Replicating genotype–phenotype associations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,320 · see citing works

Principal components analysis corrects for stratification in genome-wide association studies

Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248 · see citing works

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220 · see citing works

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Finishing the euchromatic sequence of the human genome

International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971 · see citing works

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993 · see citing works

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works

Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works

Genome-wide association study identifies novel breast cancer susceptibility loci

Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D. P., Thompson, D., Ballinger, D. G., Struewing, J. P., Morrison, J., Field, H., Luben, R., et al. (2007) · Nature · doi:10.1038/nature05887 · Cited by 2,319 · see citing works

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1732 · Cited by 2,287 · see citing works

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works

A common haplotype in the complement regulatory gene factor H ( <i>HF1/CFH</i> ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works

Replication validity of genetic association studies

Ioannidis, J., Ntzani, E., Trikalinos, T., & Contopoulos-Ioannidis, D. (2001) · Nature Genetics · doi:10.1038/ng749 · Cited by 1,926 · see citing works

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900 · see citing works

Searching for genetic determinants in the new millennium

Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839 · see citing works

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

Wacholder, S., Chanock, S. J., García‐Closas, M., ghormli, L. K. E., & Rothman, N. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh075 · Cited by 1,743 · see citing works

A comprehensive review of genetic association studies

Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674 · see citing works

A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594 · see citing works

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587 · see citing works

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

Hunter, D. J., Kraft, P., Jacobs, K. B., Cox, D. G., Yeager, M., Hankinson, S. E., Wacholder, S., Wang, Z., Welch, R. A., Hutchinson, A. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2075 · Cited by 1,463 · see citing works

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

Skol, A. D., Scott, L. J., Abecasis, G. R., & Boehnke, M. (2006) · Nature Genetics · doi:10.1038/ng1706 · Cited by 1,286 · see citing works

Whole-Genome Patterns of Common DNA Variation in Three Human Populations

Hinds, D., Stuve, L., Nilsen, G. B., Halperin, E., Eskin, E., Ballinger, D., Frazer, K., & Cox, D. (2005) · Science · doi:10.1126/science.1105436 · Cited by 1,245 · see citing works

Problems of reporting genetic associations with complex outcomes

Colhoun, H. M., McKeigue, P., & Smith, G. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12715-8 · Cited by 1,203 · see citing works

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Yeager, M., Orr, N., Hayes, R. B., Jacobs, K. B., Kraft, P., Wacholder, S., Minichiello, M. J., Fearnhead, P., Yu, K. F., Chatterjee, N., et al. (2007) · Nature Genetics · doi:10.1038/ng2022 · Cited by 1,122 · see citing works

The TDT and other family-based tests for linkage disequilibrium and association.

(1996) · PubMed Central · Cited by 901 · see citing works

Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris‐Kerr, C., Wormley, B., Sadek, H., Kadambi, B., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341750 · Cited by 857 · see citing works

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24

Guðmundsson, J., Sulem, P., Manolescu, A. R., Amundadottir, L. T., Gudbjartsson, D. F., Helgason, A., Rafnar, Þ., Bergþorsson, J. Þ., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics · doi:10.1038/ng1999 · Cited by 856 · see citing works

A common variant associated with prostate cancer in European and African populations

Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1808 · Cited by 787 · see citing works

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer

Stacey, S. N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S. A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2064 · Cited by 786 · see citing works

A common genetic variant is associated with adult and childhood obesity.

Herbert, A., Gerry, N. P., McQueen, M. B., Heid, I. M., Pfeufer, A., Illig, T., Wichmann, H.-E., Meitinger, T., Hunter, D., Hu, F. B., et al. (2006) · Science · doi:10.1126/science.1124779 · Cited by 732 · see citing works

Multiple regions within 8q24 independently affect risk for prostate cancer

Haiman, C. A., Patterson, N., Freedman, M. L., Myers, S. R., Pike, M. C., Waliszewska, A., Neubauer, J., Tandon, A., Schirmer, C., McDonald, G. J., et al. (2007) · Nature Genetics · doi:10.1038/ng2015 · Cited by 663 · see citing works

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

Freedman, M. L., Haiman, C. A., Patterson, N., McDonald, G. J., Tandon, A., Waliszewska, A., Penney, K., Steen, R. G., Ardlie, K., John, E. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605832103 · Cited by 612 · see citing works

The Future of Association Studies: Gene-Based Analysis and Replication

Neale, B. M., & Sham, P. C. (2004) · The American Journal of Human Genetics · doi:10.1086/423901 · Cited by 605 · see citing works

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss

(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1439 · Cited by 547 · see citing works

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

Helgason, A., Pálsson, S., Þorleifsson, G., Grant, S. F. A., Emilsson, V., Gunnarsdottir, S., Adeyemo, A., Chen, Y., Chen, G., Reynisdóttir, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1960 · Cited by 520 · see citing works

High-Resolution Whole-Genome Association Study of Parkinson Disease

Maraganore, D. M., de Andrade, M., Lesnick, T. G., Strain, K. J., Farrer, M. J., Rocca, W. A., Pant, P. V. K., Frazer, K. A., Cox, D., & Ballinger, D. G. (2005) · The American Journal of Human Genetics · doi:10.1086/496902 · Cited by 508 · see citing works

The endophenotype concept in psychiatric genetics

FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477 · see citing works

Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis

Economou, M., Trikalinos, T. A., Loizou, K. T., Tsianos, E. V., & Ioannidis, J. P. A. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40304.x · Cited by 464 · see citing works

Population Stratification in Epidemiologic Studies of Common Genetic Variants and Cancer: Quantification of Bias

Wacholder, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.14.1151 · Cited by 442 · see citing works

Overcoming the Winner’s Curse: Estimating Penetrance Parameters from Case-Control Data

Zöllner, S. K., & Pritchard, J. K. (2007) · The American Journal of Human Genetics · doi:10.1086/512821 · Cited by 382 · see citing works

Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium

Rothman, N., Skibola, C. F., Wang, S., Morgan, G. J., Lan, Q., Smith, M. T., Spinelli, J. J., Willett, E. V., de Sanjosé, S., Cocco, P., et al. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70434-4 · Cited by 379 · see citing works

Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals

Saxena, R., Gianniny, L., Burtt, N. P., Lyssenko, V., Giuducci, C., Sjögren, M., Florez, J. C., Almgren, P., Isomaa, B., Orho‐Melander, M., et al. (2006) · Diabetes · doi:10.2337/db06-0381 · Cited by 373 · see citing works

The Human Phenome Project

Freimer, N., & Sabatti, C. (2003) · Nature Genetics · doi:10.1038/ng0503-15 · Cited by 372 · see citing works

Genes, environment and the value of prospective cohort studies

Manolio, T. A., Wilson, J., & Collins, F. S. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1919 · Cited by 317 · see citing works

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population

Chandak, G. R., Janipalli, C. S., Bhaskar, S., Kulkarni, S. R., Mohankrishna, P., Hattersley, A. T., Frayling, T. M., & Yajnik, C. S. (2006) · Diabetologia · doi:10.1007/s00125-006-0502-2 · Cited by 276 · see citing works

Freely associating

(1999) · Nature Genetics · doi:10.1038/8702 · Cited by 264 · see citing works

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

Groves, C. J., Zeggini, E., Minton, J. A. L., Frayling, T. M., Weedon, M. N., Rayner, N. W., Hitman, G. A., Walker, M., Wiltshire, S., Hattersley, A. T., et al. (2006) · Diabetes · doi:10.2337/db06-0355 · Cited by 252 · see citing works

Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases

Ioannidis, J. P. A., Trikalinos, T. A., & Khoury, M. J. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj259 · Cited by 245 · see citing works

Using Linkage Genome Scans to Improve Power of Association in Genome Scans

Roeder, K., Bacanu, S., Wasserman, L., & Devlin, B. (2006) · The American Journal of Human Genetics · doi:10.1086/500026 · Cited by 207 · see citing works

The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease

Bogaert, A. V. D., Schumacher, J. H., Schulze, T. G., Otte, A., Ohlraun, S., Kovalenko, S., Becker, T., Freudenberg, J., Jönsson, E. G., Mattila‐Evenden, M., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/379928 · Cited by 193 · see citing works

Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression

Bray, N. J., Preece, A. C., Williams, N. M., Moskvina, V., Buckland, P. R., Owen, M. J., & O’Donovan, M. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi199 · Cited by 186 · see citing works

Statistical false positive or true disease pathway?

Todd, J. A. (2006) · Nature Genetics · doi:10.1038/ng0706-731 · Cited by 178 · see citing works

Association of the DTNBP1 Locus with Schizophrenia in a U.S. Population

Funke, B., Finn, C. T., Plocik, A. M., Lake, S. L., DeRosse, P., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2004) · The American Journal of Human Genetics · doi:10.1086/425279 · Cited by 160 · see citing works

Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria

Kirov, G., Ivanov, D. K., Williams, N. M., Preece, A. C., Nikolov, I., Milev, R., Koleva, S., Dimitrova, A., Toncheva, D. I., O’Donovan, M. C., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.025 · Cited by 156 · see citing works

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

Horikoshi, M., Hara, K., Ito, C., Nagai, R., Froguel, P., & Kadowaki, T. (2007) · Diabetologia · doi:10.1007/s00125-006-0588-6 · Cited by 152 · see citing works

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Christian Dina, C., Meyre, D., Samson, C., Tichet, J., Marre, M., Jouret, B., Charles, M.-A. A., Balkau, B., & Froguel, P. (2007) · Science · doi:10.1126/science.1129402 · Cited by 125 · see citing works

Analysis of High-Resolution HapMap of DTNBP1 (Dysbindin) Suggests No Consistency between Reported Common Variant Associations and Schizophrenia

Mutsuddi, M., Morris, D. W., Waggoner, S. G., Daly, M. J., Scolnick, E. M., & Sklar, P. B. (2006) · The American Journal of Human Genetics · doi:10.1086/508942 · Cited by 119 · see citing works

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Loos, R. J. F., Barroso, I., O’Rahilly, S., & Wareham, N. J. (2007) · Science · doi:10.1126/science.1130012 · Cited by 115 · see citing works

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Rosskopf, D., Bornhorst, A., Rimmbach, C., Schwahn, C., Kayser, A., Krüger, A., Tessmann, G., Geissler, I., Kroemer, H. K., & Völzke, H. (2007) · Science · doi:10.1126/science.1130571 · Cited by 112 · see citing works

Determinants of the success of whole-genome association testingPreprint

Clark, A. G., Boerwinkle, E., Hixson, J. E., & Sing, C. F. (2005) · Genome Research · doi:10.1101/gr.4244005 · Cited by 111 · see citing works

Lymphotoxin-α Gene and Risk of Myocardial Infarction in 6,928 Cases and 2,712 Controls in the ISIS Case-Control Study

Clarke, R., Xu, P., Bennett, D., Lewington, S., Zondervan, K. T., Parish, S., Palmer, A., Clark, S., Cardon, L. R., Peto, R., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020107 · Cited by 84 · see citing works

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

Field, S. F., Howson, J. M. M., Smyth, D. J., Walker, N. M., Dunger, D. B., & Todd, J. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0506-y · Cited by 72 · see citing works

Variants in common diseases

Freimer, N. B., & Sabatti, C. (2007) · Nature · doi:10.1038/nature05568 · Cited by 64 · see citing works

Many hypotheses but no replication for the association between PDE4D and stroke

Rosand, J. M., Bayley, N., Rost, N. S., et al. (2006) · Nature Genetics · doi:10.1038/ng1006-1091 · Cited by 62 · see citing works

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families

Hall, D. H., Rahman, T., Avery, P. J., & Keavney, B. D. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-83 · Cited by 61 · see citing works

The Interpretation of Epidemiologic Studies

Angell, M. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231209 · Cited by 58 · see citing works

Genomewide Association, Parkinson Disease, and PARK10

Farrer, M. J., Haugarvoll, K., Ross, O. A., Stone, J. T., Milkovic, N. M., Cobb, S. A., Whittle, A. J., Lincoln, S., Hulihan, M., Heckman, M. G., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504728 · Cited by 56 · see citing works

Conflicting Results Regarding the Semaphorin Gene (SEMA5A) and the Risk for Parkinson Disease

Clarimón, J., Scholz, S. W., Fung, H., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504727 · Cited by 55 · see citing works

No Evidence for Association with Parkinson Disease for 13 Single-Nucleotide Polymorphisms Identified by Whole-Genome Association Screening

Goris, A., Williams‐Gray, C. H., Foltynie, T., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504726 · Cited by 46 · see citing works

A Case-Control Association Study of the 12 Single-Nucleotide Polymorphisms Implicated in Parkinson Disease by a Recent Genome Scan

Li, Y., Rowland, C. M., Schrodi, S. J., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504725 · Cited by 39 · see citing works

Common Genetic Variants for Breast Cancer: 32 Largely Refuted Candidates and Larger Prospects

Ioannidis, J. P. A. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj392 · Cited by 36 · see citing works

Considerations for Genomewide Association Studies in Parkinson Disease

Myers, R. H. (2006) · The American Journal of Human Genetics · doi:10.1086/504730 · Cited by 33 · see citing works

Replication Publication

Patterson, M. N., & Cardon, L. R. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030327 · Cited by 24 · see citing works

Comment on the Phosphodiesterase 4D Replication Study by Bevan et al

Grétarsdóttir, S., Gulcher, J. R., Þorleifsson, G., Kong, A., & Stefánsson, K. (2005) · Stroke · doi:10.1161/01.str.0000176497.94458.27 · Cited by 4 · see citing works

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891 · see citing works

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis

Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works

ClinGen — The Clinical Genome Resource

Rehm, H. L., Berg, J. S., Brooks, L. D., Bustamante, C. D., Evans, J. P., Landrum, M. J., Ledbetter, D. H., Maglott, D. R., Martin, C. L., Nussbaum, R. L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmsr1406261 · Cited by 1,496 · see citing works

Genomewide Association Studies and Assessment of the Risk of Disease

Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512 · see citing works

Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346 · see citing works

Guidelines for investigating causality of sequence variants in human disease

MacArthur, D. G., Manolio, T. A., Dimmock, D. P., Rehm, H. L., Shendure, J., Abecasis, G. R., Adams, D. R., Altman, R. B., Antonarakis, S. E., Ashley, E. A., et al. (2014) · Nature · doi:10.1038/nature13127 · Cited by 1,224 · see citing works

Genetic architectures of psychiatric disorders: the emerging picture and its implications

Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works

Methods of integrating data to uncover genotype-phenotype interactions

Ritchie, M. D., Holzinger, E. R., Li, R., Pendergrass, S. A., & Kim, D. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3868 · Cited by 1,085 · see citing works

Human genetic variation and its contribution to complex traits

Frazer, K. A., Murray, S. S., Schork, N. J., & Topol, E. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2554 · Cited by 1,073 · see citing works

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

Duncan, L. E., & Keller, M. C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020191 · Cited by 1,032 · see citing works

A HapMap harvest of insights into the genetics of common disease

Manolio, T. A., Brooks, L. D., & Collins, F. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34772 · Cited by 889 · see citing works

The Genetics of Alzheimer Disease: Back to the Future

Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834 · see citing works

STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement

Little, J., Higgins, J. P. T., Ioannidis, J. P. A., Moher, D., Gagnon, F., von Elm, E., Khoury, M. J., Cohen, B., Davey-Smith, G., Grimshaw, J., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000022 · Cited by 811 · see citing works

How to Make More Published Research True

Ioannidis, J. P. A. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001747 · Cited by 760 · see citing works

Common vs. rare allele hypotheses for complex diseases

Schork, N. J., Murray, S. S., Frazer, K. A., & Topol, E. J. (2009) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2009.04.010 · Cited by 649 · see citing works

Tobacco-smoking-related differential DNA methylation: 27K discovery and replication

Breitling, L. P., Yang, R., Korn, B., Burwinkel, B., & Brenner, H. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.003 · Cited by 640 · see citing works

Cytokines and their relationship to the symptoms and outcome of cancer

Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652 · see citing works

Discovering susceptibility genes for asthma and allergy

Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635 · see citing works

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of Prospective Meta-Analyses of Genome-Wide Association Studies From 5 Cohorts

Psaty, B. M., O'Donnell, C. J., Gudnason, V., Lunetta, K. L., Folsom, A. R., Rotter, J. I., Uitterlinden, A. G., Harris, T. B., Witteman, J. C. M., & Boerwinkle, E. (2009) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.108.829747 · Cited by 599 · see citing works

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

PSP Genetics Study Group, Höglinger, G. U., Melhem, N. M., Dickson, D. W., Sleiman, P. M. A., Wang, L.-S., Klei, L., Rademakers, R., de Silva, R., Litvan, I., et al. (2011) · Nature Genetics · doi:10.1038/ng.859 · Cited by 603 · see citing works

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works

Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease

Li, H., Wetten, S., Li, L., St. Jean, P. L., Upmanyu, R., Surh, L., Hosford, D., Barnes, M. R., Briley, J. D., Borrie, M., et al. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.3 · Cited by 499 · see citing works

Association of host genome with intestinal microbial composition in a large healthy cohort

GEM Project Research Consortium, Turpin, W., Espin-Garcia, O., Xu, W., Silverberg, M. S., Kevans, D., Smith, M. I., Guttman, D. S., Griffiths, A., Panaccione, R., et al. (2016) · Nature Genetics · doi:10.1038/ng.3693 · Cited by 460 · see citing works

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause

He, C., Kraft, P., Chen, C., Buring, J. E., Paré, G., Hankinson, S. E., Chanock, S. J., Ridker, P. M., Hunter, D. J., & Chasman, D. I. (2009) · Nature Genetics · doi:10.1038/ng.385 · Cited by 379 · see citing works

Epigenetics of endometriosis

Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328 · see citing works

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations

Panagiotou, O. A., Ioannidis, J. P. A., & for the Genome-Wide Significance Project (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr178 · Cited by 286 · see citing works

Toxicology and risk assessment of coumarin: Focus on human data

Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A. (2010) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200900281 · Cited by 292 · see citing works

The Psychiatric GWAS Consortium: Big Science Comes to Psychiatry

Sullivan, P. F. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.003 · Cited by 285 · see citing works

Grading the strength of a body of evidence when assessing health care interventions: an EPC update

Berkman, N. D., Lohr, K. N., Ansari, M. T., Balk, E. M., Kane, R., McDonagh, M., Morton, S. C., Viswanathan, M., Bass, E. B., Butler, M., et al. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.11.023 · Cited by 279 · see citing works

When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment

Szucs, D., & Ioannidis, J. P. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00390 · Cited by 298 · see citing works

Genetic basis of chronotype in humans: insights from three landmark GWAS

Kalmbach, D. A., Schneider, L. D., Cheung, J., Bertrand, S. J., Kariharan, T., Pack, A. I., & Gehrman, P. R. (2017) · Sleep · doi:10.1093/sleep/zsw048 · Cited by 243 · see citing works

Genes Controlling Affiliative Behavior as Candidate Genes for Autism

Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172 · see citing works

Registration of observational studies: Is it time?

Williams, R. J., Tse, T., Harlan, W. R., & Zarin, D. A. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.092252 · Cited by 152 · see citing works

Guilt beyond a reasonable doubt

Altshuler, D., & Daly, M. (2007) · Nature Genetics · doi:10.1038/ng0707-813 · Cited by 151 · see citing works

Direct-to-consumer genetic testing

Horton, R., Crawford, G., Freeman, L., Fenwick, A., Wright, C. F., & Lucassen, A. (2019) · BMJ · doi:10.1136/bmj.l5688 · Cited by 151 · see citing works

ASsociation of gsk3β polymorphisms with brain structural changes in major depressive disorder

Inkster, B., Nichols, T. E., Saemann, P. G., Auer, D. P., Holsboer, F., Muglia, P., & Matthews, P. M. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.70 · Cited by 127 · see citing works

Serum Metabolite Concentrations and Decreased GFR in the General Population

Goek, O.-N., Döring, A., Gieger, C., Heier, M., Koenig, W., Prehn, C., Römisch-Margl, W., Wang-Sattler, R., Illig, T., Suhre, K., et al. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.01.014 · Cited by 121 · see citing works

Macrophage migration inhibitory factor and autism spectrum disorders

Grigorenko, E. L., Han, S. S., Yrigollen, C. M., Leng, L., Mizue, Y., Anderson, G. M., Mulder, E. J., de Bildt, A., Minderaa, R. B., Volkmar, F. R., et al. (2008) · PEDIATRICS · doi:10.1542/peds.2007-3604 · Cited by 118 · see citing works

Meta-analysis of genetic association studies: methodologies, between-study heterogeneity and winner's curse

Nakaoka, H., & Inoue, I. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.95 · Cited by 111 · see citing works

DNA methylation in endometriosis (Review)

KOUKOURA, O., SIFAKIS, S., & SPANDIDOS, D. A. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4925 · Cited by 103 · see citing works

Schizophrenia Genetics: Where Next?

Kim, Y., Zerwas, S., Trace, S. E., & Sullivan, P. F. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr031 · Cited by 101 · see citing works

Genomics

Bossé, Y., Mathieu, P., & Pibarot, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.031 · Cited by 82 · see citing works

Genome-wide association studies and the genetic dissection of complex traits

Sebastiani, P., Timofeev, N., Dworkis, D. A., Perls, T. T., & Steinberg, M. H. (2009) · American Journal of Hematology · doi:10.1002/ajh.21440 · Cited by 67 · see citing works

Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms.

Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works

Transferability and Fine-Mapping of Genome-Wide Associated Loci for Adult Height across Human Populations

Shriner, D., Adeyemo, A., Gerry, N. P., Herbert, A., Chen, G., Doumatey, A., Huang, H., Zhou, J., Christman, M. F., & Rotimi, C. N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008398 · Cited by 56 · see citing works

Bias in genetic association studies and impact factor

Munafò, M. R., Stothart, G., & Flint, J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.77 · Cited by 60 · see citing works

Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies

Zoldoš, V., Horvat, T., & Lauc, G. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2012.12.007 · Cited by 56 · see citing works

Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

Sambo, M. R., Trovoada, M. J., Benchimol, C., Quinhentos, V., Gonçalves, L., Velosa, R., Marques, M. I., Sepúlveda, N., Clark, T. G., Mustafa, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011141 · Cited by 50 · see citing works

No association between a common single nucleotide polymorphism, rs4141463, in the <i>MACROD2</i> gene and autism spectrum disorder

Curran, S., Bolton, P., Rozsnyai, K., Chiocchetti, A., Klauck, S. M., Duketis, E., Poustka, F., Schlitt, S., Freitag, C. M., Lee, I., et al. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31201 · Cited by 34 · see citing works

Genome-Wide Association Study of Autistic-Like Traits in a General Population Study of Young Adults

Jones, R. M., Cadby, G., Melton, P. E., Abraham, L. J., Whitehouse, A. J., & Moses, E. K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00658 · Cited by 33 · see citing works

Serotonin reuptake inhibitors and serotonin transporter genotype modulate performance monitoring functions but not their electrophysiological correlates

Fischer, A. G., Endrass, T., Reuter, M., Kubisch, C., & Ullsperger, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.5124-14.2015 · Cited by 29 · see citing works

Neurocognitive Phenotypes and Genetic Dissection of Disorders of Brain and Behavior

Congdon, E., Poldrack, R. A., & Freimer, N. B. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.007 · Cited by 22 · see citing works

Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

Andiappan, A. K., Nilsson, D., Halldén, C., De Yun, W., Säll, T., Cardell, L. O., & Tim, C. F. (2013) · BMC Medical Genetics · doi:10.1186/1471-2350-14-51 · Cited by 20 · see citing works

Choline: Clinical Nutrigenetic/Nutrigenomic Approaches for Identification of Functions and Dietary Requirements

Zeisel, S. H. (2010) · Journal of Nutrigenetics and Nutrigenomics · doi:10.1159/000324357 · Cited by 9 · see citing works

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works

Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratum

Platenkamp, G. A. J., & Foin, T. C. (1990) · Oecologia · doi:10.1007/bf00317753 · Cited by 21 · see citing works