The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Adult-specific functions of animal microRNAs
Open accessAbstract
MicroRNAs (miRNAs) are ~22 nt RNAs that coordinate vast regulatory networks in animals and thereby influence myriad processes. This Review examines evidence that miRNAs have continuous roles in adults in ways that are separable from developmental control. Adult-specific activities for miRNAs have been described in various stem cell populations, in the context of neural function and cardiovascular biology, in metabolism and ageing, and during cancer. In addition to reviewing recent results, we also discuss methods for studying miRNA activities specifically in adults and evaluate their relative strengths and weaknesses. A fuller understanding of continuous functions of miRNAs in adults has bearing on efforts and opportunities to manipulate miRNAs for therapeutic purposes.
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2 retracted
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Cited by
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
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Self-citation
Metadata
- Authors
- Sun, K., & Lai, E. C.
- Venue
- Nature Reviews Genetics
- Published
- 2013-07-02
- Volume
- 14
- Issue
- 8
- Pages
- 535-548
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2074695498
- Cited by
- 334
- References
- 194
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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