, H. H., Peterson, S. J., Bellner, L., Choudhary, A., Levy, L., Gancz, L., Sasson, A., Trainer, J., Rezzani, R., Resnick, A., et al. (2020) · Antioxidants · doi:10.3390/antiox9060489 · Cited by 35
“Although WAT exists in subcutaneous depots, a much stronger link has been made between metabolic disorders, insulin resistance, and expansion of WAT deposits in the viscera [9,10].”
RetractedParcha, V., Patel, N., Kalra, R., Suri, S. S., Arora, G., Wang, T. J., & Arora, P. K. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018689 · Cited by 36
Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction
Lau, E. S., Paniagua, S. M., Zarbafian, S., Hoffman, U., Long, M. T., Hwang, S., Courchesne, P. L., Yao, C., Ma, J., Larson, M. G., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020215 · Cited by 34
BAJAJ, H. S., Brennan, D. M., Hoogwerf, B. J., Doshi, K. B., & Kashyap, S. R. (2009) · Obesity · doi:10.1038/oby.2009.44 · Cited by 36
Hickson, D. A., Burchfiel, C. M., Liu, J., Petrini, M. F., Harrison, K. L., White, W., & Sarpong, D. F. (2011) · Lung · doi:10.1007/s00408-011-9296-1 · Cited by 35
Matsushita, Y., Nakagawa, T., Yamamoto, S., Takahashi, Y., Yokoyama, T., Mizoue, T., & Noda, M. (2012) · Diabetes Care · doi:10.2337/dc11-1320 · Cited by 35
Nicholson, J. M., Orsso, C. E., Nourouzpour, S., Elangeswaran, B., Chohan, K., Orchanian‐Cheff, A., Fidler, L. M., Mathur, S., & Rozenberg, D. (2022) · Chronic Respiratory Disease · doi:10.1177/14799731221133387 · Cited by 34
“Visceral adiposity has been demonstrated to be a more metabolically active tissue compared to subcutaneous tissue on abdominal CT scans.(7,62) However, a unique adiposity tissue compartment is epicardial tissue evaluated in three studies,(19,33,36) which is considered a visceral fat depot associated with coronary arte…”
BackgroundAdipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation
Polkinghorne, M., West, H. W., & Antoniades, C. A. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-021346 · Cited by 35
Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark
Hannemann, A., Thuesen, B. H., Friedrich, N., Völzke, H., Steveling, A., Ittermann, T., Hegenscheid, K., Nauck, M. A., Linneberg, A. R., & Wallaschofski, H. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0019-0 · Cited by 34
“This is of importance, as visceral adipose tissue (VAT) better reflects metabolic and cardiovascular risk than subcutaneous adipose tissue (SAT) [10, 11].”
BackgroundMure, K., MAEDA, S., Mukoubayashi, C., Mugitani, K., Iwane, M., Kinoshita, F., Mohara, O., & Takeshita, T. (2013) · Nutrition · doi:10.1016/j.nut.2013.01.011 · Cited by 33
Lv, X., Zhou, W., Sun, J., Lin, R., Ding, L., Xu, M., Xu, Y., Zhao, Z., Chen, Y., Bi, Y., et al. (2016) · Journal of Diabetes · doi:10.1111/1753-0407.12499 · Cited by 34
Brown adipose tissue detected by PET/CT imaging is associated with less central obesity
Green, A. L., Bağcı, U., Hussein, S., Kelly, P. V., Muzaffar, R., Neuschwander‐Tetri, B. A., & Osman, M. (2017) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000691 · Cited by 34
Association Between Regional Adipose Tissue Distribution and Risk of Heart Failure Among Blacks
Pandey, A., Kondamudi, N., Patel, K. V., Ayers, C. R., Simek, S. C., Hall, M. E., Musani, S. K., Blackshear, C. T., Mentz, R. J., Khan, H., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005629 · Cited by 36
Meyer‐Gerspach, A. C., Peterli, R., Moor, M., Madoerin, P., Schötzau, A., Nabers, D., Borgwardt, S., Beglinger, C., Bieri, O., & Wölnerhanssen, B. K. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03897-2 · Cited by 33
“Visceral adipose tissue (VAT) is associated with the highest risk to develop comorbidities [21, 22].”
BackgroundReang, T., Goswami, B., Sarkar, S., Sengupta, S., & Bhattacharjee, B. (2020) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_187_20 · Cited by 34
“Fox et al.[19] reported that body visceral fat had significant positive correlation with the TG (P < 0.0001) among 3001 Americans, which was similar to present study.”
BackgroundInfluentialZając-Gawlak, I., Pelclová, J., Groffik, D., Přidalová, M., Nawrat–Szołtysik, A., Kroemeke, A., Gába, A., & Sadowska‐Krępa, E. (2021) · BMC Geriatrics · doi:10.1186/s12877-020-01952-7 · Cited by 34
An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish
Lumaquin, D., Johns, E., Weiss, J., Montal, E. D., Ola, D., Abuhashem, A., & White, R. M. (2021) · eLife · doi:10.7554/elife.64744 · Cited by 34
Torres, J. L., Usategui‐Martín, R., Hernández‐Cosido, L., Bernardo, E., Manzanedo-Bueno, L., Hernández-García, I., Mateos-Díaz, A.-M., Rozo, O., Matesanz, N., Salete-Granado, D., et al. (2021) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-021-05216-6 · Cited by 38
Henry, J. A., Abdesselam, I., Deal, O., Lewis, A., Rayner, J. J., Bernard, M., Dutour, A., Gaborit, B., Kober, F., Soghomonian, A., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1092777 · Cited by 35
“Although obesity implies a global increase in total body fat, on an individual basis fat is deposited differentially into specific subcutaneous and visceral compartments of the body and also ectopically within organs (1).”
BackgroundVisceral fat loss induced by a low‐calorie diet: a direct comparison between women and men
Gasteyger, C., Larsen, T. M., Vercruysse, F., Pedersen, D. C., Toubro, S., & Astrup, A. V. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.01025.x · Cited by 34
Chemerin as a novel non-invasive serum marker of intrahepatic lipid content in obese children
Kłusek-Oksiuta, M., Białokoz‐Kalinowska, I., Tarasów, E., Wojtkowska, M., Werpachowska, I., & Lebensztejn, D. M. (2014) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-014-0084-4 · Cited by 34
“Additionally, fat distribution seems to be a better predictor of (CVD) compared to obesity alone [5].”
BackgroundOver expression of resistin in adipose tissue of the obese induces insulin resistance
Sadashiv (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i7.135 · Cited by 34
Cardiovascular disease predictors and adipose tissue macrophage polarization: Is there a link?
Lesná, I. K., Petráš, M., Čejková, S., Králová, A., Froněk, J., Janoušek, L., Thieme, F., Tyll, T., & Poledne, R. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317743355 · Cited by 34
Ren, Y., Cheng, L. L., Qie, R., Han, M., Kong, L., Yan, W., Li, Z., Li, Y., & Lei, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1187381 · Cited by 33
Bhatt, S. P., Misra, A., Sharma, M., Guleria, R., Pandey, R. M., Luthra, K., & Vikram, N. K. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0303 · Cited by 33
“27 Furthermore, experimental studies indicate that differences in sunlight exposure are not enough to account for the differences in 25(OH) D concentrations seen between obese and nonobese volunteers.”
Hickson, D. A., Lewis, T. T., Liu, J., Mount, D. L., Younge, S. N., Jenkins, W. C., Sarpong, D. F., & Williams, D. R. (2012) · Annals of Behavioral Medicine · doi:10.1007/s12160-011-9334-5 · Cited by 35
Bouchi, R., Nakano, Y., Ohara, N., Takeuchi, T., Murakami, M., Asakawa, M., Sasahara, Y., Numasawa, M., Minami, I., Izumiyama, H., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0384-7 · Cited by 33
“Abdominal visceral fat has been strongly associated with cardiovascular risks [5, 6].”
BackgroundLiu, P. J., Ma, F., Lou, H. P., & Zhu, Y. N. (2016) · Public Health Nutrition · doi:10.1017/s1368980016003281 · Cited by 32
“Some studies found that BRI was not superior to the traditional obesity indices (including BMI and WC) for determining the presence of diabetes and CVD as well as CVD risk factors(27,32).”
BackgroundInfluentialJanghorbani, M., Salamat, M. R., Aminorroaya, A., & Amini, M. (2017) · Endocrinology and Metabolism · doi:10.3803/enm.2017.32.2.221 · Cited by 33
Noumura, Y., Kamishima, T., Sutherland, K. L., & Nishimura, H. (2017) · British Journal of Radiology · doi:10.1259/bjr.20170253 · Cited by 33
Mytton, O. T., Ogilvie, D., Griffin, S. J., Brage, S., Wareham, N. J., & Panter, J. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.10.017 · Cited by 33
“(Fox et al., 2007) Comparison with other studies Our findings are consistent with other reports that active travel is associated with reduced BMI relative to car-use,(Berglund et al., 2016; Flint et al., 2014; Flint and Cummins, 2016; Gordon-Larsen et al., 2009; Larouche et al., 2016; Laverty et…”
BackgroundResultWatanabe, J., Kakehi, E., Kotani, K., Kayaba, K., Nakamura, Y., & Ishikawa, S. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0398-2 · Cited by 35
Association between kidney function, nutritional status and anthropometric measures in older people
Guligowska, A., Corsonello, A., Pigłowska, M., Roller‐Wirnsberger, R., Wirnsberger, G. H., Ärnlöv, J., Carlsson, A. C., Tap, L., Mattace-Raso, F. U. S., Formiga, F., et al. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01699-1 · Cited by 34
“This phenotype is associated with metabolic disturbances and several chronic diseases [37, 38].”
BackgroundYokokawa, H., Fukuda, H., Saita, M., Goto, K., Kaku, T., Miyagami, T., Takahashi, Y., Hamada, C., Hisaoka, T., & Naito, T. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00646-3 · Cited by 33
Visceral Adipose Tissue and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes
Nobarani, S., Alaei-Shahmiri, F., Aghili, R., Malek, M., Poustchi, H., Lahouti, M., & Khamseh, M. E. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06953-z · Cited by 35
Adipose tissue and skeletal muscle plasticity modulates metabolic health
Ukropec, J., Ukropcová, B., Kurdiová, T., Gašperíková, D., & Klimeś, I. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802535812 · Cited by 36
Hoenig, M. R. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.2008.04.01.143 · Cited by 33
Hannon, B. A., Thompson, S. V., Edwards, C., Skinner, S. K., Niemiro, G. M., Burd, N. A., Holscher, H. D., Terán-Garcı́a, M., & Khan, N. A. (2018) · Current Developments in Nutrition · doi:10.1093/cdn/nzy094 · Cited by 33
Ferrer‐Lorente, R., Béjar, M. T., & Badimón, L. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0070 · Cited by 35
“Subcutaneous adipose tissue (SCWAT) accumulation is a weaker risk factor [4,5], even associated with protection from cardiometabolic disease [6,7], whereas expansion of visceral adipose tissue (VWAT) is closely linked to systemic metabolic alterations [8], being a key contributor to the development of insulin resistan…”
Sanghai, S., Sardana, M., Hansra, B., Lessard, D., Dahlberg, S. T., Aurigemma, G. P., Fitzgibbons, T. P., & McManus, D. D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00076 · Cited by 34
Effect of tirzepatide on body fat distribution pattern in people with type 2 diabetes
Cariou, B., Linge, J., Neeland, I. J., Leinhard, O. D., Petersson, M., Landó, L. F., Bray, R., & Rodríguez, Á. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15566 · Cited by 37
“28,29 6 – 8 However, a skewed fat distribution pattern between VAT and aSAT ( z -aSAT <0 and z -VAT >0) has been linked to a higher risk of both incident CVD and T2D compared with a balanced fat distribution pattern between VAT and aSAT, still with excessive amounts of both fats in relation to BMI…”
BackgroundPark, J., Lim, Y., Kim, K., Kim, S. G., Kim, J. H., Lim, H. G., & Shin, J. (2012) · Hypertension Research · doi:10.1038/hr.2012.194 · Cited by 32
The role of insulin resistance in the association between body fat and autonomic function
Hillebrand, S., Swenne, C. A., Gast, K. B., Maan, A. C., le Cessie, S., Jukema, J. W., Rosendaal, F. R., den Heijer, M., & de Mutsert, R. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.07.009 · Cited by 32
Liu, P. J., Ma, F., Lou, H. P., & Zhu, Y. N. (2016) · Climacteric · doi:10.1080/13697137.2016.1202229 · Cited by 31
Schlecht, I., Gronwald, W., Behrens, G., Baumeister, S. E., Hertel, J., Hochrein, J., Zacharias, H. U., Fischer, B., Oefner, P. J., & Leitzmann, M. F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175133 · Cited by 34
Impact of Visceral Adipose Tissue on Clinical Outcomes After Acute Ischemic Stroke
Kim, J., Choi, K., Kang, K. W., Kim, J., Choi, S., Lee, S., Park, M., Kim, B. C., Kim, M., & Cho, K. (2019) · Stroke · doi:10.1161/strokeaha.118.023421 · Cited by 33
Rado, S. D., Lorbeer, R., Gatidis, S., Machann, J., Storz, C., Nikolaou, K., Rathmann, W., Hoffmann, U., Peters, A., Bamberg, F., et al. (2019) · British Journal of Radiology · doi:10.1259/bjr.20180562 · Cited by 32
Self-citationMultifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions
Liu, Y., Wang, C., Wei, M., Yang, G., & Yuan, L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.669429 · Cited by 32
Du, L., Chang, T., An, B., Liang, M., Deng, T., Li, K., Cao, S., Du, Y., Gao, X., Xu, L., et al. (2022) · Genes · doi:10.3390/genes14010037 · Cited by 32
“Studies reported higher concentrations of SAT contributed to being protective against metabolic diseases, conversely, VAT accumulation was prone to metabolic syndrome [8].”
Pan, L., Zhang, H., Huang, Z., Sun, Q., Chen, Z., Li, Z., Yang, S., Li, X.-Y., & Li, X. (2015) · Metabolism · doi:10.1016/j.metabol.2015.06.003 · Cited by 33
“[33] Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al.”
BackgroundZhong, C., Xia, W., Zhong, X., Xu, T., Li, H., Zhang, M., Wang, A., Xu, T., Sun, Y., & Zhang, Y. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33514 · Cited by 31
Quan, H.-Y., Baek, N., & Chung, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2050763 · Cited by 29
Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents
Stansfield, B. K., Fain, M. E., Bhatia, J. J. S., Gutin, B., Nguyen, J., & Pollock, N. K. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.012 · Cited by 32
Variants in the CNR1 and the FAAH Genes and Adiposity Traits in the Community
Lieb, W., Manning, A. K., Florez, J. C., Dupuis, J., Cupples, L. A., McAteer, J. B., Vasan, R. S., Hoffmann, U., O’Donnell, C. J., Meigs, J. B., et al. (2009) · Obesity · doi:10.1038/oby.2008.608 · Cited by 32
Self-citationŠram, M., Vrselja, Z., Lekšan, I., Ćurić, G., Selthofer-Relatić, K., & Radić, R. (2015) · International Journal of Endocrinology · doi:10.1155/2015/456293 · Cited by 31
Wagenmakers, M. A. E. M., Roerink, S. H. P. P., Gil, L., Plantinga, T. S., Smit, J. W. A., Netea-Maier, R. T., & Hermus, A. R. (2014) · Clinical Endocrinology · doi:10.1111/cen.12639 · Cited by 31
Riddle, E., Campbell, M. S., Lang, B. Y., Bierer, R., Wang, Y., Bagley, H. N., & Joss-Moore, L. (2014) · Journal of Obesity · doi:10.1155/2014/829862 · Cited by 32
“Although IUGR infants are born smaller than their appropriately grown counterparts, the rate of adipose deposition in IUGR infants is accelerated throughout childhood and favors deposition of visceral adipose tissue (VAT) over subcutaneous adipose tissue (SAT) [9].”
BackgroundObesity and coronary risk in patients treated with second-generation antipsychotics
Correll, C. U., Kane, J. M., & Manu, P. (2010) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-010-0177-z · Cited by 31
Park, J., Lim, Y., Kim, K., Kim, S. G., Kim, J. H., Lim, H. G., & Shin, J. (2013) · Journal of Women s Health · doi:10.1089/jwh.2012.4035 · Cited by 31
Guglielmi, V., Maresca, L., D’Adamo, M., Roma, M. D., Lanzillo, C., Federici, M., Lauro, D., Preziosi, P., Bellia, A., & Sbraccia, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103381 · Cited by 35
PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner
Gude, M. F., Hjortebjerg, R., Oxvig, C., Thyø, A. A., Magnusson, N. E., Bjerre, M., Pedersen, S. B., & Frystyk, J. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0569 · Cited by 31
Schousboe, J. T., Langsetmo, L., Schwartz, A. V., Taylor, B. C., Vo, T., Kats, A. M., Barrett-Connor, E. L., ORWOLL, E. S., Marshall, L. M., Miljkovic, I., et al. (2017) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2017.01.004 · Cited by 31
Ueda, K., Takimoto, E., Lu, Q. R., Liu, P., Fukuma, N., Adachi, Y., Suzuki, R., Chou, S., Baur, W. E., Aronovitz, M. J., et al. (2018) · Diabetes · doi:10.2337/db17-1342 · Cited by 31
BMI Change During Puberty Is an Important Determinant of Adult Type 2 Diabetes Risk in Men
Ohlsson, C., Bygdell, M., Nethander, M., Rosengren, A., & Kindblom, J. M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01339 · Cited by 30
Cho, D.-H., Kim, M., Joo, H. J., Shim, W. J., Lim, D., & Park, S. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.01.007 · Cited by 31
Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss
Jiang, Y., Spurny, M., Schübel, R., Nonnenmacher, T., Schlett, C. L., von Stackelberg, O., Ulrich, C. M., Kaaks, R., Kauczor, H., Kuhn, T. E., et al. (2019) · Nutrients · doi:10.3390/nu11040912 · Cited by 31
“In contrast to PFC, VAT, which has been recognized as a major risk factor of metabolic and cardiovascular diseases [28], was associated with several metabolic biomarkers in our cohort.”
Wilechansky, R. M., Pedley, A., Massaro, J. M., Hoffmann, U., Benjamin, E. J., & Long, M. T. (2019) · Liver International · doi:10.1111/liv.14125 · Cited by 32
Self-citationPastore, M., Grimaudo, S., Pipitone, R. M., Lori, G., Raggi, C., Petta, S., & Marra, F. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00604 · Cited by 31
Depot-specific adipocyte-extracellular matrix metabolic crosstalk in murine obesity
Strieder‐Barboza, C., Baker, N. A., Flesher, C. G., Karmakar, M., Patel, A., Lumeng, C. N.-K., & O’Rourke, R. W. (2020) · Adipocyte · doi:10.1080/21623945.2020.1749500 · Cited by 31
“metabolic disease in mice and humans than subcutaneous adipose tissue (SAT, approximated by inguinal subcutaneous adipose tissue in mice) [1,2].”
BackgroundCheung, Y.-M. M., Roff, G., & Grossmann, M. (2020) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2020.10.005 · Cited by 33
Obesity is the basis of metabolic syndrome
Verbovoy, A. F., Verbovaya, N. I., & Dolgikh, Y. A. (2021) · Obesity and metabolism · doi:10.14341/omet12707 · Cited by 31
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
Park, J., Lee, D. H., Ham, S., Oh, J., Noh, J., Lee, Y. K., Park, Y. J., Lee, G., Han, S. M., Han, J. S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00597-7 · Cited by 31
Age-related Changes in Abdominal Fat Distribution in Japanese Adults in the General Population
Sugihara, M., Oka, R., Sakurai, M., Nakamura, K., Moriuchi, T., Miyamoto, S., Takeda, Y., Yagi, K., & Yamagishi, M. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4292 · Cited by 30
Hairston, K. G., Scherzinger, A. L., Foy, C. G., Hanley, A. J., McCorkle, O. D., Haffner, S. M., Norris, J. M., Bryer‐Ash, M., & Wagenknecht, L. E. (2009) · Diabetes Care · doi:10.2337/dc09-0336 · Cited by 31
Early development of metabolic syndrome in patients subjected to lung transplantation
Savioli, G., Surbone, S., Giovi, I., Salinaro, F., Preti, P. S., Meloni, F., Oggionni, T., & Perlini, S. (2013) · Clinical Transplantation · doi:10.1111/ctr.12098 · Cited by 32
Pires, A., Martins, P., Pereira, A. M., Marinho, J., Silva, P. V., Marques, M., Castela, E., Sena, C. M., & Seiça, R. M. F. (2014) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2014.04.004 · Cited by 31
Jang, S. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i28.3335 · Cited by 31
Pacifico, L., Arca, M., Anania, C., Cantisani, V., Martino, M. D., & Chiesa, C. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.08.003 · Cited by 31
Metadata
- Authors
- Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., D’Agostino, R. B., & O’Donnell, C. J.
- Affiliations
- Boston University (US)
- From the National Heart, Lung and Blood Institute’s Framingham Heart Study (C.S.F., C.J.O.), Framingham, Mass; Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine (C.S.F., K.M.P.), Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass; Boston University, Department of Mathematics (J.M.M.; R.B.D.) and School of Public Health, Division of Biostatistics (C.-Y.L., L.A.C.), Boston, Mass; Radiology Department (U.H.) and Department of Medicine (J.B.M., C.J.O.),...
- ORCID
- Venue
- Circulation
- Published
- 2007-07-03
- Volume
- 116
- Issue
- 1
- Pages
- 39-48
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1989400130
- Cited by
- 2,882
- References
- 78
- Citations by year
- 2026: 102 · 2025: 163 · 2024: 172 · 2023: 164 · 2022: 190 · 2021: 196 · 2020: 162 · 2019: 161 · 2018: 161 · 2017: 157 · 2016: 182 · 2015: 182 · 2014: 184 · 2013: 151 · 2012: 124
- FWCI
- 68.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195, K24HL004334)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007529)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- visceral adipose tissue, subcutaneous adipose tissue, metabolic risk factors, metabolic syndrome, sex differences, hypertension, impaired fasting glucose, diabetes mellitus, body fat distribution, obesity, body mass index, waist circumference
- MeSH terms
- Adult, Calcium, Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Female, Humans, Hypercholesterolemia, Hyperglycemia, Hypertension, Male, Middle Aged, Obesity, Organ Size, Risk, Sex Factors, United States, Hypertriglyceridemia, Cohort Studies, Comorbidity, Body Mass Index, Glucose Intolerance, Metabolic Syndrome, Tomography, Spiral Computed, Intra-Abdominal Fat, Overweight, Subcutaneous Fat, Abdominal
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