The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Ethnic differences in atherosclerosis, cardiovascular disease and lipid metabolism
Abstract
PURPOSE OF REVIEW: Comparison of risk factors and cardiovascular disease among racial and ethnic groups is a powerful approach to study genetics and lifestyle, or environmental interactions. RECENT FINDINGS: Most, mean or median, cardiovascular risk factor levels are similar among black and white people. There are much greater differences in the distribution of risk factor level within a specific race and ethnic group than between US populations. There are also very large differences in levels of risk factors for coronary heart disease between specific ethnic migrant populations such as comparing black people in Africa with those in the US, or Japanese people in Japan with those in Hawaii and California. Differences in distribution of risk factors and disease between race and ethnic group are a function of the frequency of specific genotypes and interaction with environmental factors. Several of the most important differences between racial groups are higher blood pressure, lower triglycerides and higher HDL cholesterol among blacks, higher prevalence of diabetes and insulin resistance among Mexican Americans and American Indians, and higher triglyceride levels among the Japanese. SUMMARY: Further studies of racial and ethnic differences should focus on unique phenotypes and genotypic differences, international and migrant studies and large enough sample sizes to provide robust results. The sprinkling of a percentage of minority participants in each study is worthless. The study of racial and ethnic differences in disease and detection of risk factor levels must be based on solid hypotheses that can evaluate the interaction of lifestyle and possible genetic attributes. Many of the reported ethnic differences in risk factors and disease in US populations are primarily a function of differences in education, socioeconomic variations, and utilization of preventive and clinical treatments.
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Evaluated systematically, >70% of total cardiovascular events, 80% of CHD events, and 90% of new cases of diabetes mellitus appear to be attributable to just a handful of basic lifestyle factors.
“Evaluated systematically, Ͼ70% of total cardiovascular events, 80% of CHD events, and 90% of new cases of diabetes mellitus appear to be attributable to just a handful of basic lifestyle factors.60,61”
From Beyond Established and Novel Risk Factors: Lifestyle Risk Factors for Cardiovascular Disease (2008) · cites this paper as [60]
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- Stamler, 2003, abstract Circulation, 198, 720
- Bild, 2003, Circulation, 107, e7001
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Cited by
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Beyond Established and Novel Risk Factors: Lifestyle Risk Factors for Cardiovascular Disease
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Metadata
- Authors
- Kuller, L. H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Kuller, Lewis H
- ORCID
- Kuller, Lewis H
- Venue
- Current Opinion in Lipidology
- Published
- 2004-04
- Volume
- 15
- Issue
- 2
- Pages
- 109-113
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W1992793006
- Cited by
- 102
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- ethnic differences, racial differences, atherosclerosis, cardiovascular disease, cardiovascular risk factors, lipid metabolism, coronary artery disease, blood pressure, triglycerides, HDL cholesterol, diabetes mellitus, insulin resistance, Mexican Americans, Native Americans, Japanese Americans, migrants, gene-environment interaction, socioeconomic factors
- MeSH terms
- Arteriosclerosis, Cardiovascular Diseases, Clinical Trials as Topic, Ethnicity, Humans, Lipid Metabolism
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