The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease
Open accessAbstract
Background— Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis. Methods and Results— A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving a total of 4645 patients with myocardial infarction or CAD and 5177 controls. The mode of inheritance was determined. In addition, in 5 of the 7 studies, we genotyped 3 additional SNPs to assess a risk-associated haplotype (ACAC). Finally, a meta-analysis of the present data and previously published samples was conducted. A limited fine mapping of the locus was performed. The risk allele (C) of the lead SNP, rs1333049, was uniformly associated with CAD in each study ( P <0.05). In a pooled analysis, the odds ratio per copy of the risk allele was 1.29 (95% confidence interval, 1.22 to 1.37; P =0.0001). Haplotype analysis further suggested that this effect was not homogeneous across the haplotypic background (test for interaction, P =0.0079). An autosomal-additive mode of inheritance best explained the underlying association. The meta-analysis of the rs1333049 SNP in 12 004 cases and 28 949 controls increased the overall level of evidence for association with CAD to P =6.04×10 −10 (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29). Genotyping of 31 additional SNPs in the region identified several with a highly significant association with CAD, but none had predictive information beyond that of the rs1333049 SNP. Conclusion— This broad replication provides unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of CAD.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationGenomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044
Self-citationA Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594
A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587
Replicating genotype–phenotype associations
NCI-NHGRI Working Group on Replication in Association Studies, Chanock, S. J., Manolio, T., Boehnke, M., Boerwinkle, E., Hunter, D. J., Thomas, G., Hirschhorn, J. N., Abecasis, G., Altshuler, D., et al. (2007) · Nature · doi:10.1038/447655a · Cited by 1,352
White Cell Telomere Length and Risk of Premature Myocardial Infarction
Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000067426.96344.32 · Cited by 590
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Cited by
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Inflammation in Atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.009 · Cited by 2,228
Stroke risk factors, genetics, and prevention
Boehme, A. K., Esenwa, C., & Elkind, M. S. V. (2017) · Circulation Research · doi:10.1161/circresaha.116.308398 · Cited by 1,952
(2012) · The Lancet · doi:10.1016/s0140-6736(12)60110-x · Cited by 1,146
Myocardial Infarction Genetics Consortium (2009) · Nature Genetics · doi:10.1038/ng.327 · Cited by 1,088
Metadata
- Authors
- Schunkert, H., Götz, A., Braund, P., McGinnis, R., Tregouet, D.-A., Mangino, M., Linsel-Nitschke, P., Cambien, F., Hengstenberg, C., Stark, K., Blankenberg, S., Tiret, L., Ducimetiere, P., Keniry, A., Ghori, M. J. R., Schreiber, S., El Mokhtari, N. E., Hall, A. S., Dixon, R. J., Goodall, A. H., Liptau, H., Pollard, H., Schwarz, D. F., Hothorn, L. A., Wichmann, H. E., König, I. R., Fischer, M., Meisinger, C., Ouwehand, W., Deloukas, P., Thompson, J. R., Erdmann, J., Ziegler, A., & Samani, N. J.
- Venue
- Circulation
- Published
- 2008-04
- Volume
- 117
- Issue
- 13
- Pages
- 1675-1684
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2144062486
- Cited by
- 387
- References
- 6
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Schunkert, H., Götz, A., Braund, P., McGinnis, R., Tregouet, D.-A., Mangino, M., Linsel-Nitschke, P., Cambien, F., Hengstenberg, C., Stark, K., Blankenberg, S., Tiret, L., Ducimetiere, P., Keniry, A., Ghori, M. J. R., Schreiber, S., El Mokhtari, N. E., Hall, A. S., Dixon, R. J., . . . Samani, N. J. (2008). Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease. Circulation. https://doi.org/10.1161/circulationaha.107.730614
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
