Epidemiology and clinical course of heart failure with preserved ejection fraction
Open accessAbstract
Heart failure with preserved ejection fraction (HFPEF) is increasingly recognized as a major public health problem worldwide. Significant advances have been made in our understanding of the epidemiology of HFPEF over the past two decades, with the publication of numerous population-based epidemiological studies, large heart failure registries, and randomized clinical trials. These recent studies have provided detailed characterization of larger numbers of patients with HFPEF than ever before. This review summarizes the state of current knowledge with regards to the disease burden, patient characteristics, clinical course, and outcomes of HFPEF. Despite the wealth of available data, substantive gaps in knowledge were identified. These gaps represent opportunities for further research in HFPEF, a syndrome that is clearly a rising societal burden and that is associated with substantial morbidity and mortality.
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Thirty percent of HFpEF patients have both obesity and T2DM, and this prevalence is expected to grow worldwide.
“Thirty percent of HFpEF patients have both obesity and T2DM, and this prevalence is expected to grow worldwide due to the pandemic of these diseases, as well as the longer life expectancy [74,75].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [74]
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Myocardial Infarction in Heart Failure With Preserved Ejection Fraction
Cunningham, J. W., Vaduganathan, M., Claggett, B. L., John, J. E., Desai, A. S., Lewis, E. F., Zile, M. R., Carson, P., Jhund, P. S., Kober, L., et al. (2020) · JACC: Heart Failure · doi:10.1016/j.jchf.2020.02.007 · Cited by 33 · see citing works
Heider, K., Arzt, M., Lerzer, C., Kolb, L., Pfeifer, M., Maier, L. S., Gfüllner, F., & Malfertheiner, M. V. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1203-9 · Cited by 26 · see citing works
- Authors
- Lam, C. S. P., Donal, E., Kraigher-Krainer, E., & Vasan, R. S.
- Affiliations
- Framingham Heart Study (US)
- Centre Hospitalier Universitaire de Rennes (FR)
- Department of Cardiology, Medical University of Graz , Graz ,
- Boston University (US)
- Corresponding author
- Vasan, Ramachandran S.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 18-28
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- PMC
- PMC3003453
- OpenAlex
- W2008074040
- Cited by
- 709
- References
- 80
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 29 · 2023: 51 · 2022: 51 · 2021: 60 · 2020: 62 · 2019: 50 · 2018: 55 · 2017: 62 · 2016: 59 · 2015: 53 · 2014: 53 · 2013: 37 · 2012: 30
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Heart Failure (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heart failure with preserved ejection fraction, epidemiology, disease burden, clinical course, patient characteristics, clinical outcomes, morbidity and mortality, heart failure registry
- MeSH terms
- Europe, Heart Failure, Hemodynamics, Humans, Mortality, Public Health, Risk Factors, Stroke Volume, Ultrasonography, United States, Incidence, Prevalence, Ventricular Function, Left, Disease Progression
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