Cited by 150Intracerebral and Subarachnoid Hemorrhage ResearchLipoproteins and Cardiovascular HealthAcute Ischemic Stroke Management

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Low-Density Lipoprotein Cholesterol Concentrations and Death Due to Intraparenchymal Hemorrhage: The Ibaraki Prefectural Health Study

Noda, Hiroyuki, Iso, Hiroyasu, Irie, Fujiko, Sairenchi, Toshimi, Ohtaka, Emiko, Doi, Mikio, Izumi, Yoko, Ohta, Hitoshi·2009·Circulation

DOI 10.1161/circulationaha.108.795666

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Abstract

Background— Few studies have examined the association between low levels of low-density lipoprotein (LDL) cholesterol and risk of intraparenchymal hemorrhage. Methods and Results— A total of 30 802 men and 60 417 women, 40 to 79 years of age with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993 under the auspices of the Ibaraki Prefectural Health Study. Systematic mortality surveillance was performed through 2003, and 264 intraparenchymal hemorrhage deaths were identified. LDL cholesterol levels were calculated with the Friedewald formula. Persons with LDL cholesterol ≥140 mg/dL had half the sex- and age-adjusted risk of death due to intraparenchymal hemorrhage of those with LDL cholesterol <80 mg/dL. After adjustment for cardiovascular risk factors, the multivariable hazard ratio compared with persons with LDL cholesterol <80 mg/dL was 0.65 (95% CI 0.44 to 0.96) for those with LDL cholesterol 80 to 99 mg/dL, 0.48 (0.32 to 0.71) for 100 to 119 mg/dL, 0.50 (0.33 to 0.75) for 120 to 139 mg/dL, and 0.45 (0.30 to 0.69) for ≥140 mg/dL. These inverse associations were not altered substantially after the exclusion of persons with hypertriglyceridemia, after analysis with a Cox proportional hazard model with time-dependent covariates, or in sensitivity analysis for the potential effect of competing risks. Conclusions— Low LDL cholesterol levels are associated with elevated risk of death due to intraparenchymal hemorrhage.

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Authors: Noda, H., Iso, H., Irie, F., Sairenchi, T., Ohtaka, E., Doi, M., Izumi, Y., & Ohta, H.
Affiliations: Ministry of the Environment (JP)
ORCID: Noda, Hiroyuki
Iso, Hiroyasu
Irie, Fujiko
Sairenchi, Toshimi
Izumi, Yoko
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-04-28
Volume: 119
Issue: 16
Pages: 2136-2145
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.108.795666
OpenAlex: W1979346724
Cited by: 150
References: 40
Citations by year: 2026: 4 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 15 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 7
FWCI: 8.96
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: LDL cholesterol, intraparenchymal hemorrhage, low LDL cholesterol, stroke risk factors, hypertriglyceridemia, competing risks, Friedewald formula
MeSH terms: Adult, Aged, Female, Follow-Up Studies, Humans, Japan, Cholesterol, LDL, Male, Middle Aged, Prospective Studies, Risk Factors, Survival Rate, Multivariate Analysis, Proportional Hazards Models, Intracranial Hemorrhages, Asian People

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Low-Density Lipoprotein Cholesterol Concentrations and Death Due to Intraparenchymal Hemorrhage: The Ibaraki Prefectural Health Study

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