The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice
Open accessAbstract
Background— T cells play an important role during the immune response that accompanies atherosclerosis. To date, the role for interleukin (IL)-17A in atherogenesis is not well defined. Here, we tested the hypothesis that atherosclerosis-prone conditions induce the differentiation of IL-17A–producing T cells, which in turn promote atherosclerosis. Methods and Results— IL-17A was found to be elevated in the plasma and tissues of apolipoprotein E–deficient ( Apoe −/− ) mice. IL-17A–expressing T cells were significantly increased in the aortas, spleen, and lamina propria of aged Apoe −/− mice compared with age-matched C57BL/6 mice. IL-17A + T cells resided in both adventitia and aortas of aged Apoe −/− mice fed a chow diet. Elevated levels of IL-17A + T cells were also detected in the aortas of 21-week-old Apoe −/− mice fed a Western diet for 15 weeks. IL-17A + T cells were characterized as predominantly CD4 + T helper 17 (Th17) cells and γδ + T cells. Blockade of IL-17A in Apoe −/− mice by use of adenovirus-produced IL-17 receptor A reduced plaque burden in Apoe −/− mice fed a Western diet for 15 weeks. In addition, the treatment diminished circulating IL-6 and granulocyte colony-stimulating factor levels and limited CXCL1 expression and macrophage content within the aortas. Conversely, IL-17A treatment of whole aorta isolated from Apoe −/− mice promoted aortic CXCL1 expression and monocyte adhesion in an ex vivo adhesion assay. Conclusions— These results demonstrate that atherosclerosis-prone conditions induce the differentiation of IL-17A–producing T cells. IL-17A plays a proatherogenic inflammatory role during atherogenesis by promoting monocyte/macrophage recruitment into the aortic wall.
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Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
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Self-citationRao, D. A., Eid, R. E., Qin, L., Yi, T., Kirkiles-Smith, N. C., Tellides, G., & Pober, J. S. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081661 · Cited by 86
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Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
Self-citationInflammation and atherosclerosis: signaling pathways and therapeutic intervention
Kong, P., Cui, Z.-Y., Huang, X.-F., Zhang, D.-D., Guo, R.-J., & Han, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00955-7 · Cited by 1,183
Immunity, atherosclerosis and cardiovascular disease
Frostegård, J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-117 · Cited by 1,040
The immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982
Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis
Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C., & Soehnlein, O. (2010) · Circulation · doi:10.1161/circulationaha.110.961714 · Cited by 698
Metadata
- Authors
- Smith, E., Prasad, K.-M. R., Butcher, M., Dobrian, A., Kolls, J. K., Ley, K., & Galkina, E.
- Venue
- Circulation
- Published
- 2010-04-20
- Volume
- 121
- Issue
- 15
- Pages
- 1746-1755
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2167962196
- Cited by
- 421
- References
- 8
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, E., Prasad, K.-M. R., Butcher, M., Dobrian, A., Kolls, J. K., Ley, K., & Galkina, E. (2010). Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice. Circulation. https://doi.org/10.1161/circulationaha.109.924886
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