The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction
Open accessAbstract
Background— Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusion ameliorates left ventricular function in rats with acute myocardial infarction (MI). Clinically, however, this approach is not feasible, because expansion of autologous CPCs after acute MI requires several weeks. Therefore, we sought to determine whether CPCs are beneficial in the more clinically relevant setting of an old MI (scar). Methods and Results— One month after coronary occlusion/reperfusion, rats received an intracoronary infusion of vehicle or enhanced green fluorescent protein–labeled CPCs. Thirty-five days later, CPC-treated rats exhibited more viable myocardium in the risk region, less fibrosis in the noninfarcted region, and improved left ventricular function. Cells that stained positive for enhanced green fluorescent protein that expressed cardiomyocyte, endothelial, and vascular smooth muscle cell markers were observed only in 7 of 17 treated rats and occupied only 2.6% and 1.1% of the risk and noninfarcted regions, respectively. Transplantation of CPCs was associated with increased proliferation and expression of cardiac proteins by endogenous CPCs. Conclusions— Intracoronary administration of CPCs in the setting of an old MI produces beneficial structural and functional effects. Although exogenous CPCs can differentiate into new cardiac cells, this mechanism is not sufficient to explain the benefits, which suggests paracrine effects; among these, the present data identify activation of endogenous CPCs. This is the first report that CPCs are beneficial in the setting of an old MI when given by intracoronary infusion, the most widely applicable therapeutic approach in patients. Furthermore, this is the first evidence that exogenous CPC administration activates endogenous CPCs. These results open the door to new therapeutic applications for the use of autologous CPCs in patients with old MI and chronic ischemic cardiomyopathy.
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1 retracted
Gonzalez, A., Rota, M., Nurzynska, D., Misao, Y., Tillmanns, J., Ojaimi, C., Padin-Iruegas, M. E., Müller, P., Esposito, G., Bearzi, C., et al. (2008) · Circulation Research · doi:10.1161/circresaha.107.165464 · Cited by 181
Self-citationRetractedAdult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00687-1 · Cited by 3,534
Self-citationWRITING COMMITTEE MEMBERS, Smith, S. C., Feldman, T. E., Hirshfeld, J. W., Jacobs, A. K., Kern, M. J., King, S. B., Morrison, D. A., O’Neill, W. W., Schaff, H. V., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.170815 · Cited by 2,218
Ryan, T. J., Faxon, D. P., Gunnar, R. M., Kennedy, J. W., King, S. B., Loop, F. D., Peterson, K. L., Reeves, T. J., Williams, D. O., & Winters, W. L. (1988) · Circulation · doi:10.1161/01.cir.78.2.486 · Cited by 2,123
Kinnaird, T., Stabile, E., Burnett, M. S., Shou, M., Lee, C. W., Barr, S., Fuchs, S., & Epstein, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000124062.31102.57 · Cited by 1,305
Askari, A. T., Unzek, S., Popovic, Z. B., Goldman, C. K., Forudi, F., Kiedrowski, M., Rovner, A., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14232-8 · Cited by 1,270
Gnecchi, M., He, H., Noiseux, N., Liang, O. D., Zhang, L., Morello, F., Mu, H., Melo, L. G., Pratt, R. E., Ingwall, J. S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5211com · Cited by 1,157
Yamaguchi, J.-I., Kusano, K. F., Masuo, O., Kawamoto, A., Silver, M., Murasawa, S., Bosch-Marce, M., Masuda, H., Losordo, D. W., Isner, J. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000055313.77510.22 · Cited by 1,149
King, S. B., Smith, S. C., Hirshfeld, J. W., Jacobs, A. K., Morrison, D. A., Williams, D. O., 2005 WRITING COMMITTEE MEMBERS, Smith, S. C., Feldman, T. E., Hirshfeld, J. W., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.188208 · Cited by 1,014
Bearzi, C., Rota, M., Hosoda, T., Tillmanns, J., Nascimbene, A., De Angelis, A., Yasuzawa-Amano, S., Trofimova, I., Siggins, R. W., LeCapitaine, N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706760104 · Cited by 980
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Cited by
Bolli, R., Chugh, A. R., D'Amario, D., Loughran, J. H., Stoddard, M. F., Ikram, S., Beache, G. M., Wagner, S. G., Leri, A., Hosoda, T., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61590-0 · Cited by 1,288
Self-citationRetractedLaflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,206
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
Mirotsou, M., Jayawardena, T. M., Schmeckpeper, J., Gnecchi, M., & Dzau, V. J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.08.005 · Cited by 486
Li, T.-S., Cheng, K., Malliaras, K., Smith, R. R., Zhang, Y., Sun, B., Matsushita, N., Blusztajn, A., Terrovitis, J., Kusuoka, H., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.029 · Cited by 461
Ye, L., Chang, Y.-H., Xiong, Q., Zhang, P., Zhang, L., Somasundaram, P., Lepley, M., Swingen, C., Su, L., Wendel, J. S., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.009 · Cited by 454
Metadata
- Authors
- Tang, X.-L., Rokosh, G., Sanganalmath, S. K., Yuan, F., Sato, H., Mu, J., Dai, S., Li, C., Chen, N., Peng, Y., Dawn, B., Hunt, G., Leri, A., Kajstura, J., Tiwari, S., Shirk, G., Anversa, P., & Bolli, R.
- Venue
- Circulation
- Published
- 2010-01-19
- Volume
- 121
- Issue
- 2
- Pages
- 293-305
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1985797014
- Cited by
- 390
- References
- 28
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Tang, X.-L., Rokosh, G., Sanganalmath, S. K., Yuan, F., Sato, H., Mu, J., Dai, S., Li, C., Chen, N., Peng, Y., Dawn, B., Hunt, G., Leri, A., Kajstura, J., Tiwari, S., Shirk, G., Anversa, P., & Bolli, R. (2010). Intracoronary Administration of Cardiac Progenitor Cells Alleviates Left Ventricular Dysfunction in Rats With a 30-Day-Old Infarction. Circulation. https://doi.org/10.1161/circulationaha.109.871905
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