The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mode of Death in Patients With Heart Failure and a Preserved Ejection Fraction: Results From the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) Trial
Abstract
Background— The mode of death has been well characterized in patients with heart failure and a reduced ejection fraction; however, less is known about the mode of death in patients with heart failure and a preserved ejection fraction (HFPEF). The purpose of this study was to examine the mode of death in patients with HFPEF enrolled in the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial and to determine whether irbesartan altered the distribution of mode of death in HFPEF. Methods and Results— All deaths were reviewed by a clinical end-point committee, and the mode of death was assigned by consensus of the members. The annual mortality rate was 5.2% in the I-Preserve trial. There were no significant differences in mortality rate between the placebo and irbesartan groups. The mode of death was cardiovascular in 60% (including 26% sudden, 14% heart failure, 5% myocardial infarction, and 9% stroke), noncardiovascular in 30%, and unknown in 10%. There were no differences in the distribution of mode-specific mortality rates between placebo and irbesartan. Conclusions— Sixty percent of the deaths in patients with HFPEF were cardiovascular, with sudden death and heart failure death being the most common. Treatment with irbesartan did not affect overall mortality or the distribution of mode-specific mortality rates. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00095238.
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Citations
Cites
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Self-citationCardiac Resynchronization in Chronic Heart Failure
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Self-citationEffect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
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Irbesartan in patients with heart failure and preserved ejection fraction
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Self-citationCombination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
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Epidemiology and clinical course of heart failure with preserved ejection fraction
Lam, C. S. P., Donal, E., Kraigher-Krainer, E., & Vasan, R. S. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq121 · Cited by 709
Zile, M. R., Gottdiener, J. S., Hetzel, S. J., McMurray, J. J., Komajda, M., McKelvie, R., Baicu, C. F., Massie, B. M., & Carson, P. E. (2011) · Circulation · doi:10.1161/circulationaha.110.011031 · Cited by 517
Self-citationRisk stratification for sudden cardiac death: Current status and challenges for the future
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Metadata
- Authors
- Zile, M. R., Gaasch, W. H., Anand, I. S., Haass, M., Little, W. C., Miller, A. B., Lopez-Sendon, J., Teerlink, J. R., White, M., McMurray, J. J., Komajda, M., McKelvie, R., Ptaszynska, A., Hetzel, S. J., Massie, B. M., & Carson, P. E.
- Venue
- Circulation
- Published
- 2010-03-30
- Volume
- 121
- Issue
- 12
- Pages
- 1393-1405
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2100454833
- Cited by
- 335
- References
- 12
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- closed
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