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Atrial Arrhythmias in Adults With Congenital Heart Disease
Abstract
Background Atrial arrhythmias increase disease burden in the general adult population. Adults with congenital heart lesions constitute a rapidly growing group of patients with cardiovascular disease. We hypothesized that atrial arrhythmias increase with age and impair health outcomes in this population. Methods and results We conducted a population-based analysis of prevalence, lifetime risk, mortality, and morbidity associated with atrial arrhythmias in adults with congenital heart disease from l983 to 2005. In 38 428 adults with congenital heart disease in 2005, 5812 had atrial arrhythmias. Overall, the 20-year risk of developing atrial arrhythmia was 7% in a 20-year-old subject and 38% in a 50-year-old subject. More than 50% of patients with severe congenital heart disease reaching age 18 years developed atrial arrhythmias by age 65 years. In patients with congenital heart disease, the hazard ratio of any adverse event in those with atrial arrhythmias compared with those without was 2.50 (95% confidence interval, 2.38 to 2.62; P Conclusions Atrial arrhythmias occurred in 15% of adults with congenital heart disease. The lifetime incidence increased steadily with age and was associated with a doubling of the risk of adverse events. An increase in resource allocation should be anticipated to deal with this increasing burden.
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“By age 50 years, approximately 38% of patients with ACHD will develop an atrial arrhythmia, and by age 65 years, >50% of patients with severe CHD will develop atrial arrhythmias (660).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [660]
In the citing paper
“By age 50 years, approximately 38% of patients with ACHD will develop an atrial arrhythmia, and by age 65 years, >50% of patients with severe CHD will develop atrial arrhythmias (660).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [660]
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Lifetime Prevalence of Congenital Heart Disease in the General Population From 2000 to 2010
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Epidemiology of cardiovascular disease in young individuals
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“of intermittent anterograde conduction (291).”
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“Preamble inconsequential and benign to poorly tolerated and potentially Nearly one third of all major congenital anomalies are heart defects, with an estimated 9 per 1000 live births afflicted by congenital heart disease (CHD) worldwide.1 Remarkable advances in care have resulted in impressive gains in survival such t…”
BackgroundInfluential
Metadata
- Authors
- Bouchardy, J., Therrien, J., Pilote, L., Ionescu-Ittu, R., Martucci, G., Bottega, N., & Marelli, A. J.
- Affiliations
- McGill University Health Centre (CA)
- From the McGill Adult Unit for Congenital Heart Disease Excellence, McGill University Health Center and the Jewish General Hospital (J.B., J.T., R.I.-I., G.M., N.B., A.J.M.) and Division of Internal Medicine, McGill University Health Centre Research Institute (L.P., R.I.-I.), Montreal, Quebec, Canada.
- Venue
- Circulation
- Published
- 2009-10-27
- Volume
- 120
- Issue
- 17
- Pages
- 1679-1686
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2075290555
- Cited by
- 476
- References
- 0
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 33 · 2023: 36 · 2022: 22 · 2021: 30 · 2020: 32 · 2019: 34 · 2018: 44 · 2017: 47 · 2016: 25 · 2015: 34 · 2014: 18 · 2013: 24 · 2012: 20
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial arrhythmias, adult congenital heart disease, atrial fibrillation, lifetime risk, prevalence, mortality, stroke, heart failure, cardiac interventions, health burden, aging
- MeSH terms
- Adult, Age Factors, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Cohort Studies, Young Adult
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