The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells
Open accessAbstract
Summary Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute myocardial infarction (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiomyocytes, endothelial cells, and smooth muscle cells, in combination with a 3D fibrin patch loaded with insulin growth factor (IGF)-encapsulated microspheres. hiPSC-derived cardiomyocytes integrated into host myocardium and generated organized sarcomeric structures, and endothelial and smooth muscle cells contributed to host vasculature. Tri-lineage cell transplantation significantly improved left ventricular function, myocardial metabolism, and arteriole density, while reducing infarct size, ventricular wall stress and apoptosis without inducing ventricular arrhythmias. These findings in a large animal MI model highlight the potential of utilizing hiPSC-derived cells for cardiac repair.
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“In the worst cases, adverse side effects lead to fatalities, as was the case with the serotonin agonist, cisparide, which caused 125 deaths before its use ceased [12].”
BackgroundMulti-lineage human iPSC-derived platforms for disease modeling and drug discovery
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Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications
Yoshida, Y., & Yamanaka, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.311080 · Cited by 264
Metadata
- Authors
- Ye, L., Chang, Y.-H., Xiong, Q., Zhang, P., Zhang, L., Somasundaram, P., Lepley, M., Swingen, C., Su, L., Wendel, J. S., Guo, J., Jang, A., Rosenbush, D., Greder, L., Dutton, J. R., Zhang, J., Kamp, T. J., Kaufman, D. S., Ge, Y., & Zhang, J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 15
- Issue
- 6
- Pages
- 750-761
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2086876030
- Cited by
- 454
- References
- 28
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-01-08)
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
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- Ye, L., Chang, Y.-H., Xiong, Q., Zhang, P., Zhang, L., Somasundaram, P., Lepley, M., Swingen, C., Su, L., Wendel, J. S., Guo, J., Jang, A., Rosenbush, D., Greder, L., Dutton, J. R., Zhang, J., Kamp, T. J., Kaufman, D. S., Ge, Y., & Zhang, J. (2014). Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells. Cell Stem Cell. https://doi.org/10.1016/j.stem.2014.11.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
