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Longitudinal Tracking of Left Atrial Diameter Over the Adult Life Course: Clinical Correlates in the Community
Open accessAbstract
Background— Increased left atrial diameter (LAD) is associated with elevated risk of atrial fibrillation (AF) and cardiovascular disease. Information is limited regarding the short- or long-term correlates of LAD. Methods and Results— We evaluated clinical correlates of LAD for a 16-year period in 4403 Framingham Study participants (mean age, 45 years; 52% women; median observations/participant=3) using multilevel modeling. We related age, sex, body mass index (BMI), systolic and diastolic blood pressure (BP), diabetes, and antihypertensive treatment to LAD. Sex-specific growth curves for LAD were estimated for individuals with low, intermediate, and high risk factor burden. We also related risk factors to changes in LAD during a 4-year period in 3365 participants. Age, male sex (3.83 mm compared to women), greater BMI, higher systolic BP (0.24 mm per 10 mm Hg increment), and antihypertensive treatment (0.54 mm) were associated positively with LAD ( P <0.001). Men had a greater increase in LAD with BMI than women (2.02 versus 1.77 mm in women, per 5-unit increment), and individuals receiving antihypertensive treatment experienced a greater increase in LAD with age (0.95 versus 0.63 mm per 10-year age increment) when compared with those not receiving antihypertensive treatment. Overall, greater risk factor burden was positively associated with LAD. These risk factors were also associated positively with 4-year change in LAD ( P <0.001). Conclusions— Our longitudinal study of a large community-based sample identified higher BP and greater BMI as key modifiable correlates of LAD, suggesting that maintaining optimal levels of these risk factors through the life course may prevent atrial remodeling and AF.
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“The link between female sex and stroke might vary across populations and age groups.75–84”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [81]
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Metadata
- Authors
- McManus, D. D., Xanthakis, V., Sullivan, L. M., Zachariah, J., Aragam, J., Larson, M. G., Benjamin, E. J., & Vasan, R. S.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Circulation
- Published
- 2010-02-09
- Volume
- 121
- Issue
- 5
- Pages
- 667-674
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC2823068
- OpenAlex
- W2103738832
- Cited by
- 112
- References
- 49
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 15 · 2012: 6
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1, 5r01hl080124-05)
- National Heart, Lung, and Blood Institute (R01-HL080124, N01‐HC25195, K24HL004334, N01-HC-025195, T32HL007572, R01HL092577)
- National Institute of Neurological Disorders and Stroke (R01NS017950)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- left atrial diameter, atrial remodeling, atrial fibrillation, body mass index, blood pressure, antihypertensive therapy, sex differences, risk factor burden, Framingham Heart Study, cardiovascular risk factors
- MeSH terms
- Adult, Age Factors, Aged, Aging, Antihypertensive Agents, Atrial Fibrillation, Blood Pressure, Female, Heart Atria, Humans, Longitudinal Studies, Male, Middle Aged, Organ Size, Body Mass Index
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