The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling
Open accessAbstract
Background— Dicer , an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the significance of miRNAs biogenesis in mammalian biology. Methods and Results— To circumvent the embryonic lethality associated with germline null mutations for Dicer , we triggered conditional Dicer loss through the use of a tamoxifen-inducible Cre recombinase in the postnatal murine myocardium. Targeted Dicer deletion in 3-week-old mice provoked premature death within 1 week accompanied by mild ventricular remodeling and dramatic atrial enlargement. In the adult myocardium, loss of Dicer induced rapid and dramatic biventricular enlargement, accompanied by myocyte hypertrophy, myofiber disarray, ventricular fibrosis, and strong induction of fetal gene transcripts. Comparative miRNA profiling revealed a set of miRNAs that imply causality between miRNA depletion and spontaneous cardiac remodeling. Conclusions— Overall, these results indicate that modifications in miRNA biogenesis affect both juvenile and adult myocardial morphology and function.
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Cites
Widespread changes in protein synthesis induced by microRNAs
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The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
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Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus
Davis, T. H., Cuellar, T. L., Koch, S. M., Barker, A. J., Harfe, B. D., McManus, M. T., & Ullian, E. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4815-07.2008 · Cited by 447
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
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Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease
Corsten, M. F., Dennert, R., Jochems, S., Kuznetsova, T., Devaux, Y., Hofstra, L., Wagner, D. R., Staessen, J. A., Heymans, S., & Schroen, B. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.957415 · Cited by 794
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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
Ucar, A., Gupta, S. K., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., Dangwal, S., Kumarswamy, R., Bang, C., Holzmann, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms2090 · Cited by 610
MicroRNAs Add a New Dimension to Cardiovascular Disease
Small, E. M., Frost, R. J. A., & Olson, E. N. (2010) · Circulation · doi:10.1161/circulationaha.109.889048 · Cited by 599
Adult-specific functions of animal microRNAs
Sun, K., & Lai, E. C. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3471 · Cited by 334
Metadata
- Authors
- da Costa Martins, P. A., Bourajjaj, M., Gladka, M., Kortland, M., van Oort, R. J., Pinto, Y. M., Molkentin, J. D., & De Windt, L. J.
- Venue
- Circulation
- Published
- 2008-10-07
- Volume
- 118
- Issue
- 15
- Pages
- 1567-1576
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2046704452
- Cited by
- 293
- References
- 5
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling. https://app.cochat.ai/papers/10.1161/circulationaha.108.769984
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- da Costa Martins, P. A., Bourajjaj, M., Gladka, M., Kortland, M., van Oort, R. J., Pinto, Y. M., Molkentin, J. D., & De Windt, L. J. (2008). Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling. Circulation. https://doi.org/10.1161/circulationaha.108.769984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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