The DOI matches its Crossref record; 116 of the 124 references it cites were found in a registry or an index; 1 of the 43 sources its claims cite were checked for support.
Beyond Established and Novel Risk Factors: Lifestyle Risk Factors for Cardiovascular Disease
Abstract
D yslipidemia, hypertension, and diabetes mellitus have been appropriately highlighted as established predictors of cardiovascular disease.These risk factors have become preeminent targets for influencing cardiovascular risk; their assessment, treatment, and monitoring are major emphases of clinical care, research investigation, treatment guidelines, organization position papers, and measures of physician and hospital performance.Notably, lifestyle risk factors, including dietary habits, physical inactivity, smoking, and adiposity, strongly influence the established cardiovascular risk factors and also affect novel pathways of risk such as inflammation/oxidative stress, endothelial function, thrombosis/coagulation, and arrhythmia.Furthermore, modest alterations of these lifestyle risk factors are achievable and have substantial effects on cardiovascular risk.Thus, basic lifestyle habits should be considered fundamental risk factors for cardiovascular disease.Although efforts to combat established and novel risk factors with pharmacological treatments are important and should continue, we call for a systematic rebalancing of current research, clinical care, and policy efforts to focus more on lifestyle.The rising costs of healthcare and the epidemics of overweight and obesity highlight the inadequacies of our current strategy.Substantially more resources should be directed toward research on lifestyle risk factors, their determinants, and effective interventions to change them.The clinical evaluation and treatment of dietary, physical activity, and smoking habits must become as routine and familiar as assessment of blood pressure, cholesterol, and glucose levels.Major policy initiatives and reimbursement guidelines must also be rebalanced to emphasize lifestyle risk factors.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review argues that lifestyle risk factors—diet, physical inactivity, smoking, and adiposity—are fundamental causes of cardiovascular disease and should be prioritized alongside established and novel risk factors. It calls for rebalancing research, clinical care, and policy toward lifestyle assessment and intervention.
Key findings
- Lifestyle factors account for most cardiovascular and diabetes burden: >70% of total cardiovascular events, 80% of CHD events, and 90% of new diabetes cases are attributable to a handful of basic lifestyle factors.
- Modest lifestyle changes have large effects: smoking cessation reduces total mortality by approximately one third; physical activity/fitness is associated with 30% to 50% lower cardiovascular event risk; oily fish (1–2 servings/week) reduces CHD death by 36% and total mortality by 17%; a Mediterranean-type diet reduced myocardial infarction or cardiac death by 72% over 4 years; lifestyle intervention reduced diabetes incidence by 58% versus placebo and 39% versus metformin.
- Population behavior can change: US per capita tobacco use fell nearly two thirds since the 1950s; from 1977 to 2000, average fat consumption declined from 36.4% to 32.8% of calories and carbohydrate increased from 44.3% to 50.3%, while total calories rose from 2000 to 2250 kcal/d.
- Adherence is imperfect for both lifestyle and drugs: in the Women’s Health Initiative, 40% stopped the study drug at an average 5.2 years and 54% at 6.8 years; in the Diabetes Prevention Project, 58% maintained the physical activity goal, 38% achieved the weight loss goal, and 67% were ≥80% adherent to drug therapy; lipid-lowering or antihypertensive adherence typically ranges from 65% to 85% in trials to <50% in practice.
Methods
- Design: narrative review/commentary, not original research; it synthesizes evidence from epidemiological studies and randomized controlled trials.
- Data or sample: no primary sample; it cites prior studies and trials (e.g., Framingham, DPP, WHI, Lyon Diet Heart Study, Look AHEAD) and MEDLINE publication counts as of December 2007.
- Main analysis: narrative synthesis and argument for rebalancing research, clinical care, and policy toward lifestyle risk factors.
Limitations
- The paper states that direct evidence comparing adherence to modest lifestyle changes versus lifelong drug use is scant; additional research is needed on optimal behavior-change strategies; and the quality of evidence for some cardiovascular drugs exceeds that for some lifestyle changes because of discrepancies in the sizes and numbers of large randomized trials.
- Evident from the text: as a narrative review, it lacks a systematic search, formal meta-analysis, risk-of-bias assessment, or primary data, and its evidence selection and emphasis reflect the authors’ perspective.
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Claims the paper makes
20 Not checked yet · 7 Own interpretation · 2 No basis given · 1 Partly supported · 1 Own method · accuracy not yet measured
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In the paper
“large disparities in both the prevalence of established risk factors and the rates of cardiovascular events in genetically similar populations both over time and across regions confirm that genetic effects are subordinate to lifestyle and environmental influences.50 -52,57-59”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
What the sources say
boosteddirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Lifestyle behaviors can strongly affect the slopes of these changes, attenuating or even reversing the increases seen over time.55,56”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
What the sources say
- Not checked yetcites [55]
- Not checked yetcites [56] source
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Among populations with traditional healthy lifestyle behaviors, the prevalences of obesity, dyslipidemia, hypertension, and diabetes mellitus are far less than in industrialized populations, even after adjustment for age.49 -52”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“a major advance in medicine has been confirmation in pharmaceutical trials that blood pressure and blood lipids are in the casual pathway for cardiovascular events”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > From Prediction to Treatment
What the sources say
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Nevertheless, measurement and treatment of blood lipids, blood pressure, and glucose levels have became the major emphases for cardiovascular risk reduction.”
- Also stated in: § From Prediction to Treatment · plain
“Assessment and pharmacological treatment of elevated blood pressure, cholesterol, and glucose levels have become standards of cardiovascular care and the major emphases of practice guidelines, organization position papers, healthcare quality indicators, and reimbursement standards.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > From Prediction to Treatment
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Also stated in: § From Prediction to Treatment · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“suggesting that elevated glucose may at least partly signify more proximal pathology (eg, adipocyte stress and dysfunction) that increases macrovascular risk.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > From Prediction to Treatment
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These basic lifestyle habits-poor diet, physical inactivity, and smoking-are thus the most proximal risk factors for cardiovascular disease.”
- Also stated in: § Abstract · plain
“Thus, basic lifestyle habits should be considered fundamental risk factors for cardiovascular disease.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Sources of Funding
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Abstract · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, modest alterations of these lifestyle risk factors are achievable and have substantial effects on cardiovascular risk.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“although diabetes mellitus and elevated glucose levels clearly predict CHD risk, lowering of glucose by drug treatment generally has not produced anticipated reductions in CHD events, 11,12,12a”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > From Prediction to Treatment
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Consistent with these pleiotropic benefits, physical activity and fitness are associated with 30% to 50% lower risk of cardiovascular events.38,40,67”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Cardiovascular Risk
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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- It may state two separate claims as one. 15
- Probably not a substantial claim. 3
None of the sources cited for this claim have been checked yet.
In the paper
“Evaluated systematically, Ͼ70% of total cardiovascular events, 80% of CHD events, and 90% of new cases of diabetes mellitus appear to be attributable to just a handful of basic lifestyle factors.60,61”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
hedgeddirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Conversely, prevalence of diabetes mellitus has risen steadily, largely because of an epidemic of adiposity 35”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
What the sources say
- Not checked yetcites [35] source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Prediction models make no assumptions (and allow no inferences) about the presence or extent of confounding, magnitude of causal effects, or hierarchy of variables along causal pathways.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > From Prediction to Treatment
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“In the United States, the prevalence of high cholesterol, hypertension, and smoking, together with age-adjusted cardiovascular deaths, has declined over several decades.35,36”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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None of the sources cited for this claim have been checked yet.
In the paper
“Notably, lifestyle risk factors, including dietary habits, physical inactivity, smoking, and adiposity, strongly influence the established cardiovascular risk factors and also affect novel pathways of risk such as inflammation/oxidative stress, endothelial function, thrombosis/coagulation, and arrhythmia.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Abstract
What the sources say
boosteddirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, modest alterations of these lifestyle risk factors are achievable and have substantial effects on cardiovascular risk.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“emphases on more downstream risk factors such as hypertension, dyslipidemia, and diabetes mellitus address neither the root causes of adiposity nor its full cardiovascular consequences.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
plain- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Because adiposity is largely caused by poor diet (excess calories) and inadequate activity”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“these unfortunate changes will likely mitigate further improvements in cardiovascular mortality and even reverse the decline in cardiovascular disease incidence.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Lifestyle Risk Factors
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“For example, in a trial among 5145 diabetics, lifestyle advice lowered systolic blood pressure, diastolic blood pressure, triglycerides, fasting glucose, hemoglobin A 1c , and proteinuria; in-creased high-density lipoprotein cholesterol; increased weight loss and physical fitness; and reduced use of diabetic, antihypertensive, and lipid-lowering medications.103”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Changing Behavior
What the sources say
- Not checked yetcites [103] source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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In the paper
“In another trial, modest lifestyle recommendations (advice to consume a healthy low-calorie diet and be moderately active, such as walking briskly Ϸ20 min/d) reduced incidence of diabetes mellitus by 58% compared with placebo and by 39% compared with metformin.55”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Cardiovascular Risk
What the sources say
- Not checked yetcites [55]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Ironically, a large proportion of healthcare expenditures, including costs to individuals, businesses, and society, is attributable to poor lifestyle behaviors, 114 -117 and these costs are lowered by initiatives that promote healthy lifestyles. 118”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > The Need for Balance
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Major gaps remain, but strategies to lessen smoking in the United States have been effective, reducing per capita tobacco use by nearly two thirds since the 1950s.34”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Changing Behavior
What the sources say
- Not checked yetcites [34] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In patients with established cardiovascular disease, physical activity reduces angina symptoms, benefits heart failure, decreases claudication, and lowers mortality after myocardial infarction.38”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Cardiovascular Risk
What the sources say
- Not checked yetcites [38] source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Modest consumption of oily fish (1 to 2 servings per week) reduces CHD death by 36%, with 17% reduction in total mortality in randomized controlled trials of fish oil in higher-risk populations.46”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Cardiovascular Risk
What the sources say
- Not checked yetcites [46] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Although both lifestyle and metformin lowered glucose levels (lessening the nominal diagnosis of diabetes mellitus), only the lifestyle intervention improved multiple other established cardiovascular risk factors related to inactivity, adiposity, and poor dietary habits.56”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Cardiovascular Risk
What the sources say
- Not checked yetcites [56] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The funding sources had no role in study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.”
§ Beyond Established and Novel Risk Factors Lifestyle Risk Factors for Cardiovascular Disease > Sources of Funding
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Providers should recognize that while patient compliance with both lifestyle and medications is similarly imperfect, such strategies, even imperfectly implemented, improve clinical outcomes.397”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [397]
Citations
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“…additional controls for health-related variables and behaviours known to impact cardiovascular health, such as smoking status, alcohol consumption, regular exercise frequency, and the use of anti-hyperlipidemic medications (Gastaldelli et al., 2010; Loprinzi et al., 2016; Mozaffarian et al., 2008).”
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Background
Metadata
- Authors
- Mozaffarian, D., Wilson, P. W. F., & Kannel, W. B.
- Affiliations
- Boston University (US)
- Venue
- Circulation
- Published
- 2008-06-10
- Volume
- 117
- Issue
- 23
- Pages
- 3031-3038
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2080422716
- Semantic Scholar
- 44db2926f62498cbf063abbef4a9ea753762de82
- Cited by
- 456
- References
- 124
- Citations by year
- 2026: 19 · 2025: 41 · 2024: 30 · 2023: 33 · 2022: 39 · 2021: 24 · 2020: 27 · 2019: 19 · 2018: 15 · 2017: 12 · 2016: 28 · 2015: 21 · 2014: 36 · 2013: 26 · 2012: 25
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1, 1k08hl075628-01)
- National Heart, Lung, and Blood Institute (K08-HL-075628, N01‐HC25195)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- cardiovascular risk factors, lifestyle risk factors, dyslipidemia, hypertension, diabetes mellitus, physical inactivity, smoking, adiposity, inflammation, oxidative stress, endothelial function, thrombosis, cardiac arrhythmias, dietary habits, lifestyle intervention, healthcare policy, reimbursement guidelines
- MeSH terms
- Cardiovascular Diseases, Humans, Life Style, Risk Factors, Risk Reduction Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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