White Cell Telomere Length and Risk of Premature Myocardial Infarction
Abstract
Objective— Biological age may be distinct from chronological age and contribute to the pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myocardial infarction (MI) had shorter leukocyte telomeres. Methods and Results— Mean terminal restriction fragment (TRF) length, a measure of average telomere size, was compared in leukocyte DNA of 203 cases with a premature MI (<50 years) and 180 controls. Age- and sex-adjusted mean TRF length of cases was significantly shorter than that of controls (difference 299.7±69.3 base pairs, P <0.0001) and on average equivalent to controls 11.3 years older. The difference in mean TRF length between cases and controls was not accounted for by other coronary risk factors. Compared with subjects in the highest quartile for telomere length, the risk of myocardial infarction was increased between 2.8- and 3.2-fold ( P <0.0001) in subjects with shorter than average telomeres. Conclusions— The findings support the concept that biological age may play a role in the etiology of coronary heart disease and have potentially important implications for our understanding of its genetic etiology, pathogenesis, and variable age of onset.
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Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.
“Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [12]
Shorter age-and sex-adjusted mean LTL has been found to be associated with risk of several age-related diseases, including CAD.
“Furthermore, shorter age-and sex-adjusted mean LTL has been found to be associated with risk of several age-related diseases, including CAD12–15 and has been advanced as a marker of biological ageing16.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [12]
In cross-sectional population studies, mean LTL is longer in women than in men and is inversely associated with age, declining by between 20-40 base pairs per year.
“In cross-sectional population studies mean LTL is longer in women than in men and is inversely associated with age (declining by between 20–40 base-pairs (bp) per year)9, 12–14.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [12]
Many prior studies using Southern blotting have shown that mean LTL attrition rate is about ~30 bp per year.
“However, many prior studies that have used Southern blotting to measure LTL have shown that mean LTL attrition rate is about ~30 bp per year8, 12–14, 25.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [12]
One of the most widely reported associations for LTL to date has been that between shorter mean LTL and CAD.
“One of the most widely reported associations for LTL to date has been that between shorter mean LTL and CAD12–14, 25.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [12]
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596 · see citing works
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200 · see citing works
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works
Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins
Marenberg, M. E., RISCH, N. J., Berkman, L. F., Floderus, B., & Fairé, U. D. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301503 · Cited by 1,256 · see citing works
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence
Eikelboom, J. W., Lonn, E., Genest, J. J., Hankey, G. J., & Yusuf, S. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-5-199909070-00008 · Cited by 908 · see citing works
Heterogeneity in telomere length of human chromosomes
Lansdorp, P. M. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.5.685 · Cited by 879 · see citing works
Telomeres: Beginning to Understand the End
Zakian, V. A. (1995) · Science · doi:10.1126/science.270.5242.1601 · Cited by 849 · see citing works
Lipoprotein-Associated Phospholipase A 2 as an Independent Predictor of Coronary Heart Disease
Packard, C. J., O’Reilly, D. S. J., CASLAKE, M. J., McMahon, A. D., Ford, I., Cooney, J., Macphee, C. H., Suckling, K. E., Krishna, M., Wilkinson, F. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431603 · Cited by 822 · see citing works
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works
Telomere length and replicative aging in human vascular tissues.
Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 621 · see citing works
Telomere shortening in atherosclerosis
Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609 · see citing works
Self-citationRole of Oxidative Stress in Telomere Length Regulation and Replicative Senescence
von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06639.x · Cited by 445 · see citing works
Evidence for a Critical Telomere Length in Senescent Human Fibroblasts
Allsopp, R., & Harley, C. B. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1213 · Cited by 391 · see citing works
Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 352 · see citing works
Morphology of the endothelium over atherosclerotic plaques in human coronary arteries.
Davies, M. J., Woolf, N., Rowles, P. M., & Pepper, J. (1988) · Heart · doi:10.1136/hrt.60.6.459 · Cited by 248 · see citing works
Shortened telomere length in white blood cells of patients with IDDM.
Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217 · see citing works
Homocysteine accelerates endothelial cell senescence
Xu, D. L., Neville, R. F., & Finkel, T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01278-3 · Cited by 207 · see citing works
The endothelium of advanced arteriosclerotic plaques in humans.
Bürrig, K. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1678 · Cited by 177 · see citing works
Comi, P., Chiaramonte, R., & Maier, J. A. M. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1232 · Cited by 112 · see citing works
Oxidative stress and coronary artery disease.
Harrison, D. G. (1998) · PubMed · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
Vascular smooth muscle cells in atherosclerosis
Bennett, M. R., Sinha, S., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306361 · Cited by 2,179 · see citing works
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933 · see citing works
Self-citationLeucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856 · see citing works
Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis
Cronkhite, J. T., Xing, C., Raghu, G., Chin, K. M., Torres, F., Rosenblatt, R. L., & Kim Garcia, C. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-550oc · Cited by 573 · see citing works
Vascular Cell Senescence: Contribution to Atherosclerosis
Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542 · see citing works
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516 · see citing works
Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508 · see citing works
A systematic review of leukocyte telomere length and age in adults
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.003 · Cited by 474 · see citing works
Cell aging in relation to stress arousal and cardiovascular disease risk factors
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., & Blackburn, E. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.011 · Cited by 450 · see citing works
Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., Svenson, U., Roos, G., Hosgood, H. D., Shen, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020466 · Cited by 376 · see citing works
“Several studies have documented correlations between shortened telomeres and multiple human diseases associated with age, such as Alzheimer’s disease [6], myocardial infarction [7], vascular dementia [8], liver cirrhosis [9], atherosclerosis [10], ulcerative colitis [11] and premature aging syndromes [12].”
D’Mello, M. J. J., Ross, S. A., Briel, M., Anand, S. S., Gerstein, H., & Paré, G. (2015) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.113.000485 · Cited by 350 · see citing works
Bekaert, S., De Meyer, T., Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., Langlois, M., Segers, P., Cooman, L., Van Damme, P., Cassiman, P., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00321.x · Cited by 348 · see citing works
Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres
Epel, E., Daubenmier, J., Moskowitz, J. T., Folkman, S., & Blackburn, E. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04414.x · Cited by 324 · see citing works
Telomere Length: A Review of Methods for Measurement
Montpetit, A. J., Alhareeri, A. A., Montpetit, M., Starkweather, A. R., Elmore, L. W., Filler, K., Mohanraj, L., Burton, C. W., Menzies, V. S., Lyon, D. E., et al. (2014) · Nursing Research · doi:10.1097/nnr.0000000000000037 · Cited by 293 · see citing works
The Effect of Lutein on Eye and Extra-Eye Health
Buscemi, S., Corleo, D., Di Pace, F., Petroni, M. L., Satriano, A., & Marchesini, G. (2018) · Nutrients · doi:10.3390/nu10091321 · Cited by 260 · see citing works
Mapping of a Major Locus that Determines Telomere Length in Humans
Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J. R., Braund, P., Clemitson, J.-R., Mason, A., Bodycote, C. L., Raleigh, S. M., Louis, E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/426734 · Cited by 257 · see citing works
Self-citationCellular senescence in vivo: Its relevance in ageing and cardiovascular disease
Erusalimsky, J. D., & Kurz, D. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.010 · Cited by 252 · see citing works
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
Richards, J. B., Valdes, A. M., Gardner, J. P., Paximadas, D., Kimura, M., Nessa, A., Lu, X., Surdulescu, G. L., Swaminathan, R., Spector, T. D., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1420 · Cited by 237 · see citing works
Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway
Warboys, C. M., de Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., White, A., Biswas, S., Khamis, R., Chong, C. K., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303415 · Cited by 227 · see citing works
Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E., & Whooley, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008612 · Cited by 203 · see citing works
Short telomere length, myocardial infarction, ischemic heart disease, and early death
Weischer, M., Bojesen, S. E., Cawthon, R. M., Freiberg, J. J., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.237271 · Cited by 197 · see citing works
Telomeres and human aging: facts and fibs
Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198 · see citing works
Vascular smooth muscle cell senescence in atherosclerosis
GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.004 · Cited by 196 · see citing works
Wilson, W. R. W., Herbert, K. E., Mistry, Y., Stevens, S. E., Patel, H. R., Hastings, R. A., Thompson, M. M., & Williams, B. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn386 · Cited by 185 · see citing works
Human telomere biology: pitfalls of moving from the laboratory to epidemiology
Aviv, A., Valdes, A. M., & Spector, T. D. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl169 · Cited by 172 · see citing works
Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0357-5 · Cited by 164 · see citing works
Ageing induced vascular smooth muscle cell senescence in atherosclerosis
Uryga, A. K., & Bennett, M. R. (2016) · The Journal of Physiology · doi:10.1113/jp270923 · Cited by 160 · see citing works
Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool
van de Berg, P. J. E. J., Griffiths, S. J., Yong, S.-L., Macaulay, R., Bemelman, F. J., Jackson, S., Henson, S. M., ten Berge, I. J. M., Akbar, A. N., & van Lier, R. A. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903442 · Cited by 157 · see citing works
Hartmann, N., Boehner, M., Groenen, F., & Kalb, R. (2010) · Depression and Anxiety · doi:10.1002/da.20749 · Cited by 156 · see citing works
Shiels, P. G., McGlynn, L. M., MacIntyre, A., Johnson, P. C. D., Batty, G. D., Burns, H., Cavanagh, J., Deans, K. A., Ford, I., McConnachie, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022521 · Cited by 143 · see citing works
Leeansyah, E., Cameron, P. U., Solomon, A., Tennakoon, S., Velayudham, P., Gouillou, M., Spelman, T., Hearps, A., Fairley, C., Smit, D. V., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit006 · Cited by 136 · see citing works
Mechanisms of cardiovascular disease in accelerated aging syndromes
Capell, B. C., Collins, F. S., & Nabel, E. G. (2007) · Circulation Research · doi:10.1161/circresaha.107.153692 · Cited by 134 · see citing works
Blood Cell Telomere Length Is a Dynamic Feature
Svenson, U., Nordfjäll, K., Baird, D., Roger, L., Osterman, P., Hellenius, M.-L., & Roos, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021485 · Cited by 132 · see citing works
Aging, telomeres, and atherosclerosis
EDO, M., & ANDRES, V (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.007 · Cited by 112 · see citing works
Xu, X., Chen, X., Zhang, X., Liu, Y., Wang, Z., Wang, P., Du, Y., Qin, Y., & Chen, Z.-J. (2016) · Human Reproduction · doi:10.1093/humrep/dew283 · Cited by 109 · see citing works
Brouilette, S. W., Whittaker, A., Stevens, S. E., van der Harst, P., Goodall, A. H., & Samani, N. J. (2008) · Heart · doi:10.1136/hrt.2007.139675 · Cited by 96 · see citing works
Self-citationAutonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children
Kroenke, C. H., Epel, E., Adler, N., Bush, N. R., Obradović, J., Lin, J., Blackburn, E., Stamperdahl, J. L., & Boyce, W. T. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318229acfc · Cited by 89 · see citing works
Guan, J.-Z., Guan, W.-P., Maeda, T., Guoqing, X., GuangZhi, W., & Makino, N. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2274-1 · Cited by 84 · see citing works
Telomere length and bipolar disorder
Powell, T. R., Dima, D., Frangou, S., & Breen, G. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.125 · Cited by 78 · see citing works
Aviv, A. (2020) · The FASEB Journal · doi:10.1096/fj.202001025 · Cited by 73 · see citing works
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
Zhai, G., Aviv, A., Hunter, D. J., Hart, D. J., Gardner, J. P., Kimura, M., Lu, X., Valdes, A. M., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.056903 · Cited by 72 · see citing works
Raschenberger, J., Kollerits, B., Ritchie, J., Lane, B., Kalra, P. A., Ritz, E., & Kronenberg, F. (2015) · Scientific Reports · doi:10.1038/srep11887 · Cited by 66 · see citing works
Longer telomere length in patients with schizophrenia
Nieratschker, V., Lahtinen, J., Meier, S., Strohmaier, J., Frank, J., Heinrich, A., Breuer, R., Witt, S. H., Nöthen, M. M., Rietschel, M., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.043 · Cited by 63 · see citing works
Carroll, J. E., Diez-Roux, A. V., Adler, N. E., & Seeman, T. E. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.024 · Cited by 56 · see citing works
Bennaceur, K., Atwill, M., Al Zhrany, N., Hoffmann, J., Keavney, B., Breault, D., Richardson, G., von Zglinicki, T., Saretzki, G., & Spyridopoulos, I. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.020 · Cited by 51 · see citing works
Nollet, E., Hoymans, V. Y., Rodrigus, I. R., De Bock, D., Dom, M., Van Hoof, V. O. M., Vrints, C. J., & Van Craenenbroeck, E. M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.03.023 · Cited by 17 · see citing works
Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression
Martínez‐González, K., Islas‐Hernández, A., Martínez‐Ezquerro, J. D., Bermúdez‐Rattoni, F., & Garcia‐delaTorre, P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14877 · Cited by 8 · see citing works
- Authors
- Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J.
- Affiliations
- University of Leicester (GB)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2003-05
- Volume
- 23
- Issue
- 5
- Pages
- 842-846
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2127657628
- Cited by
- 590
- References
- 27
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 27 · 2020: 26 · 2019: 21 · 2018: 31 · 2017: 26 · 2016: 25 · 2015: 24 · 2014: 37 · 2013: 32 · 2012: 33
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- leukocyte telomere length, premature myocardial infarction, biological age, terminal restriction fragments, coronary artery disease, coronary risk factors, age of onset, telomere shortening
- MeSH terms
- Adult, Aging, Coronary Disease, England, Female, Humans, Leukocytes, Male, Middle Aged, Myocardial Infarction, Retrospective Studies, Risk, Risk Factors, Telomere, Age of Onset
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