Cited by 397MicroRNA in disease regulationAngiogenesis and VEGF in CancerWound Healing and Treatments

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

Open access

Caporali, Andrea, Meloni, Marco, Völlenkle, Christine, Bonci, Desiree, Sala-Newby, Graciela B., Addis, Roberta, Spinetti, Gaia, Losa, Sergio, Masson, Rachel, Baker, Andrew H., Agami, Reuven, le Sage, Carlos, Condorelli, Gianluigi, Madeddu, Paolo, Martelli, Fabio, Emanueli, Costanza·2011·Circulation

DOI 10.1161/circulationaha.110.952325

Open this paper in CoChat — free account

Abstract

Background—: Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood. microRNAs negatively regulate the expression of target genes mainly by interaction in their 3′ untranslated region. Methods and Results—: We found that microRNA-503 (miR-503) expression in ECs is upregulated in culture conditions mimicking diabetes mellitus (high D-glucose) and ischemia-associated starvation (low growth factors). Under normal culture conditions, lentivirus-mediated miR-503–forced expression inhibited EC proliferation, migration, and network formation on Matrigel (comparisons versus lentivirus.GFP control). Conversely, blocking miR-503 activity by either adenovirus-mediated transfer of a miR-503 decoy ( Ad.decoymiR-503 ) or by antimiR-503 (antisense oligonucleotide) improved the functional capacities of ECs cultured under high D-glucose/low growth factors. We identified CCNE1 and cdc25A as direct miR-503 targets which are downregulated by high glucose/low growth factors in ECs. Next, we obtained evidence that miR-503 expression is increased in ischemic limb muscles of streptozotocin-diabetic mice and in ECs enriched from these muscles. Moreover, Ad.decoymiR-503 delivery to the ischemic adductor of diabetic mice corrected diabetes mellitus–induced impairment of postischemic angiogenesis and blood flow recovery. We finally investigated miR-503 and target gene expression in muscular specimens from the amputated ischemic legs of diabetic patients. As controls, calf biopsies of nondiabetic and nonischemic patients undergoing saphenous vein stripping were used. In diabetic muscles, miR-503 expression was remarkably higher, and it inversely correlated with cdc25 protein expression. Plasma miR-503 levels were also elevated in the diabetic individuals. Conclusions—: Our data suggest miR-503 as a possible therapeutic target in diabetic patients with critical limb ischemia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/circulationaha.110.952325

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,294
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel-Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,617
MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J. S., Fox, H., Doebele, C., Ohtani, K., et al. (2009) · Science · doi:10.1126/science.1174381 · Cited by 1,214
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
Satyanarayana, A., & Kaldis, P. (2009) · Oncogene · doi:10.1038/onc.2009.170 · Cited by 800
MicroRNAs Add a New Dimension to Cardiovascular Disease
Small, E. M., Frost, R. J., & Olson, E. N. (2010) · Circulation · doi:10.1161/circulationaha.109.889048 · Cited by 604
A guide through present computational approaches for the identification of mammalian microRNA targets
Sethupathy, P., Megraw, M. S., & Hatzigeorgiou, A. G. (2006) · Nature Methods · doi:10.1038/nmeth954 · Cited by 550

Flagged first, then by citations

Show all 30 references

Sorted by citations

Items 301–396 of 396

MiR-34b-3p Impaired HUVECs Viability and Migration via Targeting PDK1 in an In Vitro Model of Gestational Diabetes Mellitus
Song, F., Cai, A., Ye, Q., Chen, X. '., Lin, L., & Hao, X. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10064-9 · Cited by 9
MicroRNA‐503 Exacerbates Myocardial Ischemia/Reperfusion Injury via Inhibiting PI3K/Akt‐ and STAT3‐Dependent Prosurvival Signaling Pathways
He, Y., Cai, Y., Sun, T., Zhang, L., Irwin, M. G., Xu, A.-M., & Xia, Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3449739 · Cited by 9
MicroRNA changes in rat mesentery and serum associated with drug-induced vascular injury
Thomas, R. A., Scicchitano, M. S., Mirabile, R. C., Chau, N. T., Frazier, K. S., & Thomas, H. C. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.05.009 · Cited by 9
microRNAs in ischaemic cardiovascular diseases
Greco, S., Zaccagnini, G., Voellenkle, C., & Martelli, F. (2016) · European Heart Journal Supplements · doi:10.1093/eurheartj/suw012 · Cited by 8
Self-citation
New Insight into Molecular and Hormonal Connection in Andrology
Francomano, D., Sanguigni, V., Capogrosso, P., Dehò, F., & Antonini, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111908 · Cited by 8
MicroRNA Changes Up to 24 h following Induced Hypoglycemia in Type 2 Diabetes
Ramanjaneya, M., Bettahi, I., Pawar, K., Halabi, N. M., Moin, A. S. M., Sathyapalan, T., Abou‐Samra, A., Atkin, S. L., & Butler, A. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314696 · Cited by 9
Role of microRNA-503 in the suppression of osteosarcoma cell proliferation and migration via modulation of fibroblast growth factor 2
Wu, B., & Bi, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4399 · Cited by 8
Dynamic changes in microRNA expression during differentiation of rat cochlear progenitor cells in vitro
Hei, R., Chen, J., Li, Q., Xu, L., Mao, X., Qiu, J., & Qu, J. (2011) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2011.05.005 · Cited by 9
The Role of miRNA in Stem Cell Pluripotency and Commitment to the Vascular Endothelial Lineage
White, K. M., Kane, N. M., Milligan, G., & Baker, A. H. (2012) · Microcirculation · doi:10.1111/j.1549-8719.2012.00161.x · Cited by 7
Self-citation
Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review
Buzaș, R., Rogobete, A. F., Popovici, S. E., Mateescu, T., Hoinoiu, T., Șorop, V.-B., Bratu, T., Ticlea, M., Popoiu, C. M., & Săndesc, D. (2018) · Journal of Cardiovascular Emergencies · doi:10.2478/jce-2018-0008 · Cited by 7
Gene Therapy for Critical Limb Ischemia: Per Aspera ad Astra
Tarantul, V. Z., & Gavrilenko, A. V. (2021) · Current Gene Therapy · doi:10.2174/1566523221666210712185742 · Cited by 8
Impact of Sacubitril/Valsartan on Circulating microRNA in Patients with Heart Failure
Brioschi, M., D’Alessandra, Y., Mapelli, M., Mattavelli, I., Salvioni, E., Eligini, S., Mallia, A., Ricci, V., Gianazza, E., Ghilardi, S., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11041037 · Cited by 7
mRNAs expression profiles of high glucose-induced memory in human umbilical vein endothelial cells
Jin, G., Wang, Q., Pei, X., Li, X., Hu, X., Xu, E., & Li, M. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s206270 · Cited by 7
Advancements in Gene-Based Therapeutic Angiogenesis for Chronic Limb-Threatening Ischemia
Wang, P., Di, X., Li, F., Rong, Z., Lian, W., Sun, G., Liu, C., & Ni, L. (2025) · Human Gene Therapy · doi:10.1089/hum.2024.245 · Cited by 7
Circulating salivary and serum miRNA-182, 320a, 375 and 503 expression levels in type 2 diabetes
Monfared, Y. K., Honardoost, M., Cea, M., Gholami, S., Mirzaii‐Dizgah, I., Hashemipour, S., Sarookhani, M. R., & Farzam, S. A. (2022) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-022-01082-4 · Cited by 6
Down-regulated miR-15a mediates the epithelial–mesenchymal transition in renal tubular epithelial cells promoted by high glucose
Sun, T., Yang, J., Dong, W., Wang, R., Ma, P., Kang, P., Zhang, H., Xie, C., Du, J., & Zhao, L. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.936345 · Cited by 6
Regulation of Gut Barrier Function by RNA-Binding Proteins and Noncoding RNAs
Chung, H. K., Rao, J. N., & Wang, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00059-1 · Cited by 6
The Causes and Consequences of Mir-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer
He, Y., Cai, Y., Pai, P. M., Ren, X., & Xia, Z. (2021) · Vide Leaf, Hyderabad eBooks · doi:10.37247/up.1.2021.21 · Cited by 9
Personalized Cardiovascular Regenerative Medicine: Targeting the Extreme Stages of Life
Madeddu, P. R., Avolio, E., Alvino, V. V., Santopaolo, M., & Spinetti, G. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00177 · Cited by 6
Self-citation
Printed electrochemical biosensors for microRNA detection: Materials innovation, surface engineering, and integrated platform development
Faizan, M., Liu, C., Fatima, M., & Wu, W.-C. (2026) · Electrochimica Acta · doi:10.1016/j.electacta.2026.148527 · Cited by 5
Emerging roles of non-coding RNAs in endothelial cell function
Mitić, T., & Caporali, A. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100672 · Cited by 5
Self-citation
Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function
Lam, Y. T., Lee, B. S. L., Hung, J., Michael, P. L., Santos, M., Tan, R. P., Liu, R., & Wise, S. G. (2023) · Nanomaterials · doi:10.3390/nano13162360 · Cited by 5
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type 2 Diabetes
Karolina, D. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-011 · Cited by 5
miRNA Biology in Pathological Processes
Zhang, X., Dong, H., & Tian, Y. (2015) · Springer briefs in molecular science · doi:10.1007/978-3-662-47293-4_2 · Cited by 5
GroEL of Porphyromonas gingivalis‐induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells
Lin, F., Tsai, Y., Huang, C., Lai, Z., Tsai, C., Shih, C., Lin, C., & Lin, Y. (2023) · Molecular Oral Microbiology · doi:10.1111/omi.12415 · Cited by 4
Novel insights into the angiogenic function of JMJD2B in diabetic hind limb ischemia: involvement of activating Wnt/β-catenin pathway
Wang, Z., Li, M., Liu, Y., Qiao, Z., Zu, X., Cao, T., & Bai, T. (2023) · Human Cell · doi:10.1007/s13577-023-00874-x · Cited by 4
Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease
Guo, J., Wang, Q., Liu, Y., Lu, L., Hua, Y., Hu, R., Wang, M., Li, Z., Wang, X., Wang, B. H., et al. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.08.005 · Cited by 4
FoxO1 Deficiency Enhances Cell Proliferation and Survival Under Normoglycemia and Promotes Angiogenesis Under Hyperglycemia in the Placenta
Ding, Z., McCauley, N., Qin, Y., Lawless, L., Guo, S., Zhang, L., Zhang, K. K., & Xie, L. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2022.100017 · Cited by 3
miRNA in type 2 diabetes
Szweda-Gandor, N., & Łaczmański, Ł. (2016) · Clinical Diabetology · doi:10.5603/dk.2016.0016 · Cited by 3
Salivary Diagnostics
Kaczor‐Urbanowicz, K. E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73372 · Cited by 3
MicroRNomics of Diabetic Cardiomyopathy
Mishra, P. K., & Tyagi, S. C. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9317-4_10 · Cited by 3
MicroRNAs and Cardiovascular Diseases
Ono, K. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch29 · Cited by 3
Novel microRNA pathways of impaired angiogenesis in human peripheral artery disease adipose tissue
Okazaki, R. A., Rizvi, S. H. M., Bretón‐Romero, R., Zhou, Y., Weisbrod, R. M., Li, Z., Farb, M. G., Farber, A. M., & Hamburg, N. M. (2025) · Vascular Medicine · doi:10.1177/1358863x251359542 · Cited by 2
Exome Sequencing of a Type 1 Diabetes Mellitus Family Exposes Both Common and Individualized Rare Variants Contributing to Pathogenesis
Ibrahim, T. A. M., Ali, R. S., Abdullah, M. A., & Ibrahim, M. E. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/3346256 · Cited by 2
From Cradle to the Grave: Tissue-specific microRNA signatures in detecting clinical progression of diabetes
Farr, R. J., Taylor, C. J., Satoor, S. N., Williams, M. D., & Joglekar, M. V. (2013) · Non-coding RNAs in Endocrinology · doi:10.2478/micrnado-2013-0004 · Cited by 2
MicroRNA regulation of vascular function
Mellis, D. J., & Caporali, A. (2019) · Vascular Biology · doi:10.1530/vb-19-0009 · Cited by 2
Self-citation
Rephrasing the ‘David-Goliath’ story in the field of diabetes
Dey, N. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09618-y · Cited by 2
Influence of RNA Labeling on Expression Profiling of MicroRNAs
Kaddis, J. S., Wai, D., Bowers, J., Hartmann, N., Bäriswyl, L., Bajaj, S. V., Anderson, M. J., Getts, R. C., & Triche, T. J. (2011) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2011.08.005 · Cited by 2
Diabetes-Associated Kidney and Vascular Complications: Mechanisms of Disease Progression and Alternative Therapeutic Options
Brizzi, M. F. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-022 · Cited by 2
MicroRNAs as Potential Therapeutic Targets in Peripheral Arterial Disease
Cunningham, A., & Dokun, A. O. (2014) · International Journal of Diabetology & Vascular Disease Research · doi:10.19070/2328-353x-1400013 · Cited by 2
Molecular Determinants of Cardiac Neovascularization
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00009-3 · Cited by 3
MicroRNA Regulation of Angiogenesis
Sen, C. K., & Chan, Y. C. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1428-5_9 · Cited by 2
Altered microRNAs as novel therapeutic approaches to cardiovascular diseases: An exciting challenge
Huang, F., Huang, J., Chen, C., & Chen, M. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.11.097 · Cited by 2
Genetic polymorphisms and diabetic foot ulcer susceptibility: a systematic review and meta-analysis of Indian populations
Kumar, Y. S., Megha, A. S., Ramula, M., & Ramachandran, M. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01793-4 · Cited by 1
MicroRNAs in type 2 diabetes mellitus and its cardiovascular complications: mechanistic insights and translational potential
Corrao, S., Orlando, V., Manno, S. B., Cangialosi, V., & Argano, C. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04281-6 · Cited by 1
MicroRNAs in diabetes - are they perpetrators in disguise or just epiphenomena?
Puthanveetil, P., Thomas, A. A., & Chakrabarti, S. (2014) · Non-coding RNAs in Endocrinology · doi:10.2478/micrnado-2014-0002 · Cited by 1
Hyperglycemia, Oxidative Stress, and Vascular Complications: Role of Epigenetic Mechanisms
Simo‐Cheyou, E. R., & Srivastava, A. K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9317-4_6 · Cited by 1
Small but Smart
Schroen, B. L. M., & Heymans, S. R. B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800039-7.00013-x · Cited by 1
Mechanisms of Impaired Angiogenesis in Diabetes Mellitus: do Methylglyoxal and Autophagy Play a Role?
Xu, J. (2013) · Cited by 1
MicroRNA-337 participates in the progression of early-stage diabetic retinopathy by upregulating MAP3K12
Shi, Q., Yu, J., Li, P. A., Lü, X., & Wang, W. (2021) · Minerva Medica · doi:10.23736/s0026-4806.20.07035-4 · Cited by 1
Circulation Editors' Picks
Editors, T. (2012) · Circulation · doi:10.1161/circulationaha.112.091207 · Cited by 1
Regulation of head and neck tumor microenvironment by microRNAs
De, A. J., Ghosh, B., Chatterjee, N., Chakrabarty, S., Basu, S., Naser, S. S., & Verma, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15968-8.00008-9 · Cited by 1
The role of therapeutic MicroRNA in arteriogenesis process in limb ischemia: A systematic review
Ismail, M. T., Anggrahini, D. W., Haryana, S. M., & Setianto, B. Y. (2024) · F1000Research · doi:10.12688/f1000research.147482.2 · Cited by 1
MicroRNA and Cardiovascular Disorders with a Focus on Angiogenesis
Cavarretta, E., Frati, G., & Condorelli, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-5857-9_25 · Cited by 1
Self-citation
Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitus
Surendran, S., & Kartha, C. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_15 · Cited by 1
Cellular and Molecular Mechanisms of Impaired Angiogenesis and Delayed Wound Healing in Type 2 Diabetes: Amelioration Using siRNA-Pluronic Acid-Based Technology
Bitar, M. S. (2017) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_44 · Cited by 1
Prospective Advances in Non-coding RNAs Investigation
Jan, M. I., Ali, T., Ishtiaq, A., Mushtaq, I., & Murtaza, I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1671-9_24 · Cited by 1
Peripheral Vascular Disease in Circulation and the Circulation Subspecialty Journals
Editors, T. (2012) · Circulation · doi:10.1161/circulationaha.112.108464 · Cited by 1
MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment
Barb, I., Vogel, B., Katus, H. A., & Meder, B. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_13 · Cited by 1
Plasma microRNAs as Biomarkers of Human Diseases
Ćuk, K., Madhavan, D., Turchinovich, A. A., & Burwinkel, B. (2013) · Wiley eBooks · doi:10.1002/9781118695999.ch23 · Cited by 1
The impact of lncRNAs MIR503HG, TTN-AS1, and FEZF1-AS1 and their association with miR-107 expression in type 2 diabetes mellitusPreprint
Abedi, Z., Salehi, Z., Zaersabet, M., Sojoudi, K., Mashayekhi, F., & Motamed, B. (2024) · Research Square · doi:10.21203/rs.3.rs-3753374/v1 · Cited by 1
Circulating Nucleic Acids and Diabetes Mellitus
Butt, A., & Swaminathan, R. (2014) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-94-017-9168-7_9
MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
Kucharzewska, P. (2011)
Reprogramação fenotípica por excesso de glicocorticoides: participação de micro-RNAs no desenvolvimento hepático e possíveis repercussões na vida adulta.
Pantaleão, L. C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2015.tde-01062015-162513
MicroRNAs in Vascular Remodeling and Repair
Howard, L., Caporali, A., Shantikumar, S., & Emanueli, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00023-x
Self-citation
from right ventricular hypertrophy to failure Dynamic microRNA expression during the transition
Ghosh, Z., Rajagopalan, V., Wu, J. C., Bernstein, D., Reddy, S., Zhao, M., Hu, D., Fajardo, G., Hu, S., Tang, H., et al. (2015)
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type
Maskomani, S., Armugam, A., & Jeyaseelan, K. (2014)
IDENTIFICATION OF BIOMARKERS FOR THE ASSESSMENT OF FARM RUMINANT HEALTH STATUS
Dilda, F. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/dilda-francesca_phd2013-02-07
Perfil de expressão de microRNAs circulantes após uma sessão aguda de exercício em indivíduos com doença arterial periférica: papel da N-acetilcisteína
Júnior, N. D. D. S. (2016) · doi:10.11606/t.5.2016.tde-06092016-151124
MicroRNAs in Diabetes and Its Vascular Complications
Shantikumar, S., Rovira‐Llopis, S., Spinetti, G., & Emanueli, C. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-52945-5_3
Self-citation
Genetic Basis for Increased Risk for Vascular Diseases in Diabetes
Bharadwaj, D., & Singh, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_2
Cellular And Molecular Insight Into Autonomic Function And Dysfunction
Wu, Y. (2022) · Digital Archive @ GSU · doi:10.57709/12426547
Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis
Zhu, H., & Fan, G. (2013) · CRC Press eBooks · doi:10.1201/b14663-13
The role of muscle-enriched microRNAs as markers of failed myocardial reperfusion
Lima, C., & Anselmo, J. (2019)
p75(NTR)-dependent activation of NF-B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia
Besnier, L. (2016)
Adventitial and Skeletal Muscle Pericytes in Health and Ischemic Tissue Regeneration
Rampin, A., Campagnolo, P., Mastrullo, V., Madeddu, P. R., & Spinetti, G. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-62129-2_11
Self-citation
Vésicules extracellulaires et maladies cardiovasculaires
Coly, P., & Loyer, X. (2021) · médecine/sciences · doi:10.1051/medsci/2021204 · Cited by 1
Circulation Editors’ Picks
Editors, T. (2013) · Circulation · doi:10.1161/circulationaha.113.007431
Circulation Editors' Picks
Editors, T. (2012) · Circulation · doi:10.1161/circulationaha.112.145292
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
Samak, M. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9776
Role of MicroRNAs in Vascular Remodeling and Repair
Ben‐Aicha, S., Caporali, A., Srivastava, P. K., & Emanueli, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00017-x
Self-citation
Transplantation of induced endothelial progenitor-like cells pretreated with Defined Factors promotes Diabetic Wound HealingPreprint
Cheng, F., Zhang, Y., Jiang, Q., Du, F., Pan, C., Ye, Y., Zhang, L., Su, D., Ren, Y., Zhao, P., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2940133/v1
MicroRNA modulation in metabolic syndrome: A novel insight into cardiometabolic diseases
Kumar, S., Li, L., & Gupta, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00010-4
The role of therapeutic MicroRNA in arteriogenesis process in limb ischemia: A systematic review
Ismail, M. T., Anggrahini, D. W., Haryana, S. M., & Setianto, B. Y. (2024) · F1000Research · doi:10.12688/f1000research.147482.1 · Cited by 1
Interação gene-dieta em camundongos suplementados com metionina nos períodos fetal e pós-natal: estudos de instabilidade genômica, metilação e expressão de genes relacionados com doenças cardiovasculares
Aissa, A. F. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2014.tde-02072024-102344
Poly(amidoamine)-based dendrimers for biomedical applications
Beena, M., Ramesh, P., & Palaniappan, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95233-0.00017-0
From Injury to Recovery: The Role of miRNAs in Wound Healing
Sachan, M., & Feinberg, M. W. (2025) · Springer eBooks · doi:10.1007/978-3-031-93677-7_1
MiRNA Profiling in Premalignant Lesions and Early Glottic Cancer
Rzepakowska, A., Zajkowska, A., Mękarska, M., Śladowska, J., Borowy, A., & Małecki, M. (2025) · Cancers · doi:10.3390/cancers17172883
Bridging miRNA Research with Clinical Applications in Cardiovascular Diseases: Advances in Delivery Systems and Therapeutic Strategies
He, S., & Li, X. (2025) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575420982251027053329
Additional file 1 of Identification of biomarkers associated with metabolic cardiovascular disease using mRNA-SNP-miRNA regulatory network analysis
Fan, Z., Peng, W., Wang, Z., Zhang, L., & Liu, K. (2021) · Figshare · doi:10.6084/m9.figshare.15047695
Multiomics of Peripheral Artery Disease
Sherafati, A., & Kullo, I. J. (2026) · Springer eBooks · doi:10.1007/978-3-031-82232-2_106
Intérêt de CD146 soluble dans le préconditionnement des progéniteurs endothéliaux issus de sang périphérique : application chez des patients atteints d'ischémie critique des membres
Essaadi, A. (2017) · theses.fr (ABES) · doi:10.70675/8db94be5zcbd2z4d54z938bz1266f37d3116
Cardiovascular Dysfunction in Type 2 Diabetes: The Role of MicroRNAs
Kayki‐Mutlu, G., & Arioglu-Inan, E. (2026) · Handbook of experimental pharmacology · doi:10.1007/164_2026_799
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation
Spanos, M., Gokulnath, P., Behera, G., Azzam, C., & Das, S. (2026) · Circulation Research · doi:10.1161/circresaha.126.327198
Exosomal lncRNA PVT1 from adipose-derived stem cell aggravates myocardial injury through CDC25A/PI3Kγ/NF-κB pathway under high glucose condition
Cheng, F., Lian, S., Li, J., & Zhong, Y. (2026) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2026.102721
Environment, Epigenetic Changes, and Cardiovascular Damage
Paneni, F., & Cosentino, F. (2015) · Springer eBooks · doi:10.1007/978-3-319-17762-5_4

Authors: Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., Agami, R., le Sage, C., Condorelli, G., Madeddu, P., Martelli, F., & Emanueli, C.
Affiliations: The Netherlands Cancer Institute (NL)
From the Regenerative Medicine (A.C., M.M., R.A., P.M., C.E.) and Vascular Biology (G.B.S.-N.) sections, School of Clinical Science, University of Bristol, Bristol, UK; IRCCS-Policlinico San Donato, Milan, Italy (C.V.), Italian Higher Institute of Health, Rome, Italy (D.B.); IRCCS-MultiMedica, Milan, Italy (G.S., S.L., G.C.); British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK (R.M., A.H.B.); Netherlands Cancer Institute, Amsterdam, the Netherlands (R...
ORCID: Caporali, Andrea
Meloni, Marco
Addis, Roberta
Spinetti, Gaia
Baker, Andrew H.
Agami, Reuven
Condorelli, Gianluigi
Madeddu, Paolo
Martelli, Fabio
Emanueli, Costanza
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-01-25
Volume: 123
Issue: 3
Pages: 282-291
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.110.952325
OpenAlex: W2112849743
Cited by: 397
References: 30
Citations by year: 2026: 6 · 2025: 9 · 2024: 9 · 2023: 16 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 28 · 2018: 39 · 2017: 30 · 2016: 29 · 2015: 37 · 2014: 37 · 2013: 40 · 2012: 35
FWCI: 15.34
Type: journal article
Language: en
Open access: green
www.openaccessrepository.it
Licence: other-oa
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Explore Bristol Research (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders: British Heart Foundation (PG/06/146/21946, BS/05/001, RG/09/005/27915)
University of Bristol
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Keywords: diabetes mellitus, endothelial dysfunction, critical limb ischemia, cyclin E1, CDC25A, high glucose, diabetic muscle, blood flow recovery, therapeutic target
MeSH terms: Animals, Biopsy, Cells, Cultured, Diabetes Mellitus, Experimental, Extremities, Glucose, Humans, Ischemia, Male, Mice, Inbred Strains, Umbilical Veins, Gene Expression, Muscle, Skeletal, Neovascularization, Physiologic, cdc25 Phosphatases, MicroRNAs, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks