Angiogenic Factors and the Risk of Adverse Outcomes in Women With Suspected Preeclampsia

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1. Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction
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2. Prediction of preeclampsia and induced delivery at <34 weeks gestation by sFLT-1 and PlGF in patients with abnormal midtrimester uterine Doppler velocimetry: a prospective cohort analysis
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3. The sFlt-1/PlGF ratio associates with prolongation and adverse outcome of pregnancy in women with (suspected) preeclampsia: analysis of a high-risk cohort
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4. Diagnostic Biomarkers in Women With Suspected Preeclampsia in a Prospective Multicenter Study
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5. Personalized Nutrition Approach in Pregnancy and Early Life to Tackle Childhood and Adult Non-Communicable Diseases
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6. Proposed clinical management of pregnancies after combined screening for pre‐eclampsia at 35–37 weeks' gestation
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7. Real-world evidence for the utility of serum soluble fms-like tyrosine kinase 1/placental growth factor test for routine clinical evaluation of hospitalized women with hypertensive disorders of pregnancy
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8. Placental Growth Factor as a Prognostic Tool in Women With Hypertensive Disorders of Pregnancy
   Ugochinyere Vivian Ukah, Jennifer A. Hutcheon, Beth A. Payne, Matthew D. Haslam, Manu Vatish, J. Mark Ansermino, Helen L Brown, Laura Ann Magee, Peter von Dadelszen · 2017 · Hypertension
9. Parental ethnicity and placental maternal vascular malperfusion pathology in healthy nulliparous women
   Melanie C. Audette, Khrystyna Levytska, Stephen James Lye, Nir Melamed, John C. Kingdom · 2018 · Placenta
10. Prenatal Clinical Assessment of sFlt-1 (Soluble fms-like Tyrosine Kinase-1)/PlGF (Placental Growth Factor) Ratio as a Diagnostic Tool for Preeclampsia, Pregnancy-induced Hypertension, and Proteinuria
    H Lehnen, N. Mosblech, Thorsten Reineke, A. Puchooa, I Menke-Möllers, Ulrich Zechner, Ulrich Gembruch · 2013 · Geburtshilfe und Frauenheilkunde
11. Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction
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12. Treatment of very preterm preeclampsia via heparin-mediated extracorporeal LDL-precipitation (H.E.L.P.) apheresis: The Freiburg preeclampsia H.E.L.P.-Apheresis study
    K. Elise Winkler, Christine Contini, B. König, Bärbel Krumrey, Gerhard Pütz, Stefan Zschiedrich, Ulrich Pecks, Dimitria Stavropoulou, H Prömpeler, Mirjam Kunze et al. · 2018 · Pregnancy Hypertension
13. VEGF (Vascular Endothelial Growth Factor) Functionalized Magnetic Beads in a Microfluidic Device to Improve the Angiogenic Balance in Preeclampsia
    Laura Trapiella‐Alfonso, Lucile Alexandre, Camille Fraichard, Kelly Pons, Simon Dumas, Lucie Huart, Jean‐François Gaucher, Marylise Hébert-Schuster, Jean Guibourdenche, Thierry Fournier et al. · 2019 · Hypertension
14. Early Detection of Maternal Risk for Preeclampsia
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15. Analysis of changes in maternal circulating angiogenic factors throughout pregnancy for the prediction of preeclampsia
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16. Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors
    Tinnakorn Chaiworapongsa, Roberto J. Romero, Nardhy Gomez‐Lopez, Manaphat Suksai, Dahiana Marcela Gallo, Eunjung Jung, Stanley M. Berry, Awoniyi Olumide Awonuga, Adi Laurentiu Tarca, David R. Bryant · 2023 · American Journal of Obstetrics and Gynecology
17. Addition of N‐terminal pro‐B natriuretic peptide to soluble fms‐like tyrosine kinase‐1/placental growth factor ratio > 38 improves prediction of pre‐eclampsia requiring delivery within 1 week: a longitudinal cohort study
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18. Preeclampsia and the anaesthesiologist: current management
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19. Maternal and Perinatal Outcomes Associated With Extremely High Values for the sFlt‐1 (Soluble fms‐Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio
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20. sFlt ‐1/ PlGF ratio as a predictive and prognostic marker for preeclampsia
    Hae Rin Jeon, Dahoe Jeong, Jin‐Young Lee, Eun Young Woo, Gwi Taek Shin, Suk‐Young Kim · 2021 · Journal of obstetrics and gynaecology research
21. The additive role of angiogenic markers for women with confirmed preeclampsia
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22. The expression of serum sEGFR, sFlt-1, sEndoglin and PLGF in preeclampsia
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23. Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
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24. Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia
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25. Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia – the PreOS study protocol
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26. Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation
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27. A Balancing Act: Navigating Hypertensive Disorders of Pregnancy at Very Advanced Maternal Age, from Preconception to Postpartum
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28. Phenotype‐Directed Management of Hypertension in Pregnancy
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29. DREAM Mediated Regulation of GCM1 in the Human Placental Trophoblast
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30. Performance of soluble fms-like tyrosine kinase-1–to–placental growth factor ratio of ≥85 for ruling in preeclampsia within 4 weeks
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31. HIV Associated Preeclampsia: A Multifactorial Appraisal
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32. Cardiovascular Biomarkers in Preeclampsia at Triage
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33. Serum protein marker panel for predicting preeclampsia
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34. The sFlt-1/PlGF ratio values within the <38, 38–85 and >85 brackets as compared to perinatal outcomes
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35. Prediction of adverse maternal outcomes of early severe preeclampsia
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36. Gestational Age-Specific Reference Ranges for the sFlt-1/PlGF Immunoassay Ratio in Twin Pregnancies
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37. Why Do Some Recovered Peripartum Cardiomyopathy Mothers Experience Heart Failure With a Subsequent Pregnancy?
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38. Development of pre-eclampsia within 4 weeks of sFlt-1/PlGF ratio > 38: comparison of performance at 31-34vs35-37 weeks' gestation
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39. Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy: a systematic review and meta-analysis
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40. In Vivo Experiments Reveal the Good, the Bad and the Ugly Faces of sFlt-1 in Pregnancy
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42. A more accurate prediction to rule in and rule out pre-eclampsia using the sFlt-1/PlGF ratio and NT-proBNP as biomarkers
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43. Risk Prediction for Peripartum Cardiomyopathy in Delivering Mothers: A Validated Risk Model
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44. sFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsia
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45. Maternal serum soluble fms‐like tyrosine kinase‐1 at 12, 22, 32 and 36 weeks' gestation in screening for pre‐eclampsia
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46. A case-based narrative review of pregnancy-associated atypical hemolytic uremic syndrome/complement-mediated thrombotic microangiopathy
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47. PlGF in a clinical setting of pregnancies at risk of preeclampsia and/or intrauterine growth restriction
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48. Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia
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49. Translation of mechanistic advances in preeclampsia to the clinic: Long and winding road
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50. Systems biology of the microvasculature
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51. Comparison of screening for pre-eclampsia at 31-34 weeks' gestation by sFlt-1/PlGF ratio and a method combining maternal factors with sFlt-1 and PlGF
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52. Role of sFlt-1/PlGF ratio and feto-maternal Doppler for the prediction of adverse perinatal outcome in late-onset pre-eclampsia
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53. sFlt-1/PlGF ratio for the prediction of delivery within 48 hours and adverse outcomes in expectantly managed early-onset preeclampsia
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54. Angiogenic factors alone or in combination with ultrasound Doppler criteria for risk classification among late‐onset small fetuses with or without pre‐eclampsia
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55. Soluble endoglin versus sFlt-1/PlGF ratio: detection of preeclampsia, HELLP syndrome, and FGR in a high-risk cohort
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56. Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia
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57. Prediction of severe pre‐eclampsia/HELLP syndrome by combination of sFlt‐1, CT‐pro‐ET‐1 and blood pressure: exploratory study
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58. A new approach to the preeclampsia puzzle; MicroRNA-326 in CD4+ lymphocytes might be as a potential suspect
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59. Evidence for extraplacental sources of circulating angiogenic growth effectors in human pregnancy
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60. Accuracy of Soluble Endoglin for Diagnosis of Preeclampsia and its Severity
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61. Antiangiogenic factors and maternal hemodynamics during intensive hemodialysis in pregnancy
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62. Simvastatin Alleviates Pathology in a Rat Model of Preeclampsia Involving ERK/MAPK Pathway
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63. Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction
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64. Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia
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65. Angiogenic factor abnormalities and risk of peripartum complications and prematurity among urban predominantly obese parturients with chronic hypertension
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66. Placental growth factor and fetoplacental Doppler indices in combination predict preterm birth reliably in pregnancies complicated by fetal growth restriction
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67. Protein Profiling of Preeclampsia Placental Tissues
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68. The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia
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69. Analysis of patents on preeclampsia detection and diagnosis: A perspective
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70. An intermediate sFlt-1/PlGF ratio indicates an increased risk for adverse pregnancy outcome
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71. The sFlt-1/PlGF ratio as a triage tool to identify superimposed preeclampsia in women with chronic hypertension in emergency rooms
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72. Ischemic placental syndrome – prediction and new disease monitoring
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73. Characterization of Antibody Specificities Associated With Preeclampsia
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74. Role of vitamin D and sFlt-1/PlGF ratio in the development of early- and late-onset preeclampsia
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75. Imaging of Headache in Pregnancy
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76. Early Fetal Growth Restriction with or Without Hypertensive Disorders: a Clinical Overview
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77. Adipsin of the Alternative Complement Pathway Is a Potential Predictor for Preeclampsia in Early Pregnancy
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78. A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study
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79. Inhibition of intrarenal PRR-RAS pathway by Ganoderma lucidum polysaccharide peptides in proteinuric nephropathy.
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80. Plasma soluble fms-like tyrosine kinase 1 to placental growth factor ratio of 11.5 multiples of median predicts preeclampsia with severe features within 2 weeks of testing
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81. Fibroblast VEGF ‐receptor 1 expression as molecular target in periodontitis
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82. Alterations in fibrin formation and fibrinolysis in early onset-preeclampsia: Association with disease severity
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83. Urinary and Serum Angiogenic Markers in Women With Preexisting Diabetes During Pregnancy and Their Role in Preeclampsia Prediction
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84. Current Approaches and Innovations in Managing Preeclampsia: Highlighting Maternal Health Disparities
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85. Pl GF enhances TLR ‐dependent inflammatory responses in human mononuclear phagocytes
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86. Correlation of Kryptor and Elecsys® immunoassay sFlt-1/PlGF ratio on early diagnosis of preeclampsia and fetal growth restriction: A case-control study
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87. Animal Models of Cardiovascular Complications of Pregnancy
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88. Bioflavonoid luteolin prevents sFlt ‐1 release via HIF ‐1α inhibition in cultured human placenta
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89. Prediction of preterm birth in growth‐restricted and appropriate‐for‐gestational‐age infants using maternal PlGF and the sFlt ‐1/ PlGF ratio—A prospective study
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90. Discoveries in peripartum cardiomyopathy
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91. Maternal Immune System and State of Inflammation Dictate the Fate and Severity of Disease in Preeclampsia
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92. Reduced angiogenic factor expression in intrauterine fetal growth restriction using semiquantitative immunohistochemistry and digital image analysis
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93. Improving the Prediction of Preeclampsia
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94. Angiogenic and antiangiogenic markers for prediction and risk classification of preeclampsia
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95. Urinary placental growth factor in preeclampsia and fetal growth restriction: An alternative to circulating biomarkers?
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96. Evaluation of the Prognostic Value of the sFlt-1/PlGF Ratio in Early-Onset Preeclampsia
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97. Association Between Endothelial Nitric Oxide Synthase (eNOS) −786 T/C and 27-bp VNTR 4b/a Polymorphisms and Preeclampsia Development
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