Angiogenic and antiangiogenic markers for prediction and risk classification of preeclampsia
Abstract
Preeclampsia is a pregnancy-specific hypertensive disorder with multisystem involvement and is a significant cause of obstetric morbidity and mortality worldwide. A major issue in the treatment of preeclampsia stems from its still significant rates of misclassification and misdiagnosis. Angiogenic factors have been speculated as a possible diagnostic modality due to a perceived imbalance in angiogenesis in preeclampsia. Factors currently studied include soluble fms-like protein kinase 1 and placental growth factor. Because of significant mortality associated with preeclampsia it is felt that both early and accurate diagnosis of preeclampsia is imperative if this disease process is to be treated.
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The increase of sVEGFR-1 causes a parallel decrease of maternal plasma concentrations of PlGF in preeclampsia.
“The increase of sVEGFR-1 causes a parallel decrease of maternal plasma concentrations of PIGF in preeclampsia(119, 143–150).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [150]
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- Authors
- MALSHE, A. K., & SIBAI, B. M.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Venue
- Clinical Obstetrics & Gynecology
- Published
- 2017-03
- Volume
- 60
- Issue
- 1
- Pages
- 134-140
- ISSN
- 0009-9201 (ISSN-L)
- OpenAlex
- W2568775363
- Cited by
- 18
- References
- 38
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- preeclampsia, angiogenic biomarkers, soluble fms-like tyrosine kinase-1, placental growth factor, risk classification, preeclampsia diagnosis, hypertensive disorders of pregnancy
- MeSH terms
- Placenta Growth Factor, Female, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Proteins, Biomarkers, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Receptor-1
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