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Cited by 257Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Influence of Excess Fat on Cardiac Morphology and Function: Study in Uncomplicated Obesity

Iacobellis, Gianluca, Ribaudo, Maria Cristina, Leto, Gaetano, Zappaterreno, Alessandra, Vecci, Elio, Di Mario, Umberto, Leonetti, Frida·2002·Obesity Research
DOI 10.1038/oby.2002.104
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Abstract

Objective: To evaluate whether or not “uncomplicated” obesity (without associated comorbidities) is really associated with cardiac abnormalities. Research Methods and Procedures: We evaluated cardiac parameters in obese subjects with long‐term obesity, normal glucose tolerance, normal blood pressure, and regular plasma lipids. We selected 75 obese patients [body mass index (BMI) >30 kg/m 2], who included 58 women and 17 men (mean age, 33.7 ± 11.9 years; BMI, 37.8 ± 5.5 kg/m 2) with a ≥10‐year history of excess fat, and 60 age‐matched normal‐weight controls, who included 47 women and 13 men (mean age, 32.7 ± 10.4 years; BMI, 23.1 ± 1.4 kg/m 2). Each subject underwent an oral glucose tolerance test to exclude impaired glucose tolerance or diabetes mellitus, bioelectrical impedance analysis to calculate fat mass and fat‐free mass, and echocardiography. Results: Obese patients presented diastolic function impairment, hyperkinetic systole, and greater aortic root and left atrium compared with normal subjects. No statistically significant differences between obese subjects and normal subjects were found in indexed left ventricular mass (LVM/body surface area, LVM/height 2.7, and LVM/fat‐free mass kg), and no changes in left ventricular geometry were observed. No statistically significant differences in cardiac parameters between extreme (BMI > 40 kg/m 2) and mild obesity (BMI < 35 kg/m 2) were observed. Discussion: In conclusion, our data showed that obesity, in the absence of glucose intolerance, hypertension, and dyslipidemia, seems to be associated only with an impairment of diastolic function and hyperkinetic systole, and not with left ventricular hypertrophy.

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Crossref · 10.1038/oby.2002.104

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42 of 42 references verified0 citation errors · 0 not checkable

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  • A few studies suggest that LV mass may be increased in obesity, but that the increase is appropriate for body size if obesity is truly uncomplicated.

    “A few studies suggest that LV mass may be increased in obesity, but that the increase is appropriate for body size if obesity is truly “uncomplicated” (i.e., lack of comorbid conditions such as hypertension, diabetes, coronary artery disease, etc.) (151, 155, 156).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [155]

  • The amount of epicardial fat parallels the amount of visceral adipose tissue and is correlated with the severity of LVH.

    “Iacobellis and colleagues (152, 155) have argued that the amount of epicardial fat parallels the amount of visceral adipose tissue and that the amount of epicardial fat is correlated with the severity of LVH.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [155]

  • Late diastolic (A-wave) velocities have been reported to be increased or unchanged in obese subjects.

    “Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [155]

  • Some studies have found reduced early diastolic (E-wave) velocities while others have found them unchanged in obese subjects.

    “Some studies have found reduced early diastolic (E-wave) velocities (155) while others have found them to be unchanged (242, 266, 274, 279, 314).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [155]

  • LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity.

    “More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [155]

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Authors
Iacobellis, G., Ribaudo, M. C., Leto, G., Zappaterreno, A., Vecci, E., Di Mario, U., & Leonetti, F.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
Iacobellis, Gianluca
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2002-08
Volume
10
Issue
8
Pages
767-773
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2002.104
OpenAlex
W2032459930
Cited by
257
References
42
Citations by year
2026: 3 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 18 · 2015: 14 · 2014: 21 · 2013: 15 · 2012: 13
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3689 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
cardiac morphology, cardiac function, diastolic dysfunction, left ventricular hypertrophy, left ventricular mass, left atrium, aortic root, body mass index, fat mass, fat-free mass, echocardiography
MeSH terms
Adipose Tissue, Adult, Aging, Body Composition, Diastole, Echocardiography, Female, Glucose Tolerance Test, Heart, Heart Atria, Humans, Male, Middle Aged, Myocardium, Obesity, Systole, Body Mass Index, Electric Impedance, Hypertrophy, Left Ventricular

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