Subclinical Brain Embolization in Left-Sided Infective Endocarditis: Results From the Evaluation by MRI of the Brains of Patients With Left-Sided Intracardiac Solid Masses (EMBOLISM) Pilot Study
Abstract
Background— Acute brain embolization (ABE) in left-sided infective endocarditis has significant implications for clinical decision making. The true incidence of ABE, including subclinical brain embolization, is unknown. Methods and Results— We prospectively studied 56 patients with definite left-sided infective endocarditis. Patients were examined by a study neurologist, and those without contraindication had magnetic resonance imaging of the brain. Patients without clinical evidence of acute stroke but with magnetic resonance imaging evidence of ABE were considered to have subclinical brain embolization. Clinical stroke was present in 14 of 56 patients (25%). Among 40 patients undergoing magnetic resonance imaging, the incidence rates of subclinical brain embolization and any ABE were 48% and 80%, respectively. ABE was present in 18 of 19 patients (95%) with Staphylococcus aureus infection. At 3 months, mortality was similar among patients with clinical stroke and subclinical brain embolization (62% versus 53%; P =NS) and was higher among patients with any ABE than among those without ABE (56% versus 12%; P =0.046). Valvular surgery was performed in 25 patients (45%), including 16 with ABE, at a median of 4 days. No patient suffered a postoperative neurological complication. Surgery was independently associated with a lower risk of mortality at 3 months (odds ratio, 0.1; 95% confidence interval, 0.03 to 0.6; P =0.008). Conclusions— Magnetic resonance imaging detected subclinical brain embolization in a substantial number of patients with left-sided infective endocarditis, suggesting that the incidence of ABE may be significantly higher than reports based on clinical and computed tomography findings have indicated. Brain magnetic resonance imaging may play a role in the complex decision about surgical intervention in infective endocarditis.
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Investigations have suggested better outcomes for infective endocarditis patients with ischemic stroke who undergo early cardiac surgery.
“Investigations have suggested better outcomes for IE patients with ischemic stroke who undergo early cardiac surgery.[268][269][270][271][272]”
From Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association (2015) · cites this paper as [268]
Clinical Outcomes (p. 4) reports lower mortality among surgical patients in the overall left-sided infective endocarditis cohort, and the Discussion (p. 6) says early surgery was associated with reduced mortality. For patients with clinical stroke or subclinical brain embolization, the paper reports no postoperative neurological events after early surgery, but it does not establish better survival specifically for patients with ischemic stroke who undergo early surgery. (LLM, conf=0.86)
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Cites
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,479 · see citing works
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110 · see citing works
Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis
Li, J. S., Sexton, D. J., Mick, N., Nettles, R., Fowler, V. G., Ryan, T., Bashore, T., & Corey, G. R. (2000) · Clinical Infectious Diseases · doi:10.1086/313753 · Cited by 4,027 · see citing works
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Bolger, A. F., Levison, M. E., Ferrieri, P., Gerber, M. A., Tani, L. Y., Gewitz, M. H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.165564 · Cited by 1,707 · see citing works
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.021 · Cited by 1,694 · see citing works
Staphylococcus aureus Endocarditis: A Consequence of Medical Progress
Fowler, V. G., Miro, J. M., Hoen, B., Cabell, C. H., Abrutyn, E., Rubinstein, E., Corey, G. R., Spelman, D., Bradley, S. F., Barsic, B., et al. (2005) · JAMA · doi:10.1001/jama.293.24.3012 · Cited by 1,174 · see citing works
Thuny, F., Disalvo, G., Belliard, O., Avierinos, J.-F., Pergola, V., Rosenberg, V., Casalta, J.-P., Gouvernet, J., Derumeaux, G., Iarussi, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.493155 · Cited by 703 · see citing works
Biomarkers in Acute Cardiac Disease
Jaffe, A. S., Babuin, L., & Apple, F. S. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.056 · Cited by 635 · see citing works
Risk of embolization after institution of antibiotic therapy for infective endocarditis
Vilacosta, I., Graupner, C., SanRomán, J., Sarriá, C., Ronderos, R., Fernández, C., Mancini, L., Sanz, O., Sanmartín, J., & Stoermann, W. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01790-4 · Cited by 468 · see citing works
Echocardiography predicts embolic events in infective endocarditis
Di Salvo, G., Habib, G., Pergola, V., Avierinos, J.-F., Philip, E., Casalta, J.-P., Vailloud, J.-M., Derumeaux, G., Gouvernet, J., Ambrosi, P., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01206-7 · Cited by 457 · see citing works
Early Predictors of In-Hospital Death in Infective Endocarditis
Chu, V. H., Cabell, C. H., Benjamin, D. K., Kuniholm, E. F., Fowler, V. G., Engemann, J., Sexton, D. J., Corey, G. R., & Wang, A. (2004) · Circulation · doi:10.1161/01.cir.0000124719.61827.7f · Cited by 429 · see citing works
Heiro, M., Nikoskelainen, J., Engblom, E., Kotilainen, E., Marttila, R., & Kotilainen, P. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.18.2781 · Cited by 415 · see citing works
Thuny, F., Avierinos, J.-F., Tribouilloy, C., Giorgi, R., Casalta, J.-P., Milandre, L., Brahim, A., Nadji, G., Riberi, A., Collart, F., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm005 · Cited by 396 · see citing works
Fibroblasts Can Be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling
Kizana, E., Ginn, S. L., Allen, D. G., Ross, D. L., & Alexander, I. E. (2005) · Circulation · doi:10.1161/01.cir.0000153812.64956.ef · Cited by 378 · see citing works
Dickerman, S. A., Abrutyn, E., Barsic, B., Bouza, E., Cecchi, E., Moreno, A., Doco-Lecompte, T., Eisen, D. P., Fortes, C. Q., Fowler, V. G., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.07.023 · Cited by 374 · see citing works
Mullins, M. E., Schaefer, P. W., Sorensen, A. G., Halpern, E. F., Ay, H., He, J., Koroshetz, W. J., & González, R. (2002) · Radiology · doi:10.1148/radiol.2242010873 · Cited by 343 · see citing works
Vikram, H. R., Buenconsejo, J., Hasbun, R., & Quagliarello, V. (2003) · JAMA · doi:10.1001/jama.290.24.3207 · Cited by 332 · see citing works
Surgical management of infective endocarditis associated with cerebral complications
Eishi, K., Kawazoe, K., Kuriyama, Y., Kitoh, Y., Kawashima, Y., & Omae, T. (1995) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70038-2 · Cited by 299 · see citing works
Bjorkman, D. J., Msph, & Sm (2002) · Journal watch · doi:10.1056/jg200202130000003 · Cited by 297 · see citing works
Neurological Outcome of Septic Cardioembolic Stroke After Infective Endocarditis
Ruttmann, E., Willeit, J., Ulmer, H., Chevtchik, O., Höfer, D., Poewe, W., Laufer, G., & Müller, L. C. (2006) · Stroke · doi:10.1161/01.str.0000229894.28591.3f · Cited by 285 · see citing works
Early Surgery in Patients with Infective Endocarditis: A Propensity Score Analysis
Aksoy, O., Sexton, D. J., Wang, A., Pappas, P. A., Kourany, W. M., Chu, V. H. Y., Fowler, V. G., Woods, C. W., Engemann, J. J., Corey, G. R., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/510583 · Cited by 225 · see citing works
Stroke is not a contraindication for urgent valve replacement in acute infective endocarditis.
Piper, C., Wiemer, M., Schulte, H. D., & Horstkotte, D. (2001) · PubMed · Cited by 142 · see citing works
Cabell, C. H., Abrutyn, E., Fowler, V. G., Hoen, B., Miró, J. M., Corey, G. R., Olaison, L., Pappas, P. A., Anstrom, K. J., Stafford, J. A., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.03.057 · Cited by 139 · see citing works
The Impact of Valve Surgery on 6-Month Mortality in Left-Sided Infective Endocarditis
Tleyjeh, I. M., Ghomrawi, H. M. K., Steckelberg, J. M., Hoskin, T. L., Mirzoyev, Z., Anavekar, N. S., Enders, F., Moustafa, S., Mookadam, F., Huskins, W. C., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.658831 · Cited by 137 · see citing works
Risk factors for “major” embolic events in hospitalized patients with infective endocarditis
Durante‐Mangoni, E., Adinolfi, L. E., Tripodi, M., Andreana, A., Gambardella, M., Ragone, E., Precone, D. F., Utili, R., & Ruggiero, G. (2003) · American Heart Journal · doi:10.1016/s0002-8703(02)94802-7 · Cited by 132 · see citing works
Predictors of Death and Impact of Surgery in Staphylococcus aureus Infective Endocarditis
Rémadi, J. P., Habib, G., Nadji, G., Brahim, A., Thuny, F., Casalta, J., Peltier, M., & Tribouilloy, C. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.09.093 · Cited by 123 · see citing works
Surgical Treatment of Active Aortic Endocarditis: Homografts Are Not the Cornerstone of Outcome
Aviérinos, J.-F., Thuny, F., Chalvignac, V., Giorgi, R., Tafanelli, L., Casalta, J., Raoult, D., Mesana, T. G., Collart, F., Metras, D. R., et al. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.06.050 · Cited by 89 · see citing works
Does a focal neurologic deficit contraindicate operation in a patient with endocarditis?
Parrino, P. E., Kron, I. L., Ross, S. D., Shockey, K. S., Kron, A. M., Towler, M. A., & Tribble, C. G. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(98)01230-2 · Cited by 52 · see citing works
Current best practices and guidelines
Olaison, L., & Pettersson, G. (2003) · Cardiology Clinics · doi:10.1016/s0733-8651(03)00029-8 · Cited by 49 · see citing works
Evaluating and Optimizing Outcomes of Surgery for Endocarditis
Durack, D. T. (2003) · JAMA · doi:10.1001/jama.290.24.3250 · Cited by 30 · see citing works
Magnetic Resonance Imaging of the Brain in Bacterial Endocarditis
Bertorini, T. E. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390040047009 · Cited by 24 · see citing works
Neuropathological complications of infective endocarditis : study of autopsy material.
Patel, F. M., Das, A., & Banerjee, A. K. (2001) · PubMed · Cited by 11 · see citing works
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2015 ESC Guidelines for the management of infective endocarditis
Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J., Zotti, F. D., Dulgheru, R., Khoury, G. A. E., Erba, P. A., Iung, B., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv319 · Cited by 5,014 · see citing works
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Tleyjeh, I. M., Rybak, M. J., Barsic, B., Lockhart, P. B., Gewitz, M. H., Levison, M. E., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000296 · Cited by 3,232 · see citing works
2023 ESC Guidelines for the management of endocarditis
Delgado, V., Marsan, N. A., de Waha, S., Bonaros, N. E., Brida, M., Burri, H., Caselli, S., Doenst, T., Éderhy, S., Erba, P. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad193 · Cited by 1,975 · see citing works
García-Cabrera, E., Fernández-Hidalgo, N., Almirante, B., Ivanova-Georgieva, R., Noureddine, M., Plata, A., Lomas, J. M., Gálvez-Acebal, J., Hidalgo-Tenorio, C., Ruíz-Morales, J., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000813 · Cited by 546 · see citing works
Silent and Apparent Cerebral Ischemia After Percutaneous Transfemoral Aortic Valve Implantation
Kahlert, P., Knipp, S. C., Schlamann, M. U., Thielmann, M., Al‐Rashid, F., Weber, M., Johansson, U., Wendt, D., Jakob, H. G., Forsting, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.855866 · Cited by 520 · see citing works
Management of infective endocarditis: challenges and perspectives
Thuny, F., Grisoli, D., Collart, F., Habib, G., & Raoult, D. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60755-1 · Cited by 437 · see citing works
Pettersson, G., Coselli, J. S., Pettersson, G., Coselli, J. S., Hussain, S. T., Griffin, B. P., Blackstone, E. H., Gordon, S. M., LeMaire, S. A., & Woc-Colburn, L. E. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.09.093 · Cited by 418 · see citing works
Duval, X., Iung, B., Klein, I., Brochet, E., Thabut, G., Arnoult, F., Lepage, L., Laissy, J.-P., Wolff, M., Leport, C., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-8-201004200-00006 · Cited by 289 · see citing works
Mechanisms of infective endocarditis: pathogen–host interaction and risk states
Werdan, K., Dietz, S., Löffler, B., Niemann, S., Bushnaq, H. S., Silber, R., Peters, G., & Müller‐Werdan, U. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.174 · Cited by 278 · see citing works
Current AATS guidelines on surgical treatment of infective endocarditis
Pettersson, G., & Hussain, S. T. (2019) · Annals of Cardiothoracic Surgery · doi:10.21037/acs.2019.10.05 · Cited by 274 · see citing works
Sonneville, R., Mirabel, M., Hajage, D., Tubach, F., Vignon, P., Perez, P., Lavoué, S., Kouatchet, A., Pajot, O., Dessap, A. M., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182120b41 · Cited by 200 · see citing works
Surgical Management of Endocarditis: The Society of Thoracic Surgeons Clinical Practice Guideline
Byrne, J. G., Rezai, K., Sánchez, J. A., Bernstein, R. A., Okum, E. J., Leacche, M., Balaguer, J. M., Prabhakaran, S., Bridges, C. R., & Higgins, R. S. D. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.01.106 · Cited by 200 · see citing works
Prediction of Symptomatic Embolism in Infective Endocarditis
Hubert, S., Thuny, F., Resseguier, N., Giorgi, R., Tribouilloy, C. M., Dolley, Y. L., Casalta, J., Ribéri, A., Chevalier, F., Ruşinaru, D., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.029 · Cited by 183 · see citing works
JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis
Nakatani, S., Ohara, T., Ashihara, K., Izumi, C., Iwanaga, S., Eishi, K., Okita, Y., Daimon, M., Kimura, T., Toyoda, Ḱ., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0549 · Cited by 180 · see citing works
Li, M., Kim, J. B., Sastry, B. K. S., & Chen, M. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01098-5 · Cited by 175 · see citing works
Fugate, J. E., Lyons, J. L., Thakur, K. T., Smith, B., Hedley‐Whyte, E. T., & Mateen, F. J. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70755-8 · Cited by 164 · see citing works
Barsic, B., Dickerman, S., Krajinovic, V., Pappas, P., Altclas, J., Carosi, G., Casabé, J. H., Chu, V. H., Delahaye, F., Edathodu, J., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis878 · Cited by 157 · see citing works
Brain MRI Findings in Neurologically Asymptomatic Patients with Infective Endocarditis
Hess, A., Klein, I. F., Iung, B., Lavallée, P. C., Ilic-Habensus, E., Dornic, Q., Arnoult, F., Mimoun, L., Wolff, M., Duval, X., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3582 · Cited by 151 · see citing works
Coagulation: At the heart of infective endocarditis
Liesenborghs, L., Meyers, S., Vanassche, T., & Verhamme, P. B. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14736 · Cited by 151 · see citing works
Staphylococcus aureusbacteraemia and endocarditis – epidemiology and outcome: a review
Ásgeirsson, H., Thalme, A., & Weiland, O. (2017) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2017.1392039 · Cited by 142 · see citing works
Narayanan, M. A., Haddad, T. M., Kalil, A. C., Kanmanthareddy, A., Suri, R. M., Mansour, G., Destache, C. J., Baskaran, J., Mooss, A. N., Wichman, T. O., et al. (2016) · Heart · doi:10.1136/heartjnl-2015-308589 · Cited by 137 · see citing works
Neurologic Complications in Infective Endocarditis
Morris, N. A., Matiello, M., Lyons, J. L., & Samuels, M. A. (2014) · The Neurohospitalist · doi:10.1177/1941874414537077 · Cited by 108 · see citing works
Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges
Kern, W. V. (2010) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32833bcc8a · Cited by 103 · see citing works
Surgical Management of Infective Endocarditis Complicated by Embolic Stroke
Yanagawa, B., Pettersson, G., Habib, G., Ruel, M., Saposnik, G., Latter, D. A., & Verma, S. (2016) · Circulation · doi:10.1161/circulationaha.116.024156 · Cited by 95 · see citing works
Infective Endocarditis: The European Viewpoint
Tornos, P., González‐Alujas, T., Thuny, F., & Habib, G. (2011) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2011.03.004 · Cited by 91 · see citing works
Infective Endocarditis: Prevention, Diagnosis, and Management
Thuny, F., Grisoli, D., Cautela, J., Ribéri, A., Raoult, D., & Habib, G. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.03.042 · Cited by 88 · see citing works
Fungal Endocarditis: Update on Diagnosis and Management
Pasha, A. K., Lee, J. Z., Low, S., DESAI, H. H., Lee, K. S. S., & Mohajer, M. A. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.05.012 · Cited by 91 · see citing works
Neurological Complications of Infective Endocarditis
Sotero, F. D., Rosário, M., Fonseca, A. C., & Ferro, J. M. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0935-x · Cited by 89 · see citing works
Determinants of Cerebral Lesions in Endocarditis on Systematic Cerebral Magnetic Resonance Imaging
Iung, B., Tubiana, S., Klein, I. F., Messika–Zeitoun, D., Brochet, É., Lepage, L., Al‐Attar, N., Ruimy, R., Leport, C., Wolff, M., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.001470 · Cited by 85 · see citing works
Infective Endocarditis at Autopsy
Guerrero, M. L. F., Álvarez, B., Manzarbeitia, F., & Renedo, G. (2012) · Medicine · doi:10.1097/md.0b013e31825631ea · Cited by 84 · see citing works
Goulenok, T. M., Klein, I. F., Mazighi, M., Messika–Zeitoun, D., Alexandra, J. F., Mourvillier, B., Laissy, J., Leport, C., Iung, B., Duval, X., et al. (2013) · Cerebrovascular Diseases · doi:10.1159/000348317 · Cited by 82 · see citing works
Okita, Y., Minakata, K., Yasuno, S., Uozumi, R., Sato, T. S., Ueshima, K., Konishi, H., Morita, N., Harada, M., Kobayashi, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw035 · Cited by 83 · see citing works
Infective endocarditis: innovations in the management of an old disease
Iung, B., & Duval, X. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0215-0 · Cited by 81 · see citing works
Yoshioka, D., Sakaguchi, T., Yamauchi, T., Okazaki, S., Miyagawa, S., Nishi, H., Yoshikawa, Y., Fukushima, S., Saito, S., & Sawa, Y. (2012) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2012.04.027 · Cited by 76 · see citing works
Management of neurological complications of infective endocarditis in ICU patients
Sonneville, R., Mourvillier, B., Bouadma, L., & Wolff, M. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-10 · Cited by 74 · see citing works
Misfeld, M., Girrbach, F. F., Etz, C. D., Binner, C., von ASPERN, K., Dohmen, P. M., Davierwala, P. M., Pfannmueller, B., Borger, M. A., & Mohr, F. (2014) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2013.10.076 · Cited by 72 · see citing works
Iung, B., Klein, I. F., Mourvillier, B., Olivot, J., Détaint, D., Longuet, P., Ruimy, R., Fourchy, D., Laurichesse, J.-J., Laissy, J., et al. (2012) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jes023 · Cited by 67 · see citing works
Value of brain MRI in infective endocarditis: a narrative literature review
Champey, J., Pavèse, P., Bouvaist, H., Kastler, A., Krainik, A., & François, P. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2523-6 · Cited by 60 · see citing works
Imaging investigations in infective endocarditis: Current approach and perspectives
Thuny, F., Gaubert, J., Jacquier, A., Tessonnier, L., Cammilleri, S., Raoult, D., & Habib, G. (2012) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2012.09.004 · Cited by 57 · see citing works
What is the optimal timing for surgery in infective endocarditis with cerebrovascular complications?
Rossi, M., Gallo, A., Silva, R. J. D., & Sayeed, R. A. (2011) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivr010 · Cited by 53 · see citing works
Selton‐Suty, C., Delahaye, F., Tattevin, P., Federspiel, C., Moing, V. L., Chirouze, C., Nazeyrollas, P., Vernet-Garnier, V., Bernard, Y. F., Chocron, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158522 · Cited by 55 · see citing works
Neurological complications of infective endocarditis: New breakthroughs in diagnosis and management
Novy, E., Sonneville, R., Mazighi, M., Klein, I. F., Mariotte, É., Mourvillier, B., Bouadma, L., & Wolff, M. (2013) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2013.09.010 · Cited by 53 · see citing works
Snygg‐Martin, U., Rasmussen, R. V., Hassager, C., Bruun, N. E., Andersson, R., & Olaison, L. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1063-3 · Cited by 51 · see citing works
Klein, M., & Wang, A. (2014) · Journal of Intensive Care Medicine · doi:10.1177/0885066614554906 · Cited by 51 · see citing works
When should we operate on patients with acute infective endocarditis?
Thuny, F., & Habib, G. (2010) · Heart · doi:10.1136/hrt.2008.151936 · Cited by 49 · see citing works
Sambola, A., Lozano-Torres, J., Boersma, E. H., Olmos, C., Ternacle, J., Calvo, F., Tribouilloy, C. M., Lukšić, V. R., Hanževački, J. Š., Park, S. W., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad507 · Cited by 51 · see citing works
Okazaki, S., Yoshioka, D., Sakaguchi, M., Sawa, Y., Mochizuki, H., & Kitagawa, K. (2013) · Cerebrovascular Diseases · doi:10.1159/000346101 · Cited by 48 · see citing works
Ferro, J. M., & Fonseca, A. C. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00007-2 · Cited by 49 · see citing works
Outcomes of surgery for infective endocarditis: a single-centre experience of 801 patients
Said, S. M., Abdelsattar, Z. M., Schaff, H. V., Greason, K. L., Daly, R. C., Pochettino, A. A., Joyce, L. D., & Dearani, J. A. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx341 · Cited by 47 · see citing works
Tam, D. Y., Yanagawa, B., Verma, S., Ruel, M., Fremes, S. E., Mazine, A., Adams, S., & Friedrich, J. O. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.05.010 · Cited by 45 · see citing works
Cimmino, G., Bottino, R., Formisano, T., Orlandi, M., Molinari, D., Sperlongano, S., Castaldo, P., D’Elia, S., Carbone, A., Palladino, A., et al. (2023) · Life · doi:10.3390/life13020377 · Cited by 43 · see citing works
Wong, D., Rubinshtein, R., & Keynan, Y. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.07.053 · Cited by 43 · see citing works
Updates on Prevention of Cardioembolic Strokes
Topçuoğlu, M. A., Liu, L., Kim, D., & Gurol, M. E. (2018) · Journal of Stroke · doi:10.5853/jos.2018.00780 · Cited by 40 · see citing works
Impact of Routine Cerebral CT Angiography on Treatment Decisions in Infective Endocarditis
Meshaal, M. S., Kassem, H. H., Samir, A., Zakaria, A., Baghdady, Y., & Rizk, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118616 · Cited by 36 · see citing works
Jillella, D. V., & Wisco, D. R. (2019) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000547 · Cited by 34 · see citing works
Sorabella, R. A., Han, S. M., Grbic, M., Wu, Y. S., Takyama, H., Kurlansky, P. A., Borger, M. A., Argenziano, M., Gordon, R. J., & George, I. (2015) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2015.03.078 · Cited by 33 · see citing works
Imazio, M. (2024) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001651 · Cited by 30 · see citing works
Monteiro, T. S., Correia, M. G., Golebiovski, W. F., Barbosa, G. I. F., Weksler, C., & Lamas, C. D. C. (2017) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2017.01.006 · Cited by 30 · see citing works
Mikaïl, N., Benali, K., Mahida, B., Vigne, J., Hyafil, F., Rouzet, F., & Guludec, D. L. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-0956-0 · Cited by 30 · see citing works
Chakraborty, T., Scharf, E. L., DeSimone, D. C., Rafei, A. E., Brinjikji, W., Baddour, L. M., Wilson, W. R., Steckelberg, J. M., Fugate, J. E., Wijdicks, E. F. M., et al. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.09.015 · Cited by 30 · see citing works
Acute Ischemic Stroke Therapy in Infective Endocarditis: Case Series and Systematic Review
Marquardt, R. J., Cho, S., Thatikunta, P., Deshpande, A., Wisco, D. R., & Uchino, K. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.04.039 · Cited by 30 · see citing works
Thuny, F., Habib, G., Dolley, Y. L., Canault, M., Casalta, J., Verdier, M., Aviérinos, J.-F., Raoult, D., Mège, J., Morange, P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018830 · Cited by 30 · see citing works
Anti-thrombotic therapy in infective endocarditis
Vanassche, T., Peetermans, W. E., Herregods, M., Herijgers, P., & Verhamme, P. B. (2011) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.11.100 · Cited by 30 · see citing works
Neurologic Complications of Infective Endocarditis: Recent Findings
Cantier, M., Mazighi, M., Klein, I. F., Désilles, J., Wolff, M., Timsit, J., & Sonneville, R. (2017) · Current Infectious Disease Reports · doi:10.1007/s11908-017-0593-6 · Cited by 32 · see citing works
Stroke Complicating Infective Endocarditis After Transcatheter Aortic Valve Replacement
del Val, D., Abdel‐Wahab, M., Mangner, N., Durand, É., Ihlemann, N., Ureña, M., Pellegrini, C., Giannini, F., Gąsior, T., Wojakowski, W., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.233 · Cited by 27 · see citing works
Presti, S. L., Elajami, T. K., Zmaili, M. A., Reyaldeen, R. M., & Xu, B. (2021) · World Journal of Cardiology · doi:10.4330/wjc.v13.i8.254 · Cited by 28 · see citing works
Infective Endocarditis in the Elderly: Challenges and Strategies
Serrano, C. B., Vela, S., García‐Blas, S., Pérez-Rivera, J.-Á., Díez‐Villanueva, P., de Gracia-León, A. I., Fuertes, E., Oltra, M. R., Ferrer, A., Belmonte-Domingo, A., et al. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9060192 · Cited by 28 · see citing works
Utility of Brain Magnetic Resonance Imaging in the Surgical Management of Infective Endocarditis
Chakraborty, T., Scharf, E. L., Rabinstein, A. A., DeSimone, D. C., Rafei, A. E., Brinjikji, W., Baddour, L. M., Wijdicks, E. F. M., Wilson, W. R., Steckelberg, J. M., et al. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.05.047 · Cited by 27 · see citing works
Surgical Management of Mitral Valve Infective Endocarditis
Evans, C. F., & Gammie, J. S. (2011) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2011.07.005 · Cited by 27 · see citing works
Neurologic Complications of Infective Endocarditis
Pruitt, A. A. (2013) · Current Treatment Options in Neurology · doi:10.1007/s11940-013-0235-8 · Cited by 27 · see citing works
Changes and advances in the field of infective endocarditis
Mills, M. T., Al‐Mohammad, A., & Warriner, D. (2022) · British Journal of Hospital Medicine · doi:10.12968/hmed.2021.0510 · Cited by 26 · see citing works
Arregle, F., Martel, H., Philip, M., Gouriet, F., Casalta, J., Ribéri, A., Torras, O., Casalta, A., Camoin‐Jau, L., Lavagna, F., et al. (2021) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2021.01.004 · Cited by 25 · see citing works
Miura, T., Hamawaki, M., Hazama, S., Hashizume, K., Ariyoshi, T., Sumi, M., Furumoto, A., Saito, N., Tsuneto, A., & Eishi, K. (2014) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-014-0377-y · Cited by 24 · see citing works
Grecu, N., Tiu, C., Terecoasă, E., & Bajenaru, O. A. (2014) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
Carneiro, T. S., Awtry, E. H., Dobrilovic, N., Fagan, M. A., Kimmel, S. D., Weinstein, Z., & Cervantes-Arslanian, A. M. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1688826 · Cited by 23 · see citing works
Papadimitriou‐Olivgeris, M., Guery, B. P., Ianculescu, N., Dunet, V., Messaoudi, Y., Pistocchi, S., Tozzi, P., Kirsch, M. E. W., & Monney, P. A. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad192 · Cited by 22 · see citing works
Infective Endocarditis in the Intensive Care Unit
Keynan, Y., Singal, R. K., Kumar, K., Arora, R. C., & Rubinstein, E. (2013) · Critical Care Clinics · doi:10.1016/j.ccc.2013.06.011 · Cited by 23 · see citing works
Embolic Events in Infective Endocarditis: A Comprehensive Review
Villalba, G. C., Pulido, P., López, J., de Miguel-Álava, M., Vilacosta, I., García‐Azorín, D., Ibáñez, A. L., Orive, A. O., Arenillas, J. F., & Román, J. A. S. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2503097 · Cited by 23 · see citing works
Early Operation in Patients With Mitral Valve Infective Endocarditis and Acute Stroke Is Safe
Ghoreishi, M., Foster, N., Pasrija, C., Shah, A. M., Watkins, A. C., Evans, C. F., Maghami, S., Quinn, R. W., Wehman, B. P., Taylor, B. S., et al. (2017) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2017.06.069 · Cited by 20 · see citing works
Diab, M., Güenther, A., Sponholz, C., Lehmann, T., Färber, G., Matz, A., Franz, M., Witte, O. W., Pletz, M. W., & Doenst, T. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-0993-x · Cited by 20 · see citing works
Management of anticoagulation in patients with infective endocarditis
Zhu, X., Wang, Z., Ferrari, M. W., Ferrari‐Kuehne, K., Hsi, D. H., Tse, G., Zhou, Q., Liang, H., Zhang, Y., & Zhang, J. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.06.010 · Cited by 18 · see citing works
Surgical management of infective endocarditis complicated by ischemic stroke
Hodges, K., Hussain, S. T., Stewart, W. J., & Pettersson, G. (2016) · Journal of Cardiac Surgery · doi:10.1111/jocs.12872 · Cited by 19 · see citing works
Management of Septic emboli in patients with infectious endocarditis
Aalaei‐Andabili, S. H., Martin, T. D., Hess, P., Hoh, B. L., Anderson, M., Klodell, C. T., & Beaver, T. M. (2017) · Journal of Cardiac Surgery · doi:10.1111/jocs.13129 · Cited by 19 · see citing works
Zhang, L. Q., Cho, S., Rice, C., Khoury, J., Marquardt, R. J., Buletko, A. B., Hardman, J., Wisco, D. R., & Uchino, K. (2020) · European Journal of Neurology · doi:10.1111/ene.14438 · Cited by 20 · see citing works
Ahn, Y., Joo, L., Suh, C. H., Kim, S., Shim, W. H., Kim, S. J., & Lee, S.-A. (2022) · American Journal of Roentgenology · doi:10.2214/ajr.21.26896 · Cited by 18 · see citing works
Neurologic complications of infective endocarditis
Chakraborty, T., Rabinstein, A. A., & Wijdicks, E. F. M. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819814-8.00008-1 · Cited by 18 · see citing works
Kin, H., Yoshioka, K., Kawazoe, K., Mukaida, M., Kamada, T., Mitsunaga, Y., Ikai, A., & Okabayashi, H. (2013) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezt101 · Cited by 18 · see citing works
Siquier-Padilla, J., Cuervo, G., Urra, X., Quintana, E., Hernández‐Meneses, M., Sandoval, E., Lapeña, P., Falces, C., Mestres, C. A., Páez-Carpio, A., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185275 · Cited by 17 · see citing works
Morita, K., Sasabuchi, Y., Matsui, H., Fushimi, K., & Yasunaga, H. (2015) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivv235 · Cited by 16 · see citing works
Contemporary Role of Positron Emission Tomography (PET) in Endocarditis: A Narrative Review
Sammartino, A. M., Bonfioli, G. B., Dondi, F., Riccardi, M., Bertagna, F., Metra, M., & Vizzardi, E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144124 · Cited by 16 · see citing works
Current treatment of active infective endocarditis with brain complications
Miura, T., & Eishi, K. (2013) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-013-0241-5 · Cited by 16 · see citing works
Multimodality Imaging of Infective Endocarditis
Broncano, J., Rajiah, P. S., Vargas, D., Alegre, M. L. S., Ocazionez-Trujillo, D., Bhalla, S., Williamson, E. E., Fernández-Camacho, J. C., & Luna, A. (2024) · Radiographics · doi:10.1148/rg.230031 · Cited by 15 · see citing works
Prevalence and prognostic impact of stroke in a national cohort of infective endocarditis
Álvarez-Zaballos, S., Vázquez-Alén, P., Muñóz, P., de Alarcón, A., Gutiérrez‐Carretero, E., Álvarez‐Uría, A., Fariñas, M. C., Rodríguez-García, R., Goenaga, M. Á., Cuervo, G., et al. (2024) · International Journal of Stroke · doi:10.1177/17474930241255560 · Cited by 15 · see citing works
Vinod, P., Khayata, M., Haouzi, A. A., & Xu, B. (2024) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2024.04.005 · Cited by 14 · see citing works
Arribas, D. G., Olmos, C., Vivas, D., & Vilacosta, I. (2017) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2017.09.004 · Cited by 14 · see citing works
Infective Endocarditis and Antithrombotic Therapy
Morelli, C., Rocca, B., & Gigante, B. (2024) · Cardiology · doi:10.1159/000538549 · Cited by 11 · see citing works
Rapti, V., Giannitsioti, E., Spernovasilis, N. A., Magiorakos, A.-P., & Poulakou, G. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062087 · Cited by 14 · see citing works
Preoperative Cerebrovascular Evaluation in Patients With Infective Endocarditis
Behrouz, R. (2015) · Clinical Cardiology · doi:10.1002/clc.22400 · Cited by 12 · see citing works
Takahashi, Y., Izumi, C., Miyake, M., Imanaka, M., Kuroda, M., Nishimura, S., Yoshikawa, Y., Amano, M., Imamura, S., Onishi, N., et al. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.04.003 · Cited by 12 · see citing works
Klein, C. F., Gørtz, S., Wohlfahrt, J., Munch, T. N., Melbye, M., Bundgaard, H., & Iversen, K. K. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy512 · Cited by 12 · see citing works
- Authors
- Cooper, H. A., Thompson, E. C., Laureno, R., Fuisz, A., Mark, A. S., Lin, M., & Goldstein, S. A.
- Affiliations
- MedStar Washington Hospital Center (US)
- Venue
- Circulation
- Published
- 2009-08-18
- Volume
- 120
- Issue
- 7
- Pages
- 585-591
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1977906308
- Semantic Scholar
- 190d1ec0ecbf913682c56068d297ff8ee63ccc64
- Cited by
- 223
- References
- 32
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 27 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 6 · 2019: 19 · 2018: 7 · 2017: 18 · 2016: 15 · 2015: 16 · 2014: 12 · 2013: 18 · 2012: 8
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- left-sided endocarditis, Staphylococcus aureus endocarditis, stroke, brain MRI, heart valve surgery, mortality, timing of surgery
- MeSH terms
- Adult, Aged, Aged, 80 and over, Brain, Echocardiography, Endocarditis, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pilot Projects, Prospective Studies, Staphylococcal Infections, Staphylococcus aureus, Incidence, Stroke, Intracranial Embolism
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