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Cited by 117Cardiovascular Function and Risk FactorsAtrial Fibrillation Management and OutcomesBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Longitudinal Tracking of Left Atrial Diameter Over the Adult Life Course: Clinical Correlates in the Community

Open access
McManus, David D., Xanthakis, Vanessa, Sullivan, Lisa M., Zachariah, Justin, Aragam, Jayashri, Larson, Martin G., Benjamin, Emelia J., Vasan, Ramachandran S.·2010·Circulation
DOI 10.1161/circulationaha.109.885806PMC PMC2823068
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Abstract

Background— Increased left atrial diameter (LAD) is associated with elevated risk of atrial fibrillation (AF) and cardiovascular disease. Information is limited regarding the short- or long-term correlates of LAD. Methods and Results— We evaluated clinical correlates of LAD for a 16-year period in 4403 Framingham Study participants (mean age, 45 years; 52% women; median observations/participant=3) using multilevel modeling. We related age, sex, body mass index (BMI), systolic and diastolic blood pressure (BP), diabetes, and antihypertensive treatment to LAD. Sex-specific growth curves for LAD were estimated for individuals with low, intermediate, and high risk factor burden. We also related risk factors to changes in LAD during a 4-year period in 3365 participants. Age, male sex (3.83 mm compared to women), greater BMI, higher systolic BP (0.24 mm per 10 mm Hg increment), and antihypertensive treatment (0.54 mm) were associated positively with LAD ( P <0.001). Men had a greater increase in LAD with BMI than women (2.02 versus 1.77 mm in women, per 5-unit increment), and individuals receiving antihypertensive treatment experienced a greater increase in LAD with age (0.95 versus 0.63 mm per 10-year age increment) when compared with those not receiving antihypertensive treatment. Overall, greater risk factor burden was positively associated with LAD. These risk factors were also associated positively with 4-year change in LAD ( P <0.001). Conclusions— Our longitudinal study of a large community-based sample identified higher BP and greater BMI as key modifiable correlates of LAD, suggesting that maintaining optimal levels of these risk factors through the life course may prevent atrial remodeling and AF.

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  1. 10.1161/circ.89.2.8313561 · DOI
  2. 10.1161/circ.92.4.835 · DOI
  3. 10.1161/hyp.39.3.739 · DOI
  4. 10.1161/circ.64.3.7261280 · DOI
  5. 10.1161/circ.96.7.2455 · DOI
  6. Sorlie P. Cardiovascular diseases and death following myocardial infarction and angina pectoris: Framingham study 20-year follow-up. In: Kannel WB Gordon T ed. The Framingham Study: An Epidemiologic Investigation of Cardiovascular Disease. Washington DC: US Government Printing Office; 1977: 77–1247.
  7. 10.1161/hyp.25.6.1155 · DOI
  8. 10.1161/res.68.6.2036710 · DOI

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Metadata

Authors
McManus, D. D., Xanthakis, V., Sullivan, L. M., Zachariah, J., Aragam, J., Larson, M. G., Benjamin, E. J., & Vasan, R. S.
Affiliations
Boston University (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-02-09
Volume
121
Issue
5
Pages
667-674
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.109.885806
PMC
PMC2823068
OpenAlex
W2103738832
Cited by
112
References
49
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 15 · 2012: 6
FWCI
6.08
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc25195-41-0-1, 5r01hl080124-05)
  • National Heart, Lung, and Blood Institute (R01-HL080124, N01‐HC25195, K24HL004334, N01-HC-025195, T32HL007572, R01HL092577)
  • National Institute of Neurological Disorders and Stroke (R01NS017950)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
left atrial diameter, atrial remodeling, atrial fibrillation, body mass index, blood pressure, antihypertensive therapy, sex differences, risk factor burden, Framingham Heart Study, cardiovascular risk factors
MeSH terms
Adult, Age Factors, Aged, Aging, Antihypertensive Agents, Atrial Fibrillation, Blood Pressure, Female, Heart Atria, Humans, Longitudinal Studies, Male, Middle Aged, Organ Size, Body Mass Index

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