The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Independent Impact of Gout on Mortality and Risk for Coronary Heart Disease
Open accessAbstract
Background— Although gout and hyperuricemia are related to several conditions that are associated with reduced survival, no prospective data are available on the independent impact of gout on mortality. Furthermore, although many studies have suggested that hyperuricemia is associated with cardiovascular disease (CVD), limited data are available on the impact of gout on CVD. Methods and Results— Over a 12-year period, we prospectively examined the relation between a history of gout and the risk of death and myocardial infarction in 51 297 male participants of the Health Professionals Follow-Up Study. During the 12 years of follow-up, we documented 5825 deaths from all causes, which included 2132 deaths from CVD and 1576 deaths from coronary heart disease (CHD). Compared with men without history of gout and CHD at baseline, the multivariate relative risks among men with history of gout were 1.28 (95% confidence interval [CI], 1.15 to 1.41) for total mortality, 1.38 (95% CI, 1.15 to 1.66) for CVD deaths, and 1.55 (95% CI, 1.24 to 1.93) for fatal CHD. The corresponding relative risks among men with preexisting CHD were 1.25 (95% CI, 1.09 to 1.45), 1.26 (95% CI, 1.07 to 1.50), and 1.24 (95% CI, 1.04 to 1.49), respectively. In addition, men with gout had a higher risk of nonfatal myocardial infarction than men without gout (multivariate relative risk, 1.59; 95% CI, 1.04 to 2.41). Conclusions— These prospective data indicate that men with gout have a higher risk of death from all causes. Among men without preexisting CHD, the increased mortality risk is primarily a result of an elevated risk of CVD death, particularly from CHD.
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Cites
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Preliminary criteria for the classification of the acute arthritis of primary gout
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Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
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Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
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Purine-Rich Foods, Dairy and Protein Intake, and the Risk of Gout in Men
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Self-citationMethotrexate and mortality in patients with rheumatoid arthritis: a prospective study
Choi, H. K., Hernán, M. A., Seeger, J. D., Robins, J. M., & Wolfe, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08213-2 · Cited by 1,127
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2016 updated EULAR evidence-based recommendations for the management of gout
Richette, P., Doherty, M., Pascual, E., Barskova, V, Becce, F., Castañeda-Sanabria, J., Coyfish, M., Guillo, S., Jansen, T. L., Janssens, H., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209707 · Cited by 1,681
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Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
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Nuesch, E., Dieppe, P., Reichenbach, S., Williams, S., Iff, S., & Juni, P. (2011) · BMJ · doi:10.1136/bmj.d1165 · Cited by 730
Hyperuricemia and coronary heart disease: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2010) · Arthritis Care & Research · doi:10.1002/acr.20065 · Cited by 671
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Metadata
- Authors
- Choi, H. K., & Curhan, G.
- Venue
- Circulation
- Published
- 2007-08-21
- Volume
- 116
- Issue
- 8
- Pages
- 894-900
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2167491049
- Cited by
- 666
- References
- 38
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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