Inflammation of atrium after cardiac surgery is associated with inhomogeneity of atrial conduction and atrial fibrillation
Abstract
BACKGROUND: Atrial fibrillation (AF) is common after cardiac surgery. Abnormal conduction is an important substrate for AF. We hypothesized that atrial inflammation alters atrial conduction properties. METHODS AND RESULTS: Normal mongrel canines (n=24) were divided into 4 groups consisting of anesthesia alone (control group); pericardiotomy (pericardiotomy group); lateral right atriotomy (atriotomy group); and lateral right atriotomy with antiinflammatory therapy (methylprednisolone 2 mg/kg per day) (antiinflammatory group). Right atrial activation was examined 3 days after surgery. Inhomogeneity of conduction was quantified by the variation of maximum local activation phase difference. To initiate AF, burst pacing was performed. Myeloperoxidase activity and neutrophil cell infiltration in the atrial myocardium were measured to quantify the degree of inflammation. The inhomogeneity of atrial conduction of the atriotomy and pericardiotomy groups was higher than that of the control group (2.02+/-0.10, 1.51+/-0.03 versus 0.96+/-0.08, respectively; P<0.005). Antiinflammatory therapy decreased the inhomogeneity of atrial conduction after atriotomy (1.16+/-0.10; P<0.001). AF duration was longer in the atriotomy and pericardiotomy groups than in the control and antiinflammatory groups (P=0.012). There also were significant differences in myeloperoxidase activity between the atriotomy and pericardiotomy groups and the control group (0.72+/-0.09, 0.41+/-0.08 versus 0.18+/-0.03 DeltaOD/min per milligram protein, respectively; P<0.001). Myeloperoxidase activity of the antiinflammatory group was lower than that of the atriotomy group (0.17+/-0.02; P<0.001). Inhomogeneity of conduction correlated with myeloperoxidase activity (r=0.851, P<0.001). CONCLUSIONS: The degree of atrial inflammation was associated with a proportional increase in the inhomogeneity of atrial conduction and AF duration. This may be a factor in the pathogenesis of early postoperative AF. Antiinflammatory therapy has the potential to decrease the incidence of AF after cardiac surgery.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This high incidence has been related to inflammatory changes in the atrial myocardium, similar to experimental pericarditis animal models, and may be prevented by anti-inflammatory corticosteroid or colchicine treatment.
“This high incidence has been related to inflammatory changes in the atrial myocardium, 213 not unlike the experimental pericarditis animal models, and it may be prevented by anti-inflammatory corticosteroid or colchicine treatment.214”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [213]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity
Krawisz, J. E., Sharon, P., & Stenson, W. F. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90202-6 · Cited by 1,770 · see citing works
Inflammation as a risk factor for atrial fibrillation
Aviles, R. J., Martin, D. O., Apperson-Hansen, C., Houghtaling, P. L., Rautaharju, P., Kronmal, R. A., Tracy, R. P., Van Wagoner, D. R., Psaty, B. M., Lauer, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103131.70301.4f · Cited by 1,425 · see citing works
C-Reactive Protein Elevation in Patients With Atrial Arrhythmias
Chung, M. K., Martin, D. O., Sprecher, D. L., Wazni, O. M., KANDERIAN, A. S., Carnes, C. A., Bauer, J. A., TCHOU, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,375 · see citing works
A multicenter risk index for atrial fibrillation after cardiac surgery
Mathew, J. P. (2004) · JAMA · doi:10.1001/jama.291.14.1720 · Cited by 1,234 · see citing works
Predictors of Atrial Fibrillation After Coronary Artery Surgery
Aranki, S. F., Shaw, D. P., Adams, D. H., Rizzo, R. J., Couper, G. S., VanderVliet, M., Collins, J. J., Cohn, L. H., & Burstin, H. R. (1996) · Circulation · doi:10.1161/01.cir.94.3.390 · Cited by 1,180 · see citing works
Hazards of postoperative atrial arrhythmias
Creswell, L. L., Schuessler, R. B., Rosenbloom, M., & Cox, J. L. (1993) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(93)90894-n · Cited by 995 · see citing works
Activation of the Complement System During and After Cardiopulmonary Bypass Surgery
Bruins, P., Velthuis, H. T., Yazdanbakhsh, A. P., Jansen, P. G. M., van Hardevelt, F. W. J., de Beaumont, E. M. F. H., Wildevuur, C. R. H., Eijsman, L., Trouwborst, A., & Hack, C. E. (1997) · Circulation · doi:10.1161/01.cir.96.10.3542 · Cited by 792 · see citing works
Atrial Fibrillation After Cardiac Surgery
Almassi, G. H., Schowalter, T., Nicolosi, A. C., Aggarwal, A., MORITZ, T. E., Henderson, W. G., Tarazi, R. Y., Shroyer, A. L., Sethi, G. K., Grover, F. L., et al. (1997) · Annals of Surgery · doi:10.1097/00000658-199710000-00011 · Cited by 711 · see citing works
MANSOUR, M. C., Mandapati, R., Berenfeld, O., Chen, J., Samie, F. H., & Jalife, J. (2001) · Circulation · doi:10.1161/01.cir.103.21.2631 · Cited by 379 · see citing works
Atrial fibrillation after coronary artery bypass grafting. Is it a disorder of the elderly?
Fuller, J. A., Adams, G. G., & Buxton, B. (1989) · PubMed · Cited by 319 · see citing works
Predictors of Atrial Fibrillation After Conventional and Beating Heart Coronary Surgery
Ascione, R., Caputo, M., Calori, G., Lloyd, C. T., Underwood, M. J., & Angelini, G. D. (2000) · Circulation · doi:10.1161/01.cir.102.13.1530 · Cited by 281 · see citing works
A perspective of postoperative atrial fibrillation in cardiac operations
Cox, J. L. (1993) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(93)90871-e · Cited by 258 · see citing works
Atrial fibrillation after coronary artery bypass grafting
Fuller, J. A., Adams, G. G., & Buxton, B. (1989) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34483-6 · Cited by 227 · see citing works
Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias
Lammers, W. J. E. P., Schalij, M. J., Kirchhof, C. J. H. J., & Allessie, M. A. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.4.h1254 · Cited by 165 · see citing works
Effects of single dose, postinduction dexamethasone on recovery after cardiac surgery
Yared, J., Starr, N. J., Torres, F. K., Bashour, C. A., Bourdakos, G., PIEDMONTE, M. R., Michener, J. A., Davis, J. A., & Rosenberger, T. E. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)01180-2 · Cited by 152 · see citing works
Fernandez-Cobo, M., Gingalewski, C. A., Drujan, D., & Maio, A. D. (1999) · Cytokine · doi:10.1006/cyto.1998.0422 · Cited by 120 · see citing works
Atrial fibrillation after beating heart surgery
Stamou, S. C., Dangas, G., Hill, P. C., Pfister, A. J., Dullum, M. K. C., Boyce, S. W., Bafi, A. S., Garcia, J. M., & Corso, P. J. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00829-8 · Cited by 108 · see citing works
The Effect of Dexamethasone on Side Effects after Coronary Revascularization Procedures
Shareafean, R., Rabbani, A., Soliemani, A., Hosainkhan, Z., & Abbaszadeh, M. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 95 · see citing works
Clinical Outcome of Patients Who Develop PAF After CABG Surgery
Kowey, P. R., STEBBINS, D., Igidbashian, L., Goldman, S., Sutter, F. P., Rials, S. J., & Marinchak, R. A. (2001) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2001.00191.x · Cited by 82 · see citing works
Atrial fibrillation after coronary artery bypass grafting without cardiopulmonary bypass
Siebert, J. (2000) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(00)00368-7 · Cited by 63 · see citing works
Electrophysiologic Effects of Interactions Between Activated Canine Neutrophils and Cardiac Myocytes
Hoffman, B. F., Feinmark, S. J., & GUO, S. (1997) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1997.tb01831.x · Cited by 55 · see citing works
Wang, Z., Feng, J., & Nattel, S. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)90845-f · Cited by 52 · see citing works
Arrhythmias Caused by Platelet Activating Factor
Hoffman, B. F., GUO, S., & Feinmark, S. J. (1996) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1996.tb00507.x · Cited by 48 · see citing works
Off-pump coronary artery bypass grafting does not decrease the incidence of atrial fibrillation
Salamon, T., Michler, R. E., Knott, K., & Brown, D. A. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04305-9 · Cited by 45 · see citing works
The closed heart MAZE: a nonbypass surgical technique
Lee, R., Nitta, T., Schuessler, R. B., Johnson, D. C., Boineau, J. P., & Cox, J. L. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)00268-4 · Cited by 36 · see citing works
Modifications of Human Cardiac Sodium Channel Gating by UVA Light
Wang, G. K., & Wang, S. Y. (2002) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1010-z · Cited by 20 · see citing works
Recombinant interleukin-2 acts like a class I antiarrhythmic drug on human cardiac sodium channels
Proebstle, T. M., Mitrovics, M., Schneider, M. P., Hombach, V., & R�del, R. (1995) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00704150 · Cited by 17 · see citing works
TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia
Mehta, J. L., Nichols, W. W., Schofield, R. S., Donnelly, W. H., & Chandna, V. K. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.5.h1402 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,119 · see citing works
Inflammation and the pathogenesis of atrial fibrillation
Hu, Y., Chen, Y., Lin, Y., & Chen, S. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.2 · Cited by 1,101 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 785 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 782 · see citing works
Mechanisms, Prevention, and Treatment of Atrial Fibrillation After Cardiac Surgery
Echahidi, N., Pîbarot, P., O’Hara, G. E., & Mathieu, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.043 · Cited by 678 · see citing works
Postoperative atrial fibrillation: mechanisms, manifestations and management
Dobrev, D., Aguilar, M., Heijman, J., Guichard, J.-B., & Nattel, S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0166-5 · Cited by 623 · see citing works
Post-operative atrial fibrillation: a maze of mechanisms
Maesen, B. A. E., Nijs, J., Maessen, J. G., Allessie, M. A., & Schotten, U. (2011) · EP Europace · doi:10.1093/europace/eur208 · Cited by 456 · see citing works
Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease
Ndrepepa, G. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.022 · Cited by 452 · see citing works
Postoperative atrial fibrillation following cardiac surgery: a persistent complication
Greenberg, J. W., Lancaster, T. S., Schuessler, R. B., & Melby, S. J. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx039 · Cited by 432 · see citing works
Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation
Imazio, M., Brucato, A. L., Ferrazzi, P., Pullara, A., Adler, Y., Barosi, A., Caforio, A. L. P., Cemin, R., Chirillo, F., Comoglio, C., et al. (2014) · JAMA · doi:10.1001/jama.2014.11026 · Cited by 359 · see citing works
Colchicine Reduces Postoperative Atrial Fibrillation
Imazio, M., Brucato, A. L., Ferrazzi, P., Rovere, M. E., Gandino, A., Cemin, R., Ferrua, S., Belli, R., Maestroni, S., Simon, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.026153 · Cited by 333 · see citing works
Savelieva, I., Kakouros, N., Kourliouros, A., & Camm, A. J. (2011) · EP Europace · doi:10.1093/europace/eur002 · Cited by 311 · see citing works
Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation
Heijman, J., Muna, A. P., Veleva, T., Molina, C. E., Sutanto, H., Tekook, M. A., Wang, Q., Abu-Taha, I., Gorka, M., Künzel, S. R., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316710 · Cited by 295 · see citing works
Postoperative atrial fibrillation: from mechanisms to treatment
Gaudino, M. F. L., Franco, A. D., Rong, L. Q., Piccini, J. P., & Mack, M. J. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad019 · Cited by 272 · see citing works
The Cox maze IV procedure: Predictors of late recurrence
Damiano, R. J., Schwartz, F. H., Bailey, M. S., Maniar, H. S., Munfakh, N. A., Moon, M. R., & Schuessler, R. B. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.08.067 · Cited by 252 · see citing works
Ho, K. M., & Tan, J. A. (2009) · Circulation · doi:10.1161/circulationaha.108.848218 · Cited by 245 · see citing works
Mechanisms of Atrial Fibrillation: Lessons From Animal Models
Nattel, S., Shiroshita-Takeshita, A., Brundel, B. J. J. M., & Rivard, L. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.06.002 · Cited by 243 · see citing works
Myeloperoxidase: A Leukocyte-Derived Protagonist of Inflammation and Cardiovascular Disease
Nußbaum, C., Klinke, A., Adam, M., Baldus, S. E., & Sperandio, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4783 · Cited by 196 · see citing works
Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases
Wang, W., & Kang, P. M. (2020) · Antioxidants · doi:10.3390/antiox9121292 · Cited by 192 · see citing works
Update on the Association of Inflammation and Atrial Fibrillation
PATEL, P., DOKAINISH, H., TSAI, P., & LAKKIS, N. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01774.x · Cited by 190 · see citing works
Wagoner, D. R. V. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31817f9398 · Cited by 188 · see citing works
Katritsis, D. G., Boriani, G., Cosio, F. G., Hindricks, G., Jaïs, P., Josephson, M. E., Keegan, R., Kim, Y.-H., Knight, B. P., Kuck, K.-H., et al. (2017) · Europace · doi:10.1093/europace/euw301 · Cited by 188 · see citing works
Atrial fibrillation following cardiac surgery: risk analysis and long-term survival
Helgadóttir, S., Sigurdsson, M. I., Ingvarsdóttir, I. L., Arnar, D. O., & Guðbjartsson, T. (2012) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-7-87 · Cited by 164 · see citing works
Red Cell Transfusion is Associated With an Increased Risk for Postoperative Atrial Fibrillation
Koch, C. G., Li, L., Wagoner, D. R. V., Duncan, A. I., Gillinov, A. M., & Blackstone, E. H. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.05.045 · Cited by 162 · see citing works
Inflammatory pathways underlying atrial fibrillation
Friedrichs, K. P., Klinke, A., & Baldus, S. E. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.05.007 · Cited by 161 · see citing works
Animal Models of Atrial Fibrillation
Schüttler, D., Bapat, A. C., Kääb, S., Lee, K., Tomsits, P., Clauß, S., & Hucker, W. J. (2020) · Circulation Research · doi:10.1161/circresaha.120.316366 · Cited by 163 · see citing works
Deftereos, S., Giannopoulos, G., Papoutsidakis, N., Panagopoulou, V., Kossyvakis, C., Raisakis, K., Cleman, M. W., & Stefanadis, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.726 · Cited by 161 · see citing works
Melduni, R. M., Schaff, H. V., Lee, H.-C., Gersh, B. J., Noseworthy, P. A., Bailey, K. R., Ammash, N. M., Cha, S. S., Fatema, K., Wysokiński, W. E., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.021952 · Cited by 151 · see citing works
Role of Inflammation in the Pathogenesis of Atrial Fibrillation
Ihara, K., & Sasano, T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.862164 · Cited by 146 · see citing works
Electroimmunology and cardiac arrhythmia
Grune, J., Yamazoe, M., & Nahrendorf, M. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00520-9 · Cited by 152 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 148 · see citing works
Gawalko, M. M., Agbaedeng, T. A., Saljic, A., Müller, D. N., Wilck, N., Schnabel, R. B., Penders, J., Rienstra, M., Gelder, I. C. V., Jespersen, T., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab292 · Cited by 144 · see citing works
Chen, M., Chang, J., Liu, W., Yang, C., Chen, Y., Tsai, T., Wang, Y., & Pan, K. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.038 · Cited by 128 · see citing works
Cardiac Fibrosis and Arrhythmogenesis
Nguyen, M., Kiriazis, H., Gao, X., & Du, X. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160046 · Cited by 151 · see citing works
Pokushalov, E. A., Kozlov, B. N., Romanov, A. B., Григорьевич, С. А., Афгановна, Б. С., Sergeevichev, D., Bogachev-Prokophiev, A. V., Иванович, Ж. С., Shipulin, V. M., Ломиворотов, В. В., et al. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003199 · Cited by 114 · see citing works
Kallergis, E. M., Manios, E. G., Kanoupakis, E. M., Mavrakis, H. E., Kolyvaki, S., Lyrarakis, G., Chlouverakis, G., & Vardas, P. E. (2007) · Heart · doi:10.1136/hrt.2006.108688 · Cited by 113 · see citing works
Heidarsdottir, R., Arnar, D. O., Skúladóttir, G. V., Torfason, B., Edvardsson, V. O., Gottskálksson, G., Pálsson, R., & Indridason, Ó. S. (2010) · EP Europace · doi:10.1093/europace/eup429 · Cited by 112 · see citing works
Huang, Z., Chen, X., Qian, C., Dong, Q., Ding, D., Wu, Q., Li, J., Wang, H., Li, W., Xie, Q., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003396 · Cited by 112 · see citing works
Romanov, A. B., Pokushalov, E. A., Ponomarev, D., Афгановна, Б. С., Шабанов, В. В., Losik, D., Геннадьевич, С. И., Анатольевич, Е. Д., Mikheenko, I., Григорьевич, С. А., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.08.019 · Cited by 110 · see citing works
Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs
Shiroshita-Takeshita, A., Brundel, B. J. J. M., Lavoie, J., & Nattel, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.028 · Cited by 108 · see citing works
Anderson, E. J., Efird, J. T., Davies, S. W., O’Neal, W. T., Darden, T. M., Thayne, K. A., Katunga, L. A., Kindell, L. C., Ferguson, T. B., Anderson, C. A., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000713 · Cited by 108 · see citing works
Postoperative Inflammatory Reaction and Atrial Fibrillation: Simple Correlation or Causation?
Anselmi, A., Possati, G., & Gaudino, M. F. L. (2009) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.01.031 · Cited by 104 · see citing works
Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease
Luan, Y., Guo, Y., Li, S., Yu, B., Zhu, S., Li, S., Li, N., Tian, Z., Peng, C., Cheng, J., et al. (2010) · EP Europace · doi:10.1093/europace/euq321 · Cited by 102 · see citing works
Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation
Lin, C., & Pan, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7408-8 · Cited by 100 · see citing works
Source of inflammatory markers in patients with atrial fibrillation
Liuba, I., Ahlmroth, H., Jonasson, L., Englund, A., Jonsson, A., Säfström, K., & Walfridsson, H. (2008) · EP Europace · doi:10.1093/europace/eun111 · Cited by 99 · see citing works
2024 EACTS Guidelines on perioperative medication in adult cardiac surgery
Jeppsson, A., (Sweden), (.-C., Rocca, B., (Italy), (.-C., Hansson, E. C., (Sweden), Guðbjartsson, T., (Iceland), James, S. K., (Sweden), et al. (2024) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezae355 · Cited by 107 · see citing works
Sandler, N., Kaczmarek, E., Itagaki, K., Zheng, Y. Z., Otterbein, L. E., Khabbaz, K. R., Liu, D., Senthilnathan, V., Gruen, R. L., & Hauser, C. J. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.02.014 · Cited by 97 · see citing works
Pinho-Gomes, A. C., Reilly, S., Brandes, R. P., & Casadei, B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5542 · Cited by 94 · see citing works
Fibrosis in Atrial Fibrillation – Role of Reactive Species and MPO
Friedrichs, K. P., Baldus, S. E., & Klinke, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00214 · Cited by 92 · see citing works
Pericardial Blood as a Trigger for Postoperative Atrial Fibrillation After Cardiac Surgery
St-Onge, S., Perrault, L. P., Demers, P., Boyle, E. M., Gillinov, A. M., Cox, J., & Melby, S. J. (2017) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2017.07.045 · Cited by 94 · see citing works
Savelieva, I., Kourliouros, A., & Camm, A. J. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0468-y · Cited by 92 · see citing works
Statins and polyunsaturated fatty acids for treatment of atrial fibrillation
Savelieva, I., & Camm, A. J. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1038 · Cited by 92 · see citing works
Inflammation and C-Reactive Protein in Atrial Fibrillation: Cause or Effect?
Galea, R., Cardillo, M. T., Caroli, A., Marini, M. G., Sonnino, C., Narducci, M. L., & Biasucci, L. M. (2014) · Texas Heart Institute Journal · doi:10.14503/thij-13-3466 · Cited by 90 · see citing works
The role of immune cells in atrial fibrillation
Liu, Y., Shi, Q., Ma, Y., & Liu, Q. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.09.007 · Cited by 87 · see citing works
Role of inflammation in atrial fibrillation: A comprehensive review of current knowledge
Nso, N., Bookani, K. R., Metzl, M. D., & Radparvar, F. (2020) · Journal of Arrhythmia · doi:10.1002/joa3.12473 · Cited by 87 · see citing works
Protective Effects of Steroids in Cardiac Surgery: A Meta-Analysis of Randomized Double-Blind Trials
Cappabianca, G., Rotunno, C., Schinosa, L. D. L. T., Ranieri, V. M., & Paparella, D. (2010) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2010.03.015 · Cited by 84 · see citing works
Rezaei, Y., Peighambari, M. M., Naghshbandi, S., Samiei, N., Ghavidel, A. A., Dehghani, M. R., Haghjoo, M., & Hosseini, S. (2019) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-019-00365-1 · Cited by 80 · see citing works
Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis
Woldendorp, K., Farag, J., Khadra, S. M., Black, D. A., Robinson, B. M., & Bannon, P. G. (2020) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2020.10.055 · Cited by 80 · see citing works
Atrial fibrillation post cardiac bypass surgery
Mostafa, A., El-Haddad, M. A., Shenoy, M. H., & Tuliani, T. A. (2012) · Avicenna Journal of Medicine · doi:10.4103/2231-0770.102280 · Cited by 79 · see citing works
Gu, J. F., Liu, X., Wang, X., Shi, H., Tan, H., Zhou, L., Gu, J., Jiang, W., & Wang, Y. (2011) · EP Europace · doi:10.1093/europace/eur131 · Cited by 80 · see citing works
Chen, D., Lin, C., Chen, Y., & Chen, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165601 · Cited by 80 · see citing works
The Blinding Period Following Ablation Therapy for Atrial Fibrillation
Gottlieb, L. A., Dekker, L., & Coronel, R. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.01.011 · Cited by 80 · see citing works
Goudis, C. A., Kallergis, E. M., & Vardas, P. E. (2012) · EP Europace · doi:10.1093/europace/eur398 · Cited by 77 · see citing works
Novel Approaches for Pharmacological Management of Atrial Fibrillation
Ehrlich, J. R., & Nattel, S. (2009) · Drugs · doi:10.2165/00003495-200969070-00001 · Cited by 73 · see citing works
Oxidant and Inflammatory Mechanisms and Targeted Therapy in Atrial Fibrillation
Gutiérrez, A., & Wagoner, D. R. V. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000313 · Cited by 74 · see citing works
Cox-Maze IV Results for Patients With Lone Atrial Fibrillation Versus Concomitant Mitral Disease
Saint, L. L., Bailey, M. S., Prasad, S. M., Guthrie, T. J., Bell, J. M., Moon, M. R., Lawton, J. S., Munfakh, N. A., Schuessler, R. B., Damiano, R. J., et al. (2012) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.12.028 · Cited by 72 · see citing works
Postoperative atrial fibrillation is not correlated to C-reactive protein
Ahlsson, A. J., Bodin, L., Lundblad, O. H., & Englund, A. G. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.11.047 · Cited by 68 · see citing works
Nattel, S., Sager, P. T., Hüser, J., Heijman, J., & Dobrev, D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab093 · Cited by 63 · see citing works
Postoperative atrial fibrillation: The role of the inflammatory response
Ishii, Y., Schuessler, R. B., Gaynor, S. L., Hames, K. Y., & Damiano, R. J. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.12.051 · Cited by 66 · see citing works
Sandesara, C. M., Chung, M. K., Wagoner, D. R. V., Barringer, T. A., Allen, K. B., Ismail, H. M., Zimmerman, B. M., & Olshansky, B. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.111.000547 · Cited by 65 · see citing works
Pericardial Effusion Provoking Atrial Fibrillation After Cardiac Surgery
Gaudino, M. F. L., Franco, A. D., Rong, L. Q., Cao, D., Pivato, C. A., Soletti, G. J., Chadow, D., Cancelli, G., Perezgrovas‐Olaria, R., Gillinov, M., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.04.029 · Cited by 65 · see citing works
Management of postoperative atrial fibrillation
Omae, T., & Kanmura, Y. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1330-9 · Cited by 61 · see citing works
Baker, W. L., White, C. M., Kluger, J., Denowitz, A., Konecny, C. P., & Coleman, C. I. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.11.026 · Cited by 61 · see citing works
Atrial fibrillation post cardiac surgery trends toward management
Alqahtani, A. (2010) · Heart Views · doi:10.4103/1995-705x.73212 · Cited by 61 · see citing works
Circulating Biomarkers Predictive of Postoperative Atrial Fibrillation
Turagam, M. K., Mirza, M., Werner, P., Sra, J. S., Kress, D. C., Tajik, A. J., & Jahangir, A. (2015) · Cardiology in Review · doi:10.1097/crd.0000000000000059 · Cited by 60 · see citing works
Brain natriuretic peptide and risk of atrial fibrillation after thoracic surgery
Amar, D., Zhang, H., Shi, W., Downey, R. J., Bains, M. S., Park, B. J., Flores, R. M., Rizk, N. P., Thaler, H. T., & Rusch, V. W. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.06.051 · Cited by 59 · see citing works
Rodrigo, R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00093 · Cited by 59 · see citing works
Miceli, A., Fino, C., Fiorani, B., Yeatman, M. F., Narayan, P., Angelini, G. D., & Caputo, M. (2009) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.03.041 · Cited by 58 · see citing works
Kjølbye, A. L., Haugan, K., Hennan, J. K., & Petersen, J. S. (2007) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00123.x · Cited by 58 · see citing works
Cardiac surgery as a stressor and the response of the vulnerable older adult
Neupane, I., Arora, R. C., & Rudolph, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.04.019 · Cited by 58 · see citing works
Mayyas, F., Sakurai, S., Ram, R., Rennison, J. H., Hwang, E.-S., Castel, L., Lovano, B. S., Brennan, M., Bibus, D. M., Lands, B., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq380 · Cited by 57 · see citing works
Zhao, Y., Sun, Q., Zeng, Z., Li, Q., Zhou, S., Zhou, M., Xue, Y., Cheng, X. C., Xia, Y., Wang, Q. K., et al. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0179-x · Cited by 57 · see citing works
Rossman, E. I., Liu, K., Morgan, G. A., Swillo, R. E., Krueger, J. A., Gardell, S. J., Butera, J. A., Gruver, M., Kantrowitz, J., Feldman, H. S., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.150102 · Cited by 56 · see citing works
Zhang, Z., Zhang, C., Wang, H., Zhao, J., Liu, L., Lee, J., He, Y., & Zheng, Q. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.024 · Cited by 54 · see citing works
Kramer, P. A., Chacko, B. K., Ravi, S., Johnson, M. S., Mitchell, T., Barnes, S., Arabshahi, A., Dell’Italia, L. J., George, D. J., Steele, C. H., et al. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.144 · Cited by 54 · see citing works
Fontes, M. L., Amar, D., Kulak, A., Koval, K. W., Zhang, H., Shi, W., & Thaler, H. T. (2009) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2009.01.030 · Cited by 51 · see citing works
Horbach, S., Lópes, R. D., Guaragna, J. C. V. D. C., Martini, F., Mehta, R. H., Petracco, J. B., Bodanese, L. C., Filho, A. C., Cirenza, C., & de Paola, Â. A. V. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.07.026 · Cited by 49 · see citing works
Impact of Dietary Fatty Acids on Cardiac Arrhythmogenesis
Rennison, J. H., & Wagoner, D. R. V. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.880773 · Cited by 49 · see citing works
Song, H., Hwang, H. J., Chang, W., Song, B., Cha, M., Kim, I., Lim, S., Choi, E. J., Ham, O., Lee, C. Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015873107 · Cited by 47 · see citing works
Surgical treatment of atrial fibrillation: an updated review
Pinho‐Gomes, A., Amorim, M. J., Oliveira, S. M., & Leite-Moreira, A. F. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezt584 · Cited by 44 · see citing works
Cardiology: Post-Cardiothoracic Surgery Atrial Fibrillation: A Review of Preventive Strategies
Baker, W. L., & White, C. M. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h594 · Cited by 43 · see citing works
Critical inflammatory mechanisms underlying arrhythmias
Vonderlin, N., Siebermair, J., Kaya, E., Köhler, M., Rassaf, T., & Wakili, R. (2019) · Herz · doi:10.1007/s00059-019-4788-5 · Cited by 41 · see citing works
Stack, J. R., Ryan, J., & McCarthy, G. (2013) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000433937.07244.e1 · Cited by 41 · see citing works
Sood, N. A., Coleman, C. I., Kluger, J., White, C. M., Padala, A., & Baker, W. L. (2008) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2008.06.009 · Cited by 41 · see citing works
Tabbalat, R. A., Alhaddad, I. A., Hammoudeh, A. J., Khader, Y. S., Khalaf, H. A., Obaidat, M., & Barakat, J. (2020) · Journal of International Medical Research · doi:10.1177/0300060520939832 · Cited by 40 · see citing works
Obesity and atrial fibrillation
Abed, H. S., & Wittert, G. (2013) · Obesity Reviews · doi:10.1111/obr.12056 · Cited by 41 · see citing works
Inflammation and arrhythmias: potential mechanisms and clinical implications
Lewek, J., Kaczmarek, K. A., Cygankiewicz, I., Wranicz, J. K., & Ptaszynski, P. A. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.942286 · Cited by 39 · see citing works
Nojiri, T., Yamamoto, K., Maeda, H., Takeuchi, Y., Funakoshi, Y., Inoue, M., & Okumura, M. (2011) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2011.09.003 · Cited by 39 · see citing works
Pharmacological strategies for prevention of postoperative atrial fibrillation
Turagam, M. K., Downey, F. X., Kress, D. C., Sra, J. S., Tajik, A. J., & Jahangir, A. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2015.1018182 · Cited by 39 · see citing works
Chen, W., Liu, H., Ling, Z., Xu, Y., Fan, J., Du, H., Xiao, P., Su, L., Liu, Z., Lan, X., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156121 · Cited by 40 · see citing works
- Authors
- Ishii, Y., Schuessler, R. B., Gaynor, S. L., Yamada, K., Fu, A. S., Boineau, J. P., & Damiano, R. J.
- Affiliations
- From the Divisions of Cardiothoracic Surgery (Y.I., R.B.S., S.L.G., A.S.F., J.P.B., R.J.D.) and Pathology (K.Y.), Washington University School of Medicine, St Louis, Mo.
- Washington University in St. Louis (US)
- ORCID
- Damiano, Ralph J.
- Venue
- Circulation
- Published
- 2005-06-07
- Volume
- 111
- Issue
- 22
- Pages
- 2881-2888
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1994401913
- Cited by
- 319
- References
- 28
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 12 · 2023: 19 · 2022: 18 · 2021: 20 · 2020: 18 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 23 · 2015: 16 · 2014: 15 · 2013: 12 · 2012: 28
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL032257)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, atrial inflammation, postoperative atrial arrhythmia, cardiac surgery, pericardiotomy, right atriotomy, methylprednisolone, anti-inflammatory therapy, myeloperoxidase, neutrophil infiltration, canine model, atrial substrate, burst pacing, atrial activation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Atrial Fibrillation, Dogs, Electrophysiology, Heart Atria, Heart Conduction System, Cardiac Surgical Procedures, Inflammation, Peroxidase, Postoperative Complications, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
