The DOI matches its Crossref record, with a small difference in title or year; 37 of the 38 references it cites were found in a registry or an index.
Net Clinical Benefit of Warfarin in Patients With Atrial Fibrillation: A Report From the Swedish Atrial Fibrillation Cohort Study
Open accessAbstract
Background—: Known risk factors for bleeding during anticoagulant treatment are largely the same as those predicting thromboembolic events in patients with atrial fibrillation (AF). Our objective was to investigate how to maximize the likelihood of avoiding both stroke and bleeding. Methods and Results—: All 182 678 subjects with atrial fibrillation in the Swedish Hospital Discharge Register were studied for an average of 1.5 years (260 000 patient-years at risk). Patients were stratified according to risk scores with the use of historic International Classification of Disease diagnostic codes in the register. Information about medication was obtained from the Swedish Drug Registry. Our primary end point was net benefit defined as number of avoided ischemic strokes with anticoagulation minus the number of excess intracranial bleedings with a weight of 1.5 to compensate for the generally more severe outcome with intracranial bleedings. The adjusted net clinical benefit favored anticoagulation for almost all atrial fibrillation patients. The exceptions were patients at very low risk of ischemic stroke with a CHA 2 DS 2 -VASc score of 0 and moderately elevated bleeding risk (−1.7%/y). The results were broadly similar with CHADS 2 , except for patients with very low embolic risk; the CHA 2 DS 2 -VASc was able to identify those patients (n=6205, 3.9% of all patients) who had no net clinical benefit or even some disadvantage from anticoagulant treatment. Conclusions—: In almost all patients with atrial fibrillation, the risk of ischemic stroke without anticoagulant treatment is higher than the risk of intracranial bleeding with anticoagulant treatment. Analysis of the net benefit indicates that more patients may benefit from anticoagulant treatment.
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“this issue was addressed by instead performing a thorough cost accounting from 2 specific exemplar interventions.30,31”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [30]
Citations
Cites
Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430
Apixaban versus warfarin in patients with atrial fibrillation
Granger, C. B., Alexander, J. H., McMurray, J. J. V., Lopes, R. D., Hylek, E. M., Hanna, M., Al-Khalidi, H. R., Ansell, J., Atar, D., Avezum, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107039 · Cited by 8,943
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879
Self-citationGuidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,954
Self-citationExternal review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793
Pisters, R., Lane, D. A., Nieuwlaat, R., de Vos, C. B., Crijns, H. J. G. M., & Lip, G. Y. H. (2010) · CHEST Journal · doi:10.1378/chest.10-0134 · Cited by 4,517
Self-citationApixaban in patients with atrial fibrillation
Connolly, S. J., Eikelboom, J., Joyner, C., Diener, H.-C., Hart, R., Golitsyn, S., Flaker, G., Avezum, A., Hohnloser, S. H., Diaz, R., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007432 · Cited by 2,483 · cited 3×
“Frequent falls, n (%) 9294 (10) 2647 (4) 0.”
Self-citationStroke Prevention in Atrial Fibrillation Study. Final results.
Prevention, S., & Atrial Fibrillation Investigators (1991) · Circulation · doi:10.1161/01.cir.84.2.527 · Cited by 1,696
Mant, J., Hobbs, F. R., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., & Murray, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61233-1 · Cited by 1,556 · cited 1×
“COPD/emphysema, n (%) 7555 (8) 4619 (7) 0.”
Self-citationOlesen, J. B., Lip, G. Y. H., Hansen, M. L., Hansen, P. R., Tolstrup, J. S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.-M. S., Gislason, G. H., et al. (2011) · BMJ · doi:10.1136/bmj.d124 · Cited by 1,428
Self-citationCanadian atrial fibrillation anticoaguiation (CAFA) study
Connolly, S. J., Laupacis, A., Gent, M., Roberts, R. S., Cairns, J. A., & Joyner, C. D. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90585-w · Cited by 1,109
Lip, G. Y. H., Frison, L., Halperin, J. L., & Lane, D. A. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.024 · Cited by 1,077
Self-citationHylek, E. M., Evans‐Molina, C., Shea, C., Henault, L. E., & Regan, S. (2007) · Circulation · doi:10.1161/circulationaha.106.653048 · Cited by 1,063
The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N., & Go, A. S. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00003 · Cited by 655
Independent predictors of stroke in patients with atrial fibrillation
The Stroke Risk in Atrial Fibrillation Working Group (2007) · Neurology · doi:10.1212/01.wnl.0000267275.68538.8d · Cited by 545
Wan, Y., Heneghan, C., Perera, R., Roberts, N., Hollowell, J., Glasziou, P., Bankhead, C., & Xu, Y. (2008) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.108.796185 · Cited by 514
Bleeding During Antithrombotic Therapy in Patients With Atrial Fibrillation
(1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.4.409 · Cited by 436
Lip, G., Lindhardsen, J., Lane, D., Ahlehoff, O., Hansen, M., Raunsø, J., Tolstrup, J., Hansen, P., Gislason, G., Torp-Pedersen, C., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0364 · Cited by 428
Self-citationThe Validity of a Diagnosis of Heart Failure in a Hospital Discharge Register
Ingelsson, E., Ärnlöv, J., Sundström, J., & Lind, L. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.12.007 · Cited by 417
Cairns, J. A., Connolly, S. J., McMurtry, S., Stephenson, M., & Talajic, M. R. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.007 · Cited by 285
Smith, J. G., Platonov, P. G., Hedblad, B., Engström, G., & Melander, O. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-009-9404-1 · Cited by 275
van Staa, T. P., Setakis, E., Tanna, G. L. D., Lane, D. A., & Lip, G. Y. H. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04085.x · Cited by 273
Self-citationWieloch, M., Själander, A., Frykman, V., Rosenqvist, M., Eriksson, N., & Svensson, P. J. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr134 · Cited by 261
Self-citationStroke Risk in Atrial Fibrillation Working Group (2008) · Stroke · doi:10.1161/strokeaha.107.501825 · Cited by 242
Sjöblom, L., Hårdemark, H., Lindgren, A., Norrving, B. G., Fahlén, M., Samuelsson, M., Stigendal, L., Stockelberg, D., Taghavi, A., Wallrup, L., et al. (2001) · Stroke · doi:10.1161/hs1101.098523 · Cited by 228
Bleeding with anticoagulation therapy – Who is at risk, and how best to identify such patients
Cosmi, B., & Palareti, G. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-11-0730 · Cited by 224
Stroke prophylaxis in atrial fibrillation: who gets it and who does not?
Friberg, L., Hammar, N., Ringh, M., Pettersson, H., & Rosenqvist, M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl146 · Cited by 175
Self-citation(1994) · PubMed · Cited by 167
Recent time trends in acute myocardial infarction in Stockholm, Sweden
Linnersjö, A., Hammar, N., Gustavsson, A., & Reuterwall, C. (2000) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00366-1 · Cited by 77
Warfarin and intracranial haemorrhage
Appelboam, R., & Thomas, E. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.05.001 · Cited by 55
Tennvall, G. R., Apelqvist, J., & Eneroth, M. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00748.x · Cited by 39
Frost, L., Andersen, L. V., Vestergaard, P., Husted, S., & Mortensen, L. S. (2006) · Neuroepidemiology · doi:10.1159/000092795 · Cited by 37
Research works printed but not linked: 1
- 10.1001/archinte.1996.00440040081009 · DOI
Cited by
Sorted by citations
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · EP Europace · doi:10.1093/europace/eus305 · Cited by 3,823
Self-citationJoglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A. M., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001193 · Cited by 3,145
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs253 · Cited by 2,929
Self-citationEpidemiology of atrial fibrillation: European perspective
Zoni-Berisso, M., Lercari, F., Carazza, T., & Domenicucci, S. (2014) · Clinical Epidemiology · doi:10.2147/clep.s47385 · Cited by 1,275
Campbell, B. C. V., & Khatri, P. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31179-x · Cited by 1,197
Metadata
- Authors
- Friberg, L., Rosenqvist, M., & Lip, G. Y. H.
- Affiliations
- Birmingham City Hospital (GB)
- Danderyds sjukhus (SE)
- Venue
- Circulation
- Published
- 2012-05-15
- Volume
- 125
- Issue
- 19
- Pages
- 2298-2307
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2165762371
- Cited by
- 454
- References
- 38
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 9 · 2023: 14 · 2022: 16 · 2021: 28 · 2020: 31 · 2019: 33 · 2018: 26 · 2017: 30 · 2016: 57 · 2015: 50 · 2014: 54 · 2013: 57 · 2012: 24
- FWCI
- 38.08
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- atrial fibrillation, warfarin, anticoagulation, net clinical benefit, ischemic stroke, intracranial hemorrhage, CHA2DS2-VASc score, CHADS2 score, stroke risk stratification, bleeding risk, hospital discharge registry
- MeSH terms
- Aged, Anticoagulants, Atrial Fibrillation, Cerebral Hemorrhage, Female, Follow-Up Studies, Humans, Male, Middle Aged, Registries, Risk Factors, Sweden, Warfarin, Cohort Studies, Incidence, Stroke, Intracranial Embolism
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